2024-03-28T20:34:48Zhttps://kuscholarworks.ku.edu/oai/requestoai:kuscholarworks.ku.edu:1808/269452018-10-25T20:10:16Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Chennathukuzhi, Vargheese M
Farahbakhsh, Mina
Blanco, Gustavo
Rongish, Brenda J
Nothnick, Warren B
Jensen, Roy A
2018-10-22T22:34:37Z
2018-10-22T22:34:37Z
2017-05-31
2017
http://dissertations.umi.com/ku:15247
http://hdl.handle.net/1808/26945
Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on patients with symptoms of abdominal pain, pressure, uterine bleeding, and infertility; creating a great liability for the US economy with an annual estimated cost of up to $34 billion. Currently there are no long-term treatments for fibroids that will leave fertility intact, mainly because the mechanism of pathogenesis of these tumors is largely unknown. One of the key characteristics of uterine fibroids is the excessive deposition and reorganization of extracellular matrix (ECM). Altered ECM, which amplifies growth factor signaling and disrupts mechanosensing, has been proposed to promote fibroid tumor growth. Analysis of available gene expression datasets from GEO database indicates that ADAM12 expression is dramatically upregulated in fibroids. As a member of the A-Disintegrin And Metalloprotease family of matrix modifying enzymes, ADAM12 is known to cleave ECM proteins, activate epidermal growth factor (EGF) and Insulin-like growth factor (IGF) signaling and promote tumorigenesis. Our lab has recently shown the expression of RE1 suppressing transcription factor /neuron-restrictive silencing factor (REST/NRSF), a known tumor suppressor, to be lost in fibroids. Upon further analysis, we found silencing REST in primary myometrial SMCs led to an increase in a number of downstream target genes, a profile similar to what is seen in fibroid tumor samples. Furthermore, Ingenuity® pathway analyses of gene expression datasets for fibroids indicate that the loss of REST and the increase in ADAM12 expression in leiomyomas could be linked through microRNA-29 (miR-29). In addition, in cultured mammary tumor cell lines, miR-29 is known to directly regulate ADAM12 expression. Compared to normal myometrium, uterine fibroids express significantly lower levels of miR-29. In its promoter, miR-29 contains an RE1 element, a putative binding site for REST. In order to see how the loss of REST in fibroids could affect miR-29, we silenced REST in primary myometrial SMCs and saw a significant decrease in miR-29 expression. In addition, Western blot analysis showed an increase in ADAM12 expression and EGF receptor (EGFR) phosphorylation when REST was knocked-down in primary myometrial cells. We further investigated the link between miR-29 and ADAM12 expression by treating primary myometrial and leiomyoma cells with miR-29 inhibitors and mimics, respectively. We found that inhibiting miR-29 in myometrial cells results in an increase in the expression of ADAM12. Conversely, the opposite effects were seen when fibroid cells were treated with miR-29 mimics. Furthermore, overexpression of ADAM12 in primary myometrial SMCs was found to induce activation of multiple tumorigenic signaling pathways including EGFR, Mitogen-activated protein kinase (MAPK), the phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/Akt), and mammalian target of rapamycin (mTOR) and Notch pathways. In conclusion, we report a novel druggable pathway that links the loss of REST, down regulation of miR-29, increased ADAM12 expression, and the activation of multiple tumorigenic pathways in uterine fibroids.
137 pages
en
University of Kansas
Copyright held by the author.
openAccess
Physiology
ADAM12
Leiomyoma
MicroRNA-29
Notch
REST
Uterine Fibroids
Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
Dissertation
Molecular & Integrative Physiology
Ph.D.
THUMBNAIL
Farahbakhsh_ku_0099D_15247_DATA_1.pdf.jpg
Farahbakhsh_ku_0099D_15247_DATA_1.pdf.jpg
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MD5
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Farahbakhsh_ku_0099D_15247_DATA_1.pdf.txt
Farahbakhsh_ku_0099D_15247_DATA_1.pdf.txt
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247692
https://kuscholarworks.ku.edu/bitstream/1808/26945/2/Farahbakhsh_ku_0099D_15247_DATA_1.pdf.txt
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MD5
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1808/26945
oai:kuscholarworks.ku.edu:1808/26945
2018-10-25 15:10:16.548
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/205992020-06-24T15:38:35Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Bryant, Homer L.
2016-03-29T16:05:05Z
2016-03-29T16:05:05Z
1924
http://hdl.handle.net/1808/20599
Thesis (M.A.)--University of Kansas, Physiology, 1924.
en_US
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
The effect of thyroparathyroidectomy on body activities
Thesis
Physiology
M.A.
3424567
THUMBNAIL
bryant_1924_3424567.pdf.jpg
bryant_1924_3424567.pdf.jpg
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https://kuscholarworks.ku.edu/bitstream/1808/20599/4/license.txt
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bryant_1924_3424567.pdf.txt
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https://kuscholarworks.ku.edu/bitstream/1808/20599/3/bryant_1924_3424567.pdf.txt
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oai:kuscholarworks.ku.edu:1808/20599
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KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/239882018-01-31T20:07:51Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Cannon, Chad M
Miller, Ross
Cannon, Chad M
Nazir, Niaman
Barth, Bradley
Thornton, Stephen
2017-05-08T02:38:59Z
2017-05-08T02:38:59Z
2016-05-31
2016
http://dissertations.umi.com/ku:14539
http://hdl.handle.net/1808/23988
Objectives: Trauma systems currently rely on imperfect and subjective tools to prioritize responses and resources, thus there is a critical need to develop a more accurate trauma severity score. Our objective was to modify the Rapid Emergency Medicine Score (REMS is a simple, non-invasive, and objective version of the APACHE II score) for the trauma population and test its accuracy as a predictor of in-hospital mortality when compared to other currently used scores, including the Revised Trauma Score (RTS), the Injury Severity Score (ISS), the “Mechanism, Glasgow Coma Scale, Age and Arterial Pressure” (MGAP) score, and the Shock Index (SI) score. Methods: This was a two-part study design. The first part incorporated a retrospective analysis of a local trauma database (3,680 patients) where three components of REMS were modified to more accurately represent the trauma population. Using clinical judgment and goodness of fit tests, systolic blood pressure was substituted for mean arterial pressure, the weighting of age was reduced, and the weighting of GCS was increased. The second part comprised of validating the new mREMS score retrospectively on a U.S. national trauma database that included 429,711 patients admitted with trauma over a 1-year period. The discriminate power of modified REMS (mREMS) was compared to other trauma scores using the area under the receiver operating characteristic (ROC) curve. Results: The mREMS score (AUC 0.97) was demonstrated to be higher than RTS (AUC 0.96), ISS (AUC 0.78), MGAP (AUC 0.96), and SI (AUC 0.67) in predicting in-hospital mortality. Discussion: In the trauma population, mREMS is an accurate predictor of in-hospital mortality, outperforming other used scores. Simple and objective, mREMS may hold value in the pre-hospital and emergency department setting in order to guide trauma team responses.
26 pages
en
University of Kansas
Copyright held by the author.
openAccess
Medicine
Emergency Medicine
Mortality
Trauma
Trauma Score
Triage
The Modified Rapid Emergency Medicine Score: A Novel Trauma Triaging Tool for Predicting In-hospital Mortality
Thesis
Preventive Medicine and Public Health
M.S.
ORIGINAL
Miller_ku_0099M_14539_DATA_1.pdf
Miller_ku_0099M_14539_DATA_1.pdf
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Miller_ku_0099M_14539_DATA_1.pdf.txt
Miller_ku_0099M_14539_DATA_1.pdf.txt
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40459
https://kuscholarworks.ku.edu/bitstream/1808/23988/2/Miller_ku_0099M_14539_DATA_1.pdf.txt
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1808/23988
oai:kuscholarworks.ku.edu:1808/23988
2018-01-31 14:07:51.654
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/97252020-06-24T15:47:51Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Nishimune, Hiroshi
Billings, Sara Elizabeth
Ackley, Brian D
Durham, Dianne
2012-06-03T14:11:10Z
2012-06-03T14:11:10Z
2011-12-31
2011
http://dissertations.umi.com/ku:11840
http://hdl.handle.net/1808/9725
The cytoskeletal matrix of the active zone (CAZ) and synaptic voltage-dependent calcium channels (VDCCs) are both required for the organization and regulation of synaptic vesicle release. Here we report a novel interaction between the CAZ protein family ELKS and VDCC β subunits. We found that two isoforms of ELKS (ELKS2 and ELKS1b) and two isoforms of VDCC β subunits (β1b and β4) co-immunoprecipitated. Using fluorescent immunohistochemistry, we observed colocalization between ELKS1b and VDCC β4 at synapses in the molecular layer of the cerebellum, suggesting a synaptic role for the interaction of these two proteins. Analysis of a P/Q-type VDCC knockout mouse (Cacna1a-/-) revealed that the localization of the VDCC β4 subunit to the molecular layer was disrupted, although ELKS1b protein localization was not affected. The results demonstrate that two isoforms of the ELKS family and two VDCC β subunits interact and suggest that their interaction may play a role in the organization of the active zone.
48 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Neurosciences
Cell biology
Biology
Active zone
Cast
Cytomatrix of the active zone
Elks
Synapse
Voltage-dependent calcium channel
The interaction of ELKS with Ca2+ channel β subunits may contribute to active zone organization
Thesis
Anatomy & Cell Biology
M.A.
na
This item does not meet KU Open Access policy criteria.
7643432
THUMBNAIL
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Billings_ku_0099M_11840_DATA_1.pdf.txt
Billings_ku_0099M_11840_DATA_1.pdf.txt
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https://kuscholarworks.ku.edu/bitstream/1808/9725/2/Billings_ku_0099M_11840_DATA_1.pdf.txt
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Billings_ku_0099M_11840_DATA_1.pdf
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1808/9725
oai:kuscholarworks.ku.edu:1808/9725
2020-06-24 10:47:51.088
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/67582020-06-22T20:47:56Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Jensen, Roy A.
Wang, Wenjia
Fields, Patrick
Li, Linheng
Tawfik, Ossama
Vines, Charlotte
Vivian, Jay
2010-10-03T04:24:28Z
2010-10-03T04:24:28Z
2010-07-30
2010
http://dissertations.umi.com/ku:11105
http://hdl.handle.net/1808/6758
Transcriptional and functional regulation of the breast cancer susceptibility gene 1 (BRCA1) in the pathogenesis of sporadic breast cancers is poorly understood. We developed a functional assay, which assesses the ability of BRCA1 to localize to sites of DNA damage and form ionizing radiation-induced foci (IRIF), to screen a kinase siRNA library and thirty-two potential positive regulators of BRCA1 were identified. Subsequent validation resulted in fourteen kinases that consistently diminished BRCA1 IRIF. Secondary screening assays for three selected kinases determined whether siRNA-mediated knockdown of the kinases caused an expression or function defect of BRCA1. Repair capacity and cell survival after DNA damage were characterized following siRNA-mediated knockdown of these three kinases. Our long term goal is to describe signaling pathways that explain how the identified kinases are able to regulate BRCA1. This knowledge could potentially translate into a novel therapeutic approach for sporadic breast cancers expressing low levels of BRCA1.
237 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Molecular biology
Brca1
Fgfr2
Hck
Ionizing radiation-induced foci (irif)
Kinase sirna library screen
Map3k1
Identification and Characterization of Novel Kinases that Regulate BRCA1 Expression and Function
Dissertation
Pathology & Laboratory Medicine
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085551
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oai:kuscholarworks.ku.edu:1808/267082018-09-08T08:01:13Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Brown, Jerry William
2018-09-07T13:12:27Z
2018-09-07T13:12:27Z
1951
http://hdl.handle.net/1808/26708
Dissertation (Ph.D.)--University of Kansas, Anatomy, 1951.
eng
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
The effect of protein deficiency on the hemopoietic organs and the blood of the albino rat
Dissertation
Anatomy
Ph.D.
3427617
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oai:kuscholarworks.ku.edu:1808/81782020-06-22T20:36:11Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Barlow, Steven M
Poore, Meredith Ann
Brady, Nancy
Searl, Jeffrey
Jongman, Allard
Loeb, Diane
2011-10-09T13:33:24Z
2011-10-09T13:33:24Z
2011-08-31
2011
http://dissertations.umi.com/ku:11585
http://hdl.handle.net/1808/8178
The vocalizations and jaw kinematics of 30 infants aged 6-8 months were recorded using a Motion Analysis System and audiovisual technologies. This study represents the first attempt to determine the effect of play environment on infants' rate of vocalization and jaw movement. Four play conditions were compared: watching videos, social interaction with an adult, playing alone with small toys, and playing alone with large toys. The fewest vocalizations and the least amount of spontaneous movement was observed when infants were watching videos and social interaction with an adult. Infants vocalized most when playing with large toys. The gross motor movement (e.g. waving, banging, shaking) naturally elicited by small toys was predicted to be the reason it educed fewer vocalizations than large toy play. This study was also the first to examine the kinematics of both vocalized and non-vocalized jaw movements from infants 6-8 months of age. Infants produced many spontaneous jaw movements without vocalization. When vocalizing, infants were not likely to move their jaw. This contradicts current theories that infants' canonical-stage vocalizations are jaw-dominant. Also, the onset of canonical babbling has been predicted to be driven by a change in oromotor skill. However, no differences were found in the jaw kinematics of infants who were canonical babbling versus those who were not. Results of the current study can inform both environmental and motor theories of infants' canonical babbling.
104 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Speech therapy
Language, linguistics
Biomechanics
Canonical babbling
Environment
Infant language
Infant speech
Jaw kinematics
Vocalization
ENVIRONMENTAL CATALYSTS AND OROFACIAL KINEMATICS OF EMERGENT CANONICAL SYLLABLES
Dissertation
Clinical Research
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7643073
THUMBNAIL
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oai:kuscholarworks.ku.edu:1808/301852021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Buller, Carol
Smith, Michele Diane
Olds, Danielle
2020-03-25T19:29:19Z
2020-03-25T19:29:19Z
2019-12-31
2019
http://dissertations.umi.com/ku:16878
http://hdl.handle.net/1808/30185
Abstract According to the American Cancer Society, colorectal cancer is estimated to affect 145,000 people and is expected to cause over 51,000 deaths in the year 2019. The way to prevent colorectal cancer is by early detection through colonoscopy starting at age 50 or, age 40 if there is a strong family history. To cleanse the bowel for this procedure, patients drink a preparation (prep) fluid that induces bowel evacuation. If the preparation is poor, polyps, abnormal tissue, or masses can be missed warranting a repeat procedure. The purpose of this project was focused on determining the best practice for bowel prep for patients with a history of constipation. The project utilized retrospective chart review and assessed the frequency of poor prep diagnoses in persons with a history of constipation and association with the type of prep prescribed for colonoscopy at two Gastrointestinal (GI) clinic locations associated with a Midwest medical center. The overall rate of poor bowel prep was 34% but there was no statistical difference between each clinic’s bowel prep practice in the rates of poor prep among this population. This project also determined that the current rate of repeat colonoscopy completion due to poor bowel prep was 62.5%, 25% of patients at Clinic 1 and 37.5% of patients at Clinic 2. Clinician-perceived barriers to bowel prep standardization included barriers such as: cost to the patient, poor understanding of instructions, and fluid restrictions for comorbidities. The findings from this project determined that there is no need for bowel prep standardization across clinic sites based on prep, as best practice was not determined based on this project, however, prep should be based on patient preference, cost, price, and ability to understand instructions. Keywords: colonoscopy prep, poor colonoscopy prep, constipation and colonoscopy prep
26 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Determining Best Practice for Colonoscopy Preparation for Persons with Constipation
Dissertation
Nursing
D.N.P.
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https://kuscholarworks.ku.edu/bitstream/1808/30185/2/Smith_ku_0099D_16878_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/30185
2021-03-05 10:53:01.555
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/145062020-06-22T21:11:20Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
McIff, Terence E
Smirnova, Irina V
Witherspoon, Jessica Waine'ette
Liu, Wen
Loudon, Janice
Wright, Doug
2014-07-05T15:40:19Z
2014-07-05T15:40:19Z
2014-05-31
2014
http://dissertations.umi.com/ku:13214
http://hdl.handle.net/1808/14506
Shoulder instability is the most frequently occurring shoulder injury. Instability is caused by repetitive stress or a traumatic event that leads to excessive joint laxity. A major concern with instability is the high recurrence rate post treatment. Although the occurrence and recurrence of instability are primarily associated with capsule and labrum injury, the tissue characteristics of the capsule and labrum are not well understood. Therefore, we sought to explore the tissue properties of the capsule and labrum. We also explored the relationship between the tissue properties and passive joint motion. To carry out this body of work, we dissected five fresh and three frozen human cadaveric shoulder pairs, removing the muscle and subcutaneous tissue while leaving the capsule and labrum intact. The cadaveric specimens included four males and four females of ages 23, 55, 58, 62, 76, 81 (x2), and 98. We then assessed glenohumeral joint laxity and joint stiffness using a materials testing machine. Following this assessment, we further dissected the shoulder removing the capsule and labrum from the anteroinferior (most common region of injury) and posteroinferior (least common region of injury) areas of the glenohumeral joint. The majority of the tissue was used for studying mechanoreceptors. A small portion was stored and used later for determining collagen content. Mechanoreceptor distribution and neural count were determined by first staining the tissue using our improved gold chloride staining method and light microscopy. Collagen content was determined using an acid-pepsin digestion for extracting collagen and the Sircol Collagen Dye assay for quantifying collagen. Joint laxity and joint stiffness assessment revealed a significant relationship (r = -.824, P<.001) between joint laxity and joint stiffness where joint stiffness decreased as joint laxity increased. From the neural staining, we created neuroanatomical maps for the capsule and labrum based on mechanoreceptor distribution. Not only did we discover a mechanoreceptor distribution pattern, but we also observed a strong positive relationship between neural count and joint laxity specifically in the capsule (r = .710, p = .003). Though this relationship was not significant in the labrum, when taking the capsule and labrum neural count into consideration, the overall relationship was significant (r =.646, p =.009). Unlike neural count and joint laxity, we did not observe a significant relationship between collagen content and joint stiffness in the capsule or labrum except when injury was taken into consideration. In the presence of injury, we observed strong negative relationships in the capsule (r = -.803, p =.016), labrum (r = -.755, p = .030), and overall, when including the capsule and labrum (r = -.814, p = .014). Based on our results, we were able to identify potential contributing factors to the unstable shoulder that may help guide future treatment thereby reducing the recurrence rate. We identified mechanoreceptor scarce regions from the neuroanatomical map that may be more apt for surgical repair that allows for mechanoreceptor preservation. We also observed a relationship between neural count and joint laxity that further supports the need to preserve neural structure integrity during treatment. The relationship between collagen content and joint stiffness, in the presence of injury, suggests that changes in collagen content should be considered during rehabilitative treatment when joint stiffness is compromised. Joint laxity, joint stiffness, mechanoreceptor distribution, neural count, and collagen content are all factors that should be studied in greater detail when developing treatments for the unstable shoulder.
174 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Neurosciences
Biochemistry
Biomechanics
Collagen
Instability
Mechanoreceptors
Shoulder
Surgery
Neural and Collagen Tissue Properties As They Relate to Glenohumeral Joint Laxity and Stiffness
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
8086450
ORIGINAL
Witherspoon_ku_0099D_13214_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/14506/1/Witherspoon_ku_0099D_13214_DATA_1.pdf
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open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/256372018-08-28T19:08:35Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Hamilton-Reeves, Jill M.
Taylor, Jacob M.
Sullivan, Debra K.
Carlson, Susan E.
Gibson, Cheryl A.
Grantham, Jared J.
