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The conformation of nascent polylysine and polyphenylalanine peptides on ribosomes
dc.contributor.author | Picking, William D. | |
dc.contributor.author | Odom, Obed W. | |
dc.contributor.author | Tsalkova, Tamara | |
dc.contributor.author | Serdyuk, Igor | |
dc.contributor.author | Hardesty, Boyd | |
dc.date.accessioned | 2016-09-09T16:26:42Z | |
dc.date.available | 2016-09-09T16:26:42Z | |
dc.date.issued | 1991-01-25 | |
dc.identifier.citation | Picking, W. D., Odom, O. W., Tsalkova, T., Serdyuk, I., & Hardesty, B. (1991). The conformation of nascent polylysine and polyphenylalanine peptides on ribosomes. Journal of Biological Chemistry, 266(3), 1534-1542. | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/21483 | |
dc.description.abstract | Polypeptide synthesis using either phenylalanine or lysine was initiated on Escherichia coli ribosomes; then the position and conformation of the nascent peptide were monitored by fluorescence techniques. To this end, fluorophores had been attached to the amino terminus of each nascent peptide, and major differences were observed as chain extension occurred. Polyphenylalanine appeared to build up as a hydrophobic mass adjacent to the peptidyl transferase center while polylysine apparently was extended directly from the ribosome into the surrounding solution. An explanation for these differences may be provided by the physical and chemical properties of each polypeptide. These properties may be responsible for the route by which each peptide exits the peptidyl transferase center as demonstrated by the different sensitivity of each to inhibition by erythromycin. | en_US |
dc.publisher | American Society for Biochemistry and Molecular Biology | en_US |
dc.relation.isversionof | www.jbc.org/content/266/3/1534.abstract | |
dc.rights | This research was originally published in Journal of Biological Chemistry. W. D. Picking, O. W. Odom, T. Tsalkova, I. Serdyuk and B. Hardesty . The conformation of nascent polylysine and polyphenylalanine peptides on ribosomes. Journal of Biological Chemistry. 1991; 266, 1534-1542. © the American Society for Biochemistry and Molecular Biology. | en_US |
dc.title | The conformation of nascent polylysine and polyphenylalanine peptides on ribosomes | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Picking, William D. | |
kusw.kudepartment | Pharmaceutical Chemistry | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess |