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Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans
Cao, Pengxiu Yuan, Yiyuan Pehek, Elizabeth A. Moise, Alexander R. Huang, Ying Palczewski, Krzysztof Feng, Zhaoyang
Cao, Pengxiu
Yuan, Yiyuan
Pehek, Elizabeth A.
Moise, Alexander R.
Huang, Ying
Palczewski, Krzysztof
Feng, Zhaoyang
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Abstract
Disruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human α-synuclein in C. elegans results in dopaminergic neuron degeneration, the effects of α-synuclein on dopamine homeostasis and its contribution to dopaminergic neuron degeneration in C. elegans have not been reported. Here, we examined the effects of α-synuclein overexpression on worm dopamine homeostasis. We found that α-synuclein expression results in upregulation of dopamine synthesis and content, and redistribution of dopaminergic synaptic vesicles, which significantly contribute to dopaminergic neuron degeneration. These results provide in vivo evidence supporting a critical role for dopamine homeostasis in supporting dopaminergic neuron integrity.
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This is the publisher's version, also available electronically from http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009312
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2010-02-19
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Public Library of Science
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Cao, Penxiu et al. (2010). Alpha-Synuclein Disrupted Dopamine Homeostasis Leads to Dopaminergic Neuron Degeneration in Caenorhabditis elegans. PLOS One 5(2):e9312. http://www.dx.doi.org/10.1371/journal.pone.0009312