Aksenov, Nicolai A.Aksenov, Alexander V.Prityko, Lidiya A.Aksenov, Dmitrii A.Aksenova, Daria S.Nobi, Mezvah A.Rubin, Michael2022-07-112022-07-112022-04-15Aksenov NA, Aksenov AV, Prityko LA, Aksenov DA, Aksenova DS, Nobi MA, Rubin M. Oxidative Cyclization of 4-(2-Aminophenyl)-4-oxo-2-phenylbutanenitriles into 2-(3-Oxoindolin-2-ylidene)acetonitriles. ACS Omega. 2022 Apr 15;7(16):14345-14356. doi: 10.1021/acsomega.2c01238. PMID: 35573208; PMCID: PMC9089741.https://hdl.handle.net/1808/32826A facile and highly efficient method for the preparation of 2-(3-oxoindolin-2-ylidene)acetonitriles from 4-(2-aminophenyl)-4-oxo-2-phenylbutanenitriles is described. The featured transformation operates via nucleophilic intramolecular cyclization and involves oxidation of the aniline moiety. Overall, this modification allowed for the improvement of yields and expansion of the reaction scope.© 2022 The Authors. Published by American Chemical Society. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND).http://creativecommons.org/licenses/by-nc-nd/4.0/Article10.1021/acsomega.2c01238https://orcid.org/ 0000-0002-6644-9949https://orcid.org/ 0000-0002-1668-9311PMC35573208openAccess