Pharmaceutical Chemistry Dissertations and Theses: Recent submissions
Now showing items 21-40 of 141
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B CELL EPITOPE MAPPING OF RIVAX, A CANDIDATE RICIN VACCINE ANTIGEN
(University of Kansas, 2018-12-31)Ricin toxin’s enzymatic A subunit (RTA) is a 267 amino acid RNA N-glycosidase that depurinates a conserved adenine residue of 28S rRNA, resulting in ribosome arrest and apoptosis. One of the leading subunit vaccine candidates ... -
Degradation of therapeutic proteins: Screening methods and identification of epimerized amino acids and local conformational changes in light exposed proteins
(University of Kansas, 2017-12-31)Protein-based pharmaceuticals are a fast growing class of therapeutics, which are widely used in the treatment of various diseases such as cancers and autoimmune diseases. Proteins are susceptible to multiple degradation ... -
EVALUATING NOVEL ANALYTICAL TECHNIQUES TO ASSESS THE INITIAL STEPS OF PROTEIN AGGREGATION USING VARIOUS ANTIBODY SOLUTIONS
(University of Kansas, 2018-08-31)Antibody-based therapeutics continue to be a fast growing field in pharmaceutics due to their increased selectivity for a specific target over small molecule drugs. Antibody solutions are often formulated at high protein ... -
Light It Up: A Pre-Clinical Fluorescent Model to Illustrate Immunogenic Cell Death
(University of Kansas, 2018-05-31)Immunogenic cell death is a recently identified subset of apoptotic cell death that, when activated, may improve outcomes and remission rates in cancer patients. Calreticulin is an essential early-stage damage-associated ... -
TOWARDS A BETTER UNDERSTANDING OF VACCINE STABILITY AS APPLIED TO PHARMACEUTICAL DEVELOPMENT OF VARIOUS RECOMBINANT PROTEIN VACCINE CANDIDATES
(University of Kansas, 2018-05-31)Protein based vaccine antigens and adjuvants offer several advantages over inactivated or live attenuated viruses and bacteria including ease to manufacture and improved safety. Due to the structural complexity and inherent ... -
Rational development of protein formulations in solid and solution states
(University of Kansas, 2007-05-31)Development of protein formulations in the solid and solution state involves stability studies during long-term storage (2-3 years). A long-term study of a protein under conditions leading to its rapid physical and chemical ... -
The Effects of Low Molecular Weight Polar Molecules on the Physical and Chemical Properties of Hard Gelatin Capsule Shells
(University of Kansas, 2017-12-31)Liquid filled capsule formulations offer opportunities to enhance both solubility and the oral bioavailability of new chemical entities (1,5,7). Excipients used in liquid based formulations can range from lipophilic vehicles, ... -
Analytical Methods for the Study of Opioid Peptides
(University of Kansas, 2017-12-31)Dynorphin A 1-17 [Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-Trp-Asp-Asn-Gln] is an endogenous opioid peptide. It is widely distributed in blood and CNS tissue and exhibits a high affinity to the kappa (κ) opioid ... -
Gamma-arylpropylamines as analgetic agents
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Synthesis of amebacidal acridines
(University of Kansas, 1951) -
Some potential chemotherapeutic agents derived from aralkyl ketones
(University of Kansas, 1952) -
Synthesis of unnatural amino acids for antimetabolic studies
(University of Kansas, 1950) -
Synthetic relatives of cortisone
(University of Kansas, 1951) -
A Systematic Degradation Kinetics Study of Gemcitabine Hydrochloride Injection Solution
(University of Kansas, 2017-12-31)This study was carried out to systematically evaluate the degradation kinetics of gemcitabine hydrochloride injection solution over the pH region 1–12 at 70°C. The degradation kinetics of gemcitabine were determined based ... -
Influence of antibody Fab charge, hydrophobicity, and hydrodynamic size on vitreous pharmacokinetics in rabbits
(University of Kansas, 2017-12-31)A better understanding of the molecular attributes contributing to vitreal elimination half-life could enable the design of improved therapeutics for the treatment of human posterior segment ocular disease. Here we have ... -
Quantification of Trace Levels of Active Oxygen in Pharmaceutical Excipients
(University of Kansas, 2017-12-31)Pharmaceutical drug products contain various excipients in combination with the active pharmaceutical ingredient (API), and those excipients have the potential to have as impurities reactive oxygen species that can react ... -
Determination of Pharmacokinetic Parameters of Subcutaneous Zyklophin by Quantitative Determination of Zyklophin in Mouse Plasma by LCMS/MS Analysis For Assessment As A Potential Therapeutic Agent In The Treatment of Cocaine Addiction
(University of Kansas, 2016-12-31)Pharmaceutical agents targeting the μ opioid receptors (MOR) have been widely used in the treatment and management of pain. However, serious side effects and the prevalence of abuse have complicated their administration. ... -
Adjuvant Interactions with Lipid Membranes and Their Effect on Cellular Immune Responses
(University of Kansas, 2017-05-31)Adjuvants are commonly included in vaccines and have been invaluable in making them safer and more robust. Despite their prolific use, adjuvant mechanisms of action remain poorly understood. Many receptor-mediated mechanisms ... -
Mass Spectrometry-Based Quantitative Proteomics for Drug-Metabolizing Enzymes
(University of Kansas, 2016-12-31)Quantification of highly homologous human liver drug-metabolizing enzymes (DMEs) has been a challenging task in drug metabolism and disposition research, due to a lack of specific antibodies and marker substrates. Mass ... -
LYSOZYME DEGRADATION BY AZO INITIATOR AAPH, FENTON REACTION, AND IONIZING RADIATION
(University of Kansas, 2017-08-31)Oxidant generators, such as 2,2’-azobis(2-amidinopropane) dihydrochloride (AAPH) and the Fenton reaction, have been used to elucidate protein oxidation pathways and subsequently to screen for stabilizers that could prevent ...