KU ScholarWorks: Recent submissions
Now showing items 1-20 of 26011
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3D cell culture stimulates the secretion of in vivo like extracellular vesicles
(Nature Research, 2019-09-10)For studying cellular communications ex-vivo, a two-dimensional (2D) cell culture model is currently used as the “gold standard”. 2D culture models are also widely used in the study of RNA expression profiles from tumor ... -
Genomic Data Reveal Conserved Female Heterogamety in Giant Salamanders with Gigantic Nuclear Genomes
(Genetics Society of America, 2019-10-01)Systems of genetic sex determination and the homology of sex chromosomes in different taxa vary greatly across vertebrates. Much progress remains to be made in understanding systems of genetic sex determination in non-model ... -
Metabolomic Profiling to Identify Molecular Biomarkers of Cellular Response to Methotrexate In Vitro
(Wiley Open Access, 2019-10-25)Variation in methotrexate (MTX) efficacy represents a significant barrier to early and effective disease control in the treatment of autoimmune arthritis. We hypothesize that the utilization of metabolomic techniques will ... -
Effect of Cognitive Behavioral Therapy for Insomnia on Insomnia Symptoms for Individuals With Type 2 Diabetes: Protocol for a Pilot Randomized Controlled Trial
(JMIR Publications, 2019-11-12)Background: Insomnia symptoms are a common form of sleep difficulty among people with type 2 diabetes (T2D) affecting sleep quality and health outcomes. Several interventional approaches have been used to improve sleep ... -
Responsive Asthma Care for Teens (ReACT): development protocol for an adaptive mobile health intervention for adolescents with asthma
(BMJ Publishing Group, 2019-08-20)Introduction Asthma is a leading cause of youth morbidity in the USA, affecting >8% of youth. Adherence to inhaled corticosteroids (ICS) can prevent asthma-related morbidity; however, the typical adolescent with asthma ... -
Perception, knowledge, and interest of urologic surgery: A medical student survey
(BMC, 2019-09-13)Background Although only a limited number of medical schools require a formal educational rotation in urologic surgery, urology as a medical specialty continues to attract a large number of students into the match each ... -
Impact of Body Mass Index on the Association of Ankle-Brachial Index With All-Cause and Cardiovascular Mortality Results from the National Health and Nutrition Examination Survey
(Elsevier, 2019-10-22)Objective To assess the influence of body-mass index (BMI) on the association of ankle-brachial index (ABI) with mortality. Patients and Methods We conducted a prospective study of National Health and Nutrition ... -
Sleep characteristics of individuals with chronic stroke: A pilot study
(Dove Medical Press, 2015-10-21)Changes in sleep characteristics in individuals with chronic stroke are not well described, particularly compared with healthy individuals. Therefore, the aim of this pilot study was to explore the sleep characteristics ... -
Death of Neurons following Injury Requires Conductive Neuronal Gap Junction Channels but Not a Specific Connexin
(Public Library of Science, 2015-05-27)Pharmacological blockade or genetic knockout of neuronal connexin 36 (Cx36)-containing gap junctions reduces neuronal death caused by ischemia, traumatic brain injury and NMDA receptor (NMDAR)-mediated excitotoxicity. ... -
Neuroendoscopic treatment of symptomatic giant Virchow–Robin spaces
(MDPI, 2015-02-13)Patients with the 15q11.2 BP1–BP2 microdeletion can present with developmental and language delay, neurobehavioral disturbances and psychiatric problems. Autism, seizures, schizophrenia and mild dysmorphic features are ... -
Unremitting chronic skin lesions: A case of delayed diagnosis of glucagonoma
(Taylor & Francis Open Access, 2019-11-01)A 54-year-old Caucasian male with history of hypertension, hyperlipidemia, insulin-dependent diabetes mellitus, and chronic skin rash of 4 years presented to the emergency department with worsening rash and weight loss. ... -
Disparities in Oral Health among School-Aged Children in Kansas
(Scientific Research Publishing, 2015-06)Background: The effects of age, rural-urban geographic location, and percentage of Free and Reduced Price Meal Program (FRPMP) participation on children’s oral health outcome measures (untreated decay, treated decay, and ... -
Nonsurgical Treatment for Acute Posttraumatic Distal Radioulnar Joint Instability: A Case Series
(Elsevier, 2019-12-03)Purpose We investigated the clinical outcomes of patients with acute posttraumatic distal radioulnar joint (DRUJ) instability who were treated with our nonsurgical protocol. Methods The electronic database of our ... -
Optimizing Retrieval of Biospecimens Using the Curated Cancer Clinical Outcomes Database (C3OD)
(Sage Publications, 2019-11-18)To fully support their role in translational and personalized medicine, biorepositories and biobanks must continue to advance the annotation of their biospecimens with robust clinical and laboratory data. Translational ... -
Developing a Comprehensive, Interdisciplinary Concussion Program
(Sage Publications, 2020-07-27)There has been a growing trend of local and national coverage of and interest in concussion injuries over the past 2 decades. Increasing public concern over potential catastrophic and unknown long-term effects of sports-related ... -
Similar response rates and survival with PARP inhibitors for patients with solid tumors harboring somatic versus Germline BRCA mutations: a Meta-analysis and systematic review
(BioMed Central, 2020-06-03)Background PARP inhibitors (PARPi) have recently been approved for various malignancies based on the results of several clinical trials. However, these trials have mostly recruited patients with germline BRCA mutations, ... -
A rare case of group A streptococcal toxic‐shock syndrome in a postpartum adolescent leading to multi‐organ failure
(Wiley, 2020-03-16)Teenage pregnancy is not uncommon, but given the age of the patient, experience, and competency among medical providers varies. While toxic‐shock syndrome from group A streptococcus is rare in teenage pregnancy, observed ... -
Primary Arthrodesis for Diabetic Ankle Fractures
(Sage Publications, 2020-03-24)Background: Treatment of ankle fractures in patients with diabetes is associated with increased complication rates. Ankle arthrodesis is considered a salvage procedure after failed ankle fracture fixation, yet primary ... -
Burn‐induced myocardial depression in a pediatric patient leading to fulminant cardiogenic shock and multiorgan failure requiring extracorporeal life support
(Wiley, 2020-02-22)Cardiac stress is a critical determinant of outcomes associated with severe thermal injury. The cardiovascular response to a catecholamine‐mediated surge from severe burns passes through two phases. Initial hypovolemia ... -
Esophageal Cancer in a Hereditary Hemorrhagic Telangiectasia Patient
(Karger Publishers, 2020-02-18)Hereditary hemorrhagic telangiectasia (HHT) is a disorder characterized by vascular manifestations including mucocutaneous and visceral telangiectasias and arteriovenous malformations. Herein we present the case of a ...
