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    Caenorhabditis elegans Flamingo Cadherin fmi-1 Regulates GABAergic Neuronal Development

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    LundquistE_2012.pdf (6.129Mb)
    Issue Date
    2012-03-21
    Author
    Najarro, Elvis Huarcaya
    Wong, Lianna
    Zhen, Mei
    Carpio, Edgar Pinedo
    Goncharov, Alexandr
    Garriga, Gian
    Lundquist, Erik A.
    Jin, Yishi
    Ackley, Brian D.
    Publisher
    Society for Neuroscience
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
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    Abstract
    In a genetic screen for regulators of synaptic morphology, we identified the single Caenorhabditis elegans flamingo-like cadherin fmi-1. The fmi-1 mutants exhibit defective axon pathfinding, reduced synapse number, aberrant synapse size and morphology, as well as an abnormal accumulation of synaptic vesicles at nonsynaptic regions. Although FMI-1 is primarily expressed in the nervous system, it is not expressed in the ventral D-type (VD) GABAergic motorneurons, which are defective in fmi-1 mutants. The axon and synaptic defects of VD neurons could be rescued when fmi-1 was expressed exclusively in non-VD neighboring neurons, suggesting a cell nonautonomous action of FMI-1. FMI-1 protein that lacked its intracellular domain still retained its ability to rescue the vesicle accumulation defects of GABAergic motorneurons, indicating that the extracellular domain was sufficient for this function of FMI-1 in GABAergic neuromuscular junction development. Mutations in cdh-4, a Fat-like cadherin, cause similar defects in GABAergic motorneurons. The cdh-4 is expressed by the VD neurons and seems to function in the same genetic pathway as fmi-1 to regulate GABAergic neuron development. Thus, fmi-1 and cdh-4 cadherins might act together to regulate synapse development and axon pathfinding.
    Description
    This is the publisher's version, also available electronically from http://www.jneurosci.org/content/32/12/4196.
    URI
    http://hdl.handle.net/1808/17622
    DOI
    https://doi.org/10.1523/JNEUROSCI.3094-11.2012
    Collections
    • Molecular Biosciences Scholarly Works [598]
    Citation
    Najarro, Elvis Huarcaya et al. (2012). "Caenorhabditis elegans Flamingo Cadherin fmi-1 Regulates GABAergic Neuronal Development." Journal of Neuroscience, 32(12):4196-4211. http://www.dx.doi.org/10.1523/JNEUROSCI.3094-11.2012

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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