ATTENTION: The software behind KU ScholarWorks is being upgraded to a new version. Starting July 15th, users will not be able to log in to the system, add items, nor make any changes until the new version is in place at the end of July. Searching for articles and opening files will continue to work while the system is being updated.
If you have any questions, please contact Marianne Reed at mreed@ku.edu .
Predicting evolutionary change at the DNA level in a natural Mimulus population
dc.contributor.author | Monnahan, Patrick J. | |
dc.contributor.author | Colicchio, Jack | |
dc.contributor.author | Fishman, Lila | |
dc.contributor.author | Macdonald, Stuart J. | |
dc.contributor.author | Kelly, John K. | |
dc.date.accessioned | 2022-01-10T19:20:13Z | |
dc.date.available | 2022-01-10T19:20:13Z | |
dc.date.issued | 2021-01-13 | |
dc.identifier.citation | Monnahan, P. J., Colicchio, J., Fishman, L., Macdonald, S. J., & Kelly, J. K. (2021). Predicting evolutionary change at the DNA level in a natural Mimulus population. PLoS genetics, 17(1), e1008945. https://doi.org/10.1371/journal.pgen.1008945 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/32376 | |
dc.description.abstract | Evolution by natural selection occurs when the frequencies of genetic variants change because individuals differ in Darwinian fitness components such as survival or reproductive success. Differential fitness has been demonstrated in field studies of many organisms, but it remains unclear how well we can quantitatively predict allele frequency changes from fitness measurements. Here, we characterize natural selection on millions of Single Nucleotide Polymorphisms (SNPs) across the genome of the annual plant Mimulus guttatus. We use fitness estimates to calibrate population genetic models that effectively predict allele frequency changes into the next generation. Hundreds of SNPs experienced “male selection” in 2013 with one allele at each SNP elevated in frequency among successful male gametes relative to the entire population of adults. In the following generation, allele frequencies at these SNPs consistently shifted in the predicted direction. A second year of study revealed that SNPs had effects on both viability and reproductive success with pervasive trade-offs between fitness components. SNPs favored by male selection were, on average, detrimental to survival. These trade-offs (antagonistic pleiotropy and temporal fluctuations in fitness) may be essential to the long-term maintenance of alleles. Despite the challenges of measuring selection in the wild, the strong correlation between predicted and observed allele frequency changes suggests that population genetic models have a much greater role to play in forward-time prediction of evolutionary change. | en_US |
dc.publisher | Public Library of Science | en_US |
dc.rights | © 2021 Monnahan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.title | Predicting evolutionary change at the DNA level in a natural Mimulus population | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Monnahan, Patrick J. | |
kusw.kuauthor | Colicchio, Jack | |
kusw.kuauthor | Macdonald, Stuart J. | |
kusw.kuauthor | Kelly, John K. | |
kusw.kudepartment | Ecology and Evolutionary Biology | en_US |
kusw.kudepartment | Molecular Biosciences | en_US |
dc.identifier.doi | 10.1371/journal.pgen.1008945 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-3022-8191 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-9297-7403 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-7297-9049 | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0002-9421-002X | en_US |
dc.identifier.orcid | https://orcid.org/ 0000-0001-9480-1252 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC7837469 | en_US |
dc.rights.accessrights | openAccess | en_US |