Show simple item record

dc.contributor.authorVidoni, Eric D.
dc.contributor.authorMorris, Jill K.
dc.contributor.authorWatts, Amber
dc.contributor.authorPerry, Mark
dc.contributor.authorClutton, Jon
dc.contributor.authorvan Sciver, Angela
dc.contributor.authorKamat, Ashwini S.
dc.contributor.authorMahnken, Jonathan
dc.contributor.authorHunt, Suzanne L.
dc.contributor.authorTownley, Ryan
dc.contributor.authorHonea, Robyn
dc.contributor.authorShaw, Ashley R.
dc.contributor.authorJohnson, David K.
dc.contributor.authorVacek, James
dc.contributor.authorBurns, Jeffrey M.
dc.identifier.citationVidoni ED, Morris JK, Watts A, Perry M, Clutton J, Van Sciver A, et al. (2021) Effect of aerobic exercise on amyloid accumulation in preclinical Alzheimer’s: A 1-year randomized controlled trial. PLoS ONE 16(1): e0244893.
dc.description.abstractBackground Our goal was to investigate the role of physical exercise to protect brain health as we age, including the potential to mitigate Alzheimer’s-related pathology. We assessed the effect of 52 weeks of a supervised aerobic exercise program on amyloid accumulation, cognitive performance, and brain volume in cognitively normal older adults with elevated and sub-threshold levels of cerebral amyloid as measured by amyloid PET imaging.

Methods and findings This 52-week randomized controlled trial compared the effects of 150 minutes per week of aerobic exercise vs. education control intervention. A total of 117 underactive older adults (mean age 72.9 [7.7]) without evidence of cognitive impairment, with elevated (n = 79) or subthreshold (n = 38) levels of cerebral amyloid were randomized, and 110 participants completed the study. Exercise was conducted with supervision and monitoring by trained exercise specialists. We conducted 18F-AV45 PET imaging of cerebral amyloid and anatomical MRI for whole brain and hippocampal volume at baseline and Week 52 follow-up to index brain health. Neuropsychological tests were conducted at baseline, Week 26, and Week 52 to assess executive function, verbal memory, and visuospatial cognitive domains. Cardiorespiratory fitness testing was performed at baseline and Week 52 to assess response to exercise. The aerobic exercise group significantly improved cardiorespiratory fitness (11% vs. 1% in the control group) but there were no differences in change measures of amyloid, brain volume, or cognitive performance compared to control.

Conclusions Aerobic exercise was not associated with reduced amyloid accumulation in cognitively normal older adults with cerebral amyloid. In spite of strong systemic cardiorespiratory effects of the intervention, the observed lack of cognitive or brain structure benefits suggests brain benefits of exercise reported in other studies are likely to be related to non-amyloid effects.
dc.publisherPublic Library of Scienceen_US
dc.rights© 2021 Vidoni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License.en_US
dc.titleEffect of aerobic exercise on amyloid accumulation in preclinical Alzheimer’s: A 1-year randomized controlled trialen_US
kusw.kuauthorWatts, Amber
dc.identifier.orcid 0000-0002-8385-1091en_US
dc.identifier.orcid 0000-0003-3307-4949en_US
dc.identifier.orcid 0000-0001-9809-1737en_US
dc.identifier.orcid 0000-0002-3566-3969en_US
dc.identifier.orcid 0000-0003-3670-8054en_US
dc.identifier.orcid 0000-0001-7609-8954en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

Files in this item


This item appears in the following Collection(s)

Show simple item record