Khan, Afshan AfsarPaul, ArghyaAbbasi, SanaPrakash, Satya2015-10-142015-10-142011-05-24Prakash, Satya, Afshan Afsar Khan, Arghya Paul, and Sana Abbasi. "Mitotic and Antiapoptotic Effects of Nanoparticles Coencapsulating Human VEGF and Human Angiopoietin-1 on Vascular Endothelial Cells." International Journal of Nanomedicine IJN (2011): 1069. http://dx.doi.org/10.2147/IJN.S15054.https://hdl.handle.net/1808/18689Research towards the application of nanoparticles as carrier vehicles for the delivery of therapeutic agents is increasingly gaining importance. The angiogenic growth factors, human vascular endothelial growth factor (VEGF) and human angiopoietin-1 are known to prevent vascular endothelial cell apoptosis and in fact to stimulate human vascular endothelial cell (HUVEC) proliferation. This paper aims to study the combined effect of these bioactive proteins coencapsulated in human serum albumin nanoparticles on HUVECs and to evaluate the potential application of this delivery system towards therapeutic angiogenesis.This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.phphttp://creativecommons.org/licenses/by-nc/3.0/Growth factorsEncapsulationNanoparticlesNanobiotechnologyAngiogenesisRegenerative medicineArticle10.2147/IJN.S15054openAccess