2017-12-11T22:51:52Z
2017-12-11T22:51:52Z
2015-12-31
2015
http://dissertations.umi.com/ku:14277
http://hdl.handle.net/1808/25637
Introduction: Dietary factors (sodium, protein, acid precursors, and fluid) have been observed to influence cyst growth in human and animal studies of autosomal dominant polycystic kidney disease (ADPKD). However, no studies have been conducted to control such dietary constituents. Body mass index (BMI) and high-density lipoprotein (HDL), factors associated with dietary behaviors, have also been reported to associate with ADPKD progression and warrant further examination. The following series of studies aimed to (1) determine whether patients could adhere to a low sodium, low protein, low acid precursor diet with increased fluid intake; (2) understand participants’ experiences and perspectives as they attempted to follow the diet; (3) reveal potential barriers that may reduce the likelihood of long-term adherence; (4) determine if data obtained from the electronic health record (EHR) can be used to identify risk factors associated with ADPKD progression (BMI and HDL). Methods: A four-week dietary intervention was conducted to determine if a relatively complex dietary prescription targeting salt, protein, acid precursors, and fluid intake would be adopted by adult patients with ADPKD. Consecutive 24-hour urine collections were analyzed for sodium, urea, net acid excretion (NAE), urine volume, and osmolality. Three-day diet records were analyzed for sodium, protein, net endogenous acid production (NEAP), and fluid intake. A basic metabolic panel was obtained from blood samples. Blood pressure, height, and weight were obtained by a nurse at each visit. Outcomes were measured at baseline, two weeks, and four weeks. Following the dietary intervention, interviews and a Nutrition Hassles Questionnaire (NHQ) were conducted with participants to determine how difficult it was for them to follow the diet. Finally, we collected BMI and HDL levels from the EHRs of ADPKD patients seen at the University of Kansas Medical Center and determined their associations with the age of reaching kidney failure (estimated glomerular filtration rate (eGFR) ≤ 15ml/min/1.73m2). Results: The dietary changes caused a decrease in daily sodium excretion (-20%), urea excretion (-28%), and NAE (-46%) while increasing urine volume 35% above baseline. Subjects eating the experimental diet reached the daily goals for sodium (≤ 1.5 mmol/kg), protein (≤ 1 g/kg), and fluid intake (mean 24h urine osmolality ≤ 285 mosm/kg) prescribed for each patient and were sustained for four weeks. NEAP decreased 58 mEq/d from baseline. Only one participant reported hassles on the NHQ as “moderately severe” and no hassles were reported as “extremely severe”. The NHQ also showed that 10 out of 11 individuals were “somewhat confident” or “very confident” that they could manage the new diet. The interviews conducted following the dietary intervention found a general consensus that reducing portion sizes of meat and increasing intake of fruits and vegetables were the easiest components of the diet while keeping track of what they ate and reaching the prescribed goal amount for fruits and vegetables each day were the most difficult components. Participants met their fluid goal and believed it to be an attainable amount long-term. Travel and meals away from home made following and tracking the diet more difficult. Participants stated a cell phone app may have mitigated some of these issues. Data collected from the EHR did not show an association of BMI with age at kidney failure (p=0.69, HR=1.096, 95% CI 0.697-1.724). By contrast, those with a desirable HDL (Men & Women: ≥60 mg/dL) had a significantly slower disease progression compared to individuals with low (Men: <40 mg/dL; Women <50 mg/dL) (p=0.0147, HR=0.271, 95% CI 0.095-0.774) and acceptable (Men: 40-59 mg/dL; Women 50-59 mg/dL) HDL levels (p=0.0436, HR=0.319, 95% CI 0.105-0.968). Conclusion: Dietary sodium, protein, and acid precursors can be effectively reduced while increasing fluid intake, and sustained for at least four weeks in patients with ADPKD. Eight out of twelve participants reported they could follow the diet over a much longer period of time. It is reasonable to suppose that our experimental diet could be used to ameliorate cyst growth in patients with ADPKD; however, long-term, adequately powered studies that evaluate structural and functional changes in kidney function need to be examined. Furthermore, participants reported that to move forward to a long-term dietary trial, the development of an app to help monitor and track dietary intake in individuals with ADPKD is necessary. Participants thought an app would help them be successful tracking and adhering to the diet long-term. The results of these studies provide new ways worthy of more robust, long-term testing to determine the efficacy of slowing disease progression. Additionally, analysis of ADPKD histories in the EHR confirms that HDL is positively associated with the age at kidney failure whereas BMI is not. Monitoring and improving HDL levels through dietary and lifestyle behaviors may provide additional benefits when included as part of a comprehensive lifestyle intervention. Collaborative efforts that would permit the mining of EHR data from multiple centers would allow for assessment of large-scale laboratory and clinical measurements to determine if additional risk factors for ADPKD progression should be routinely monitored in patients. If successful, these modifiable risk factors could be targeted in clinical trials in an effort to halt disease progression through dietary, lifestyle, or behavioral modifications.
127 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nutrition
Health sciences
dietary acid load
net acid excretion
net endogenous acid production
polycystic kidney disease
potential renal acid load
renal nutrition
DIETARY FACTORS ASSOCIATED WITH THE PROGRESSION OF AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE
Dissertation
Dietetics & Nutrition
Ph.D.
TEXT
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Taylor_ku_0099D_14277_DATA_1.pdf
Taylor_ku_0099D_14277_DATA_1.pdf
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e8e67e78e5dba0de82ff69a8403b2714
MD5
3
open access
1808/25637
oai:kuscholarworks.ku.edu:1808/25637
2018-08-28 14:08:35.681
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/248262018-01-31T20:07:48Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Trainor, Paul A
Tjaden, Naomi Elaine Butler
Rongish, Brenda J
Fields, Timothy
Almadhoun, Osama
Cheney, Paul
Abrahamson, Dale
2017-08-13T22:15:11Z
2017-08-13T22:15:11Z
2015-05-31
2015
http://dissertations.umi.com/ku:14022
http://hdl.handle.net/1808/24826
Retinol dehydrogenase 10 (RDH10) catalyzes the first oxidative step in the metabolism of vitamin A to its active form retinoic acid (RA). Insufficient or excess RA can result in various congenital abnormalities, such as Hirschsprung disease (HSCR). In HSCR, neurons are absent from variable lengths of the gastrointestinal tract due to a failure of neural crest cell (NCC) colonization or development, leading to megacolon and/or the failure to pass meconium. Enteric neurons are derived from neural crest cells (NCC); hence HSCR is associated with incomplete NCC development or colonization of the GI tract. We investigated our hypothesis that RDH10 is necessary for proper NCC contribution to the enteric nervous system (ENS). The mouse point mutant Rdh10trex/trex exhibits decreased retinoid signaling and colonic aganglionosis. Organ explant culture and in utero retinal supplementation experiments define a temporal requirement for RA in ENS development between E7.5-E9.5. Tamoxifen-inducible temporal deletion of RDH10 at E6.5-E7.5 confirms this early retinal role, while later RDH10 deletion suggests retinal independence for continued enteric NCC colonization. Removing RDH10 from NCCs shows no gross or ENS-specific neuronal defects, suggesting that RDH10 is not intrinsically required in enteric NCCs for proper colonization of the gut, but rather is necessary as a paracrine signal in the vagal NCC microenvironment. We investigated signaling cascades that are known to play a role in gut microenvironment maintenance that may be altered in these RDH10 mutants using both a targeted expression analysis approach as well as RNA-sequencing. Candidates include GDNF and its signaling family members such as RET and GFRα1, as well as extracellular matrix proteins. Novel models of HSCR, such as Rdh10trex/trex will improve our understanding of RA contribution to intestinal development and may lead to innovative non-surgical treatment approaches to reduce the morbidity and mortality of this common congenital disease.
252 pages
en
University of Kansas
Copyright held by the author.
openAccess
Developmental biology
Enteric Nervous System
Gastrointestinal tract
Hirschsprung Disease
RDH10
Retinoic acid
Vitamin A
RDH10 is Necessary for Initial Vagal Neural Crest Cell Contribution to Embryonic Gastrointestinal Tract Development
Dissertation
Anatomy & Cell Biology
Ph.D.
ORIGINAL
Tjaden_ku_0099D_14022_DATA_1.pdf
Tjaden_ku_0099D_14022_DATA_1.pdf
application/pdf
11025077
https://kuscholarworks.ku.edu/bitstream/1808/24826/1/Tjaden_ku_0099D_14022_DATA_1.pdf
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LICENSE
24826.pdf
24826.pdf
application/pdf
206509
https://kuscholarworks.ku.edu/bitstream/1808/24826/4/24826.pdf
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1808/24826
oai:kuscholarworks.ku.edu:1808/24826
2018-01-31 14:07:48.646
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/270792018-12-03T21:33:17Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Zückert, Wolfram
Eusey, Jonathan
Biswas, Indranil
Fenton, Aron
2018-10-26T20:21:14Z
2018-10-26T20:21:14Z
2018-05-31
2018
http://dissertations.umi.com/ku:15754
http://hdl.handle.net/1808/27079
Borrelia burgdorferi infection, aka Lyme disease, is one of the most prevalent vector borne illnesses in the world. With an estimated 300,000 infections per year in the United States alone, this pathogen places a large burden on the health care system, as well as causing debilitating symptoms in the individuals who are not adequately treated for the disease in a prompt manner. While the normal life cycle is based upon transmission by ticks from small mammals to large mammals, mainly deer, human infection results in a dead end for Borrelia. The maintenance of this life cycle is a key feature of Borrelia, and understanding its ability to live in two contrasting environments gives researchers a framework for understanding the disease. Genes for bacterial lipoproteins (lipid modified proteins) make up a large portion of Borrelia species’ genomes and play important role in the infection/transmission cycle. While lipoprotein modification and localization is understood in several bacterial species, such as Escherichia coli and Bacillus subtilis, a few key components of the lipoprotein localization pathway are missing in Borrelia. Furthermore, the signals involved in proper lipoprotein sorting are less clear than in other species. Based on earlier studies in the laboratory, there are two proposed pathway components that are missing from a minimally functioning lipoprotein sorting machinery in Borrelia: a lipoprotein chaperone, which stabilizes the newly translocated lipoprotein in the outer membrane, and a lipoprotein “flippase”, which allows lipoproteins to pass through the outer membrane to the surface. To facilitate identification of these two hypothetical pathway components in functional screens, we embarked on two approaches. First, a mutational analysis of the complement binding protein CspA was performed with the aim to generate a subsurface mutant of CspA. CspA is a complement factor H binding protein that renders the bacteria serum-resistant. The resulting subsurface mutant would provide a basis for a functional suppressor screen, selecting for pathway mutants that are capable of transporting the mutant CspA to the surface. Additionally, the analysis would reveal the amino acids involved in localization of this lipoprotein, adding to the existing dataset with other Borrelia lipoproteins. In a parallel secondary approach, two separate binding proteins (Calmodulin and LysM) were setup to bind their respective targets (Calmodulin Binding Peptide and peptidoglycan) within the periplasm of B. burgdorferi, in an effort to stall the localization process. Based on our earlier work with Borrelia surface lipoproteins, a series of deletions within the intrinsically disordered N-terminal CspA tether were generated. Deletions of both the first and second halves of the tether peptide in CspA failed to yield a subsurface phenotype. Starting with a second-half tether deletion, escalating stepwise 4-amino acid deletions in an N-terminal direction were made. Still, no subsurface CspA mutant was recovered, with the first 4 CspA tether amino acids still supporting the lipoprotein’s surface exposure. Additionally tether swapping with a subsurface localizing lipoprotein tether yielded no subsurface CspA. Second, two protein trapping methods were attempted. These were designed to stall the interaction between pathway components and lipoproteins inside of the periplasm. The introduction into the bacterial periplasm of the mammalian binding protein Calmodulin and surface sorting lipoprotein fused to a tag derived from a Calmodulin Binding Peptide yielded no transformants in single or multiple plasmid systems. Plasmids encoding for each of the individual components could be readily transformed separately. Alternatively, introduction of a fusion protein that links a surface red fluorescent protein reporter lipoprotein to a native peptidoglycan binding peptide tag yielded significant filamentous growth as well as overall growth defects in E. coli, and no B. burgdorferi transformants were recovered.
62 pages
en
University of Kansas
Copyright held by the author.
openAccess
Microbiology
Borrelia
Lipoproteins
Lyme Disease
Screen design for Borrelia burgdorferi lipoprotein secretion pathway components using periplasmic protein capture and suppressor mutations
Thesis
Microbiology, Molecular Genetics & Immunology
M.S.
THUMBNAIL
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Eusey_ku_0099M_15754_DATA_1.pdf
Eusey_ku_0099M_15754_DATA_1.pdf
application/pdf
1397392
https://kuscholarworks.ku.edu/bitstream/1808/27079/1/Eusey_ku_0099M_15754_DATA_1.pdf
d830cb659b9c543b94028a9b85f1235d
MD5
1
open access
1808/27079
oai:kuscholarworks.ku.edu:1808/27079
2018-12-03 15:33:17.832
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/268932018-10-25T19:03:04Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Si, Kausik
Cheney, Paul
Li, Liying
Piotrowski, Tatjana
Nishimune, Hiroshi
Gibson, Matthew
2018-10-22T15:47:31Z
2018-10-22T15:47:31Z
2017-08-31
2017
http://dissertations.umi.com/ku:15506
http://hdl.handle.net/1808/26893
How a transient experience creates an enduring yet dynamic memory remains a fundamental unresolved issue in studies of memory. Experience-dependent aggregation of the RNA-binding protein CPEB/Orb2 is one of the candidate mechanisms of memory maintenance. Here, using tools that allow rapid and reversible inactivation of Orb2 protein I find that Orb2 activity is required for encoding and recall of memory. Blocking the Orb2 oligomerization process by interfering with the protein phosphorylation pathway or expressing an anti-amyloidogenic peptide impairs long-term memory. Facilitating Orb2 aggregation by a DNA-J family chaperone, JJJ2, enhances the animal’s capacity to form long-term memory. Finally, I have developed tools to visualize training-dependent aggregation of Orb2. I find that aggregated Orb2 in subset of mushroom body neurons can serve as a “molecular signature” of memory and predict memory strength. My data indicate that self-sustaining aggregates of Orb2 may serve as a physical substrate of memory and provide a molecular basis for the perduring yet malleable nature of memory.
154 pages
en
University of Kansas
Copyright held by the author.
openAccess
Neurosciences
Molecular biology
CPEB
engram
long-term memory
prion-like molecule
Drosophila CPEB, Orb2, a Putative Biochemical Engram of Long-term Memory
Dissertation
Molecular & Integrative Physiology
Ph.D.
THUMBNAIL
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TEXT
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Li_ku_0099D_15506_DATA_1.pdf.txt
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ORIGINAL
Li_ku_0099D_15506_DATA_1.pdf
Li_ku_0099D_15506_DATA_1.pdf
application/pdf
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https://kuscholarworks.ku.edu/bitstream/1808/26893/1/Li_ku_0099D_15506_DATA_1.pdf
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MD5
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1808/26893
oai:kuscholarworks.ku.edu:1808/26893
2018-10-25 14:03:04.313
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/277502020-10-13T19:44:28Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wright, Doug
Cooper, Michael A
Christianson, Julie
Thyfault, John
Geiger, Paige
McCarson, Kenneth
2019-04-19T20:28:25Z
2019-04-19T20:28:25Z
2018-05-31
2018
http://dissertations.umi.com/ku:15798
http://hdl.handle.net/1808/27750
https://orcid.org/0000-0002-9312-0399
Obesity and metabolic syndrome are a rising worldwide epidemic and have driven a subsequent increase in prediabetes and type 2 diabetes. We now know that patients who have prediabetes will begin to develop debilitating alterations in sensation due to early damage of peripheral sensory axons. There have been few therapies proposed to help patients developing metabolic syndrome induced painful neuropathies and those that have been developed often exhibit minimal benefit. While the mechanisms of prediabetes-induced peripheral neuropathy are still poorly understood, previous work has been able to show there is a significant benefit from physical activity that improve abnormal sensation and pain. Early studies in this work demonstrate that exercise alters the metabolic status of peripheral neurons and can normalize heightened mechanical sensitivity induced by a high fat diet. Utilizing a genetic rat model of differing intrinsic aerobic levels, our results show that genetic differences that result in varied metabolism alters peripheral nerve function and sensation. Highlighting the importance of metabolism, our studies show that exercise increases the utilization of fat based fuels, providing a novel mechanism for improved sensation. We performed studies in mice utilizing a ketogenic diet that is high in fat and low in carbohydrates to push fat utilization in nerves. These studies revealed that consumption of a ketogenic improved abnormal peripheral sensation. Contrary to exercise or a control diet, a ketogenic diet was able to prevent and also reverse high fat diet induced mechanical allodynia. In addition to improved sensation, a ketogenic diet increased axonal growth in vitro and in vivo. This exciting result of improved nerve growth has the potential to benefit millions of patients worldwide experiencing neuropathy and pain due to axonal degeneration.
226 pages
en
University of Kansas
Copyright held by the author.
openAccess
Neurosciences
Exercise
High-Fat Diet
Ketogenic Diet
Metabolism
Pain
Peripheral Nerves
A KETOGENIC DIET AND PHYSICAL ACTIVITY’S EFFECT ON PERIPHERAL NERVE FUNCTION
Dissertation
Anatomy & Cell Biology
Ph.D.
TEXT
Cooper_ku_0099D_15798_DATA_1.pdf.txt
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236212
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bd950d595da06298cdd30c307426d29d
MD5
2
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THUMBNAIL
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ORIGINAL
Cooper_ku_0099D_15798_DATA_1.pdf
Cooper_ku_0099D_15798_DATA_1.pdf
Available after: 2019-05-31
application/pdf
34629600
https://kuscholarworks.ku.edu/bitstream/1808/27750/1/Cooper_ku_0099D_15798_DATA_1.pdf
27915cbba34d0d06580903ea41c31056
MD5
1
open access
1808/27750
oai:kuscholarworks.ku.edu:1808/27750
2020-10-13 14:44:28.927
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/301722021-03-05T16:54:48Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Mahnken, Jonathan D
Grabarczyk, Ted
Roberts, Andrew
Grauer, Dennis W
2020-03-25T18:27:04Z
2020-03-25T18:27:04Z
2019-12-31
2019
http://dissertations.umi.com/ku:16892
http://hdl.handle.net/1808/30172
https://orcid.org/0000-0002-5048-2154
Purpose: Prior evidence suggests that early, improved control of glycemic control likely lowers the risk of some combination of microvascular and/or macrovascular complications. Furthermore, growing evidence suggests that not only achieving a certain degree of control, but how that control varies also may matter in terms of outcomes. Finally, there is some initial evidence that clinical pharmacy specialist (CPS) services can, on average, lower glycosylated hemoglobin (HbA1c) and improve glycemic control. However, there is insufficient evidence characterizing variation in glycemic control outcomes in patients receiving CPS management of diabetes and factors associated with greater chance of success with that management. Methods: This is an observational, multicenter, retrospective cohort study of Veterans with type-2 diabetes in Veterans Integrated Service Network 15 managed by clinical pharmacy specialists between 7/1/2013 and 7/1/2017 with a baseline HbA1c level ≥ 8%. Glycosylated hemoglobin measurements were collected for two years following the index date and used to group patients into distinct patterns of HbA1c trajectories over time using group-based trajectory modeling and posterior probabilities of group membership. Characteristics associated with successful HbA1c trajectories and association of assigned trajectories with all-cause and diabetes-related hospitalizations were analyzed using logistic regression. Results: A total of 4,119 Veterans were included and successfully divided into six distinct HbA1c trajectory groups: High Gradually Decreasing (n=325, 7.9%), Moderate Early Decline (n=1692, 41.1%), Large Early Decline (n=231, 5.6%), Uncontrolled Stable (n=1468, 35.6%), Early Decline / Subsequent Increase (n=266, 6.5%), and Very Uncontrolled Stable (n=137, 3.3%). The Large Early Decline, Moderate Early Decline, and High gradually decreasing groups were classified as successful. Successful trajectories were more likely to reach a target HbA1c of ≤ 7%, have shorter duration of pharmacist management, greater utilization of nutrition clinic services. The distinguishing factor between successful and less successful trajectories appears to be the progress made within the first six months of pharmacist management. Conclusion: Patients managed for diabetes can be grouped into distinct patterns of change in glycemic control over time. The first six months of the clinical pharmacist/patient relationship may be important in determining a patient’s overall success. Future research is needed to identify pharmacist interventions that increase the likelihood of achieving successful glycemic control trajectory patterns.
63 pages
en
University of Kansas
Copyright held by the author.
openAccess
Medicine
Diabetes Mellitus
Pharmacist
Pharmacy
Trajectories of Glycemic Control with Clinical Pharmacy Specialist Management of Veterans with Type 2 Diabetes
Thesis
Preventive Medicine and Public Health
M.S.
ORIGINAL
Grabarczyk_ku_0099M_16892_DATA_1.pdf
Grabarczyk_ku_0099M_16892_DATA_1.pdf
Available after: 2020-06-30
application/pdf
871064
https://kuscholarworks.ku.edu/bitstream/1808/30172/1/Grabarczyk_ku_0099M_16892_DATA_1.pdf
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MD5
1
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TEXT
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87338
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c6341a09928c15cb809f9cb8719a63c6
MD5
2
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1808/30172
oai:kuscholarworks.ku.edu:1808/30172
2021-03-05 10:54:48.566
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/148482020-06-22T20:34:55Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Pierce, Janet
Bennetts, Paul S.
Bergquist-Beringer, Sandra
Diaz, Francisco J.
Geiger, Paige C.
Piamjariyakul, Ubolrat
2014-07-28T02:46:14Z
2014-07-28T02:46:14Z
2013-08-31
2013
http://dissertations.umi.com/ku:12851
http://hdl.handle.net/1808/14848
Abstract Hemorrhagic shock (HS) and fluid resuscitation triggers ischemia-reperfusion injury in cells and increases the production of reactive oxygen species (ROS) which are known to activate the intrinsic pathway of apoptosis and contribute to organ dysfunction.1 Ubiquinol is a potent free radical scavenger which is produced endogenously and functions as part of the mitochondrial respiratory chain.2 No study has been conducted to investigate the effects of ubiquinol related to HS. The overall aim of this study was to examine the effects of ubiquinol on leukocyte mitochondria and in the lungs, diaphragm, heart and kidneys as a supplemental treatment for HS. A randomized experimental design was used for this study. Adult male Sprague-Dawley rats (n = 20) were anesthetized and HS was induced by withdrawing 40% of the rat's blood volume to maintain a mean arterial pressure of 45-55 mmHg for 60 minutes. Following HS the rats were resuscitated with blood and lactated Ringer's (LR) with or without ubiquinol (1 mg per 100 g of body weight). The rats were monitored for 120 minutes, the animals were euthanized and the organs harvested. Leukocyte mitochondria superoxide (O2*⁻) was measured by flow cytometry using MitoSOX Red, a mitochondrial-targeted variant of the fluorescent probe hydroethidine. Superoxide levels were measured at baseline, end of HS and 120 minutes following fluid resuscitation. Arterial blood values were also recorded at these times. At the end of experiment, diaphragms were evaluated for hydrogen peroxide (H2O2) using the fluorescent probe dihydrofluorescein-diacetate (Hfluor). The lungs, diaphragm, heart, and kidneys were examined for percent of apoptotic nuclear membrane damage using a differential dye uptake method with acridine orange and ethidium bromide. No significant differences were found between groups with regard to the volume of blood removed, hemodynamic status or arterial blood values (p 0.05). Ubiquinol decreased leukocyte mitochondrial production of O2*⁻ at the end of the experiment by 35% compared to the control group (4687.2 ± 265.4 versus 7227.9 ± 534.5, p ˂ 0.001). Similarly, the mean fluorescence intensity (MFI) of diaphragm H2O2 was significantly lower in the ubiquinol group compared to control (4193 ± 333 versus 23513 ± 5098, p ˂ 0.001). The percent of apoptosis in the lungs, diaphragm, heart, and kidneys was significantly reduced in the animals treated with ubiquinol compared to the control group (6.0 ± 0.7% versus 39.2 ± 1.1%, 4.7 ± 0.5% versus 30.6 ± 2.4%, 2.9 ± 0.6% versus 23.6 ± 1.2%, 2.4 ± 0.3% versus 42.1± 1.9%, respectively, p ˂ 0.001). Ubiquinol was effective in decreasing leukocyte mitochondrial O2*⁻ formation, which suggests that ubiquinol scavenged O2*⁻ within the mitochondria. Since ubiquinol is a potent antioxidant, it also probably scavenged other free radicals outside the mitochondria. The increased concentration of ubiquinol within the mitochondria would assist in maintaining the activities within the electron transport chain during HS. In addition, the decreased mitochondrial O2*⁻ would result in lower H2O2 production. The significant reduction in the percent of apoptosis in lungs, diaphragm, heart and kidneys between the control and treatment rats, suggests that decreased ROS production attenuated the activation of the intrinsic (mitochondrial) apoptosis pathway.3 The findings could also be attributed to the stabilization of the mitochondrial membrane by ubiquinol, which has been demonstrated in a previous study.4 In conclusion, ubiquinol may have application as a supplemental treatment to reduce free radical damage and apoptosis- related injury following HS and fluid resuscitation.
