Bioengineering Program Scholarly Works: Recent submissions
Now showing items 21-40 of 152
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Photo-Mediated Ultrasound Therapy for the Treatment of Corneal Neovascularization in Rabbit Eyes
(Association for Research in Vision and Ophthalmology, 2020-12-09)Purpose: Corneal neovascularization (CNV) is the invasion of new blood vessels into the avascular cornea, leading to reduced corneal transparency and visual acuity, impaired vision, and even blindness. Current treatment ... -
Combining genetic algorithm with machine learning strategies for designing potent antimicrobial peptides
(BMC, 2021-05-11)Background Current methods in machine learning provide approaches for solving challenging, multiple constraint design problems. While deep learning and related neural networking methods have state-of-the-art performance, ... -
Reconfigurable Dual Peptide Tethered Polymer System Offers a Synergistic Solution for Next Generation Dental Adhesives
(MDPI, 2021-06-18)Resin-based composite materials have been widely used in restorative dental materials due to their aesthetic, mechanical, and physical properties. However, they still encounter clinical shortcomings mainly due to recurrent ... -
Ultra-high-resolution computed tomography shows changes in the lungs related with airway hyperresponsiveness in a murine asthma model
(Nature Research, 2021-09-02)In vivo presentation of airway hyper-responsiveness (AHR) at the different time points of the allergic reaction is not clearly understood. The purpose of this study was to investigate how AHR manifests in the airway and ... -
Self-assembling antimicrobial peptides on nanotubular titanium surfaces coated with calcium phosphate for local therapy
(Elsevier, 2018-09-12)Bacterial infection is a serious medical problem leading to implant failure. The current antibiotic based therapies rise concerns due to bacterial resistance. The family of antimicrobial peptides (AMP) is one of the promising ... -
Coordination of trunk and foot acceleration during gait is affected by walking velocity and fall history in elderly adults
(Elsevier, 2018-09-07)Background: Falling is a significant concern for many elderly adults but identifying individuals at risk of falling is difficult, and it is not clear how elderly adults adapt to challenging walking. Aims: The aim of ... -
Multivalent antigen arrays exhibit high avidity binding and modulation of B cell receptor-mediated signaling to drive efficacy against experimental autoimmune encephalomyelitis
(American Chemical Society, 2017-05-05)A pressing need exists for antigen-specific immunotherapies (ASIT) that induce selective tolerance in autoimmune disease while avoiding deleterious global immunosuppression. Multivalent soluble antigen arrays (SAgAPLP:LABL), ... -
Acute B-Cell Inhibition by Soluble Antigen Arrays Is Valency-Dependent and Predicts Immunomodulation in Splenocytes
(American Chemical Society, 2019-04-17)Antigen valency plays a fundamental role in directing the nature of an immune response to be stimulatory or tolerogenic. Soluble Antigen Arrays (SAgAs) are an antigen-specific immunotherapy that combats autoimmunity through ... -
Cell Separations and Sorting
(American Chemical Society, 2019-12-20) -
Soluble Antigen Arrays Displaying Mimotopes Direct the Response of Diabetogenic T Cells
(American Chemical Society, 2019-06-17)Type 1 diabetes (T1D) is an autoimmune disorder which develops when insulin-producing, pancreatic beta cells are destroyed by an aberrant immune response. Current therapies for T1D either treat symptoms or cause global ... -
Microsphere-Based Osteochondral Scaffolds Carrying Opposing Gradients Of Decellularized Cartilage And Demineralized Bone Matrix
(American Chemical Society, 2016-06-23)Extracellular matrix (ECM) “raw materials” such as demineralized bone matrix (DBM) and cartilage matrix have emerged as leading scaffolding materials for osteochondral regeneration owing to their capacity to facilitate ... -
Mitigation of peri-implantitis by rational design of bifunctional peptides with antimicrobial properties
(American Chemical Society, 2019-09-24)The integration of molecular and cell biology with materials science has led to strategies to improve the interface between dental implants with the surrounding soft and hard tissues in order to replace missing teeth and ... -
3D cell culture stimulates the secretion of in vivo like extracellular vesicles
(Nature Research, 2019-09-10)For studying cellular communications ex-vivo, a two-dimensional (2D) cell culture model is currently used as the “gold standard”. 2D culture models are also widely used in the study of RNA expression profiles from tumor ... -
Chronic stability of single-channel neurophysiological correlates of gross and fine reaching movements in the rat
(Public Library of Science, 2019-10-30)While substantial task-related neural activity has been observed during motor tasks in rodent primary motor cortex and premotor cortex, the long-term stability of these responses in healthy rats is uncertain, limiting the ... -
Hepatocyte nuclear receptor SHP suppresses inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis
(American Society for Biochemistry and Molecular Biology, 2018-04-17)Nonalcoholic fatty liver disease (NAFLD) is a burgeoning health problem worldwide, ranging from nonalcoholic fatty liver (NAFL, steatosis without hepatocellular injury) to the more aggressive nonalcoholic steatohepatitis ... -
Stacked PZT Discs Generate Necessary Power for Bone Healing through Electrical Stimulation in a Composite Spinal Fusion Implant
(MDPI, 2018-10-08)Electrical stimulation devices can be used as adjunct therapy to lumbar spinal fusion to promote bone healing, but their adoption has been hindered by the large battery packs necessary to provide power. Piezoelectric ... -
Repeatedly Applied Peptide Film Kills Bacteria on Dental Implants
(Springer Verlag, 2019-01-01)The rising use of titanium dental implants has increased the prevalence of peri-implant disease that shortens their useful life. A growing view of peri-implant disease suggests that plaque accumulation and microbiome ... -
Extended bioreactor conditioning of mononuclear cell–seeded heart valve scaffolds
(SAGE Publications, 2018-01)The tissue-engineered heart valve may be the ideal valve replacement option but still must overcome challenges in leaflet recellularization. This study sought to investigate the potential for leaflet matrix restoration and ... -
Fabrication of hybrid crosslinked network with buffering capabilities and autonomous strengthening characteristics for dental adhesives
(Elsevier, 2018-02)Ingress of bacteria and fluids at the interfacial gaps between the restorative composite biomaterial and the tooth structure contribute to recurrent decay and failure of the composite restoration. The inability of the ... -
Effect of Follower Load on Motion and Stiffness of the Human Thoracic Spine with Intact Rib Cage
(Elsevier, 2016-10-03)Researchers have reported on the importance of the rib cage in maintaining mechanical stability in the thoracic spine and on the validity of a compressive follower preload. However, dynamic mechanical testing using both ...