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dc.contributor.authorWozniak, David F.
dc.contributor.authorValnegri, Pamela
dc.contributor.authorDearborn, Joshua T.
dc.contributor.authorFowler, Stephen C.
dc.contributor.authorBonni, Azad
dc.date.accessioned2020-11-24T20:53:34Z
dc.date.available2020-11-24T20:53:34Z
dc.date.issued2019-03-13
dc.identifier.citationWozniak, D. F., Valnegri, P., Dearborn, J. T., Fowler, S. C., & Bonni, A. (2019). Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice. Scientific reports, 9(1), 4379. https://doi.org/10.1038/s41598-019-40714-3en_US
dc.identifier.urihttp://hdl.handle.net/1808/30915
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractHere we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parallel fiber presynaptic boutons and functional parallel fiber/Purkinje cell synapses. We report that conditional UBC13 knockout mice exhibit reliable deficits on several gait-related variables when their velocity of ambulation is tightly controlled by a moving treadmill and by restricting space for movement. Selected gait parameters and movement patterns related to spontaneous exploration in an open field may also be affected in conditional UBC13 knockout mice. Analysis of open-field data as a function of test session half using force-plate actometer instrumentation suggest that conditional UBC13 knockout mice have alterations in emotionality, possibly affecting gait and movement variables. These findings suggest that conditional UBC13 knockout mice represent a valuable platform for assessing the effects of disturbances in cerebellar granule cell circuitry on gait and other aspects of locomotion. Also, the possibility that psychological factors such as altered emotionality may impact gait and movement patterns in these mice suggest that these mice may provide a useful model for evaluating analogous behavioral impairments in autism spectrum disorders and other neurodevelopmental syndromes associated with deregulation of ubiquitin signaling.en_US
dc.description.sponsorshipNIH NS051255en_US
dc.description.sponsorshipIntellectual and Developmental Disabilities Research Center at Washington University (NICHD U54 HD087011)en_US
dc.description.sponsorshipMathers Foundationen_US
dc.publisherNature Researchen_US
dc.rights© The Author(s) 2019en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.titleConditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in miceen_US
dc.typeArticleen_US
kusw.kuauthorFowler, Stephen C.
kusw.kudepartmentPharmacology and Toxicologyen_US
dc.identifier.doi10.1038/s41598-019-40714-3en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6416404en_US
dc.rights.accessrightsopenAccessen_US


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© The Author(s) 2019
Except where otherwise noted, this item's license is described as: © The Author(s) 2019