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Parallel solid-phase synthesis of diaryltriazoles

dc.contributor.authorWrobel, Matthias
dc.contributor.authorAubé, Jeffrey
dc.contributor.authorKönig, Burkhad
dc.date.accessioned2014-04-17T20:03:34Z
dc.date.available2014-04-17T20:03:34Z
dc.date.issued2012-07-06
dc.identifier.citationWrobel, Matthias, Jeffrey Aube, and Burkhard Konig. 2012. “Parallel Solid-Phase Synthesis of Diaryltriazoles.” Beilstein Journal of Organic Chemistry 8 : 1027–36. http://dx.doi.org/10.3762/bjoc.8.115
dc.identifier.urihttp://hdl.handle.net/1808/13541
dc.description.abstractA series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein–protein interactions.
dc.description.sponsorshipFinancial support from the National Institute of General Medical Sciences (KU CMLD center, P50 GM69663).
dc.publisherBeilstein-Institut
dc.rightsThis is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
dc.rights.urihttp://creativecommons.org/licenses/by/2.0
dc.subjectChemical diversity
dc.subjectHuisgen cycloaddition
dc.subjectLibrary synthesis
dc.subjectPeptidomimetics
dc.subjectSolid phase synthesis
dc.subjectTriazole
dc.titleParallel solid-phase synthesis of diaryltriazoles
dc.typeArticle
kusw.kuauthorAubé, Jeffrey
kusw.kudepartmentDepartment of Medicinal Chemistry
dc.identifier.doi10.3762/bjoc.8.115
dc.identifier.orcidhttps://orcid.org/0000-0003-1049-5767
kusw.oaversionScholarly/refereed, publisher version
kusw.oapolicyThis item meets KU Open Access policy criteria.
dc.rights.accessrightsopenAccess


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This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)
Except where otherwise noted, this item's license is described as: This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)