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Fluorescent Mimics of Cholesterol that Rapidly Bind Surfaces of Living Mammalian Cells
Hymel, David ; Cai, Sutang ; Henkhaus, Rebecca S. ; Perera, Chamani ; Peterson, Blake R.
Hymel, David
Cai, Sutang
Henkhaus, Rebecca S.
Perera, Chamani
Peterson, Blake R.
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Abstract
Mammalian cells acquire cholesterol, a critical membrane constituent, through multiple mechanisms. We synthesized mimics of cholesterol, fluorescent N-alkyl-3β-cholesterylamine-glutamic acids, that are rapidly incorporated into cellular plasma membranes compared with analogous cholesteryl amides, ethers, esters, carbamates, and a sitosterol analogue. This process was inhibited by ezetimibe, indicating a receptor-mediated uptake pathway.
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2016-10-07
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Royal Society of Chemistry
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Hymel, David, Sutang Cai, Qi Sun, Rebecca S. Henkhaus, Chamani Perera, and Blake R. Peterson. "Fluorescent Mimics of Cholesterol That Rapidly Bind Surfaces of Living Mammalian Cells." Chem. Commun. 51.78 (2015): 14624-4627.