164 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Physiology
Health sciences
Antioxidants
Apoptosis
Hemorrhage
Mitosox red
Multiple organ failure
Reactive oxygen species
Effects of Ubiquinol with Fluid Resuscitation following Hemorrhagic Shock
Dissertation
Nursing
Ph.D.
8086056
ORIGINAL
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oai:kuscholarworks.ku.edu:1808/219212018-01-31T20:07:48Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Teel, Cynthia
Groller, Karen Diane
Stegenga, Kristin
Bosak, Kelly
El Chaar, Maher
Sullivan, Debra
2016-11-11T00:06:46Z
2016-11-11T00:06:46Z
2015-12-31
2015
http://dissertations.umi.com/ku:14374
http://hdl.handle.net/1808/21921
Weight loss surgery (WLS) is a surgical option that can help obese patients achieve a healthy bodyweight when combined with behavioral lifestyle changes. Patients who struggle with adhering to postoperative regimens are more likely to experience weight recidivism approximately one year after WLS. Nationally accredited WLS centers are required to support patients in making necessary lifestyle changes before and after surgery through educational programs. A literature review showed the current state of WLS education is neither evidence-based nor patient-centered, as it varies in curriculum, teaching methods and type of educator for both preoperative and postoperative WLS phases. The purpose of this qualitative descriptive study was to obtain in-depth descriptions from patients about their WLS experience, specifically about education received before and after the surgery and recommendations to improve the experience for future patients. Eleven volunteers participated in a private, semi-structured interview after being randomly selected from one northeastern Pennsylvania WLS practice database and meeting study inclusion criteria. The interview data were used to answer the following research questions: a) How do patients describe their overall WLS experience? b) How do patients describe the education received during their WLS experience? and c) What factors contribute to patient satisfaction with WLS education? The study results were depicted using the concept of A New Me-Version 2.0, through three main themes. Theme 1: Programming and Tools explained how obese individuals become ready to take charge with a healthier lifestyle and the available educational and support programming offered to support that change. Theme 2: Updates and Upgrades, is where participants reflected on their quality of life before and after surgery and daily challenges still experienced. Theme 3: Lessons Learned and Considerations for Future Versions identified participant’s level of satisfaction with the WLS experience and provided suggestions to improve the WLS experience. Obese patients used WLS to initiate movement towards lifestyle changes for better health. Patients perceived education and support programs as collaborative necessity that positively reinforces continued progression toward healthier lifestyles. These study results reveal patient perspectives about the WLS educational experience and satisfaction with that experience. Recommendations provided may facilitate improvements for WLS patient experiences by refining education practices that were suggested by post-WLS patients, inform accreditation standards with results and facilitate change based on evidence and encourage development of future studies to evaluate the impact WLS patient education has on clinical outcomes.
159 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Health education
Behavioral sciences
bariatric surgery
patient education
postoperative education
preoperative education
qualitative descriptive
weight loss surgery
Patient Descriptions About Weight Loss Surgery Education Practices
Dissertation
Nursing
Ph.D.
THUMBNAIL
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Groller_ku_0099D_14374_DATA_1.pdf
Groller_ku_0099D_14374_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/21921/1/Groller_ku_0099D_14374_DATA_1.pdf
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Groller_ku_0099D_14374_DATA_1.pdf.txt
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2018-01-31 14:07:48.83
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oai:kuscholarworks.ku.edu:1808/145142019-07-17T05:15:56Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wright, Douglas E
Groover, Anna Lois
Berman, Nancy E
Geiger, Paige C
McCarson, Kenneth E
Nishimune, Hiroshi
2014-07-05T15:58:51Z
2014-07-05T15:58:51Z
2014-05-31
2014
http://dissertations.umi.com/ku:13364
http://hdl.handle.net/1808/14514
Diabetic neuropathy (DN) is the most common and debilitating complication of type 1 and type 2 diabetes with approximately half of all patients developing neuropathy during the course of their lives. Additionally, patients with prediabetes also develop neuropathy, often presenting with painful symptoms, including burning and stinging sensations, as well as hyperalgesia and allodynia. Research suggests that altered neurotrophism may account for the development and maintenance of PDN, resulting in a dying back of peripheral neurons, leading to pain. Furthermore, patients suffering from painful diabetic neuropathy (PDN) have few therapeutic options, as pharmaceuticals are rarely effective and are only palliative in nature. However, recent research suggests that exercise may be beneficial in reducing PDN. The purpose of this work was to test the effects of obesity and a high-fat diet on the development of DN, to investigate how diabetes alters neurotrophins and to determine if voluntary exercise is capable of reducing PDN. Initial studies used a model of obese, type 2 diabetes and investigated if voluntary exercise could reverse PDN. Diabetes resulted in mechanical allodynia, yet because these mice did not exercise, no benefit was gained; however, there was a significant correlation between physical activity and mechanical withdrawal thresholds. Additionally, we found that glial cell line-derived neurotrophic factor (GDNF) was decreased in the diabetic mice. These results suggest that diabetes does alter neurotrophin levels, which may lead to PDN. Next, using a high-fat diet to induce prediabetes, we found increased levels of nerve growth factor (NGF) protein, a neurotrophin known to mediate pain signaling, in the periphery, while exercise normalized these levels. Furthermore, prediabetes resulted in a switching of axonal phenotypes in the skin, increasing peptidergic nerve fibers, which was reversed with exercise. These results suggest that increased NGF plays a critical role in mediating pain sensation in prediabetes and that exercise is capable of reversing this increase. Particularly, this study suggests that the ratio of peptidergic to nonpeptidergic axons may mediate the occurrence of PDN and may be more clinically significant than overall fiber density measures. Finally, we demonstrated that high-fat diet-induced PDN was reversed with a blocking antibody to NGF. In addition to decreases in mechanical withdrawal thresholds, anti-NGF treatment also normalized NGF levels within the DRG as well as normalizing epidermal innervation. Taken together, these studies demonstrate that exercise is capable of attenuating PDN, possibly through mediating NGF levels. It therefore appears that exercise and anti-NGF treatment are effective therapeutic strategies to prevent and reverse PDN.
172 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Biology
Animal diseases
Diabetes
Diabetic neuropathy
Exercise
Neurotrophins
Pain
Prediabetes
Voluntary Exercise and Neurotrophin Signaling Affect the Development and Presentation of Painful Neuropathy
Dissertation
Anatomy & Cell Biology
Ph.D.
TEXT
Groover_ku_0099D_13364_DATA_1.pdf.txt
Groover_ku_0099D_13364_DATA_1.pdf.txt
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Groover_ku_0099D_13364_DATA_1.pdf
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KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/296262019-11-05T23:51:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bosak, Kelly
Czerw, Michelle
Peterson, JoAnn
Mitchell, Suzanne
2019-10-14T16:58:57Z
2019-10-14T16:58:57Z
2019-08-31
2019
http://dissertations.umi.com/ku:16719
http://hdl.handle.net/1808/29626
Accurate assessment of burn percentage and depth are critical aspects in the initial assessment of the burn patient and guide both the immediate clinical management and subsequent need for follow up. To better assist providers in out-lying facilities, The University of Kansas Health System (TUKHS) Burnett Burn Center developed the Burnett Burn Assessment and Management Tool (BBAMT), which was recently distributed to referring hospitals and clinics. The purpose of this project was to assess the knowledge and perceived needs of outside providers of the burn wound triage and referral process, by evaluating 1) the implementation of the evidence based BBAMT with outlying providers; and, 2) the perceived needs of referring providers for accurate triage of burn wounds to TUKHS inpatient Burnett Burn Center or Outpatient Burn and Wound Care Clinic (OBWCC). A convenience sample of providers (n=14) were recruited, to evaluate the use of the BBAMT for treatment of a patient. The email addresses of referring providers were recorded and a needs assessment survey was sent by email using open-ended and likert style questions. Tool accessibility was moderate (mean of 3.6), provider’s understanding and confidence were higher (mean 4.5 and 4.4, respectively). The BBAMTs helpfulness in determining burn %TBSA, burn depth, and referral to inpatient vs. outpatient was also high (mean 4.1). Four common themes were identified from the open-ended question: overwhelming; inpatient vs. outpatient care; fluid calculation; and valuable. This study provided new knowledge of the perspective and competency needs of outside providers of the burn wound triage and referral process. Recommendations for improvements to the BBAMT and the distribution process of the tool to surrounding facilities have been made.
42 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Accuracy
Body surface area
Burns
Burn size estimation
Referral
Assessment of Referring Providers Use and Perceptions of the Burnett Burn Assessment and Management Tool for Estimating Burn Size
Dissertation
Nursing
D.N.P.
ORIGINAL
Czerw_ku_0099D_16719_DATA_1.pdf
Czerw_ku_0099D_16719_DATA_1.pdf
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Czerw_ku_0099D_16719_DATA_1.pdf.txt
Czerw_ku_0099D_16719_DATA_1.pdf.txt
Extracted text
text/plain
63780
https://kuscholarworks.ku.edu/bitstream/1808/29626/2/Czerw_ku_0099D_16719_DATA_1.pdf.txt
3b8e4894e0465b7aceada124ff3db4e2
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Czerw_ku_0099D_16719_DATA_1.pdf.jpg
IM Thumbnail
image/jpeg
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https://kuscholarworks.ku.edu/bitstream/1808/29626/3/Czerw_ku_0099D_16719_DATA_1.pdf.jpg
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1808/29626
oai:kuscholarworks.ku.edu:1808/29626
2019-11-05 17:51:42.255
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/295222019-11-05T23:51:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Baird, Martha B.
Herbst, Amy Marie
Whitney, Lucinda J.
2019-09-04T22:06:22Z
2019-09-04T22:06:22Z
2019-05-31
2019
http://dissertations.umi.com/ku:16424
http://hdl.handle.net/1808/29522
Problem: Up to 29% of those with a mental illness are readmitted to a psychiatric hospital within 30 days. Hospital readmissions to inpatient psychiatric hospitals are costly, averaging $7,200 per readmission. Major challenges of inpatient psychiatric care are nonadherence to medication and transition of follow-up care upon discharge. Further limitations are experienced when the patient is without health insurance and can result in a cycle of repeated psychiatric admissions. Project Aim: The Donabedian Model guided the primary aim of this Quality Improvement (QI) project which was to determine if a Discharge Medication Assistance Program (DMAP) at CoxHealth in Springfield, Missouri reduced the 30-day readmission rates on three inpatient psychiatric units. Project Method: A retrospective analysis of discharge and 30-day readmission data from January 2018 through June 2018. Findings: Patients discharged on DMAP had 12% lower readmission rates than those not on DMAP. Clinical Implications: Psychiatric programs that provide medications to patients at discharge can reduce 30-day readmission rates.
50 pages
en
University of Kansas
Copyright held by the author.
openAccess
Mental health
inpatient psychiatry
medication assistance program
readmission
Evaluation of a Discharge Medication Assistance Program (DMAP) to Reduce Psychiatric Readmissions
Dissertation
Nursing
D.N.P.
THUMBNAIL
Herbst_ku_0099D_16424_DATA_1.pdf.jpg
Herbst_ku_0099D_16424_DATA_1.pdf.jpg
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https://kuscholarworks.ku.edu/bitstream/1808/29522/3/Herbst_ku_0099D_16424_DATA_1.pdf.jpg
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Herbst_ku_0099D_16424_DATA_1.pdf.txt
Herbst_ku_0099D_16424_DATA_1.pdf.txt
Extracted text
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72777
https://kuscholarworks.ku.edu/bitstream/1808/29522/2/Herbst_ku_0099D_16424_DATA_1.pdf.txt
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Herbst_ku_0099D_16424_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/29522/1/Herbst_ku_0099D_16424_DATA_1.pdf
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MD5
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1808/29522
oai:kuscholarworks.ku.edu:1808/29522
2019-11-05 17:51:42.368
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/88302020-09-03T14:49:24Zcom_1808_197com_1808_1260col_1808_18171col_1808_7158
Burket, Ivan R.
2012-03-28T20:27:08Z
2012-03-28T20:27:08Z
1911
http://hdl.handle.net/1808/8830
en
The University of Kansas
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
The Influence of Adrenalin, Modified By Salt Solutions, On Blood-Pressure of the Frog and Cat
Thesis
Physiology
na
This item does not meet KU Open Access policy criteria.
3423949
ORIGINAL
ETD_1911_Burket_IR_Medium.pdf
ETD_1911_Burket_IR_Medium.pdf
application/pdf
9064693
https://kuscholarworks.ku.edu/bitstream/1808/8830/1/ETD_1911_Burket_IR_Medium.pdf
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MD5
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license.txt
text/plain
2569
https://kuscholarworks.ku.edu/bitstream/1808/8830/2/license.txt
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MD5
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THUMBNAIL
ETD_1911_Burket_IR_Medium.pdf.jpg
ETD_1911_Burket_IR_Medium.pdf.jpg
Generated Thumbnail
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https://kuscholarworks.ku.edu/bitstream/1808/8830/4/ETD_1911_Burket_IR_Medium.pdf.jpg
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TEXT
ETD_1911_Burket_IR_Medium.pdf.txt
ETD_1911_Burket_IR_Medium.pdf.txt
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24619
https://kuscholarworks.ku.edu/bitstream/1808/8830/3/ETD_1911_Burket_IR_Medium.pdf.txt
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oai:kuscholarworks.ku.edu:1808/8830
2020-09-03 09:49:24.437
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/301712022-02-24T15:58:30Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Kluding, Patricia
Santos, Marcio
Yahya, Abdalghani A
Kluding, Patricia
Santos, Marcio
Pasnoor, Mamatha
Liu, Wen
Wick, Jo
2020-03-25T18:24:23Z
2020-03-25T18:24:23Z
2019-12-31
2019
http://dissertations.umi.com/ku:16956
http://hdl.handle.net/1808/30171
https://orcid.org/0000-0001-5484-3706
There is cumulative evidence that fine motor skills and hand function are deficient in individuals with type 2 diabetes (T2D) and associated diabetic peripheral neuropathy (DPN). This might impact their ability to perform essential tasks such as buttoning a shirt, picking up pills, and monitoring blood sugar. Understanding the nature of such deficits is of utmost importance. This dissertation explores the sensorimotor involvement to deficits in hand dexterity: Sensory such as proprioception and motor such as grip force control. Several questions were addressed. First, does T2D and DPN cause finger proprioception deficits? Second, does T2D and DPN affect grip force control? Third, what is the role of sensation, specifically proprioception, in motor performance? Because little is known about testing proprioception in a manner relevant to dexterity tasks, data presented in Chapter 2 tested the reliability and feasibility of a novel device and methods of pinch proprioception. Twenty-one healthy subjects attempted to actively reproduce a target position between the index finger and thumb without visual feedback over two consecutive days. Nineteen subjects performed the same procedure, but in a one-day setting and under two conditions: With and without vibration applied to the dorsal part of their dominant hand. Two additional subjects with T2D and DPN were tested as well. Similar results of pinch proprioception were achieved between the two consecutive days indicating that the device and methods were reliable in tracking proprioception between the index finger and thumb. Also, disruption of pinch proprioception sense was achieved as subjects were less accurate in matching the target position under the influence of vibration. The two subjects with T2D and DPN showed less accuracy in matching the target position indicating that their sense of proprioception is affected by their disease. While the pinch proprioception device and methods showed promise in detecting proprioception deficits in subjects with T2D and DPN as shown in Chapter 2, we did not know whether DPN is the leading cause of such deficits. It is known that DPN causes sensory deficits hindering proprioception in the lower extremities, but the evidence is limited on the hands. To address this limitation, Chapter 3 describes an experiment with 13 subjects with T2D and DPN, 11 subjects with T2D without DPN, and 12 healthy subjects; all groups were age-matched. All subjects were tested for pinch proprioception utilizing the same device and methods described in Chapter 2. It was found that the accuracy and precision of the pinch proprioception were particularly affected in subjects with T2D and DPN. The T2D without DPN subjects showed similar findings to the healthy subjects indicating that DPN is a contributing factor to these deficits. Therefore, building on the findings from Chapter 2, it was concluded that damage to muscle spindles associated with DPN is very likely what caused pinch proprioceptive deficits. In Chapter 4, the focus shifted to grip force control. Several recent studies have shown deficits in controlling grip force in people with diabetes (type 1 and T2D). For instance, some studies showed an increase in grip force magnitude while others demonstrated that this variable was decreased in diabetic subjects with and without DPN. The same subjects described in the previous chapter were asked to grip and lift an object and then hold it at a specific height to address the inconsistent findings. Grip force magnitude, as well as temporal parameters of grip force control, were analyzed. It was found that the grip force magnitude was higher in subjects with T2D and DPN, and they took longer to perform the lifting task as compared to those with T2D without DPN and healthy subjects. These data provide evidence that T2D by itself does not present with any deficits in grip force control, and DPN might be responsible for deficits in grip force magnitude and temporal parameters. Finally, Chapter 5 is focused on the study of dexterous motor activities that involve object manipulation and require sensory feedback that plays a major role in adjusting grip forces when holding an object. Deficits in hand dexterity in people with T2D have been shown via Jebsen-Taylor Hand Function Test (JTHFT) and Moberg Pickup Test (MPUT); i.e., subjects spent more prolonged time to perform functional tasks. In addition to the finding of impairments in pinch proprioception, grip force control, and hand dexterity in people with T2D and DPN, decrements in pinch proprioception were positively correlated with longer time to perform dexterity tasks. Other aspects of sensory deficits (tactile sensation) were more associated with higher grip force magnitude. It was concluded that while tactile sensation was more associated with higher grip forces, pinch proprioception deficits appear to contribute to increasing the time needed to perform a lifting task. Overall, the results suggest that DPN is a major concern that causes proprioceptive, grip force control, and hand dexterity problems. The integrity of proprioceptive signals, as well as tactile sensation, affect different profiles of grip force control to different degrees. Proprioception is more related to timing while tactile sensation appears to affect the grip force production. Therefore, intact sensory information (tactile and proprioceptive) is necessary to perform dexterity tasks which seem to be problematic for subjects who suffer from T2D and DPN. Clinicians should be aware of the nature of hand dexterity deficits in the presence of DPN when screening and developing rehabilitation programs.
163 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health sciences
Physical therapy
Physical therapy
The Impact of Type 2 Diabetes and Associated Diabetic Peripheral Neuropathy on Grip Force Control and Hand Function
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
ORIGINAL
Yahya_ku_0099D_16956_DATA_1.pdf
Yahya_ku_0099D_16956_DATA_1.pdf
Available after: 2021-12-31
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oai:kuscholarworks.ku.edu:1808/295162020-10-13T14:37:14Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Busenhart, Cara
Carlson, Courtney Elizabeth
Peterson, Moya
2019-09-04T21:58:04Z
2019-09-04T21:58:04Z
2019-05-31
2019
http://dissertations.umi.com/ku:16377
http://hdl.handle.net/1808/29516
https://orcid.org/0000-0002-5774-0486
Diabetes Mellitus is a dangerous condition known to cause adverse effects to both mother and fetus. Rates of diabetes are increasing worldwide. Research indicates that undiagnosed pre-existing, or overt, diabetes may increase poor outcomes in pregnancy; therefore, new recommendations from healthcare organizations endorse first-trimester screening for undiagnosed pre-existing diabetes in at-risk patients. Diabetes screening during pregnancy has long-been studied, and universal screening for gestational diabetes between 24 and 28 weeks gestation is endorsed by all major healthcare organizations. However, until recently, little research explored pre-existing diabetes and related effects on pregnancy. In 2018, the American College of Obstetricians and Gynecologists released new recommendations regarding screening at-risk patients in the first trimester of pregnancy. However, many providers have not yet begun to implement this testing. This project chronicles the development and evaluation of a protocol designed to identify and screen at-risk patients in the High-Risk Obstetrics clinic in an academic medical center located in a Midwestern city. After a review of the current literature, an evidence-based protocol for screening for overt diabetes in early pregnancy was developed. An inter-professional expert panel evaluated the protocol using the REDCap system, and the results were analyzed using qualitative and quantitative methods. Upon review and analysis, much of the evaluation results were positive, but some areas for improvement were clear. Evaluation was broken down by theme, to identify patterns in results. This information was then employed in developing a second, and final, draft of the Protocol. The response of a multi-professional provider review team supports adoption of this protocol; therefore, after making recommended alterations in format and content, this protocol will be considered for introduction in the High-Risk Obstetrics Clinic detailed in this document. Indicated follow-up study should include determining the early diagnosis rates of diabetes in pregnancy, as well as a cost analysis of the available methods of testing in early pregnancy. Keywords: diabetes, prenatal care, screening, protocol, diabetes in pregnancy, overt diabetes
47 pages
en
University of Kansas
Copyright held by the author.
openAccess
Medicine
Nursing
diabetes
diabetes in pregnancy
overt diabetes
prenatal care
protocol
screening
Development and Evaluation of Protocol for Early Screening For Diabetes in Pregnancy: A Quality Improvement Initiative
Dissertation
Nursing
D.N.P.
