Motiwala, Hashim F.Yin, QinAubé, Jeffrey2020-12-012020-12-012015-12-29Motiwala, H. F., Yin, Q., & Aubé, J. (2015). Improved Schmidt Conversion of Aldehydes to Nitriles Using Azidotrimethylsilane in 1,1,1,3,3,3-Hexafluoro-2-propanol. Molecules (Basel, Switzerland), 21(1), E45. https://doi.org/10.3390/molecules21010045https://hdl.handle.net/1808/30938This work is licensed under a Creative Commons Attribution 4.0 International License.The Schmidt reaction of aromatic aldehydes using a substoichiometric amount (40 mol %) of triflic acid is described. Low catalyst loading was enabled by a strong hydrogen-bond-donating solvent hexafluoro-2-propanol (HFIP). This improved protocol tolerates a broad scope of aldehydes with diverse functional groups and the corresponding nitriles were obtained in good to high yields without the need for aqueous work up.© 2015 by the authors. Licensee MDPI, Basel, Switzerland.http://creativecommons.org/licenses/by/4.0/Schmidt reactionAldehydesNitrilesHFIPArticle10.3390/molecules21010045https://orcid.org/0000-0003-1049-5767PMC6273554openAccess