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COVID-19 in a mosaic trisomy 13 patient with polycystic kidney disease
Ost, Natalie K. Minchew, Heather M. Garcia, Andrew Ganatra, Hammad A.
Ost, Natalie K.
Minchew, Heather M.
Garcia, Andrew
Ganatra, Hammad A.
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Abstract
Presentation, management, and outcomes of COVID-19 infections among younger patients is an area of medicine with deficits in research, likely due to the lower incidence of severe COVID-19 disease among the younger population. Management can be challenging, and clinicians often guide their decision-making based on the ever-changing protocols that are tailored mostly to the elderly population. Even more underrepresented in COVID-19 research are patients with chromosomal abnormalities and trisomy syndromes, as they appear less frequently, but have risk of increased morbidity and mortality due to underlying medical conditions. We describe a case of severe COVID-19 infection in a young patient with mosaic trisomy 13 and pre-existing polycystic kidney disease, who developed severe acute hypoxic respiratory failure and acute chronic kidney injury. The patient was provided maximal pharmacological support and her clinical course helps to shape the understanding of COVID-19 infections in the setting of chromosomal abnormalities and complex medical history.
Description
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
Date
2022-08-17
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SAGE Publications
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Keywords
COVID-19, Trisomy 13, Mosaic, Patau syndrome, Polycystic kidney disease
Citation
Ost NK, Minchew HM, Garcia A, Ganatra HA. COVID-19 in a mosaic trisomy 13 patient with polycystic kidney disease. SAGE Open Medical Case Reports. 2022;10. doi:10.1177/2050313X221118732