TEXT
Carlson_ku_0099D_16377_DATA_1.pdf.txt
Carlson_ku_0099D_16377_DATA_1.pdf.txt
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Carlson_ku_0099D_16377_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/102942019-07-17T05:18:03Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Lai, Sue-Min
Heller, Aaron
McIff, Terence
Burton, Douglas
2012-10-28T16:26:26Z
2012-10-28T16:26:26Z
2012-08-31
2012
http://dissertations.umi.com/ku:12342
http://hdl.handle.net/1808/10294
Summary: We reviewed 371 consecutive patients from Oct. 2008 to Sept. 2011 who underwent posterior instrumented spinal arthrodesis and received intrawound vancomycin powder prior to closure and compared their acute, deep infection rate to 371 consecutive patients from Oct. 2008 to Apr. 2005 who underwent posterior spinal instrumented arthrodesis and did not receive intrawound vancomycin. We found the use of vancomycin powder decreased the acute, deep Staphylococcus infection rate from 2.05% to 0 (p=0.008). Vancomycin powder is an effective way to decrease acute, deep S. aureus infections following spine surgery. Introduction: Surgical site infection is a serious complication for patients undergoing instrumented spinal surgery. Staphylococcus aureus is the most common causative agent associated with post-op wound infections. Recent studies have reported a decreased infection rate with intrawound vancomycin use in spine surgeries. We sought to determine if intrawound vancomycin would decrease the rates of acute, deep S. aureus infections in our posterior instrumented spinal arthrodesis patients. Methods: This is a historical cohort study. All procedures were performed by a single surgeon. 371 consecutive patients undergoing posterior instrumented spinal arthrodesis received intrawound vancomycin in addition to standard antimicrobial prophylaxis beginning in Oct. 2008 through Sept. 2011 (Vanco cohort). We compared them to 371 consecutive patients from Oct. 2008 to Apr. 2005 who did not receive intrawound vancomyin (Historical cohort). We excluded any superficial infection (above the lumbosacral fascia) or any infection occurring after 90 days. Infection rates were analyzed with Fisher exact test. Results: We found 8 (2.4%) acute, deep infections in the Historical cohort: 1 Enterococcus and 7 (2.05%) Staphylococcus (6 of which were S. aureus). We found 4 (1.2%) acute, deep infections in the Vanco group, none of which were S. aureus. There were 2 E.coli, 1 Klebsiella oxytoca, and 1 anaerobic Streptococcus. The difference in total acute, deep infection rate between the Historical cohort and Vanco cohort was not significant (p= 0.262), but the decrease in Staphylococcus infection rate in the Vanco group was significant (p=0.008). Conclusion: Intrawound vancomycin powder has decreased the rate of acute, deep Staphylococcus infections in our posterior instrumented spinal fusion patient population from 2.05% to 0. Our Vanco cohort was significantly older but otherwise similar in terms of risk factors to the Historical cohort, though had fewer infections. This work is adding to the growing body of evidence in support of this effective adjuvant to standard antimicrobial prophylaxis.
43 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Medicine
Spine surgery
Surgical site infection
Vancomycin powder
THE EFFECT OF INTRAWOUND VANCOMYCIN POWDER ON SURGICAL SITE INFECTIONS IN POSTERIOR INSTRUMENTED SPINAL ARTHRODESES
Thesis
Clinical Research
M.S.
na
This item does not meet KU Open Access policy criteria.
ORIGINAL
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Heller_ku_0099M_12342_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/10294
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open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/301872021-03-05T16:53:56Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peltzer, Jill
Westfall, Aren Emmaline
Busenhart, Cara
Mitchell, Suzanne
2020-03-25T19:33:02Z
2020-03-25T19:33:02Z
2019-12-31
2019
http://dissertations.umi.com/ku:16898
http://hdl.handle.net/1808/30187
https://orcid.org/0000-0003-0900-6479
Approximately 10% of the U.S. population is living with diabetes. Diabetic foot ulcers (DFU) are one of the most prevalent and debilitating complications. One in four people with diabetes will develop a DFU at some point in their lifetime. The consequences of non-healing DFUs include risk of amputation, further disease complications, increased risk of mortality, and more frequent and extended hospital stays. Adhering to evidence-based guidelines, which include recommendations for DFU prevention, assessment, and management, is crucial for achieving complete healing and reducing risks for poor outcomes. However, research has consistently shown a significant gap in the use of these guidelines in primary care, where DFU prevention should occur and DFU assessment and management most often begins. Objective: The purpose of this quality improvement project was to evaluate the initial management and current referral process for DFU patients and make recommendations for improvements based on current evidence-based practice guidelines for DFU management. Methods: A retrospective chart review was performed at the University of Kansas Hospital’s Outpatient Burn and Wound Care Center to evaluate for adherence to evidence-based practice guidelines for initial management and referral for DFU care by referring providers. Factors associated with lack of adherence to guidelines were identified via the collection of variables from 70 randomly selected patient charts, including specific data points related to DFU prevention, assessment, and management. Descriptive statistics were utilized to analyze the data collected using means for continuous variables and frequencies and percentages for categorical variables. Results: Retrospective data indicates that evidence-based guidelines were poorly implemented for DFU assessment and management in the primary care setting. In a sample of 70 patients, neuropathy assessments were done 21.4% of the time, ischemia assessments 45.7%, and infection assessments 87.1% in the primary care setting. In contrast, all three of these assessments were performed 100% of the time at the specialty wound clinic. Making a referral was the most common management strategy utilized by primary care providers for treating a DFU and was applied 75.7% of the time, although only 23% of these referrals were made to a wound care clinic. Debridement and offloading were infrequently seen in primary care with the former being utilized in 10% of cases and the latter 18.6%. Most often, referrals to wound care were made by a specialist, which was the case 49% of the time. Sixty-one percent of patients required more than one referral before being evaluated by a wound care specialist. Average total duration of a DFU from onset to resolution was 104 days (range 13-248). Conclusion: The results of this study indicate that the initial management and referral process of DFU’s is currently inadequate and not in line with current evidence-based practice guidelines for DFU management. Further research is needed to explore the reasons for provider noncompliance in order to determine appropriate interventions to facilitate improvements in adherence to guidelines.
40 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
DFU
diabetes
referral
wounds
Evaluating the Initial Management and Referral Process for Patients with Diabetic Foot Ulcers
Dissertation
Nursing
D.N.P.
TEXT
Westfall_ku_0099D_16898_DATA_1.pdf.txt
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2021-03-05 10:53:56.124
open access
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lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/269432018-10-25T20:08:40Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Chennathukuzhi, Vargheese M
McWilliams, Michelle Marie
Nothnick, Warren B
Kumar, T. Rajendra
Blanco, Gustavo
Durham, Dianne
2018-10-22T22:31:32Z
2018-10-22T22:31:32Z
2017-05-31
2017
http://dissertations.umi.com/ku:15151
http://hdl.handle.net/1808/26943
Uterine Leiomyoma (UL), also known as Uterine Fibroids, are benign, hormone-sensitive tumors arising in the smooth muscle tissue layer of the uterus, the myometrium. UL are the most common female reproductive tract tumors, with lifetime occurrence in up to 77% of all women. A third of women with UL require treatment for clinically significant symptoms of menorrhagia, severe pain, anemia and fertility complications, resulting in over 200,000 hysterectomies and up to $34.4 billion in medical costs in the United States each year. Despite the prevalence of UL, currently no treatment for UL is long-term, cost effective and leaves fertility intact. There is a pressing need to develop better pharmacotherapies for the treatment of UL. Remarkably, very little is known about the molecular pathogenesis of UL. Environmental estrogen exposure is one of the most recognized risk factors associated with the development of UL tumors. At the cellular level, extensive evidence has linked the cell proliferation, survival and growth of UL tumors to the over-activation of the PI3K/AKT-mTOR pathway. This work establishes, for the first time, a comprehensive molecular pathway starting from known environmental estrogen risk factors leading to activation of the most crucial cell proliferation pathway in UL. We identified the most overexpressed G-protein coupled receptor in UL as the neuronspecific GPR10 (PRLHR), which activates the PI3K/AKT-mTOR pathway in UL cells upon stimulation by its ligand, PrRP (Prolactin-Releasing Peptide). Epigenetic silencing of GPR10 in non-neuronal cells is accomplished by the tumor-suppressor REST (Repressor Element Silencing Transcription factor), which we found to be drastically down-regulated at the protein level in UL tissue. In addition to GPR10, many of the most dysregulated genes in UL tissue are direct targets iv of REST, implicating the central role of the loss of REST in the pathogenesis of UL. In our investigations on the degradation of REST in UL, we found significant under-expression of PRICKLE1, the protein required for REST localization to the nucleus. We have found that PRICKLE1 expression in the uterine myometrium is regulated by estrogen through Estrogen Receptor-α and that the loss of PRICKLE1 leads to the destabilization and degradation of REST protein in UL. We found overexpression of the polycomb repressor complex protein EZH2 (Enhancer of Zeste Homolog 2) participates in repression of PRICKLE1 in UL. Furthermore, we provide two important preclinical mouse models, which are among the first in the UL field that recapitulate genes dysregulated in human UL. We show that mice expressing hGPR10 in the uterus, and a conditional knockout of REST in the reproductive tract, show UL phenotype. This work establishes a novel molecular pathway in UL pathogenesis linking upstream estrogen signaling to downstream PI3K/AKT-mTOR pathway activation and provides potential drug targets and preclinical mouse models for improved treatment of UL.
322 pages
en
University of Kansas
Copyright held by the author.
openAccess
Molecular biology
Physiology
Endocrinology
animal models
developmental reprogramming
environmental estrogens
uterine fibroids
uterine leiomyoma
uterine pathophysiology
A Novel Molecular Pathway Involving GPR10, REST, and PRICKLE1 in the Pathogenesis of Uterine Leiomyoma
Dissertation
Molecular & Integrative Physiology
Ph.D.
TEXT
McWilliams_ku_0099D_15151_DATA_1.pdf.txt
McWilliams_ku_0099D_15151_DATA_1.pdf.txt
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507964
https://kuscholarworks.ku.edu/bitstream/1808/26943/2/McWilliams_ku_0099D_15151_DATA_1.pdf.txt
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McWilliams_ku_0099D_15151_DATA_1.pdf
McWilliams_ku_0099D_15151_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/26943/1/McWilliams_ku_0099D_15151_DATA_1.pdf
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1808/26943
oai:kuscholarworks.ku.edu:1808/26943
2018-10-25 15:08:40.112
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/79282020-06-22T20:56:03Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Smith, Carol
Bergquist-Beringer, Sandra
Shen, Qiuhua
Bosak, Kelly
Piamjariyakul, Ubolrat
Keighley, John
Yeh, Hung-Wen (Henry)
2011-08-04T19:41:35Z
2011-08-04T19:41:35Z
2011-04-19
2011
http://dissertations.umi.com/ku:11399
http://hdl.handle.net/1808/7928
The relationship between depression and insulin resistance has been evaluated in previous studies but with conflicting results. No study was found that investigates the role of race/ethnicity in the relationship between depression and insulin resistance. The purpose of this study was to: 1) determine the prevalence of major depression and insulin resistance among nondiabetic young adults aged 20-39 years in the United States, 2) examine the relationship between major depression and insulin resistance among nondiabetic young adults aged 20-39 years in the United States, and 3) determine whether this relationship varies by gender, race/ethnicity, or measure of depression. Analyses of cross-sectional data from the National Health and Nutrition Examination Survey (NHANES) 1999-2008 were performed. The study sample consisted of 1,054 (46.5%) men and 1,211 (53.5%) women who were nondiabetic and aged 20-39 years (N = 2,265). Major depression was measured by the Composite International Diagnostic Interview in NHANES 1999-2004 and by the Patient Health Questionnaire-9 in NHANES 2005-2008. Insulin resistance was measured by the homeostasis model assessment for insulin resistance. The prevalence of major depression and insulin resistance among nondiabetic U.S. adults aged 20-39 years in the study was 3.7% (n = 84; weighted % = 3.8) and 25.7% (n = 582; weighted % = 22.7) respectively. No significant association was found between major depression and insulin resistance in bivariate logistic regression analysis. However, a significant interaction effect between gender and major depression was observed. For men, major depression was negatively associated with insulin resistance after adjusting for age, race/ethnicity, systolic blood pressure, triglyceride level, high-sensitivity C-reactive protein, obesity, leisure time physical activity, smoking, and alcohol consumption. In contrast, no significant association between major depression and insulin resistance among women was found. There was no significant interaction between race/ethnicity and major depression. No significant variations in the relationship between major depression and insulin resistance by measure of depression were revealed. Study findings provide support for a significant positive relationship between insulin resistance and 1) systolic blood pressure, 2) triglyceride level, 3) and obesity as measured by body mass index or waist circumference among nondiabetic young adults aged 20-39 years.
326 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Gender
Insulin resistance
Major depression
Race/ethnicity
Risk factors
Young adults
MAJOR DEPRESSION AND INSULIN RESISTANCE AMONG NONDIABETIC U.S. ADULTS AGED 20-39 YEARS: THE ROLES OF GENDER AND RACE/ETHNICITY
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7642970
ORIGINAL
Shen_ku_0099D_11399_DATA_1.pdf
Shen_ku_0099D_11399_DATA_1.pdf
application/pdf
2272404
https://kuscholarworks.ku.edu/bitstream/1808/7928/1/Shen_ku_0099D_11399_DATA_1.pdf
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open access
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TEXT
Shen_ku_0099D_11399_DATA_1.pdf.txt
Shen_ku_0099D_11399_DATA_1.pdf.txt
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https://kuscholarworks.ku.edu/bitstream/1808/7928/2/Shen_ku_0099D_11399_DATA_1.pdf.txt
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MD5
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open access
1808/7928
oai:kuscholarworks.ku.edu:1808/7928
2020-06-22 15:56:03.881
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/59802020-06-23T00:32:34Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wambach, Karen
Rosen, Elizabeth Anne Averill
Breedlove, Ginger
Aaronson, Lauren
Lee, Kathryn
Colombo, John
2010-03-18T04:42:10Z
2010-03-18T04:42:10Z
2009-12-09
2009
http://dissertations.umi.com/ku:10691
http://hdl.handle.net/1808/5980
Sleep loss is a common concern frequently expressed by new mothers. This study's purpose was to investigate the difference between sleep architecture, descriptions and self-perception of sleep in breastfeeding and formula-feeding mothers, 4-6 weeks post-partum (N=44). Measurement tools were St.Mary's Hospital Sleep Questionnaire, wrist actigraphy, home polysomnography, and baseline measures: demographics, previous sleep patterns and factors impacting sleep. MANCOVA comparing the sleep architecture characteristics of light sleep, deep sleep, and REM sleep while controlling for age, education and nicotine use, and a t-test on total sleep time, did not demonstrate any significant differences between groups. The variance of sleep characteristics measured was greater within the formula-feeding mothers. There was a mean of 6.6 hours of sleep in both groups with overall sleep satisfaction. In contrast to the study being replicated, sleep did not appear to be significantly different. Wrist actigraphy data reflected more sleep than either polysomnography or self-report.
158 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Nursing
Health sciences
Obstetrics and gynecology
Women's studies
Breastfeeding
Formula-feeding
Home polysomnography
Postpartum
Sleep
Slow wave sleep
Sleep Characteristics in Breastfeeding and Formula-Feeding Mothers
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7078662
ORIGINAL
Rosen_ku_0099D_10691_DATA_1.pdf
Rosen_ku_0099D_10691_DATA_1.pdf
application/pdf
1621249
https://kuscholarworks.ku.edu/bitstream/1808/5980/1/Rosen_ku_0099D_10691_DATA_1.pdf
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LICENSE
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license.txt
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2569
https://kuscholarworks.ku.edu/bitstream/1808/5980/4/license.txt
c51a2a8181b7df93e55a9d6314ced7e1
MD5
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open access
TEXT
Rosen_ku_0099D_10691_DATA_1.pdf.txt
Rosen_ku_0099D_10691_DATA_1.pdf.txt
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259429
https://kuscholarworks.ku.edu/bitstream/1808/5980/2/Rosen_ku_0099D_10691_DATA_1.pdf.txt
1b756438a11483b6e5379e8b5f0123f5
MD5
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1808/5980
oai:kuscholarworks.ku.edu:1808/5980
2020-06-22 19:32:34.309
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/224872018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bott, Marjorie J
Barrett, Genevieve
Williams Domian, Elaine
Popkess-Vawter, Sue
Williams, Kristine
Mische Lawson, Lisa
2017-01-06T04:13:17Z
2017-01-06T04:13:17Z
2016-05-31
2016
http://dissertations.umi.com/ku:14555
http://hdl.handle.net/1808/22487
Adults aged 65 years and older are the population most often diagnosed with cancer. Although much research has been conducted on a person’s adjustment to a cancer diagnosis, there has not been a direct focus on older adults’ perceptions of their needs following a cancer diagnosis. The significance of the problem of inattention to the unique needs of older adults at their time of cancer diagnosis relates to a number of national organizational missions and goals, including Healthy People 2020, the Agency for Healthcare Research and Quality, the Institute of Medicine, the Oncology Nursing Society, and the Geriatric Oncology Consortium. This research used naturalistic inquiry within the constructivist paradigm. The goal was to explore the needs experienced by older adults (65 years and older) diagnosed with cancer within the past four months using a descriptive qualitative design. The intent of this research is to explore the needs of older adults, thereby discovering opportunities to enhance the access to comprehensive care in the older population. Literature findings related to maintaining independence, coping with the diagnosis, social support, and financial concerns provided the context for exploring factors associated with the experience of the older adult diagnosed with cancer. This research involved 14 Midwestern older adult participants, with an average age of 69 and who were an average of 9 weeks from cancer diagnosis. The participants completed semi-structured interviews, and data from the interviews and researcher field notes were analyzed using qualitative content analysis. It is from this process that the themes and categories of the study emerged. The study’s three themes include: (a) The Cancer Health Care Experience: Interactions with providers that are generally positive but not without disappointments, (b) Challenges in Managing the Cancer Experience: Barriers to feeling normal and hurdles to overcome, and (c) Coping with the Cancer Experience: Handling the cancer journey with mental adaptation and external support. These themes covered twelve categories including: Excellent Care, Trusting and Respecting Providers, Disappointments in Healthcare, A New Experience, What the Patient Brings to the Table, Desire for Control, Physical Limitations, Emotional Strain, Positive Outlook, Thinking of Others, Support and Encouragement, and Reflection. Implications include using these findings: (a) to meet the needs of older adults who recently have been diagnosed with cancer; (b) to integrate health care delivery teams; (c) to facilitate the maintenance of self-identity and control among older adults; (d) to improve training for healthcare providers on patient financial and workforce concerns; and (e) to explore further research with additional perspectives and broader samples.
106 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Oncology
Gerontology
cancer
needs
older adult
A Qualitative Descriptive Study of the Needs of Older Adults Recently Diagnosed with Cancer
Dissertation
Nursing
Ph.D.
TEXT
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oai:kuscholarworks.ku.edu:1808/63712020-06-23T00:53:18Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Warren, Judith J
Menninger-Corder, Mary Lynn
Connors, Helen
Gajewski, Byron
Grasso, Michael
Brixey, Juliana
2010-07-05T22:20:43Z
2010-07-05T22:20:43Z
2010-04-27
2010
http://dissertations.umi.com/ku:10860
http://hdl.handle.net/1808/6371
The purpose of this study was to identify the electronic health record functionalities of acute care hospitals in the state of Kansas with regard to nursing practice. From the perspective of the Chief Nursing Officer, what was the nurses' role in implementation of the electronic health record, what nursing documentation was in the electronic health record, and what factors led to the acceptance of the electronic health record by the nursing staff? It was also concerned with how, as the Chief Nursing Officer, the perception of their social capital might affect the implementation of their electronic health record. A survey was developed for this descriptive study to quantify the components of individual hospital's electronic health record, using the theoretical framework of Technology Acceptance Theory and Social Capital Theory. Chief Nursing Officers who were members of the Kansas Hospital Association were surveyed with a 48.8 % return. The results of the study revealed the Chief Nursing Officers were deeply aware of the importance of the electronic health record for promoting best possible outcomes for patients and for improving the delivery of quality nursing care. Social capital was not significantly correlated with the implementation of the electronic health record (r = -.013, p = .936). The study also revealed that for this population of Chief Nursing Officers, they felt powerful in their profession, felt the use of the electronic health record was important to provide safe, quality care to their patients and were active in their hospital's electronic health record implementation team. The Institute of Medicine challenged healthcare providers to transform the health care system in the United States into one that is fair, equitable, efficient, safe, and provides quality patient care, the results from this study may be a step towards that goal. vi Key words: electronic health record, functionalities, technology acceptance theory, social network theory, social capital, social capital theory.
155 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Nursing
Electronic health records
Social capital theory
Technology acceptance theory
THE ELECTRONIC HEALTH RECORD FUNCTIONALITIES IN THE STATE OF KANSAS WITH REGARD TO NURSING PRACTICE
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7078764
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oai:kuscholarworks.ku.edu:1808/278642020-10-14T15:20:45Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Busenhart, Cara A.
Ford, Debra J.
