Maletsky, LorinMane, Amitkumar M.2012-06-032012-06-032012-05-312012http://dissertations.umi.com/ku:11948https://hdl.handle.net/1808/9822Kinematics variation is the inheritant part of the joint mechanics; factors such as patient anatomy, joint loading and implant alignments are all variable in nature. Improvement in the design of orthopedic implants requires a good understanding of the roles that anatomy and implant alignment plays in guiding joint motion. The proposed research focuses on describing the relationship of various anatomical and implants alignment factors with the tibiofemoral kinematics during passive envelope and walk. An experimental method to manually assess passive knee envelope was described. Principal component (PC) model was developed for the varus-valgus (V-V), internal-external (I-E) and anterior-posterior (A-P) envelope using twenty-one native cadaveric knees and the mode of envelope variations were identified. Subsequently, gait simulation was run on seventeen knees using the Kansas Knee Simulator. Effects of variation in V-V and I-E envelope and anatomy on the envelope along with the gait kinematics were assessed using another PC model. Same PC model was used to understand the effect of anatomy and the implant alignment features on the post-TKA envelope and gait kinematics.113 pagesenThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.Mechanical engineeringBiomechanicsBiostatisticsAnatomyImplant alignmentKinematicsPcaDissertationopenAccess