Hamill, Danielle R.Davis, JillDrawbridge, JulieSuprenant, Kathy A.2015-03-232015-03-231994-11-15Hamill, D.; Davis, J.; Drawbridge, J.; Suprenant, Kathy A. (1994). "Polyribosome targeting to microtubules: enrichment of specific mRNAs in a reconstituted microtubule preparation from sea urchin embryos." Journal of Cell Biology, 127(3-4):973-984. http://www.dx.doi.org/10.1083/jcb.127.4.973.0021-9525https://hdl.handle.net/1808/17171This is the publisher's version, also available electronically from http://jcb.rupress.org/content/127/4/973.A subset of mRNAs, polyribosomes, and poly(A)-binding proteins copurify with microtubules from sea urchin embryos. Several lines of evidence indicate that the interaction of microtubules with ribosomes is specific: a distinct stalk-like structure appears to mediate their association; ribosomes bind to microtubules with a constant stoichiometry through several purification cycles; and the presence of ribosomes in these preparations depends on the presence of intact microtubules. Five specific mRNAs are enriched with the microtubule-bound ribosomes, indicating that translation of specific proteins may occur on the microtubule scaffolding in vivo.Article10.1083/jcb.127.4.973openAccess