Miner, Julya Louise
2019-05-10T17:21:07Z
2019-05-10T17:21:07Z
2018-12-31
2018
http://dissertations.umi.com/ku:16230
http://hdl.handle.net/1808/27864
Maternal mortality rate/ratio (MMR) is a significant indicator of the overall quality of health care. While MMR is declining globally, the United States is one of only eight countries where MMR continues to rise. Sadly, many of the issues contributing to MMR, such as delay in diagnosis or treatment, and failure to recognize patients at risk, are preventable. Deficits in staff knowledge or training are common causative factors in preventable maternal deaths. Simulation, e-learning, and instructor-led courses have been implemented globally in an effort to address preventable factors. The Model for Improvement dictates the need for outcome evaluation to determine if a change is an improvement. The purpose of this doctoral project was to evaluate perinatal outcomes following the inclusion of an assessment-driven, individualized e-learning platform focused on obstetric emergencies within a blended learning environment. The Kirkpatrick Model for training evaluation provided a structure for this performance improvement project. Sources for perinatal patient outcome data were identified. Pre- and post-implementation data were charted. Improvements in perinatal outcomes with reduction in maternal morbidity were noted following implementation of the e-learning platform for obstetric emergencies. A slight decrease in overall obstetrical hemorrhage rates was noted (average 54.7/1,000 deliveries down from 56.4/1,000 deliveries at baseline). A slight decrease in massive transfusion rates (4 units pRBC) was realized (average 2.2/1,000 deliveries down from 2.4/1,000 deliveries at baseline). Three consecutive months at the end of the performance period noted 0 cases of massive transfusion indicating improved management of obstetrical hemorrhage. The most significant improvement was with a downward shift in maternal intensive care unit (ICU) admission (average 1.5/1,000 deliveries down from 2.9/1,000 deliveries). Zero ICU admits were noted 6 of the last 7 months of the performance period. Tracking clinical outcomes validated the effectiveness of the e-learning program within a blended learning environment. Data-driven education reduced waste by right-sizing the training for providers and nurses. The intentional focus on closing gaps in knowledge and training in obstetric emergencies for nurses and providers may help reduce maternal morbidity and mortality moving forward. Keywords: e-learning, Kirkpatrick Model, maternal morbidity, maternal mortality, Model for Improvement, obstetric, perinatal outcomes, obstetric hemorrhage
47 pages
en
University of Kansas
Copyright held by the author.
openAccess
Obstetrics
Nursing
Adult education
e-learning
Kirkpatrick Model
maternal morbidity
maternal mortality
obstetric hemorrhage
perinatal outcomes
Evaluating the Effect of an Online, Assessment-Driven Learning Platform for Obstetric Providers and Nurses
Dissertation
Nursing
D.N.P.
ORIGINAL
Miner_ku_0099D_16230_DATA_1.pdf
Miner_ku_0099D_16230_DATA_1.pdf
Available after: 2019-12-31
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https://kuscholarworks.ku.edu/bitstream/1808/27864/1/Miner_ku_0099D_16230_DATA_1.pdf
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Miner_ku_0099D_16230_DATA_1.pdf.txt
Miner_ku_0099D_16230_DATA_1.pdf.txt
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https://kuscholarworks.ku.edu/bitstream/1808/27864/2/Miner_ku_0099D_16230_DATA_1.pdf.txt
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Miner_ku_0099D_16230_DATA_1.pdf.jpg
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1808/27864
oai:kuscholarworks.ku.edu:1808/27864
2020-10-14 10:20:45.188
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/232932020-06-23T20:24:55Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Sauer, Frederick Charles
2017-02-28T19:57:45Z
2017-02-28T19:57:45Z
1931
http://hdl.handle.net/1808/23293
Thesis (M.A.)--University of Kansas, Anatomy, 1931.
eng
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
Sex differences in the proportion of cortex and medulla in the chicken suprarenal
Thesis
Anatomy
M.A.
3245620
ORIGINAL
sauer_1931_3245620.pdf
application/pdf
30912139
https://kuscholarworks.ku.edu/bitstream/1808/23293/1/sauer_1931_3245620.pdf
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MD5
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open access
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sauer_1931_3245620.pdf.txt
sauer_1931_3245620.pdf.txt
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40971
https://kuscholarworks.ku.edu/bitstream/1808/23293/2/sauer_1931_3245620.pdf.txt
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https://kuscholarworks.ku.edu/bitstream/1808/23293/3/sauer_1931_3245620.pdf.jpg
97819c09840de4db90f19e0fc1c30ab0
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1808/23293
oai:kuscholarworks.ku.edu:1808/23293
2020-06-23 15:24:55.71
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/278252020-07-09T21:30:53Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Cheng, Nikki
Yao, Min
Fan, Fang
Fields, Patrick E
Fields, Timothy A
Wambi, Joan L
2019-05-10T15:38:38Z
2019-05-10T15:38:38Z
2017-12-31
2017
http://dissertations.umi.com/ku:15622
http://hdl.handle.net/1808/27825
Breast cancer is the most common cancer diagnosed in women in the United States. The basal-like breast cancer subtype represents about 12% of breast cancer and has the worst outcome in patients due to lack of effective therapies. Tumor stroma plays an important role in cancer progression. Cancer associated fibroblasts (CAFs) are the most abundant stromal cells in breast cancer, but their function in cancer progression has not been fully understood. We previously identified that the chemokine CCL2 was highly expressed in breast cancer associated fibroblasts. CCL2 is known to recruit monocyte/macrophage and promotes cancer progression. We previously found that recombinant CCL2 can directly signal to breast cancer cells and promote cell survival and invasion in vitro. In this study, we aimed to determine the functional importance of CCL2 signaling mediated fibroblast-cancer cell interactions in the breast cancer progression. We evaluated the expression of CCL2 and fibroblast marker Fsp1 in breast cancer tissue microarray containing 427 samples by immunohistochemistry. Expression of CCL2 and Fsp1 were co-upregulated in invasive ductal carcinoma compared to normal breast. High stromal CCL2 expression associated with reduced recurrence free survival in the basal-like subtype. Further data mining in the breast cancer TCGA and METABRIC datasets revealed that the CCL2/CCR2 pair expressed highest in the basal-like subtype. We confirmed high CCL2 expression from CAFs isolated from primary human and mouse breast cancer samples. CAFs with high CCL2 expression significantly promoted xenograft growth when co-grated with human basal-like breast cancer MCF10A-CA1D cell line. Reduction of CCL2 expression by CRISPR mutation or shRNA knockdown in human or mouse CAFs significantly reduced tumor growth in the co-graft model. Fibroblasts condition medium or recombinant CCL2 directly promoted CA1D cancer cell growth in vitro. Mutation of the CCL2 receptor CCR2 receptor in CA1D cancer cell significantly reduced cancer cells growth in vitro and in vivo in response to CCL2 stimulation. The CCL2/CCR2 signaling activated PKC and SRC pathways in cancer cells, and contributed to growth promotion. We aimed to test the therapeutic efficacy by blocking CCL2 in breast cancer mouse model through continuous delivery of CCL2 neutralizing antibody. Despite the steady delivery of the antibody, CCL2 blocking did not significantly affect tumor progression. Examination of CCL2 level in blood and tumor sites revealed that CCL2 blocking significantly induced higher free CCL2 level, which may contribute to lack of efficacy. In summary, our studies have showed that CCL2 derived from cancer associated fibroblasts plays an important role in basal-like breast cancer progression. Direct signaling to cancer cells via CCR2 is an important mechanism in CCL2 function. Thus, the CCL2/CCR2 signaling may serve as potential therapeutic targets in basal-like breast cancer. CCL2 blocking by neutralizing antibody can lead to undesired increased CCL2 level, and alternative targeting approaches are needed to achieve therapeutic efficacy.
131 pages
en
University of Kansas
Copyright held by the author.
openAccess
Biology
Canadian history
Basal-like breast cancer
Breast cancer
Cancer Associated Fibroblast
CCL2
CCR2
Chemokine
The chemokine CCL2/CCR2 signaling mediates cancer associated fibroblasts-cancer cells interaction and promotes basal-like breast cancer progression
Dissertation
Pathology & Laboratory Medicine
Ph.D.
THUMBNAIL
Yao_ku_0099D_15622_DATA_1.pdf.jpg
Yao_ku_0099D_15622_DATA_1.pdf.jpg
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Yao_ku_0099D_15622_DATA_1.pdf
Yao_ku_0099D_15622_DATA_1.pdf
Available after: 2019-12-31
application/pdf
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https://kuscholarworks.ku.edu/bitstream/1808/27825/1/Yao_ku_0099D_15622_DATA_1.pdf
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MD5
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Yao_ku_0099D_15622_DATA_1.pdf.txt
Yao_ku_0099D_15622_DATA_1.pdf.txt
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text/plain
203717
https://kuscholarworks.ku.edu/bitstream/1808/27825/2/Yao_ku_0099D_15622_DATA_1.pdf.txt
d4a9fc50cb7efe8aba12eac432e8c29d
MD5
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1808/27825
oai:kuscholarworks.ku.edu:1808/27825
2020-07-09 16:30:53.312
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/43272020-06-22T20:37:07Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Berman, Nancy EJ
Liverman, Christopher S.
McCarson, Kenneth E
Wright, Douglas E
Smith, Peter G
Stehno-Bittel, Lisa
Roby, Katherine F
Klein, Robert M
2009-02-02T05:34:07Z
2009-02-02T05:34:07Z
2008-01-01
2008
http://dissertations.umi.com/ku:10015
http://hdl.handle.net/1808/4327
Migraine is much more common in women than in men, and painful episodes are linked to the hormonal fluctuations of the menstrual cycle. The MAP kinase extracellular-signal regulated kinase (ERK) is activated in experimental models of chronic pain, and is also activated by estrogen in sensory neurons. We used an established model of inflammatory trigeminal pain, injection of Complete Freund's adjuvant (CFA) into the masseter muscle, to determine whether ERK activation may play a role in hormone-related trigeminal pain disorders. We measured withdrawal responses to stimulation of the masseter (V3, primary allodynia) and whisker pad (V2, secondary allodynia) using graded monofilaments. Estrogen treatment in the presence of inflammation increased withdrawal response to stimulation of either masseter or whisker pad compared to inflammation alone, indicating an additive effect of inflammation and estrogen on both primary and secondary allodynia. We examined ERK activation in trigeminal ganglia from each treatment group using Western blot and immunohistochemistry. Both masseter inflammation and estrogen treatment increased ERK activation, and combined treatment had an additive effect. Both masseter inflammation and estrogen increased the percentage of pERK immunoreactive neurons in divisions 1 and 2 (V1/2), and combined treatment increased pERK immunoreactivity in V1/2 compared to inflammation alone. We stereotactically administered ERK antagonist U0126, or inactive control U0124, to the trigeminal ganglion of CFA+E2-treated rats. U0126 decreased withdrawal responses to mechanical stimulation of the whisker pad compared to U0124-treated rats. Because the secondary allodynia in V2 after inflammation in V3 was reduced by antagonizing ERK activation in the periphery, these data suggest a peripheral component to secondary trigeminal allodynia mediated through ERK activation. Cellular responses to estrogen can occur through both `genomic' and `nongenomic' pathways. The novel estrogen receptor GPR30 (G-protein coupled receptor 30) activates mediators of signal transduction, including ERK. A goal of this study was to determine which estrogen receptor is required for behavioral sensitization. In order to determine whether GPR30 is present in neurons of the trigeminal ganglion, we performed Western blots for GPR30 on trigeminal ganglion from ovariectomized female Sprague-Dawley rats. Our results show the presence of GPR30 protein in the trigeminal ganglion. Immunohistochemistry for GPR30 in trigeminal ganglion sections showed that GPR30 immunoreactivity was localized to neuronal cell bodies. To determine the subpopulation of neurons that express GPR30, we measured the diameters of GPR30 positive and negative neurons. Neurons expressing GPR30 were significantly smaller in diameter, suggesting that GPR30 is present in nociceptors. In order to investigate GPR30 expression within sub-populations, we co-localized GPR30 with peripherin and NFH using double label immunohistochemistry. GPR30 showed a high degree of overlap with peripherin and partial overlap with NFH, indicating that GPR30 is preferentially expressed in neurons with unmyelinated axons. ERK activation by estrogen in the trigeminal ganglion may occur through either the classical estrogen receptor ERα or through GPR30. In order to determine which estrogen receptor mediates ERK activation in trigeminal ganglion neurons, we examined ERK activation in primary cultures of trigeminal ganglion neurons treated with selective agonists for ERα (PPT), ERβ (DPN), and GPR30 (G-1). ERK was activated by selective agonists for ERα and GPR30, suggesting that activation occurs through either receptor. In order to determine which estrogen receptor mediates increased trigeminal sensitivity, we used a previously employed behavioral model of inflammatory trigeminal allodynia. Ovariectomized female Sprague-Dawley rats were injected in the masseter with CFA and subcutaneously administered G-1,PPT, or vehicle. Withdrawal response to stimulation of the whisker pad (V2) was measured using monofilaments. Either G-1 or PPT treatment increased secondary allodynia, indicating that both receptors function in trigeminal sensitization in vivo. Treatment with estrogen increased expression of ERα but not GPR30, while masseter inflammation increased GPR30 but not ERα. Differential modulation of these ERK-coupled receptors by estrogen and inflammation may play a role in increased trigeminal pain during periods of falling estrogen.
147 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Biology
Neurosciences
Erk
Estrogen
Gpr30
Trigeminal ganglion
Estrogen Signaling in Trigeminal Nociception
Dissertation
Anatomy & Cell Biology
Ph.D.
na
This item does not meet KU Open Access policy criteria.
6857288
ORIGINAL
Liverman_ku_0099D_10015_DATA_1.pdf
Liverman_ku_0099D_10015_DATA_1.pdf
application/pdf
7849247
https://kuscholarworks.ku.edu/bitstream/1808/4327/1/Liverman_ku_0099D_10015_DATA_1.pdf
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MD5
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TEXT
Liverman_ku_0099D_10015_DATA_1.pdf.txt
Liverman_ku_0099D_10015_DATA_1.pdf.txt
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207580
https://kuscholarworks.ku.edu/bitstream/1808/4327/2/Liverman_ku_0099D_10015_DATA_1.pdf.txt
3cf9c8ec04606760c261bfd0b88f3881
MD5
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open access
THUMBNAIL
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Liverman_ku_0099D_10015_DATA_1.pdf.jpg
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license.txt
license.txt
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1808/4327
oai:kuscholarworks.ku.edu:1808/4327
2020-06-22 15:37:07.18
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/42362020-06-22T20:23:05Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Krumlauf, Robb
Buckley, Rachel
Peterson, Kenneth
Rongish, Brenda
Trainor, Paul
Wright, Douglas
2008-09-29T05:12:37Z
2008-09-29T05:12:37Z
2008-08-06
2008
http://dissertations2.umi.com/ku:2684
http://hdl.handle.net/1808/4236
To investigate whether Hoxb1, as well as related proteins Hoxa1 and Hoxb2, are involved in vertebral development, we analyzed the skeletons of 18.5dpc Hoxa1, Hoxb1, and Hoxb2 loss-of-function single and double mutant embryos. Our analysis reveals that loss of Hoxb1 and Hoxb2 function leads to multiple homeotic transformations along the vertebral column. The dosages of both HoxB genes seem to be important, since the homeotic transformations significantly increase in penetrance in Hoxb1/Hoxb2 trans-heterozygotes, compared to single heterozygotes. Through the use of transgenic mouse strains, we were also able to reproduce similar transformations upon addition of extra HoxB gene copies. Interestingly, the defects observed in these loss-of-function mutants and transgenic mice occur at the boundaries between morphologically distinct vertebral domains. In conclusion, these data show that the anterior HoxB genes, particularly, Hoxb1 and Hoxb2, play a critical role in patterning the paraxial mesoderm that will give rise to the axial skeleton.
292 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Biology
Anatomy
CONTRIBUTIONS OF THE 3' HOX GENES, HOXA1, HOXB1, AND HOXB2, TO PATTERNING OF THE AXIAL SKELETON DURING DEVELOPMENT
Dissertation
Anatomy & Cell Biology
PH.D.
na
This item does not meet KU Open Access policy criteria.
6857227
ORIGINAL
umi-ku-2684_1.pdf
umi-ku-2684_1.pdf
application/pdf
7839413
https://kuscholarworks.ku.edu/bitstream/1808/4236/1/umi-ku-2684_1.pdf
cd5332d3f5d66acb1219b24d929078a6
MD5
1
open access
THUMBNAIL
umi-ku-2684_1.pdf.jpg
umi-ku-2684_1.pdf.jpg
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image/jpeg
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https://kuscholarworks.ku.edu/bitstream/1808/4236/3/umi-ku-2684_1.pdf.jpg
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MD5
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open access
TEXT
umi-ku-2684_1.pdf.txt
umi-ku-2684_1.pdf.txt
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text/plain
349174
https://kuscholarworks.ku.edu/bitstream/1808/4236/2/umi-ku-2684_1.pdf.txt
ba6b16075d28d480f6415c93a23ecb25
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license.txt
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https://kuscholarworks.ku.edu/bitstream/1808/4236/4/license.txt
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1808/4236
oai:kuscholarworks.ku.edu:1808/4236
2020-06-22 15:23:05.186
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/301312021-03-05T16:54:48Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Lai, Sue M
Amin, Amanda Leigh
Wagner, Jamie L
Fan, Fang
Winblad, Onalisa D
2020-03-23T18:21:23Z
2020-03-23T18:21:23Z
2019-05-31
2019
http://dissertations.umi.com/ku:16465
http://hdl.handle.net/1808/30131
https://orcid.org/0000-0002-9784-6226
Background: Standard of care for management of ADH identified on percutaneous biopsy is surgical excision. Research efforts have focused on utilizing strict multidisciplinary review to identify patients at lowest risk for upgrade that may benefit from omission of surgery. However, having an ipsilateral breast cancer, in addition to the site of ADH, has been an exclusion criterion for consideration of observation over excision of the site of ADH. Methods: This retrospective analysis examined patients who had both a breast cancer and an additional site of ADH in the same breast diagnosed on percutaneous biopsy, who underwent surgical excision of both areas at our institution from 2008-2018. Imaging characteristics (size of cancer, size of ADH, distance between cancer and ADH, percutaneous biopsy technique) and pathologic features (histologic subtype of cancer, cancer grade and prognostic markers, extent of ADH, presence of necrosis or micropapillary features in the ADH) were reviewed from the biopsy, as well as the final surgical pathology at the site of ADH excision to determine features associated with ADH upgrade. Results: Sixty-two women had biopsy proven ADH and a breast cancer at separate sites in the same breast over the 10-year study period. The overall upgrade rate at the site of ADH was 17.7% (n=11), with 9 cases to ductal carcinoma in situ (DCIS) and 2 to invasive breast cancer (IBC). The most common associations with upgrade were the presence of ipsilateral DCIS over IBC (p=0.034), using ultrasound guidance for biopsy of ADH (p=0.019), and the presence of cell necrosis in the ADH (p=0.039). Neither the radiographic size of the ADH nor the distance of the ADH from the ipsilateral cancer were associated with upgrade. The group at lowest risk for upgrade had stereotactic biopsy of the site of ADH and no necrosis associated with ADH, which resulted in 0% upgrade rate. Conclusion: When an ipsilateral breast cancer is present, the upgrade rate at the site of ADH is on par with reported contemporary ADH upgrade rates without ipsilateral breast cancer present. Similar to those studies of ADH alone, upgrade was significantly associated with biopsy modality and presence of ADH necrosis. When considering the ipsilateral breast cancer, upgrade rate for ADH was not affected by the size of the cancer, size of atypia, or distance between the ipsilateral malignancy and atypia. This suggests that omission of surgical excision for ADH in patients with concurrent breast cancer may be appropriate, like those with isolated ADH, when a select low risk subset undergoing rigorous multidisciplinary review can be identified.
31 pages
en
University of Kansas
Copyright held by the author.
openAccess
Medicine
Surgery
atypia
atypical ductal hyperplasia
breast cancer
Ipsilateral and concurrent breast cancer and atypical ductal hyperplasia: Does atypia also need surgical excision?
Thesis
Preventive Medicine and Public Health
M.S.
TEXT
Amin_ku_0099M_16465_DATA_1.pdf.txt
Amin_ku_0099M_16465_DATA_1.pdf.txt
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text/plain
45169
https://kuscholarworks.ku.edu/bitstream/1808/30131/2/Amin_ku_0099M_16465_DATA_1.pdf.txt
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Amin_ku_0099M_16465_DATA_1.pdf
Amin_ku_0099M_16465_DATA_1.pdf
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1808/30131
oai:kuscholarworks.ku.edu:1808/30131
2021-03-05 10:54:48.332
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/239392018-01-31T20:07:48Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Si, Kausik
Khan, Mohammed Repon
LeVine, Steven M
Wright, Douglas E
Zeitlinger, Julia
Li, Linheng
Conaway, Ron
2017-05-07T19:56:19Z
2017-05-07T19:56:19Z
2015-12-31
2015
http://dissertations.umi.com/ku:14347
http://hdl.handle.net/1808/23939
How a transient experience creates a persistent memory remains a fundamental unresolved issue in neuroscience. One of the molecular processes that is believed to be critical for long- lasting memory is synthesis of new protein at the synapse. However, how synaptic protein synthesis is regulated and how these new proteins confers persistence of memory is largely unknown. Previous studies in Drosophila and Aplysia have implicated that a family of mRNA binding proteins known as Cytoplasmic Polyadenylation Element (CPE) binding proteins is essential for persistent change in experience-dependent synaptic efficacy and persistence of memory. Moreover specific CPEB family members demonstrate biophysical properties that are associated with prion-like proteins. They exist in two distinct physical states: a monomeric and a dominant self-sustaining amyloidogenic aggregated state. This suggested a model in which a transient experience creates persistence molecular alteration in the nervous system via recruiting a stable and self-sustaining amyloidogenic aggregates of neuronal CPEB. The primary objective of this thesis is to determine how Drosophila neuronal CPEB, Orb2, regulates protein synthesis and how conversion to the aggregated state effects its function. Combining in vitro and in vivo studies we find that the monomeric Orb2 represses, while the amyloidogenic oligomeric Orb2 enhances translation and imparts its translational state onto the monomer. The monomer removes, whereas the oligomer stabilizes and elongates the polyA tail of mRNA. In support of these findings, we have identified a two novel proteins: CG13928, which binds only to monomeric Orb2, promotes deadenylation, and CG4612, a putative polyA binding protein, promotes oligomeric Orb2-dependent translation. We posit that monomeric Orb2 keeps target mRNA in a translationally dormant state and experience-dependent conversion of Orb2 to the stable amyloidogenic state activates translation, resulting in persistent alteration of synaptic activity and stabilization of memory. This study also provides an example of an amyloid-based protein switch that turns a repressor into an activator.
