Zang, QinZhou, AihuaJaved, SalimMaity, Pradip K.Knudtson, Christopher AntonBi, DanseHastings, Jared J.Basha, Fatima Z.Hanson, Paul R.2017-06-132017-06-132012-12-31Zang, Q., Zhou, A., Javed, S., Maity, P. K., Knudtson, C. A., Bi, D., … Hanson, P. R. (2012). Synthesis of a Library of 1,5,2-Dithiazepine 1,1-Dioxides. Part 1: A One-Pot Sulfonylation/Thia-Michael Protocol. Heterocycles, 86(2), 10.3987/COM–12–S(N)121. http://doi.org/10.3987/COM-12-S(N)121https://hdl.handle.net/1808/24480A novel one-pot sulfonylation/intramolecular thia-Michael protocol is reported for the synthesis of 1,5,2-dithiazepine 1,1-dioxides. Sulfonylation between cysteine ethyl ester/cysteamine and 2-chloroethanesulfonyl chloride, followed by in situ intramolecular thia-Michael addition, was achieved and afforded the titled 1,5,2-dithiazepine-1,1-dioxide scaffolds. Diversification was demonstrated for future library synthesis.This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License 4.0 (CC BY-NC-ND 4.0), which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.http://creativecommons.org/licenses/by-nc-nd/4.0/Article10.3987/COM-12-S(N)121.PMC3873773openAccess