Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers

Modaresi, Saman; Pacelli, Settimio; Whitlow, Jonathan; Paul, Arghya

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Issue Date

2018-04-06

Author

Modaresi, Saman

Pacelli, Settimio

Whitlow, Jonathan

Paul, Arghya

Publisher

Royal Society of Chemistry

Type

Article

Article Version

Scholarly/refereed, author accepted manuscript

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Abstract

This study investigates the role of substrate stiffness on non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize hASCs expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.

Citation

Modaresi, S., Pacelli, S., Whitlow, J., & Paul, A. (2018). Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers. Nanoscale, 10(19), 8947–8952. http://doi.org/10.1039/c8nr01516c

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