KU ScholarWorks: Recent submissions
Now showing items 1-20 of 26930
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Antidiscrimination Interventions, Political Ads on Transgender Rights, and Public Opinion: Results From Two Survey Experiments on Adults in the United States
(Frontiers Media, 2021-08-19)Political advertisements can shift attitudes and behaviors to become more exclusionary toward social out-groups. However, people who engage in an antidiscrimination exercise in the context of an experiment may respond ... -
A synopsis of the Bee occurrence data of northern Tanzania
(Pensoft Publishers, 2021-08-17)Background Bees (Hymenoptera: Apoidea: Anthophila) are the most important group of pollinators with about 20,507 known species worldwide. Despite the critical role of bees in providing pollination services, studies aiming ... -
Visual and somatosensory feedback mechanisms of precision manual motor control in autism spectrum disorder
(BMC, 2021-09-08)Background Individuals with autism spectrum disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and somatosensory feedback each have been ... -
“I Have Nowhere to Go”: A Multiple-Case Study of Transgender and Gender Diverse Youth, Their Families, and Healthcare Experiences
(MDPI, 2021-09-01)Transgender and gender diverse (TGD) youth experience health disparities due to stigma and victimization. Gender-affirming healthcare mitigates these challenges; yet, we have limited understanding of TGD youth’s healthcare ... -
Challenges in updating habitat suitability models: An example with the lesser prairie-chicken
(Public Library of Science, 2021-09-20)Habitat loss from land-use change is one of the top causes of declines in wildlife species of concern. As such, it is critical to assess and reassess habitat suitability as land cover and anthropogenic features change for ... -
Maternal care in Mid-Cretaceous lagonomegopid spiders
(The Royal Society, 2021-09-15)Maternal care benefits the survival and fitness of offspring, often at a cost to the mother's future reproduction, and has evolved repeatedly throughout the animal kingdom. In extant spider species, this behaviour is very ... -
Leakage pressures for gasketless superhydrophobic fluid interconnects for modular lab-on-a-chip systems
(Springer Nature, 2021-09-07)Chip-to-chip and world-to-chip fluidic interconnections are paramount to enable the passage of liquids between component chips and to/from microfluidic systems. Unfortunately, most interconnect designs add additional ... -
Electrophilically Activated Nitroalkanes in Double Annulation of [1,2,4]Triazolo[4,3-a]quinolines and 1,3,4-Oxadiazole Rings
(MDPI, 2021-09-20)Nitroalkanes activated with polyphosphoric acid could serve as efficient electrophiles in reactions with amines and hydrazines, enabling various cascade transformations toward heterocyclic systems. This strategy was developed ... -
Cutting Performance of Randomly Distributed Active Abrasive Grains in Gear Honing Process
(MDPI, 2021-09-17)In power gear honing, the random distribution of abrasive grains on the tooth surface of the honing wheel is the main factor that influences the machining performance of high-quality hardened gears. In order to investigate ... -
Struggling with Fit: Patterns, Positions, and Radical Adjustments in a "Post"-Pandemic
(2021-10-20)This closing talk discusses social justice issues of data librarian position descriptions through a metaphor of garment sewing and pattern fitting. A common concept of making space for bodies in both garments and positions ... -
Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
(MDPI, 2021-09-17)G protein-coupled receptors (GPCRs) are targets of extracellular stimuli and hence occupy a key position in drug discovery. By specific and not yet fully elucidated coupling profiles with α subunits of distinct G protein ... -
Impact of Inpatient Unit Design Features on Overall Patient Experience and Perceived Room-Level Call Button Response
(MDPI, 2021-09-16)This study explores the relationship between inpatient unit design and patient experience and how spatial features and visibility impact patients’ perception of staff responsiveness. The first part of this study is a ... -
Dissecting Multiple Pathways in the Relaxation Dynamics of Helix <==> Coil Transitions with Optimum Dimensionality Reduction
(MDPI, 2021-09-12)Fast kinetic experiments with dramatically improved time resolution have contributed significantly to understanding the fundamental processes in protein folding pathways involving the formation of a-helices and b-hairpin, ... -
Formulation Development and Improved Stability of a Combination Measles and Rubella Live-Viral Vaccine Dried for Use in the Nanopatch(TM) Microneedle Delivery System
(Taylor and Francis, 2021-05-06)Measles (Me) and rubella (Ru) viral diseases are targeted for elimination by ensuring a high level of vaccination coverage worldwide. Less costly, more convenient MeRu vaccine delivery systems should improve global vaccine ... -
Quantifying Value-based Determinants of Drug and Non-Drug Decision Dynamics
(Springer, 2021-04-10)Rationale A growing body of research suggests that substance use disorder (SUD) may be characterized as disorders of decision making. However, drug choice studies assessing drug-associated decision making often lack more ... -
In Vivo Brain Delivery and Brain Deposition of Proteins with Various Sizes
(American Chemical Society, 2019-10-30)It is very challenging to develop protein drugs for the treatment of brain diseases; this is due to the difficulty in delivering them into the brain because of the blood–brain barrier (BBB). Thus, alternative delivery ... -
Triheptanoin Mitigates Brain ATP Depletion and Mitochondrial Dysfunction in a Mouse Model of Alzheimer’s Disease
(IOS Press, 2020-10-27)Background: Brain energy failure is an early pathological event associated with synaptic dysfunction in Alzheimer’s disease (AD). Thus, mitigation or enhancement of brain energy metabolism may offer a therapeutic avenue. ... -
Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay
(Elsevier, 2021-11)We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting ... -
Development of an In Vitro Model to Screen CYP1B1-Targeted Anticancer Prodrugs
(SAGE Publications, 2016-11-09)Cytochrome P450 1B1 (CYP1B1) is an anticancer therapeutic target due to its overexpression in a number of steroid hormone–related cancers. One anticancer drug discovery strategy is to develop prodrugs specifically activated ... -
Cytochrome P450 and flavin-containing monooxygenase families: Age-dependent differences in expression and functional activity
(Springer Nature, 2017-11-01)Background Age-dependent differences in pharmacokinetics exist for metabolically cleared medications. Differential contributions in the cytochrome P450 3A (CYP3A), CYP2C, and flavin-containing monooxygenases (FMOs) families ...
