Shao, Wei2015-10-142015-10-142012-03-23Prakash, Satya, Ms Wei Shao, Arghya Paul, Sana Abbasi, Parminder Chahal, Jimmy A. Mena, Johnny Montes, and Amine Kamen. "A Novel Polyethyleneimine-coated Adeno-associated Virus-like Particle Formulation for Efficient SiRNA Delivery in Breast Cancer Therapy: Preparation and in Vitro Analysis." International Journal of Nanomedicine IJN (2012): 1575. http://dx.doi.org/10.2147/IJN.S26891https://hdl.handle.net/1808/18692Systemic delivery of small interfering RNA (siRNA) is limited by its poor stability and limited cell-penetrating properties. To overcome these limitations, we designed an efficient siRNA delivery system using polyethyleneimine-coated virus-like particles derived from adeno-associated virus type 2 (PEI-AAV2-VLPs).This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution - Non Commercial (unported, v3.0) License. The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. Permissions beyond the scope of the License are administered by Dove Medical Press Limited. Information on how to request permission may be found at: http://www.dovepress.com/permissions.phphttp://creativecommons.org/licenses/by-nc/3.0/Adeno-associated virus type 2Virus-like particlesSmall interfering RNA deliveryBreast cancer therapyNanomedicineArticle10.2147/IJN.S26891openAccess