dc.contributor.author | Wang, Xiaochen | |
dc.contributor.author | Ward, Robert E., IV | |
dc.date.accessioned | 2011-02-23T17:19:49Z | |
dc.date.available | 2011-02-23T17:19:49Z | |
dc.date.issued | 2010-01-28 | |
dc.identifier.citation | Wang, X. and Ward, R. E. 2010. Sec61α is Required for Dorsal Closure during Drosophila Embryogenesis through its Regulation of Dpp Signaling. Developmental Dynamics 239:784-797 http://onlinelibrary.wiley.com/doi/10.1002/dvdy.22219/abstract;jsessionid=99578CFB34EE034AC314E5675B93ACAA.d01t01 | |
dc.identifier.issn | PMID: 20112345 | |
dc.identifier.issn | PMC2975395 | |
dc.identifier.uri | http://hdl.handle.net/1808/7125 | |
dc.description.abstract | During dorsal closure in Drosophila, signaling events in the dorsalmost row of epidermal cells (DME cells) direct the migration of lateral epidermal sheets towards the dorsal midline where they fuse to enclose the embryo. A Jun amino-terminal kinase (JNK) cascade in the DME cells induces the expression of Decapentaplegic (Dpp). Dpp signaling then regulates the cytoskeleton in the DME cells and amnioserosa to affect the cell shape changes necessary to complete dorsal closure. We identified a mutation in Sec61α that specifically perturbs dorsal closure. Sec61α encodes the main subunit of the translocon complex for co-translational import of proteins into the ER. JNK signaling is normal in Sec61α mutant embryos, but Dpp signaling is attenuated and the DME cells fail to maintain an actinomyosin cable as epithelial migration fails. Consistent with this model, dorsal closure is rescued in Sec61α mutant embryos by an activated form of the Dpp receptor Thick veins. | |
dc.description.sponsorship | National Institutes of Health; Grant numbers: R01HD047570 and P20 RR15563 | |
dc.language.iso | en_US | |
dc.publisher | John Wiley and sons | |
dc.subject | Drosophila | |
dc.subject | Dorsal closure | |
dc.subject | Morphogenesis | |
dc.subject | Sec61α | |
dc.subject | Translocon | |
dc.subject | Dpp | |
dc.subject | Thick veins | |
dc.subject | JNK | |
dc.subject | Cuticle | |
dc.title | Sec61α is Required for Dorsal Closure during Drosophila Embryogenesis through its Regulation of Dpp Signaling | |
dc.type | Article | |
kusw.kuauthor | Ward, Robert IV | |
kusw.kudepartment | Molecular Biosciences | |
kusw.oastatus | fullparticipation | |
dc.identifier.doi | 10.1002/dvdy.22219/abstract;jsessionid=99578CFB34EE034AC314E5675B93ACAA.d01t01 | |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | |
kusw.oapolicy | This item meets KU Open Access policy criteria. | |
dc.rights.accessrights | openAccess | |