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Invasion of the P elements: Tolerance is not futile
Meiklejohn, Colin D. ; Blumenstiel, Justin P.
Meiklejohn, Colin D.
Blumenstiel, Justin P.
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Abstract
Organisms are locked in an eternal struggle with parasitic DNA sequences that live inside
their genomes and wreak havoc on their host’s chromosomes as they spread through populations.
To combat these parasites, host species have evolved elaborate mechanisms of
resistance that suppress their activity. A new study in Drosophila indicates that, prior to the
acquisition of resistance, individuals can vary in their ability to tolerate the activity of these
genomic parasites, ignoring or repairing the damage they induce. This tolerance results
from variation at genes involved in germline development and DNA damage checkpoints
and suggests that these highly conserved cellular processes may be influenced by current
and historical intragenomic parasite loads.
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2018-10-30
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Public Library of Science
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Meiklejohn CD, Blumenstiel JP (2018)
Invasion of the P elements: Tolerance is not futile.
PLoS Biol 16(10): e3000036. https://doi.org/
10.1371/journal.pbio.3000036