Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers
Issue Date
2018-04-06Author
Modaresi, Saman
Pacelli, Settimio
Whitlow, Jonathan
Paul, Arghya
Publisher
Royal Society of Chemistry
Type
Article
Article Version
Scholarly/refereed, author accepted manuscript
Metadata
Show full item recordAbstract
This study investigates the role of substrate stiffness on non-viral transfection of human adipose-derived stem cells (hASCs) with the aim to maximize hASCs expression of vascular endothelial growth factor (VEGF). The results confirm the direct effect of substrate stiffness in regulating cytoskeletal remodeling and corresponding plasmid internalization.
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Citation
Modaresi, S., Pacelli, S., Whitlow, J., & Paul, A. (2018). Deciphering the role of substrate stiffness to enhance internalization efficiency of plasmid DNA in stem cells using lipid-based nanocarriers. Nanoscale, 10(19), 8947–8952. http://doi.org/10.1039/c8nr01516c
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