125 pages
en
University of Kansas
Copyright held by the author.
openAccess
Neurosciences
Long term memory
Prion
Translation
Role of Drosophila Orb2 (CPEB) in Synaptic Protein Synthesis
Dissertation
Molecular & Integrative Physiology
Ph.D.
ORIGINAL
Khan_ku_0099D_14347_DATA_1.pdf
Khan_ku_0099D_14347_DATA_1.pdf
application/pdf
2163045
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Khan_ku_0099D_14347_DATA_1.pdf.txt
Khan_ku_0099D_14347_DATA_1.pdf.txt
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231188
https://kuscholarworks.ku.edu/bitstream/1808/23939/2/Khan_ku_0099D_14347_DATA_1.pdf.txt
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Khan_ku_0099D_14347_DATA_1.pdf.jpg
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https://kuscholarworks.ku.edu/bitstream/1808/23939/3/Khan_ku_0099D_14347_DATA_1.pdf.jpg
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1808/23939
oai:kuscholarworks.ku.edu:1808/23939
2018-01-31 14:07:48.816
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/270722018-12-03T21:33:17Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
He, Jianghua
Chalise, Prabhakar
Zhong, Yi
Gajewski, Byron
Wick, Jo
Hagan, Christy
2018-10-26T19:33:07Z
2018-10-26T19:33:07Z
2018-05-31
2018
http://dissertations.umi.com/ku:15959
http://hdl.handle.net/1808/27072
This research focuses on using statistical learning methods on high-dimensional biological data analysis. In our implementation of high-dimensional biological data analysis, we primarily utilize the statistical learning methods in selecting important predictors and to build predictive classification models. Traditionally, cross-validation methods have been used in order to determine the tuning or threshold parameter for the feature selection. We propose improvements over the methods by adding repeated and nested cross validation techniques. Also, several types of machine learning methods such as lasso, support vector machine and random forest have been used by many previous studies. Those methods have their own merits and demerits. We also propose ensemble feature selection out of the results of the three machine learning methods by capturing their strengths in order to find the more stable feature subset and to optimize the prediction accuracy. We utilize DNA microarray gene expression datasets to describe our methods. We have summarized our work in the following order: (1) the structure of high dimensional biological datasets and the statistical methods to analyze such data; (2) several statistical and machine learning algorithms to analyze high-dimensional biological datasets; (3) improved cross-validation and ensemble learning method to achieve better prediction accuracy and (4) examples using the DNA microarray data to describe our method
110 pages
en
University of Kansas
Copyright held by the author.
openAccess
Statistics
cross-validation
feature selection
statistical learning
Feature selection and classification for high-dimensional biological data under cross-validation framework
Dissertation
Biostatistics
Ph.D.
THUMBNAIL
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Zhong_ku_0099D_15959_DATA_1.pdf
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Zhong_ku_0099D_15959_DATA_1.pdf.txt
Zhong_ku_0099D_15959_DATA_1.pdf.txt
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text/plain
175295
https://kuscholarworks.ku.edu/bitstream/1808/27072/2/Zhong_ku_0099D_15959_DATA_1.pdf.txt
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1808/27072
oai:kuscholarworks.ku.edu:1808/27072
2018-12-03 15:33:17.729
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/296252019-11-05T23:51:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Trees, Karen K
Bosak, Kelly A
Anderson, Judith
2019-10-14T16:57:33Z
2019-10-14T16:57:33Z
2019-08-31
2019
http://dissertations.umi.com/ku:16710
http://hdl.handle.net/1808/29625
Informal caregivers of persons with Alzheimer’s disease and related dementias (ADRD) are known to have increased caregiver burden. Research has shown caregiver burden places persons with ADRD and their caregivers at increased risk for poor health outcomes. Screening caregivers for increased caregiver burden is essential to identifying caregivers in need of additional support and improving such outcomes. Therefore, the purpose of this project was to conduct a needs assessment to determine if routine screening of informal caregivers of patients with ADRD for caregiver burden would identify increased caregiver burden and the need for intervention at an internal medicine clinic in the upper Midwest. This project utilized the Zarit Burden Interview (ZBI-12) tool to screen informal caregivers over a 6-week period. All caregivers with increased caregiver burden were offered a referral to respite care, counseling, or case management. Results were used to evaluate the need for routine screening for increased caregiver burden. The number of referrals was also evaluated to determine the practicality of the provider in the clinic initiating referrals for additional support services. Of the 22 caregivers screened, 12 (54.5%) were found to have increased caregiver burden. Caregivers with increased caregiver burden were more likely to be female (9, 75%) and college educated (12,100%). Of those with increased caregiver burden, only 3 (25%) requested referral for support services. These findings indicate that over half of caregivers screened had increased caregiver burden. However, few requested referral for support services. Routine screening of informal caregivers may help identify increased caregiver burden; however, the limited number of caregivers interested in additional support services, requires further investigation. Keywords: Alzheimer’s disease, dementia, informal caregivers, screening, short form Zarit Burden Interview.
49 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Gerontology
Aging
Alzheimer's disease
Cargiver burden
Dementia
Informal caregivers
Screening
Short form Zarit burden interview
Utilization of the Short Form Zarit Burden Interview to Screen Dementia Caregivers for Caregiver Burden in the Clinic Setting
Dissertation
Nursing
D.N.P.
TEXT
Anderson_ku_0099D_16710_DATA_1.pdf.txt
Anderson_ku_0099D_16710_DATA_1.pdf.txt
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78163
https://kuscholarworks.ku.edu/bitstream/1808/29625/2/Anderson_ku_0099D_16710_DATA_1.pdf.txt
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ORIGINAL
Anderson_ku_0099D_16710_DATA_1.pdf
Anderson_ku_0099D_16710_DATA_1.pdf
application/pdf
636070
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MD5
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THUMBNAIL
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Anderson_ku_0099D_16710_DATA_1.pdf.jpg
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896
https://kuscholarworks.ku.edu/bitstream/1808/29625/3/Anderson_ku_0099D_16710_DATA_1.pdf.jpg
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MD5
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1808/29625
oai:kuscholarworks.ku.edu:1808/29625
2019-11-05 17:51:42.252
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/194712018-12-14T17:37:07Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bergquist-Beringer, Sandra
Mitchell, Suzanne Stewart
Smith, Carol
Spaulding, Ryan
Kim, Heejung
Yeh, Hung-Wen
2016-01-02T17:42:24Z
2016-01-02T17:42:24Z
2015-08-31
2015
http://dissertations.umi.com/ku:14150
http://hdl.handle.net/1808/19471
The number of verified burn centers across the U.S. has dramatically decreased, negatively impacting access to burn care. Telehealth is a solution for burn care, however there is minimal research evaluating burn care through telehealth. The primary purpose of this mixed method feasibility study was to examine the reliability of using a Motorola XOOM tablet to perform an outpatient standard burn assessment compared to the usual face-to-face examination. Qualitative information on patients’ perception of using the tablet was also evaluated. A convenience sample of 50 subjects, aged 19 to 76 years, with less than 10% total body surface area burned was recruited from an outpatient burn clinic. Descriptive statistics and the reliability of using a tablet device compared to a face-to-face encounter were measured between modalities, raters, and across raters and modalities using Cohen’s Kappa and the Spearman correlation. The reliability between two raters for the standard burn assessment showed substantial to near perfect agreement for skin graft take (Kappa = 0.892), burn depth (Kappa = 0.731), and cellulitis (Kappa = 0.847) when using a tablet device. The inter-modality reliability by rater showed substantial to perfect agreement for skin graft take (Kappa = 1.0), burn depth (Kappa = 0.848–1.0), and edema (Kappa = 0.876–0.958). The overall reliability of assessing a burn wound through a tablet device was similar to that obtained in face-to-face examination. Spearman correlations between the ratings made by the First Rater and the Second Rater when using a table device ranged from 0.531 to 0.852 and Spearman correlations from the face-to-face encounter ranged from 0.460 to 0.710. Results from this study provide support for the reliability of a tablet device to assess for burn depth and skin graft take. Findings suggest inconsistency in the reliability of a tablet device to assess the presence of cellulitis, edema and purulence. Tablet device use in burn care can augment the usual, standard face-to-face interaction between patient and provider. Continued research is necessary to further validate its use in early and accurate assessment of burn wounds, burn-related complications, the evaluation of graft take, and the development of hypertrophic scarring.
169 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Communication
Burn Care
Mixed-Method
Patient Perception
Telemedicine
A MIXED-METHOD FEASIBILITY STUDY COMPARING THE OUTPATIENT ASSESSMENT OF BURN PATIENTS USING A TABLET DEVICE VERSUS THE USUAL FACE-TO-FACE ENCOUNTER
Dissertation
Nursing
Ph.D.
ORIGINAL
MITCHELL_ku_0099D_14150_DATA_1.pdf
MITCHELL_ku_0099D_14150_DATA_1.pdf
application/pdf
1339411
https://kuscholarworks.ku.edu/bitstream/1808/19471/1/MITCHELL_ku_0099D_14150_DATA_1.pdf
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TEXT
MITCHELL_ku_0099D_14150_DATA_1.pdf.txt
MITCHELL_ku_0099D_14150_DATA_1.pdf.txt
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297981
https://kuscholarworks.ku.edu/bitstream/1808/19471/3/MITCHELL_ku_0099D_14150_DATA_1.pdf.txt
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1808/19471
oai:kuscholarworks.ku.edu:1808/19471
2018-12-14 11:37:07.347
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/258782018-02-01T17:01:37Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Weinman, Steven A
Cox, Josiah
Yankee, Thomas M
Zückert, Wolfram R
Apte, Udayan
Fields, Timothy A
2018-02-01T03:25:00Z
2018-02-01T03:25:00Z
2016-05-31
2017
http://dissertations.umi.com/ku:15101
http://hdl.handle.net/1808/25878
Trans-arterial chemoembolization (TACE) with doxorubicin is commonly used to treat hepatocellular carcinoma (HCC), but has limited efficacy due to a high level of resistance. The factors that determine the sensitivity to TACE-doxorubicin are unknown. FOXO3 is a multifunctional transcription factor that plays a role in determining cell fate in response to stress. It frequently functions as a tumor suppressor but can also promote tumor pathogenesis. FOXO3 is also known to be a mediator of doxorubicin sensitivity in many types of tumor cells, while in others it can promote resistance. The role of FOXO3 in HCC and in doxorubicin resistance in HCC is unknown. FOXO3 function is largely determined by post-translational modification (PTM). Two FOXO3 PTMs, acetylation and serine 574 (S574)-phosphorylation, are known to promote its apoptotic function. Contrary to expectations, expression of FOXO3 was increased in HCC compared to surrounding liver. Cytosolic FOXO3 was significantly greater in TACE-resistant HCC as compared to treatment-naïve tumors. In Huh7 hepatoma cells, doxorubicin induced acetylation and S574-phosphorylation of FOXO3, and these modifications promoted doxorubicin-induced cell death by suppressing the pro-survival function of FOXO3. Resveratrol, an activator of SIRT deacetylase enzymes, inhibited these doxorubicin-induced PTMs and increased doxorubicin resistance. The expression of SIRT6, a known FOXO3 deacetylase, was also increased in TACE-resistant HCC tumors and correlated with cytosolic FOXO3. SIRT6 also blocked doxorubicin-induced S574-phosphorylation of FOXO3 and increased resistance to doxorubicin in Huh7 cells. Therefore, targeting SIRT6 and/or manipulating FOXO3 modifications may prove useful in enhancing the chemotherapy sensitivity of HCC.
106 pages
en
University of Kansas
Copyright held by the author.
openAccess
Cellular biology
Medicine
The Role of FOXO3 in Mechanisms of Doxorubicin Resistance in Hepatocellular Carcinoma
Dissertation
Microbiology, Molecular Genetics & Immunology
Ph.D.
ORIGINAL
Cox_ku_0099D_15101_DATA_1.pdf
Cox_ku_0099D_15101_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/25878/1/Cox_ku_0099D_15101_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/25878/3/Cox_ku_0099D_15101_DATA_1.pdf.jpg
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1808/25878
oai:kuscholarworks.ku.edu:1808/25878
2018-02-01 11:01:37.113
open access
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oai:kuscholarworks.ku.edu:1808/270312018-10-26T08:02:08Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Banerjee, Sushanta K.
Wright, Douglas E.
Sarkar, Sandipto
Welch, Danny R.
Little, Charles D.
Christianson, Julie C.
Wright, Douglas E.
Banerjee, Sushanta K.
2018-10-25T16:15:43Z
2018-10-25T16:15:43Z
2017-12-31
2017
http://dissertations.umi.com/ku:15704
http://hdl.handle.net/1808/27031
Breast cancer is one of the deadliest malignancies worldwide and also in the United States. Patients with triple negative breast cancer (TNBC), where the cancer cells do not express nuclear hormone receptors and human epidermal growth factor receptor 2 (HER2), have worse survival rate compared to the patients with luminal subtypes of cancer. Here, we have shown that Cysteine-rich 61-Connective Tissue Growth Factor-nephroblastoma-overexpressed 5 (CCN5) induces growth arrest of TNBC cells in-vitro and in xenograft tumors. Our studies show that after being secreted into the extracellular matrix, CCN5 binds to the α6β1 integrins of the cells leading to inhibition of the PI3K-AKT signaling pathway. This leads to stabilization and nuclear localization of FOXO3A resulting in transcriptional activation of the cyclin-dependent kinase inhibitor P27KIP1. Also, we found that the CCN5-induced PI3K-AKT inactivation leads to stabilization and nuclear accumulation of P27KIP1 resulting in cell cycle arrest of TNBC cells. Next, we have shown that CCN5 protein can induce expression of estrogen receptor-α (ER-α) in mammary epithelial cells. We found that mammary epithelium-specific overexpression of CCN5 in transgenic mice leads to an increase in ER-α expression and that this impact of CCN5 is not restricted to the normal cells. CCN5 treatment leads to an expression of functional ER-α in the TNBC cells, both in-vitro and in xenograft models, and sensitizes these cells to tamoxifen, commonly used for endocrine therapies. Mechanistically, transcriptional activation of ER-α by CCN5 is also mediated by FOXO3A stabilization via PI3K-AKT inhibition. Lack of ER-α expression in TNBC cells or loss of ER-α activation after endocrine treatment of luminal cancers makes these breast cancer cells resistant to tamoxifen and other endocrine therapies. Evidently, CCN5-mediated restoration of ER-α and its downstream signaling cascades renders the TNBC cells sensitive to tamoxifen. As these tumors mostly lack CCN5 expression, we anticipate that restoration of CCN5 expression might be able to provide breakthroughs in the treatment of these tumors. Finally, we discuss the effects of CCN5 expression on yet another aggressive breast cancer subtype, characterized by HER2 overexpression. Mammary-specific expression of CCN5 in HER2 overexpressing mice delays tumor progression significantly and reduces the tumor burden. Initial observations indicate that CCN5 induces expression of P16INK4A and P19ARF, resulting in cell cycle arrest of the tumor cells. Collectively, these studies suggest that CCN5 restoration can be beneficial for the better management of breast cancer progression.
184 pages
en
University of Kansas
Copyright held by the author.
openAccess
Cellular biology
Oncology
Biology
breast
cancer
CCN5
cell-cycle
HER2
tumor
Roles of CCN5 in regulating progression and therapeutic sensitivity of breast cancer
Dissertation
Anatomy & Cell Biology
Ph.D.
THUMBNAIL
Sarkar_ku_0099D_15704_DATA_1.pdf.jpg
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Sarkar_ku_0099D_15704_DATA_1.pdf.txt
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Sarkar_ku_0099D_15704_DATA_1.pdf
Sarkar_ku_0099D_15704_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/27031/1/Sarkar_ku_0099D_15704_DATA_1.pdf
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1808/27031
oai:kuscholarworks.ku.edu:1808/27031
2018-10-26 03:02:08.319
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/99912020-06-23T00:50:32Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wambach, Karen
Horsley, Trisha Leann
Bonnel, Wanda
Fletcher, Katherine
Kraft, Margaret
Liu, Wen
2012-07-22T18:16:23Z
2012-07-22T18:16:23Z
2012-05-31
2012
http://dissertations.umi.com/ku:12108
http://hdl.handle.net/1808/9991
Nursing schools design their clinical simulation labs based upon faculty's perception of the optimal environment to meet the students' learning needs, other programs' success with integrating high-tech clinical simulation, and the funds available. No research has been conducted on nursing faculty presence during a summative evaluation. The faculty's decision of where to position themselves during a summative evaluation should not be based on convenience, preference, or tradition but on evidence from research. The purpose of this study, partially guided by the Nursing Education Simulation framework, was to determine the effect of nursing faculty presence on students' level of state anxiety, self-confidence, and clinical performance during a summative evaluation of a clinical simulation experience. Data were collected for the quasi-experimental two group pretest-posttest study from a total of 91 participants during the Fall 2011 and Spring 2012 semesters at a large university in the north central region of the United States. Five research questions were posed and analyzed using various statistical procedures. The results indicated there were no statistically significant differences in the level of state anxiety, self-confidence, clinical performance and satisfaction of nursing students who were in the experimental group (Group A) and those in the control group (Group B). Results indicated, however, that there was a statistically significant difference in change in the state anxiety scores from pretest to posttest by group. The nursing faculty's presence in the simulation lab during a summative evaluation of a simulation experience resulted in a significant rise in the state anxiety level of the nursing students in the experimental group, yet this didn't impact the students' overall clinical performance during the clinical simulation experience. In conclusion, the results provided evidence to support nursing faculty positioning themselves in the control room or at a remote viewing location for a summative evaluation in order to avoid increasing students' level of state anxiety.
149 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Adult education
Anxiety
Clinical performance
Clinical simulation
Faculty presence
Nursing education
Self-confidence
The Effect of Nursing Faculty Presence on Students' Level of Anxiety, Self-Confidence, and Clinical Performance During a Clinical Simulation Experience
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085711
ORIGINAL
Horsley_ku_0099D_12108_DATA_1.pdf
Horsley_ku_0099D_12108_DATA_1.pdf
application/pdf
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https://kuscholarworks.ku.edu/bitstream/1808/9991/1/Horsley_ku_0099D_12108_DATA_1.pdf
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1808/9991
oai:kuscholarworks.ku.edu:1808/9991
2020-06-22 19:50:32.942
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/295182019-11-05T23:51:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peterson, JoAnn
Cunningham, Hannah
Nelson-Brantley, Heather
2019-09-04T22:00:49Z
2019-09-04T22:00:49Z
2019-05-31
2019
http://dissertations.umi.com/ku:16403
http://hdl.handle.net/1808/29518
Problem Statement: Residents in rural Kansas have lower colorectal cancer screening rates and therefore are more likely to experience poorer outcomes from colorectal cancer. Purpose: Determine the effectiveness of a low-cost multicomponent intervention on improving colorectal cancer screening rates on patients seen in two primary care clinics in rural Kansas. Methods: A quality improvement pre-post intervention study design was used to determine if colorectal cancer screening rates increase within 3 months of the implementation of a multicomponent intervention. The intervention consisted of two components: 1) postcard educational mailers and electronic educational mailers and 2) medical assistant and registered nurse education on colorectal cancer screening and in-clinic order process. Inclusion Criteria: Male and female patients aged 50-75 seen at the Family Care Center in Garnett, Kansas and the Family Care Center South in Colony, Kansas from July 2018 to September 2018 who were overdue for colorectal cancer screening received a postcard mailer or an electronic mailer about colorectal cancer screening. Male and female patients aged 50-75 who visited the Clinics from October 2018 to December 2018 were assessed for colorectal cancer screening adherence and a colorectal cancer screening order was placed, if applicable. Analysis: Post-intervention colorectal cancer screening rates from Quarter 4 (October 1, 2018 to December 31, 2018) were compared to colorectal cancer screening rates pre-intervention during Quarter 3 (July 1, 2018 to September 30, 2018). Results: The Clinics had an increase in post-intervention colorectal cancer screening rate when compared to pre-intervention screening rate. The colorectal cancer screening rate had the largest increase in the two months following the intervention implementation. Significance: Improving colorectal cancer screening rates using low-cost interventions may improve the health of residents in rural Kansas. The multicomponent intervention may offer an inexpensive way to improve colorectal cancer screening adherence in rural areas of the United States where healthcare resources may be scarce. Key Words: colorectal cancer, screening, rural health, preventative health
45 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
colorectal cancer
preventative health
rural health
screening
Impact of a Low-Cost, Multicomponent Intervention to Improve Colorectal Cancer Screening Rates at Two Primary Care Clinics in Rural Kansas
Dissertation
Nursing
D.N.P.
TEXT
Cunningham_ku_0099D_16403_DATA_1.pdf.txt
Cunningham_ku_0099D_16403_DATA_1.pdf.txt
Extracted text
text/plain
72964
https://kuscholarworks.ku.edu/bitstream/1808/29518/2/Cunningham_ku_0099D_16403_DATA_1.pdf.txt
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Cunningham_ku_0099D_16403_DATA_1.pdf
Cunningham_ku_0099D_16403_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/29518/1/Cunningham_ku_0099D_16403_DATA_1.pdf
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Cunningham_ku_0099D_16403_DATA_1.pdf.jpg
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https://kuscholarworks.ku.edu/bitstream/1808/29518/3/Cunningham_ku_0099D_16403_DATA_1.pdf.jpg
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1808/29518
oai:kuscholarworks.ku.edu:1808/29518
2019-11-05 17:51:42.363
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/214922020-06-24T15:41:06Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Potter, Wilbur Furse
2016-09-12T14:11:48Z
2016-09-12T14:11:48Z
1927
http://hdl.handle.net/1808/21492
Thesis (M.A.)--University of Kansas, Physiology, 1927.
en_US
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
The effects of methyl guanidine salts on the vagus nerve of the dog
Thesis
Physiology
M.A.
