dc.contributor.author | Teague, Ryan M. | |
dc.contributor.author | Harlan, Lisa M. | |
dc.contributor.author | Benedict, Stephen H. | |
dc.contributor.author | Chan, Marcia A. | |
dc.date.accessioned | 2014-11-18T21:20:42Z | |
dc.date.available | 2014-11-18T21:20:42Z | |
dc.date.issued | 2004-07-24 | |
dc.identifier.citation | Ryan M. Teague, Lisa M. Harlan, Stephen H. Benedict, and Marcia A. Chan. Journal of Interferon & Cytokine Research. July 2004, 24(7): 403-410. http://dx.doi.org/10.1089/1079990041535656. | |
dc.identifier.uri | http://hdl.handle.net/1808/15798 | |
dc.description.abstract | The chemokine macrophage inflammatory protein-1α (MIP-1α) stimulates migration of B cells and affects B cell immunoglobulin production. However, the molecular mechanisms by which MIP-1α modulates these biologic effects have not been completely defined. Previously, we demonstrated that treatment of B cells with MIP-1α induced the transcription factor, nuclear factor (NF)-κB, to bind to DNA, concomitant with the degradation of IκBα, a cytoplasmic inhibitor of NF-κB activation. Here, we report that MIP-1α treatment of tonsil B cells induced IκB gene expression that was dependent on MIP-1α-mediated activation of a pathway(s) involving NF-κB and phosphatidylinositol-3 kinase (PI3K). The NF-κB pathway is understood to be controlled in an autoregulatory fashion, so expression of IκB is thought to provide a means by which B cells modulate this pathway after stimulation with MIP-1α. Although the idea of NF-κB autoregulation is not novel, this is the first report to suggest the regulation of B cell gene expression by MIP-1α. In addition, we observed the activation of Jun N-terminal kinase (JNK) and p38 mitogenic-activated protein kinase (MAPK), but not extracellular signal-related kinase (ERK) in response to MIP-1α. Although p38 and NF-κB activity were both necessary for B cell migration, IκB gene expression was not affected by p38 inhibition, suggesting that p38 is involved in a separate MIP-1α-mediated signal transduction pathway. | |
dc.publisher | Mary Ann Liebert, Inc. | |
dc.title | MIP-1α Induces Differential MAP Kinase Activation and IκB Gene Expression in Human B Lymphocytes | |
dc.type | Article | |
kusw.kuauthor | Teague, Ryan M. | |
kusw.kuauthor | Harlan, Lisa M. | |
kusw.kuauthor | Benedict, Stephen H. | |
kusw.kuauthor | Chan, Marcia A. | |
kusw.kudepartment | Department of Molecular Biosciences | |
kusw.oastatus | na | |
dc.identifier.doi | 10.1089/1079990041535656 | |
kusw.oaversion | Scholarly/refereed, publisher version | |
kusw.oapolicy | This item does not meet KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |