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One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
Aksenov, Nicolai A. Aksenov, Alexander V. Kurenkov, Igor A. Kirillov, Nikita K. Aksenov, Dmitrii A. Arutiunov, Nikolai A. Aksenova, Daria S. Rubin, Michael
Aksenov, Nicolai A.
Aksenov, Alexander V.
Kurenkov, Igor A.
Kirillov, Nikita K.
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Aksenova, Daria S.
Rubin, Michael
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Abstract
A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.
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Date
2022-04-28
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Publisher
MDPI
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Keywords
Nitroalkanes, Brønsted acid catalysis, Indoles, Rearrangements, Cascade transformations
Citation
Aksenov, N.A.; Aksenov, A.V.; Kurenkov, I.A.; Kirillov, N.K.; Aksenov, D.A.; Arutiunov, N.A.; Aksenova, D.S.; Rubin, M. One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles. Molecules 2022, 27, 2808. https://doi.org/10.3390/molecules27092808