3425299
TEXT
potter_1927_3425299.pdf.txt
potter_1927_3425299.pdf.txt
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44352
https://kuscholarworks.ku.edu/bitstream/1808/21492/2/potter_1927_3425299.pdf.txt
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MD5
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open access
LICENSE
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oai:kuscholarworks.ku.edu:1808/21492
2020-06-24 10:41:06.047
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KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/42312020-06-23T01:01:52Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Petroff, Margaret G
Taglauer, Elizabeth Susan
Kinsey, William H
Roby, Katherine F
Soares, Michael J
Fields, Patrick E
2008-09-29T04:57:10Z
2008-09-29T04:57:10Z
2008-08-08
2008
http://dissertations2.umi.com/ku:2642
http://hdl.handle.net/1808/4231
During pregnancy, the maternal immune system must be carefully modulated as the fetus is immunologically foreign to her leukocytes. We propose that the CD28 family immune receptor, PD-1, functions during pregnancy to control maternal immune reactions. PD-1 is expressed on T lymphocytes and following interaction with its ligand, B7-H1, prevents T cell activation. B7-H1 is expressed in the human placenta throughout gestation, therefore we studied the role of the PD-1 receptor in modulating maternal T cells during pregnancy. PD-1 is preferentially expressed on human decidual T cells and B7-H1 inhibits the inflammatory cytokine production of activated decidual T lymphocytes. In addition, possibly through B7-H1:PD-1 interactions, trophoblasts induce regulatory T cell expansion in vitro. Finally, in murine pregnancy, PD-1 controls the accumulation of paternal antigen-specific T cells in the uterus-draining lymph nodes. Overall, these studies suggest that the PD-1:B7-H1 pathway functions to help maintain maternal-fetal tolerance.
167 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Cell biology
Pregnancy
Immunology
Reproduction
T cells
Pd-1
B7-h1
The Role of the PD-1 Immunoreceptor in Pregnancy
Dissertation
Anatomy & Cell Biology
PH.D.
na
This item does not meet KU Open Access policy criteria.
6857198
ORIGINAL
umi-ku-2642_1.pdf
umi-ku-2642_1.pdf
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1808/4231
oai:kuscholarworks.ku.edu:1808/4231
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open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/253792018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Radel, Jeff
Han, Areum
Sabata, Dory
Mische-Lawson, Lisa
Anderson, Heather
Goetz, Jeannine
2017-11-16T03:47:33Z
2017-11-16T03:47:33Z
2015-08-31
2015
http://dissertations.umi.com/ku:14151
http://hdl.handle.net/1808/25379
This qualitative study aimed to explore the experience and impact of a person-centered, social program on community-dwelling people with dementia and their caregivers. I conducted semi-structured interviews with five dyads, each with a person with dementia and that person’s caregiver, 7-8 months after the program ended to assess persistence of the program’s impact. Interviews were analyzed using interpretative phenomenological analysis involving in-depth analysis of a small number of cases. Three themes emerged among people with dementia: 1) Participation in activities supporting self-identity; 2) The value of newly established intergenerational relationships; and 3) Empowerment and the student partner’s attitude. These findings suggest taking part in a person-centered, social program promoted participation in activities supporting the self-identity of people with dementia and establishment of satisfying relationships with student partners. The student partner’s attitude influenced the level of empowerment for the person with dementia in relation to participation in meaningful activities and relationships. Three themes also emerged among caregivers: 1) Benefits of the program for caregivers; 2) Initial expectations and the later perspectives of caregivers about the program; and 3) Conflicting values and perspectives between caregivers and spouses. Benefits identified by caregivers included feeling enjoyment and satisfaction of their spouses with dementia from participation in the program; having a fun time with a friend or alone separate from the spouse; and a chance to socialize with a younger person while assuming a role as an older friend or parent. Participation in the program provided a sustained benefit to one couple in particular even 7 months after the program ended, by encouraging the caregiver to resume arranging activities the couple once enjoyed but now had difficulty pursuing. Conflicting perspectives noted between people with dementia and the caregivers illustrate needs and desires expressed by both people with dementia and their caregivers need to be considered when structuring social partner activities. These findings address a gap in the literature by documenting how a person-centered, social program benefits both community-dwelling people with dementia and their family caregivers, with implications for providing insightful opportunities for social engagement as part of occupational therapy and other health care practices.
582 pages
en
University of Kansas
Copyright held by the author.
openAccess
Gerontology
Social research
Occupational therapy
Alzheimer’s disease
dementia
intergenerational relationship
personhood
qualitative research
social participation
The Benefits of a Person-centered Social Program for Community-dwelling People with Dementia and Caregivers: An Interpretative Phenomenological Analysis
Dissertation
Occupational Therapy Education
Ph.D.
THUMBNAIL
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Han_ku_0099D_14151_DATA_1.pdf.jpg
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Han_ku_0099D_14151_DATA_1.pdf
Han_ku_0099D_14151_DATA_1.pdf
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2979543
https://kuscholarworks.ku.edu/bitstream/1808/25379/1/Han_ku_0099D_14151_DATA_1.pdf
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Han_ku_0099D_14151_DATA_1.pdf.txt
Han_ku_0099D_14151_DATA_1.pdf.txt
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1413903
https://kuscholarworks.ku.edu/bitstream/1808/25379/2/Han_ku_0099D_14151_DATA_1.pdf.txt
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1808/25379
oai:kuscholarworks.ku.edu:1808/25379
2018-01-31 14:07:47.833
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/145102020-06-24T14:50:03Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Bradham, Douglas D
Taylor, Scott M.
Twumasi-Ankrah, Philip
Haan, James
2014-07-05T15:51:49Z
2014-07-05T15:51:49Z
2014-05-31
2014
http://dissertations.umi.com/ku:13226
http://hdl.handle.net/1808/14510
Background: Most critically ill patients experience pain, fear, and anxiety as part of their illness while in the Intensive Care Unit (ICU). These emotions may be amplified during the provision of life-sustaining therapies, such as mechanical ventilation (MV). Pharmacotherapy including analgesics, sedatives, and antipsychotics are considered the standard of care to optimize patient safety and comfort during MV. Although the use of analgesics, sedatives, and antipsychotic therapies in the ICU is commonplace; adverse effects, unpredictable pharmacokinetics, and inappropriate dose titrations often hinder achieving the optimal level of effectiveness.2-4 Under-treatment may lead to significant pain, agitation, myocardial ischemia, ventilator dyssynchrony, intravenous line removal, self-extubation, and post-discharge complications, including post-traumatic stress disorder (PTSD). In contrast, over-sedation has been associated with prolonged mechanical ventilation, development of decubitus skin ulcers, hospital-acquired infections, PTSD, delirium, prolonged ICU and hospital length of stay (LOS), and an increase in overall hospital costs. The aims of this study were to see if the use of analgosedation (fentanyl alone) would be non-inferior to conventional regimen (CR) in time-to-extubation and determine factors that affect ICU length of stay, mortality and re-intubation within 24 hours. Methods: The study design was a retrospective matched observational study. After inclusion/exclusion criteria were applied 254 patients were identified in the study group. Propensity score matching was used to ensure that treatment groups were similar in terms of admission diagnosis, intubation reason, and APACHE II score. A total sample of 86 patients were selected into the analytical group with 43 patients each in the fentanyl alone group (FA) and CR group to show that the effect of fentanyl alone in a sedation protocol is not worse than that of the conventional regimen Kaplan Meier methods and Cox proportional hazard models were used to analyze the primary outcome of interest; time-to-extubation. Covariates included in the Cox regression model included age, gender, ICU days, substance abuse history, number of admissions in the previous year, and insurance status. Using general linear regression modeling, we explored the effect of patient socio-demographic and clinical characteristics on ICU length of stay. Binary logistic regression modeling was used to assess the effect of patient socio-demographic and clinical characteristics risk of ICU mortality, and also for re-intubation within 24 hours. Results: Differences in patient socio-demographics characteristics between the two groups was observed for ventilator days (5.7 days FA vs. 8.3 CR p = 0.04) and history of psychiatric problems and medication (17.4% vs. 2% p Discussion: It was shown that Fentanyl-Alone in a sedation protocol was not worse off than that of the Conventional regimen in terms of duration of intubation. A larger trial is needed to determine if the analgosedation with fentanyl will provide any superior benefits in the duration of intubation. In this trial females demonstrated a much reduced length of time intubated compared to males and also the duration of admission at the ICU. A much structured study with sufficient power to determine the nature and intensity of these differences will needed. If the findings here are confirmed, it should provide some meaningful directions in health care particularly the relationship between gender and these outcomes. Finally this trial adds to the literature by being the first to use time-to-event analysis in patients receiving analgosedation.
63 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Medicine
Epidemiology
Public health
Fentanyl
Intensive care
Mechanical ventilation
Sedation
Comparative Effectiveness of Analgesic Sedation as Primary Sedation in Medical ICU Patients vs. Conventional Sedation and Analgesia Regimens
Thesis
Preventive Medicine and Public Health
M.S.
na
This item does not meet KU Open Access policy criteria.
8086535
ORIGINAL
Taylor_ku_0099M_13226_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/295152019-11-05T23:51:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bosak, Kelly
Bhatnagar, Anna Sushila
Buller, Carol
2019-09-04T21:55:11Z
2019-09-04T21:55:11Z
2019-05-31
2019
http://dissertations.umi.com/ku:16390
http://hdl.handle.net/1808/29515
https://orcid.org/0000-0003-3242-5145
Abstract Outpatient ambulatory electrocardiographic monitoring (AEM) is often used by practitioners to diagnose an arrhythmia. AEM devices can be mailed to the patient’s home or applied in the office setting. A common barrier that decreases the diagnostic utility is failure to successfully complete the monitoring. Objective: The purpose of this study is to compare the AEM completion rates between patients who self-apply the monitor at home and those who have the monitor applied in the office by clinical staff. Methods: A cross-sectional retrospective chart review was used. The electronic health records were reviewed for billable codes before and after April 2018 when a new office policy of mailing monitors to patients was implemented. A random sample of 50 patients was obtained from each timeframe. Results: The sample included the electronic medical records of adult patients (n=100) seen in the Cardiology clinic. Over half 63 (63%) were female, and the majority 88 (88%) were Caucasian, with 10 (10%) Black or African American, and 1 (1%) reporting Asian race. The average age was 59 (range 20-100). Most patients 98 (98%) had health insurance. The office application group had a significantly higher rate of successful completion 62 (62%) compared to the mail group 38 (38%). The average number of days that the AEM was worn was 18 days (range 7-30 days). Conclusion: The results of this study indicate that professional support and application of AEM in the clinic setting may lead to an increase in completion rates.
22 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Ambulatory
Cardiac
Electrocardiographic
Event
Monitor
Monitoring
Evaluating the Process of Ambulatory Electrocardiographic Monitor Application and Completion Rates
Dissertation
Nursing
D.N.P.
ORIGINAL
Bhatnagar_ku_0099D_16390_DATA_1.pdf
Bhatnagar_ku_0099D_16390_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/157672019-07-17T05:15:56Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Shireman, Theresa I
Brown, Jacob
Abdel-Rahman, Susan M
Lai, Sue-Min
2014-11-18T04:15:26Z
2014-11-18T04:15:26Z
2014-05-31
2014
http://dissertations.umi.com/ku:13457
http://hdl.handle.net/1808/15767
OBJECTIVE: The goal of this study was to establish normative values under ambient light conditions for measurements of quantitative pupillometry in children. METHODS: This was a cross-sectional analysis of pupillometry values obtained in children. Quantitative pupillomentry measurements were obtained from children between 1 and 18 years of age being seen for either a well child check or other outpatient appointment. Participants were excluded if they were in pain, on any medication known to affect pupil size (i.e. opioids, stimulants), or had any chronic neurologic conditions. RESULTS: A total of 242 children were enrolled in this study, with pupillometry readings obtained from a total of 171 children after exclusions. Maximum and minimum pupil size increased slightly with age; however, the correlation was weak (r = 0.14 and r = 0.16). Similarly weak correlations with age also were observed for maximum constriction velocity (r = -0.12) and dilation velocity (r = 0.05). No differences were observed between males and females for any of the pupil parameters. Maximum (5.35 mm vs. 4.91 mm) and minimum (3.71 mm vs. 3.36 mm) pupil sizes were significantly larger in Whites than African-American participants. CONCLUSIONS: Pupil size and reactivity show little correlation with age, appear to be relatively independent of ontogeny, and therefore would not be expected to significantly impact further exploration in utilizing pupillometry as a biomarker across the pediatric age range. Differences in race should be taken into consideration when pupillometry is used in mixed populations.
19 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Developmental biology
The Impact of Age on Quantitative Infrared Pupillometry in Healthy Children 1-18 Years
Thesis
Preventive Medicine and Public Health
M.S.
ORIGINAL
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oai:kuscholarworks.ku.edu:1808/275762019-01-16T19:36:28Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peterson, Moya
Arnold, Adriane
Peltzer, Jill
Patel, Atul
2019-01-01T20:11:35Z
2019-01-01T20:11:35Z
2018-05-31
2018
http://dissertations.umi.com/ku:15784
http://hdl.handle.net/1808/27576
Problem: Pain is a major health problem that affects patients and families and proves challenging for providers to treat. Large portions of people suffer from pain that can be attributed to musculoskeletal injuries. Providers rely on current first-line recommendations for treating patients with these injuries. Unfortunately, the pain is not being adequately treated, the underlying injury is not being fixed, and many patients develop chronic pain. The solution has been a turn to chronic opioid prescribing that has now become an epidemic. Project Purpose: Autologous platelet-rich plasma (PRP) is a therapy with little to no risks and proven benefits in surgical procedures and treatment of a variety of injuries. Recently, PRP has been gaining prevalence in research and practice regarding treatment of musculoskeletal injuries. The results have been promising but more support is needed to show PRP can not only reduce pain but also help solve the issues surrounding medication use. By following the Plan-Do-Study-Act cycle, the proposed DNP project aimed to evaluate the effects of PRP on reducing medication consumption with patients being treated for musculoskeletal injuries at a Pain Management and Rehab clinic, specifically Kansas City Bone and Joint Clinic. Methods: The DNP project used a longitudinal observational quality improvement design that consisted of a convenience sample of patients diagnosed with acute and chronic musculoskeletal injuries who were being treated with PRP as part of their standard care, for musculoskeletal conditions such as knee osteoarthritis, lateral epicondylitis, hip and pelvic pathologies, jumper’s knee, and mild to moderate hamstring muscle tears. Candidates needed to be able to speak English, read at a high-school level, give consent, and track medication consumption for follow-up data collection. The primary outcome measure was to evaluate the type, quantity, and frequency of pain medication consumption. The VAS tool and Likert scale assessed pain and patient satisfaction as secondary outcome measures. An additional document was used to track the PRP injection process. Pre-injection data was collected, with follow-up evaluations occurring at week 2 and 4, and at month 2 post-injections. Descriptive statistics regarding each data point were analyzed to determine if the results either supported or refuted the assumptions of the DNP project. Conclusions: The data did not afford clear results regarding the primary outcome. However, secondary outcome measures indicated that PRP was at least partly successful in reducing pain and thus led to some degree of patient satisfaction. Despite limitations, the DNP project poses several implications for future research and practice.
52 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Medicine
injection
musculoskeletal
opiate
pain
Platelet-rich plasma
PRP
Platelet-Rich Plasma and Pain Medication Reduction
Dissertation
Nursing
D.N.P.
TEXT
Arnold_ku_0099D_15784_DATA_1.pdf.txt
Arnold_ku_0099D_15784_DATA_1.pdf.txt
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Arnold_ku_0099D_15784_DATA_1.pdf
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1808/27576
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KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/246302017-12-08T21:42:12Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Wright, Lennel I.
2017-06-26T21:11:35Z
2017-06-26T21:11:35Z
1930
http://hdl.handle.net/1808/24630
Thesis (M.A.)--University of Kansas, Anatomy, 1930.
eng
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
Observations on the early developments of the white rat (Rattus norvegicus albinus)
Thesis
Anatomy
M.A.
3425149
ORIGINAL
wright_1930_3425149.pdf
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oai:kuscholarworks.ku.edu:1808/253802018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Shireman, Theresa I
Jaffee, Melissa
Crenner, Christopher
Gurley-Calvez, Tami
Hall, Jean
Lee, Robert
2017-11-16T03:49:02Z
2017-11-16T03:49:02Z
2015-08-31
2015
http://dissertations.umi.com/ku:14149
http://hdl.handle.net/1808/25380
This research examines severe mental illness (SMI) and avoidable emergency department (ED) utilization among Kansas Medicaid beneficiaries. We compared SMI and non-SMI subgroups in relation to ED rates and proportion of avoidable or ambulatory care sensitive (ACS) visits over time. We also evaluated the distribution of visits over the course of a year as well as the effect of SMI on ED and ACS ED visits. Finally, we compared clinical reasons behind ACS visits for the SMI and non-SMI subgroups. Paper one evaluated ED utilization and ACS ED use from a longitudinal perspective for the SMI and non-SMI subgroups. ED visit rates for the SMI group were approximately two times higher than the non-SMI group, year over year. Rates for the non-SMI group peaked in 2010, while they peaked for the SMI group in 2011. The proportion of visits considered ACS by the NYU ED algorithm were higher each year for the non-SMI group in comparison to the SMI group. However, for both subgroups, ACS visit rates slightly declined from 2007-2012. Although rates are not rising, they are still concerning at current levels. The second study suggests that, although beneficiaries with SMI use the ED more than individuals without SMI, they do not use it more for ACS visits. SMI significantly increased the likelihood of an ED visit but it did not do so for an ACS ED visit. There was also a significant positive association between primary care utilization and ED use as well as ACS ED use. SMI beneficiaries are appropriate targets for policies aimed at reducing ED utilization but not ACS ED use. Finally, we found that the clinical reasons for ACS visits between SMI and non-SMI beneficiaries are mostly consistent based on ICD9 diagnosis codes. ACS visits are also highly concentrated among these ICD9 codes. Common conditions for ACS categories regardless of SMI status include asthma, upper respiratory conditions, abdominal issues, and diabetes. A strategy focused on targeting individuals by chronic condition in order to reduce ACS visits may be more successful than one zeroing in on SMI status.
104 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health care management
Epidemiology
Mental health
ambulatory care sensitive
avoidable
emergency department
medicaid
severe mental illness
utilization
Emergency Department Utilization Among Kansas Medicaid Aged, Blind, and Disabled Beneficiaries with Severe Mental Illness: the Context and Extent of Ambulatory Care Sensitive Visits
Dissertation
Health Policy & Management
Ph.D.
ORIGINAL
Jaffee_ku_0099D_14149_DATA_1.pdf
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1808/25380
oai:kuscholarworks.ku.edu:1808/25380
2018-01-31 14:07:47.828
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KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/248142021-03-05T19:15:06Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Qiu, Jianming
Shen, Weiran
Stephens, Edward
Zhu, Hao
Lutkenhaus, Joe
Gudima, Severin O
Yankee, Thomas M
2017-08-13T21:30:21Z
2017-08-13T21:30:21Z
2016-12-31
2016
http://dissertations.umi.com/ku:14927
http://hdl.handle.net/1808/24814
Human bocavirus is a human pathogen that was identified in 2005. For the past decade, most of the studies about this virus were focused on clinical detection and its association-with diseases, while very little was known about the molecular virology. The studies presented in this thesis are composed of three parts: 1) Identification of novel HBoV1 proteins by transfection of an HBoV1 infectious clone or during HBoV1 infection; 2) exploring the interactions between the viral genome and proteins to uncover the details underlying HBoV DNA replication; and 3) providing evidence of HBoV1 hairpin independent DNA replication. In the first study, we identified three new non-structural proteins of human bocavirus 1 during infection of polarized human airway epithelium. Of the three newly identified proteins, we proved that one non-structural protein is critical for virus replication in the polarized human bronchial airway epithelium. The creation of a non-replicating infectious HBoV1 mutant may have particular utility in vaccine development for this virus. In the second study, we identified both cis- and trans-acting proteins that are required for HBoV1 DNA replication at the right-end hairpin in HEK293 cells. We also localized the minimal replication origin to a 46-nt sequence in the right-end hairpin, which contains both NS1 nicking and binding sites. The identification of these essential elements of HBoV1 DNA replication acting both in cis and trans provides opportunities for developing antiviral strategies targeting HBoV1 DNA replication, and to design next generation recombinant HBoV1 vectors, a promising tool for gene therapy of lung diseases. In the third study, we provided evidence that HBoV1 could replicate independent of hairpin sequence, which is quite different from other parvoviruses. Although the mechanisms are not fully understood, this study opened new directions for future studies of parvoviruses.
145 pages
en
University of Kansas
Copyright held by the author.
openAccess
Microbiology
Virology
hairpin replication
Human Bocavirus
non-structural protein
Parvovirus
replication
replication origin
HUMAN BOCAVIRUS 1 GENOME ORGANIZATION AND REPLICATION MECHANISM
Dissertation
Microbiology, Molecular Genetics & Immunology
Ph.D.
