Wrobel, MatthiasAubé, JeffreyKönig, Burkhad2014-04-172014-04-172012-07-06Wrobel, Matthias, Jeffrey Aube, and Burkhard Konig. 2012. “Parallel Solid-Phase Synthesis of Diaryltriazoles.” Beilstein Journal of Organic Chemistry 8 : 1027–36. http://dx.doi.org/10.3762/bjoc.8.115https://hdl.handle.net/1808/13541A series of substituted diaryltriazoles was prepared by a solid-phase-synthesis protocol using a modified Wang resin. The copper(I)- or ruthenium(II)-catalyzed 1,3-cycloaddition on the polymer bead allowed a rapid synthesis of the target compounds in a parallel fashion with in many cases good to excellent yields. Substituted diaryltriazoles resemble a molecular structure similar to established terphenyl-alpha-helix peptide mimics and have therefore the potential to act as selective inhibitors for protein–protein interactions.This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (http://www.beilstein-journals.org/bjoc)http://creativecommons.org/licenses/by/2.0Chemical diversityHuisgen cycloadditionLibrary synthesisPeptidomimeticsSolid phase synthesisTriazoleArticle10.3762/bjoc.8.115https://orcid.org/0000-0003-1049-5767openAccess