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dc.contributor.authorVidoniI, Eric D.
dc.contributor.authorMorris, Jill K.
dc.contributor.authorPalmer, Jacqueline A.
dc.contributor.authorLi, Yanming
dc.contributor.authorWhite, Dreu
dc.contributor.authorKueck, Paul J.
dc.contributor.authorJohn, Casey S.
dc.contributor.authorHonea, Robyn A.
dc.contributor.authorLepping, Rebecca J.
dc.contributor.authorLee, Phil
dc.contributor.authorMahnken, Jonathan D.
dc.contributor.authorMartin, Laura E.
dc.contributor.authorBillinger, Sandra A.
dc.identifier.citationVidoni ED, Morris JK, Palmer JA, Li Y, White D, Kueck PJ, et al. (2022) Dementia risk and dynamic response to exercise: A non-randomized clinical trial. PLoS ONE 17(7): e0265860.
dc.descriptionA grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see
dc.description.abstractBackground Physical exercise may support brain health and cognition over the course of typical aging. The goal of this nonrandomized clinical trial was to examine the effect of an acute bout of aerobic exercise on brain blood flow and blood neurotrophic factors associated with exercise response and brain function in older adults with and without possession of the Apolipoprotein epsilon 4 (APOE4) allele, a genetic risk factor for developing Alzheimer’s. We hypothesized that older adult APOE4 carriers would have lower cerebral blood flow regulation and would demonstrate blunted neurotrophic response to exercise compared to noncarriers.

Methods Sixty-two older adults (73±5 years old, 41 female [67%]) consented to this prospectively enrolling clinical trial, utilizing a single arm, single visit, experimental design, with post-hoc assessment of difference in outcomes based on APOE4 carriership. All participants completed a single 15-minute bout of moderate-intensity aerobic exercise. The primary outcome measure was change in cortical gray matter cerebral blood flow in cortical gray matter measured by magnetic resonance imaging (MRI) arterial spin labeling (ASL), defined as the total perfusion (area under the curve, AUC) following exercise. Secondary outcomes were changes in blood neurotrophin concentrations of insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and brain derived neurotrophic factor (BDNF).

Results Genotyping failed in one individual (n = 23 APOE4 carriers and n = 38 APOE4 non-carriers) and two participants could not complete primary outcome testing. Cerebral blood flow AUC increased immediately following exercise, regardless of APOE4 carrier status. In an exploratory regional analyses, we found that cerebral blood flow increased in hippocampal brain regions, while showing no change in cerebellum across both groups. Among high inter-individual variability, there were no significant changes in any of the 3 neurotrophic factors for either group immediately following exercise.

Conclusions Our findings show that both APOE4 carriers and non-carriers show similar effects of exercise-induced increases in cerebral blood flow and neurotrophic response to acute aerobic exercise. Our results provide further evidence that acute exercise-induced increases in cerebral blood flow may be regional specific, and that exercise-induced neurotrophin release may show a differential effect in the aging cardiovascular system. Results from this study provide an initial characterization of the acute brain blood flow and neurotrophin responses to a bout of exercise in older adults with and without this known risk allele for cardiovascular disease and Alzheimer’s disease.
dc.publisherPublic Library of Scienceen_US
dc.rights© 2022 Vidoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.titleDementia risk and dynamic response to exercise: A non-randomized clinical trialen_US
kusw.kuauthorVidoni, Eric D.
kusw.kuauthorMorris, Jill K.
kusw.kuauthorPalmer, Jacqueline A.
kusw.kuauthorLi, Yanming
kusw.kuauthorWhite, Dreu
kusw.kuauthorKueck, Paul J.
kusw.kuauthorJohn, Casey S.
kusw.kuauthorHonea, Robyn A.
kusw.kuauthorLepping, Rebecca J.
kusw.kuauthorLee, Phil
kusw.kuauthorMahnken, Jonathan D.
kusw.kuauthorMartin, Laura E.
kusw.kuauthorBillinger, Sandra A.
kusw.kudepartmentUniversity of Kansas Medical Centeren_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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© 2022 Vidoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.
Except where otherwise noted, this item's license is described as: © 2022 Vidoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.