Pharmacy, School of: Recent submissions
Now showing items 21-40 of 411
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Discovery of sultam-containing small-molecule disruptors of the huntingtin–calmodulin protein–protein interaction
(Springer, 2020-06-12)The aberrant protein–protein interaction between calmodulin and mutant huntingtin protein in Huntington’s disease patients has been found to contribute to Huntington’s disease progression. A high-throughput screen for small ... -
Clusterin: A multifaceted protein in the brain
(Medknow Publications, 2020-12-12) -
Synaptic Loss in Alzheimer's Disease: Mechanistic Insights Provided by Two-Photon in vivo Imaging of Transgenic Mouse Models
(Frontiers Media, 2020-12-21)Synapse loss is the strongest correlate for cognitive decline in Alzheimer's disease. The mechanisms underlying synapse loss have been extensively investigated using mouse models expressing genes with human familial ... -
TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics
(MDPI, 2021-02-04)Alzheimer’s disease (AD) is a lethal neurodegenerative disorder primarily affecting the aged population. The etiopathogenesis of AD, especially that of the sporadic type, remains elusive. The triggering receptor expressed ... -
Mitochondrial Permeability Transition: A Pore Intertwines Brain Aging and Alzheimer’s Disease
(MDPI, 2021-03-15)Advanced age is the greatest risk factor for aging-related brain disorders including Alzheimer’s disease (AD). However, the detailed mechanisms that mechanistically link aging and AD remain elusive. In recent years, a ... -
Editorial: Synaptic Loss and Neurodegeneration
(Frontiers Media, 2021-04-21) -
Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis
(Springer Nature, 2021-05-05)Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess ... -
Glycolytic Metabolism, Brain Resilience, and Alzheimer’s Disease
(Frontiers Media, 2021-04-28)Alzheimer’s disease (AD) is the most common form of age-related dementia. Despite decades of research, the etiology and pathogenesis of AD are not well understood. Brain glucose hypometabolism has long been recognized as ... -
Resveratrol Derivative, Trans-3, 5, 4-Trimethoxystilbene Sensitizes Osteosarcoma Cells to Apoptosis via ROS-Induced Caspases Activation
(Hindawi, 2021-03-26)Numerous studies have shown that resveratrol can induce apoptosis in cancer cells. Trans-3, 5, 4-trimethoxystilbene (TMS), a novel derivative of resveratrol, is a more potent anticancer compound than resveratrol and can ... -
Sialometabolism in Brain Health and Alzheimer’s Disease
(Nature Research, 2021-03-30)Sialic acids refer to a unique family of acidic sugars with a 9-carbon backbone that are mostly found as terminal residues in glycan structures of glycoconjugates including both glycoproteins and glycolipids. The highest ... -
Editorial: The Oxytocin System in Fear, Stress, Anguish, and Pain
(Frontiers Media, 2021-07-20) -
Identification of adverse drug-drug interactions through causal association rule discovery from spontaneous adverse event reports
(Elsevier, 2017-02-10)Objective Drug-drug interaction (DDI) is of serious concern, causing over 30% of all adverse drug reactions and resulting in significant morbidity and mortality. Early discovery of adverse DDI is critical to prevent patient ... -
A nationwide survey of pharmacy students’ knowledge and perceptions regarding medical cannabis
(Elsevier, 2019-08-28)Objective The primary objective of this study was to compare knowledge and perceptions of medical cannabis (MC) between pharmacy students who attended schools where MC was legal and illegal. Design A nationwide anonymous ... -
Impact of community pharmacist intervention on concurrent benzodiazepine and opioid prescribing patterns
(Elsevier, 2018-10-17)Objectives (1) To evaluate the number of opioid/benzodiazepine (BZD) prescription changes resulting from pharmacist communication to prescriber(s); (2) to determine the number of patients on concurrent opioid/BZD therapy ... -
Development of a Unique Student Pharmacist Internship in a Primary Care Provider System
(MDPI, 2019-04-13)Purpose: To describe a unique pharmacy intern program in a group of federally qualified health center (FQHC) outpatient primary care provider clinics. Summary: A pharmacy intern program was created at the North Central ... -
In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons
(POL Scientific, 2019-07-04)Agouti-related peptide (AgRP) neurons of the hypothalamus play a role in hunger-triggered food intake, stability of body weight, and long-term energy balance. A recent study showed that activation of the Gs-linked G ... -
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae
(BMC, 2019-08-06)Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular ... -
The Steroidogenesis Inhibitor Finasteride Reduces the Response to Both Stressful and Rewarding Stimuli
(MDPI, 2019-11-19)Finasteride (FIN) is the prototypical inhibitor of steroid 5α-reductase (5αR), the enzyme that catalyzes the rate-limiting step of the conversion of progesterone and testosterone into their main neuroactive metabolites. ... -
Selenium and the Methionine Sulfoxide Reductase System
(MDPI, 2009-07-01)Selenium is a chemical element participating in the synthesis of selenocysteine residues that play a pivotal role in the enzymatic activity efficiency of selenoproteines. The methionine sulfoxide reductase (Msr) system ... -
In vivo measurement of enhanced agouti-related peptide release in the paraventricular nucleus of the hypothalamus through Gs activation of agouti-related peptide neurons
(POL Scientific, 2019-07-04)Agouti-related peptide (AgRP) neurons of the hypothalamus play a role in hunger-triggered food intake, stability of body weight, and long-term energy balance. A recent study showed that activation of the Gs-linked G ...