Rolfe, AlanSamarakoon, Thiwanka BandaraHanson, Paul R.2017-03-232017-03-232010-03-19Rolfe, A., Samarakoon, T. B., & Hanson, P. R. (2010). Formal [4+3] Epoxide Cascade Reaction via a Complementary Ambiphilic Pairing Strategy. Organic Letters, 12(6), 1216–1219. http://doi.org/10.1021/ol100035ehttps://hdl.handle.net/1808/23472A formal [4+3] epoxide cascade protocol utilizing ambiphilic sulfonamides and a variety of epoxides (masked ambiphiles) has been developed for the generation of benzothiaoxazepine-1,1′-dioxides and oxathiazepine-1,1′-dioxides. This protocol combines an epoxide ring-opening with either an SNAr or oxa-Michael cyclization pathway.This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://dx.doi.org/10.1021/ol100035eArticle10.1021/ol100035eopenAccess