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    The Genetic Structure of the Kuwaiti Population: mtDNA Inter- and Intra-population Variation

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    Theyab_Al-Bustan_Crawford_2012.pdf (3.887Mb)
    Issue Date
    2012-08-01
    Author
    Theyab, Jasem
    Al-Bustan, Suzanne
    Crawford, Michael H.
    Publisher
    Wayne State University Press
    Type
    Article
    Article Version
    Scholarly/refereed, publisher version
    Published Version
    http://digitalcommons.wayne.edu/humbiol/vol84/iss4/7
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    Abstract
    This study investigated: (1) the mitochondrial DNA (mtDNA) genetic variation in 116 unrelated individuals who originated from the Arabian Peninsula, Iran, or were of Bedouin ethnicity and (2) the genetic structure of Kuwaiti populations and compared it to their neighboring populations. These subpopulations were tested for genetic homogeneity and shown to be heterogeneous. Restriction fragment length polymorphism (RFLP) and mtDNA sequencing analyses of HVRI were used to reconstruct the genetic structure of Kuwait. The results indicated that the combined Kuwaiti population has a high frequency of haplogroup R0 (17%), J (12%), and U (12%) similar to other Arabian populations. In addition, contemporary African gene flow was detected through the presence of sub-haplogroup L (L1 and L2) (2%) and the absence of L3 which is reflective of an earlier migration. Furthermore, the multidimensional scaling (MDS) plot showed that the Kuwaiti population clusters with neighboring populations, including Iran and Saudi Arabia indicating gene flow into Kuwait. According to this study, the Kuwaiti population may be undergoing an expansion in a relatively short period of time, and the maternal genetic structure of Kuwait resembles both Saudi Arabia and Iran.
    Description
    This is the publisher's version, also available electronically from http://digitalcommons.wayne.edu/humbiol/vol84/iss4/7/.
    URI
    http://hdl.handle.net/1808/13579
    Collections
    • Anthropology Scholarly Works [206]
    • Center for Russian, East European, and Eurasian Studies Scholarly Publications [546]
    Citation
    Theyab, Jasem B.; Al-Bustan, Suzanne; and Crawford, Michael H. (2012) "The Genetic Structure of the Kuwaiti Population: mtDNA Inter- and Intra-population Variation," Human Biology: Vol. 84: Iss. 4, Article 7. http://digitalcommons.wayne.edu/humbiol/vol84/iss4/7

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    785-864-8983
    KU Libraries
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    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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