Aksenov, Nicolai A.Aksenov, Alexander V.Kurenkov, Igor A.Kirillov, Nikita K.Aksenov, Dmitrii A.Arutiunov, Nikolai A.Aksenova, Daria S.Rubin, Michael2022-07-112022-07-112022-04-28Aksenov, N.A.; Aksenov, A.V.; Kurenkov, I.A.; Kirillov, N.K.; Aksenov, D.A.; Arutiunov, N.A.; Aksenova, D.S.; Rubin, M. One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles. Molecules 2022, 27, 2808. https://doi.org/10.3390/molecules27092808https://hdl.handle.net/1808/32819A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.http://creativecommons.org/licenses/by/4.0/NitroalkanesBrønsted acid catalysisIndolesRearrangementsCascade transformationsArticle10.3390/molecules27092808https://orcid.org/ 0000-0002-7125-9066https://orcid.org/ 0000-0002-0911-4093https://orcid.org/ 0000-0002-1668-9311PMC35566159openAccess