Jeon, Kyu OkRayabarapu, Dinesh KumarRolfe, AlanVolp, KellyOmar, ImanHanson, Paul R.2017-04-172017-04-172009-06-27Jeon, Kyu Ok et al. “Metathesis Cascade Strategies (ROM-RCM-CM): A DOS Approach to Skeletally Diverse Sultams.” Tetrahedron 65.26 (2009): 4992–5000.https://hdl.handle.net/1808/23722The development of a ring-opening metathesis/ring-closing metathesis/cross metathesis (ROM-RCM-CM) cascade strategy to the synthesis of a diverse collection of bi- and tricyclic sultams is reported. In this study, functionalized sultam scaffolds derived from intramolecular Diels-Alder (IMDA) reactions undergo metathesis cascades to yield a collection tricyclic sultams. Additional appendage based diversity was achieved by utilizing a variety of CM partners.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 3.0 (CC BY-NC-ND 3.0 US), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/3.0/CascadeSultamRCMDOSArticle10.1016/j.tet.2009.03.080openAccess