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dc.contributor.authorHammer, Michael J.
dc.contributor.authorBarlow, Steven M.
dc.contributor.authorLyons, Kelly E.
dc.contributor.authorPahwa, Rajesh
dc.identifier.citationHammer, M. J., Barlow, S. M., Lyons, K. E., & Pahwa, R. (2010). Subthalamic nucleus deep brain stimulation changes speech respiratory and laryngeal control in Parkinson’s disease. Journal of Neurology, 257(10), 1692–1702.
dc.description.abstractAdequate respiratory and laryngeal motor control are essential for speech, but may be impaired in Parkinson's disease (PD). Bilateral subthalamic nucleus deep brain stimulation (STN DBS) improves limb function in PD, but the effects on respiratory and laryngeal control remain unknown. We tested whether STN DBS would change aerodynamic measures of respiratory and laryngeal control, and whether these changes were correlated with limb function and stimulation parameters. Eighteen PD participants with bilateral STN DBS were tested within a morning session after a minimum of 12 h since their most recent dose of anti-PD medication. Testing occurred when DBS was on, and again 1 h after DBS was turned off, and included aerodynamic measures during syllable production, and standard clinical ratings of limb function. We found that PD participants exhibited changes with DBS, consistent with increased respiratory driving pressure (n = 9) and increased vocal fold closure (n = 9). However, most participants exceeded a typical operating range for these respiratory and laryngeal control variables with DBS. Changes were uncorrelated with limb function, but showed some correlation with stimulation frequency and pulse width, suggesting that speech may benefit more from low-frequency stimulation and shorter pulse width. Therefore, high-frequency STN DBS may be less beneficial for speech-related respiratory and laryngeal control than for limb motor control. It is important to consider these distinctions and their underlying mechanisms when assessing the impact of STN DBS on PD.en_US
dc.publisherSpringer Verlagen_US
dc.rights© Springer-Verlag 2010en_US
dc.subjectAir pressureen_US
dc.subjectAir flowen_US
dc.subjectHigh frequencyen_US
dc.subjectLaryngeal resistanceen_US
dc.titleSubthalamic nucleus deep brain stimulation changes speech respiratory and laryngeal control in Parkinson's diseaseen_US
kusw.kuauthorBarlow, Steven M.
kusw.oanotesPer SHERPA/RoMEO 5/24/2017: Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Author's pre-print on pre-print servers such as Author's post-print on author's personal website immediately Author's post-print on any open access repository after 12 months after publication Publisher's version/PDF cannot be used Published source must be acknowledged Must link to publisher version Set phrase to accompany link to published version (see policy) Articles in some journals can be made Open Access on payment of additional charge
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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