Pharmacy, School of: Recent submissions
Now showing items 41-60 of 411
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The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
(MDPI, 2018-09-18)This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate ... -
Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects
(Frontiers Media, 2018-09-28)A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well ... -
Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice
(Elsevier, 2019-02-20)Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of the ... -
Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice
(Nature Research, 2019-03-13)Here we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parallel fiber ... -
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network
(Frontiers Media, 2019-06-26)Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked ... -
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae
(BMC, 2019-08-06)Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular ... -
The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function
(MDPI, 2020-05-24)Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function. This modification is regulated ... -
Extracellular vesicles: Novel communicators in lung diseases
(BMC, 2020-07-08)The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which ... -
Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
(BMC, 2020-08-02)Background The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-3 ... -
TOMM40 ‘523 associations with baseline and longitudinal cognition in APOEε3 homozygotes
(IOS Press, 2019-08-20)TOMM40 ‘523 is associated with Alzheimer’s disease (AD), but APOE linkage disequilibrium confounds this association. In 170 APOE ε3 homozygotes, we evaluated relationships between short and very long TOMM40 alleles and ... -
Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
(MDPI, 2019-11-19)The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown strong and explicit cancer cell-selectivity, which results in little toxicity toward normal tissues, and has been recognized as a potential, ... -
NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression
(Frontiers Media, 2019-11-08)The arginine vasopressin 1b receptor (Avpr1b) plays an important role in social behaviors including aggression, social learning and memory. Genetic removal of Avpr1b from mouse models results in deficits in aggression and ... -
Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation
(Spandidos Publications, 2019-09-23)Berberine (BBR) is the main component of Coptidis rhizoma, the dried rhizome of Coptis chinensis and is a potential plant alkaloid used for the treatment of cancer due to its high antitumor activity. The present study ... -
Bioenergetic Regulation of Neuronal Vacuolar-type H+- ATPase
(University of Kansas, 2019-12-31)Neuronal vacuolar-type H+-ATPase (V-ATPase) is an ATP-dependent proton pump that functions to acidify intracellular organelles such as lysosomes and synaptic vesicles, creating a proton gradient by which neurotransmitters ... -
Receptor for advanced glycation endproducts (RAGE) modulates glyoxalase-1 enzyme activity in mouse models.
(University of Kansas, 2019-12-31)Alzheimer’s disease (AD) is the most common cause of dementia in the world. AD is characterized pathologically by the presence of Amyloid-β (Aβ) plaques and tau neurofibrillary tangles (NFTs). Advanced glycation endproducts ... -
Respiratory chain deficiency alters cellular proteostasis and triggers Alzheimer’s disease-like tau alterations
(University of Kansas, 2019-12-31)Sporadic Alzheimer’s disease (AD) is defined clinically as a progressive brain disorder resulting in memory loss and, eventually, an inability to perform simple tasks. Pathologically, AD brains accumulate insoluble protein ... -
Role of Autophagy in Alcohol-induced Adipose Atrophy and Liver Injury
(University of Kansas, 2018-12-31)Alcoholic liver disease (ALD) is a worldwide health issue claiming 2 million lives per year. The pathogenesis of ALD is characterized by steatosis, alcoholic hepatitis, fibrosis, cirrhosis, and eventually hepatocellular ... -
The Role of Mitochondrial ATP-Binding Cassette Transporter ABCB6 in Metabolism and Energy Balance
(University of Kansas, 2019-05-31)Abstract Obesity and the associated health risks represent a world-wide health and financial crisis. Lack of physical activity combined with excessive caloric intake are the root cause of the problem. Despite the increased ... -
MECHANISMS OF CYST GROWTH AND FIBROSIS IN CONGENITAL HEPATIC FIBROSIS IN AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE
(University of Kansas, 2018-08-31)Autosomal recessive polycystic kidney disease (ARPKD) is a rare genetic disorder that occurs in 1:20,000 live births. Patients present with a broad spectrum of symptoms involving the kidneys, liver, and pancreas. Renal ... -
A Longitudinal View of How Noise-Induced Hearing Loss Impacts Auditory and Non- Auditory CNS Activity and the Relationship to Tinnitus Behavior
(University of Kansas, 2018-08-31)Tinnitus, defined as the perception of sound when no corresponding external sound is present, affects 50 million people in the United States with 2 million reporting decreased quality of life. Although the etiology of ...