THUMBNAIL
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Shen_ku_0099D_14927_DATA_1.pdf
Shen_ku_0099D_14927_DATA_1.pdf
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KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/301792021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peterson, JoAnn M
Heidner, Regina L
Wambach, Karen
Potts, Maryellen
2020-03-25T19:15:45Z
2020-03-25T19:15:45Z
2019-12-31
2019
http://dissertations.umi.com/ku:16917
http://hdl.handle.net/1808/30179
Abstract Background and Review of Literature: Sepsis is a life-threatening, dysregulated human response to infection. It claims more lives than breast, lung or prostate cancer. Sepsis affects annually, 1.7 million Americans and 10,000 Kansas. The mortality rate can reach 50-80% if treatment is delayed. Early identification, prevention, and intervention, beginning in the community, before emergency room admission, is necessary. It is important to educate primary care providers and community members on early sepsis prevention, early identification, treatment, and recognition of high-risk groups. Purpose: The purpose of this quality improvement project was to increase knowledge about sepsis among community-based, primary care providers such as nurse practitioners, physician assistants, and physicians in ambulatory settings in rural, South-Central Kansas. Methods: A single group, pretest-posttest approach was used for this quality improvement project. An online educational module on sepsis early identification and treatment, created by TMF Health Quality Institute (2018), was synchronously presented to primary care providers employed in a rural, primary care health organization. Knowledge acquisition was measured using a test provided by TMF(2018). Result: Three providers participated. The overall percent increase in test scores from pretest to posttest was 16.6%. Pretest scores were low ranging from 40% -70%. Posttest scores were 70%. Discussion: Low pretest scores indicated a need for this education. The results showed an average 16.6% increase on test scores. Test score improvement demonstrated knowledge attained from the education provided and that this educational method and material was effective. This or similar projects delivered to primary care providers in an outpatient clinic could be beneficial. Keywords: sepsis, early recognition, ambulatory setting, primary care
50 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Health sciences
Public health education
Ambulatory setting
Early recognition
Primary care
Primary care provider education
Sepsis
Sepsis treatment
Early Recognition of Sepsis in Outpatient Ambulatory Settings: An Educational Program for Primary Care Providers in Rural, South Central Kansas
Dissertation
Nursing
D.N.P.
ORIGINAL
Heidner_ku_0099D_16917_DATA_1.pdf
Heidner_ku_0099D_16917_DATA_1.pdf
application/pdf
422939
https://kuscholarworks.ku.edu/bitstream/1808/30179/1/Heidner_ku_0099D_16917_DATA_1.pdf
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open access
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Heidner_ku_0099D_16917_DATA_1.pdf.txt
Heidner_ku_0099D_16917_DATA_1.pdf.txt
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text/plain
78033
https://kuscholarworks.ku.edu/bitstream/1808/30179/2/Heidner_ku_0099D_16917_DATA_1.pdf.txt
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THUMBNAIL
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open access
1808/30179
oai:kuscholarworks.ku.edu:1808/30179
2021-03-05 10:53:01.539
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/295262020-10-12T14:18:05Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Trees, Karen
Kuster, Brianna
Peltzer, Jill
El Feghaly, Rana
2019-09-04T22:11:50Z
2019-09-04T22:11:50Z
2019-05-31
2019
http://dissertations.umi.com/ku:16382
http://hdl.handle.net/1808/29526
https://orcid.org/0000-0003-3994-4757
Otitis media is one of the most common reasons for pediatric healthcare visits and a common reason for inappropriate prescribing of antibiotics. Otitis media is differentiated into two categories: acute otitis media (AOM) and otitis media with effusion (OME). OME is characterized by reduced tympanic mobility and middle ear effusion without signs of acute inflammation or infection. Approximately 80% of children will have experienced at least one episode of otitis media by their third birthday. The clinical practice guideline for managing otitis media with effusion was updated in 2016. This guideline supports three months of watchful waiting from start of symptoms or date of diagnosis over the use of antibiotics. Problem: Providers continue to use antibiotics for the treatment of OME in the presence of published guidelines. Project Aim: The purpose of this project was to understand prescribing practices among health care providers in the diagnosis, treatment and management of OME through the use of a descriptive survey. Donabedian’s Quality Framework and structure process outcome model guided the project. Project Method: A convenience sample of advanced practice registered nurses (APRNs) and physicians from three area suburban urgent cares were surveyed regarding their knowledge of the current guidelines and factors associated with adherence to prescribing practice guidelines. Results: The majority of providers recognized a middle ear effusion as a sign of an OME, however, less than half identified all other potential signs of OME. It was also found that a variety of diagnosis codes were used to document an OME or AOM. Recommendations included provider education on inclusion and exclusion criteria for OME diagnosis and using standardized diagnosis codes for AOM and OME in the urgent cares. These results will direct provider education on OME and antibiotic stewardship in the urgent cares. Keywords: Otitis media, OME, antibiotics, prescribing practices, quality improvement
57 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health sciences
Nursing
Medicine
antibiotics
OME
otitis media
prescribing practices
quality improvement
A Pilot Project to Understand Prescribing Practices of Otitis Media with Effusion
Dissertation
Nursing
D.N.P.
ORIGINAL
Kuster_ku_0099D_16382_DATA_1.pdf
Kuster_ku_0099D_16382_DATA_1.pdf
application/pdf
3189891
https://kuscholarworks.ku.edu/bitstream/1808/29526/1/Kuster_ku_0099D_16382_DATA_1.pdf
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MD5
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open access
TEXT
Kuster_ku_0099D_16382_DATA_1.pdf.txt
Kuster_ku_0099D_16382_DATA_1.pdf.txt
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text/plain
70403
https://kuscholarworks.ku.edu/bitstream/1808/29526/2/Kuster_ku_0099D_16382_DATA_1.pdf.txt
6984f8f97aabc8bd2d61374a02f1aca8
MD5
2
open access
THUMBNAIL
Kuster_ku_0099D_16382_DATA_1.pdf.jpg
Kuster_ku_0099D_16382_DATA_1.pdf.jpg
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0c92c3cf5568e7388bb0b45fc119de8f
MD5
3
open access
1808/29526
oai:kuscholarworks.ku.edu:1808/29526
2020-10-12 09:18:05.809
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/239872018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Yankee, Thomas M
Mitchell, Julie Lynne
Benedict, Stephen H
Parmely, Michael J
Peterson, Kenneth R
Stephens, Edward B
2017-05-08T02:37:23Z
2017-05-08T02:37:23Z
2016-05-31
2016
http://dissertations.umi.com/ku:14485
http://hdl.handle.net/1808/23987
The Ikaros family transcription factors are critical regulators of T cell development and leukemogenesis. Loss of function of all five family members leads to an early block in murine lymphocyte development, whereas reduced function results in the development of T cell leukemias. Loss of a single family member has only minimal affects on T cell development, suggesting compensating functions of the family members, and emphasizing a need to study expression and function of the whole Ikaros family. We analyzed the expression of all five family members in human and murine thymocytes as they progressed from the CD4–CD8– double negative (DN) to the CD4+CD8+ double positive (DP) developmental stages, and found differences in the expression of Helios and Eos mRNA between the two species. Further, whereas Ikaros and Aiolos mRNA levels increased in both species, protein levels only increased in murine thymocytes. These data suggest that regulation of Ikaros family expression during T cell development differed between the two species. To further examine expression of Ikaros family members during human T cell development, we used multi-parameter flow cytometry to identify subpopulations of human thymocytes. We defined seven populations of CD3– CD4+CD8– immature single positive (ISP) and CD3– DP cells to identify when TCRβ is expressed. We were able to delineate the pre-β-selection ISP1 and DP1 populations and the TCRβ expressing ISP2 and DP2 populations using expression of CD1a, CD28, and CD44. The ISP2 and DP2 populations had a higher percentage of proliferating cells, consistent with these being post-β-selection stages. Protein levels of Ikaros, Helios, and Aiolos all increased with β-selection, however this increase was transient for Ikaros and Helios levels. We further identified 22 populations of thymocytes that express CD3 and showed that CD4 expression is down-regulated after positive selection to create a CD8+CD4–/lo transitional single positive (TSP) developmental stage. Commitment to the CD8 T cell lineage occurs in TSP thymocytes and is marked by expression of CD27. Among CD4+ cells, expression of CD27 can first be seen in MSP2 CD4+ thymocytes, suggesting that commitment to the CD4 lineage occurs at this stage. Ikaros levels increased during the DP9 stage, and Helios and Aiolos expression increased in TSP thymocytes. The increase in Helios was transient, and Helios levels decreased as cells developed through the MSP CD4+ and MSP CD8+ stages. Aiolos levels increased in cells proceeding from the TSP to the MSP CD8+ stage. Within MSP CD4+ thymocytes, Aiolos levels increased transiently beginning in the MSP2 CD4+ thymocytes suggesting that increases in Aiolos protein are associated with CD4/CD8 lineage commitment. Pediatric T cell acute lymphoblastic leukemia (T-ALL) is a heterogeneous disease that develops as a result of clonal expansion of thymocyte populations that bypass regulatory selection steps. We analyzed expression of the Ikaros family members in the leukemic cells from pediatric T-ALL patients and compared them to normal thymic populations, finding that mRNA levels of at least one Ikaros family member were elevated in the cells from every T-ALL patient analyzed. By comparing the ratio of the Ikaros family mRNA levels, we were able to classify the T-ALL patients into groups that showed diverse expression of surface markers. The lack of correlation between Ikaros and Aiolos mRNA and protein levels within the T-ALL suggest that further studies are needed to determine the significance of both mRNA ratios and protein levels in T-ALL patients. Further, studies are required to identify the roles of the Ikaros family members during the key selection steps of normal thymic development in order to understand how altered expression may contribute to leukemogenesis.
280 pages
en
University of Kansas
Copyright held by the author.
openAccess
Immunology
Aiolos
Helios
Ikaros
T-ALL
T cell development
Multi-Parameter Flow Cytometric Analysis of Ikaros Family Expression in Human T Cell Development and T-ALL
Dissertation
Microbiology, Molecular Genetics & Immunology
Ph.D.
ORIGINAL
Mitchell_ku_0099D_14485_DATA_1.pdf
Mitchell_ku_0099D_14485_DATA_1.pdf
application/pdf
19593215
https://kuscholarworks.ku.edu/bitstream/1808/23987/1/Mitchell_ku_0099D_14485_DATA_1.pdf
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MD5
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open access
THUMBNAIL
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TEXT
Mitchell_ku_0099D_14485_DATA_1.pdf.txt
Mitchell_ku_0099D_14485_DATA_1.pdf.txt
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408187
https://kuscholarworks.ku.edu/bitstream/1808/23987/2/Mitchell_ku_0099D_14485_DATA_1.pdf.txt
f9924e29fe0e6004bfe421c59b97735f
MD5
2
open access
1808/23987
oai:kuscholarworks.ku.edu:1808/23987
2018-01-31 14:07:47.15
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/248102018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Christenson, Lane K
Hung, Wei-Ting
2017-08-13T21:20:00Z
2017-08-13T21:20:00Z
2016-12-31
2016
http://dissertations.umi.com/ku:14972
http://hdl.handle.net/1808/24810
Formation of the follicular fluid antrum within the ovarian follicle provides a unique environment for the developing oocyte. Follicular fluid contains factors including nucleic acids, proteins, lipids, hormones, and metabolic factors secreted by both ovarian somatic cells and the oocyte that are critical for follicle development. In addition, lipid bi-layer extracellular vesicles (EVs) comprised of exosomes and microvesicles are highly abundant in follicular fluid. Whether these EVs play a role in ovarian cell signaling, provide a mechanism for transport of metabolic products or are nonfunctional within the ovarian follicle is unknown. In this dissertation, I will test the hypothesis that ovarian follicular fluid EVs are unique and determine whether they can elicit functional effects on the cumulus-oocyte-complex and the mural granulosa cells. To accomplish these goals, follicular fluid from three different sizes of bovine antral follicles, [i.e. small (3-5 mm), medium (6-9 mm), and large (9 mm)] were collected and EVs were isolated and characterized by electron microscopy, nanoparticle tracking analysis (NTA), protein marker analysis, and small RNAseq. Electron microscopy and NTA indicated the presence of a uniform (50-200 nm) population of EVs that had different microRNA within them based on follicle size. An EV marker, CD81, showed decreased abundance in EVs as follicle size increased. Fluorescent labeling of the follicular fluid EVs followed by culture indicated that both cumulus and mural granulosa cells took up the fluorescent-labeled EVs. To test for functional activity, cumulus-oocyte-complexes and granulosa cells were exposed to EVs isolated from different size follicles. Extracellular vesicle treatment caused expansion of cumulus cells and increased expression of prostaglandin-endoperoxide synthase 2 (Ptgs2), pentraxin-related protein 3 (Ptx3), and tumor necrosis factor, alpha-induced protein 6 (Tnfaip6) genes, genes associated with normal cumulus expansion. Additionally, EVs from small follicles induced granulosa cell proliferation, and we determined that the Src and JNK pathways were involved in the cell proliferation induced by EVs. Moreover, we determined that the differential ability of EVs to affect granulosa cell proliferation was primarily a result of preferential uptake by EVs from small follicles versus those of medium and large follicles. In summary, these studies provide insight into the unique characteristics of EVs isolated from three different stages of antral follicles. This work also provides the first functional evidence that EVs from ovarian follicular fluid are able to elicit functional physiologic changes in both cumulus and granulosa cells and provides clues to the cell signaling pathways that are modulated in cells following exposure to these small lipid enclosed vesicles. Lastly, this study provides an approach to further purify EVs, and indicates the ovarian follicle as an excellent model for studying general extracellular vesicle biology.
229 pages
en
University of Kansas
Copyright held by the author.
openAccess
Cellular biology
EXTRACELLULAR VESICLES IN OVARIAN ANTRAL FOLLICLES: CHARACTERIZATION AND FUNCTIONS
Dissertation
Molecular & Integrative Physiology
Ph.D.
ORIGINAL
Hung_ku_0099D_14972_DATA_1.pdf
Hung_ku_0099D_14972_DATA_1.pdf
application/pdf
4008682
https://kuscholarworks.ku.edu/bitstream/1808/24810/1/Hung_ku_0099D_14972_DATA_1.pdf
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MD5
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open access
TEXT
Hung_ku_0099D_14972_DATA_1.pdf.txt
Hung_ku_0099D_14972_DATA_1.pdf.txt
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268197
https://kuscholarworks.ku.edu/bitstream/1808/24810/2/Hung_ku_0099D_14972_DATA_1.pdf.txt
2e27a8111f94fcd79f78f78a75c601f9
MD5
2
open access
THUMBNAIL
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24810.pdf
24810.pdf
application/pdf
193334
https://kuscholarworks.ku.edu/bitstream/1808/24810/4/24810.pdf
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MD5
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1808/24810
oai:kuscholarworks.ku.edu:1808/24810
2018-01-31 14:07:47.913
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/269232018-10-25T19:43:00Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Gibbs, Heather
Schaufel, Madelaine Rose
Sullivan, Debra
Goetz, Jeannine
2018-10-22T21:56:35Z
2018-10-22T21:56:35Z
2017-08-31
2017
http://dissertations.umi.com/ku:15327
http://hdl.handle.net/1808/26923
Purpose: This study aimed to investigate RDN use of nutrition-related lab testing as a potential advanced clinical skill, and to describe RDN perceptions of the adequacy of training for nutrition-related lab testing and advanced clinical skills. Methods: A 40-item survey was sent electronically by email to 4951 randomly selected RDNs who have maintained dietetic registration with the Commission on Dietetic Registration ≥ three years. Reminders were sent weekly for the first three weeks, and the survey was open for five weeks. Answers to 10 questions on professional training and practice were used to assign participants into beyond-entry-level (BEL) or advanced-practice-eligible (AP) groups, according to Academy of Nutrition and Dietetics (AND) and Commission on Dietetic Registration (CDR) definitions. Descriptive statistics and differences (Mann Whitney U or Chi-square) between BEL and AP groups were analyzed, and significance was defined as p<.05. Results: Out of 805 participants, 64% of whom were categorized as BEL, 649 surveys were completed. A majority (85%) reported use of laboratory testing where a comprehensive metabolic panel was the most frequently used test and genetic testing the most infrequently used test. There were no differences between BEL or AP groups for use of laboratory testing except in the case of nutrient status testing, where the AP group reported significantly more frequent use (p=.02). The BEL group rated their professional training as more adequate for their current level of practice (p=.03). AP RDNs more often identified the most useful training method as self-teaching (34% vs 21%, p<.001). Conclusions: There is a need for improved clinical training to support dietetic AP and nutrition-related lab testing represents one potential gap in training for advanced level clinical practice.
63 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nutrition
advanced practice
clinical skills
clinical training
dietetics
dietitian
nutrition-related laboratory testing
Perceptions, adequacy, and acquisition of clinical advanced practice training and skills in the dietetic profession
Thesis
Dietetics & Nutrition
M.S.
TEXT
Schaufel_ku_0099M_15327_DATA_1.pdf.txt
Schaufel_ku_0099M_15327_DATA_1.pdf.txt
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104943
https://kuscholarworks.ku.edu/bitstream/1808/26923/2/Schaufel_ku_0099M_15327_DATA_1.pdf.txt
bd47848c9fef4165cfcd380800378ff5
MD5
2
open access
THUMBNAIL
Schaufel_ku_0099M_15327_DATA_1.pdf.jpg
Schaufel_ku_0099M_15327_DATA_1.pdf.jpg
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823
https://kuscholarworks.ku.edu/bitstream/1808/26923/3/Schaufel_ku_0099M_15327_DATA_1.pdf.jpg
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ORIGINAL
Schaufel_ku_0099M_15327_DATA_1.pdf
Schaufel_ku_0099M_15327_DATA_1.pdf
application/pdf
684344
https://kuscholarworks.ku.edu/bitstream/1808/26923/1/Schaufel_ku_0099M_15327_DATA_1.pdf
d92c11222c8d3fe3e3d0d4da97120dde
MD5
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open access
1808/26923
oai:kuscholarworks.ku.edu:1808/26923
2018-10-25 14:43:00.714
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/146012020-06-22T20:20:53Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Carlson, Susan E
Ozias, Marlies
Brooks, William
Hull, Holly
Benedict, Stephen
Petroff, Margaret
2014-07-05T18:57:15Z
2014-07-05T18:57:15Z
2013-12-31
2013
http://dissertations.umi.com/ku:13076
http://hdl.handle.net/1808/14601
A large body of evidence demonstrates that obese pregnant women have a greater risk of pregnancy and delivery complications and poorer health outcomes compared with normal weight pregnant women. Most research on the impact of obesity in pregnancy defines obesity by body mass index (BMI), a measurement that does not consider the location of body fat. Abdominal fat mass is associated with cardiometabolic diseases so it is reasonable to postulate that it plays a greater role in obesity-related pregnancy complications, yet the role of abdominal fat in pregnancy is not well defined. It is known that obese pregnant women have higher circulating interleukin 6, C-reactive protein, and higher macrophage expression in the placenta. It is also known that T cell populations increase in non-pregnant obese individuals. However, it is not known how T cells respond to the incidence of obesity in pregnancy. The main purpose of this research is to examine the relationships between abdominal fat mass and circulating adipokines and peripheral CD4+ T cells in pregnancy. We recruited thirty-eight women from the University of Kansas Obstetrics and Gynecology Clinic in their third trimester for the Pregnancy Health Study. Recruitment was focused on women in healthy pregnancy and with respect to a full spectrum of pre-pregnancy BMI (18.5 - 40). Before delivery, blood was collected to measure circulating adipokines by ELISA and measure CD4+ T cell cytokine production by multiplex. CD4+ T cells were isolated from peripheral blood mononuclear cells by positive selection and stimulated ex vivo to examine cytokine production. Total body fat was measured by dual x-ray energy absorptiometry in the subjects within three-weeks postpartum. At the same visit, magnetic resonance imaging scans on the abdominal region occurred in a subset of twenty subjects. ImageJ was used to quantify abdominal subcutaneous and visceral fat mass from the axial images. Women categorized as overweight or obese by BMI had significantly greater amounts of abdominal subcutaneous and visceral fat mass compared to normal-weight BMI women, as well as greater total body fat. We found a strong relationship between abdominal visceral fat mass and resistin but no other adipokines measured (leptin, visfatin, and adiponectin) correlated with abdominal visceral fat mass. No relationships were observed between abdominal subcutaneous fat mass and any adipokine. Leptin was the only adipokine to correlate with total body fat and pre-pregnancy BMI. Additionally, there were no correlations between pre-pregnancy BMI, total body fat (with one exception), or abdominal subcutaneous fat with CD4+ T cell production of cytokines. We did observe a significant decrease in cytokine concentration in relationship to abdominal visceral adiposity. This dampening effect was observed across all categories of CD4+ T cell cytokines. Together, these results suggest that visceral fat mass in pregnancy has the potential to play a role in obesity-related pregnancy complications whereas BMI is a poor indicator of the effect of fat on adaptive immunity. Even though women with an overweight or obese pre-pregnancy BMI have greater amounts of abdominal fat mass, BMI was unrelated to physiologically relevant adipokines (leptin as the exception) and CD4+ T cell cytokines. Visceral fat is an ectopic fat compartment and should be studied as a physiologically relevant factor in obesity-related pregnancy complications, regardless of a woman's weight status.
120 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nutrition
Immunology
Adipokines
Inflammation
Obesity
Pregnancy
Characterization of abdominal adiposity and its relationship to adipokines and the adaptive immune response
Dissertation
Dietetics & Nutrition
Ph.D.
8086420
LICENSE
license.txt
license.txt
text/plain
2569
https://kuscholarworks.ku.edu/bitstream/1808/14601/4/license.txt
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MD5
4
open access
ORIGINAL
Ozias_ku_0099D_13076_DATA_1.pdf
Ozias_ku_0099D_13076_DATA_1.pdf
application/pdf
1505261
https://kuscholarworks.ku.edu/bitstream/1808/14601/1/Ozias_ku_0099D_13076_DATA_1.pdf
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MD5
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open access
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TEXT
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1808/14601
oai:kuscholarworks.ku.edu:1808/14601
2020-06-22 15:20:53.939
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/253812018-11-20T17:37:57Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Satterwhite, Catherine
Bohm, Parker E.
Satterwhite, Catherine
Arnold, Paul
Brown, Lexie
2017-11-16T03:50:39Z
2017-11-16T03:50:39Z
2015-08-31
2015
http://dissertations.umi.com/ku:14164
http://hdl.handle.net/1808/25381
Background Context: Cervical Spondylotic Myelopathy (CSM) is a progressive, degenerative condition and the most common cause of spinal cord dysfunction worldwide. A timed 30-meter walking test (30MWT) has previously been recommended for testing disease severity in patients with CSM because of its objectivity, quantitative nature, and ease of administration. However, very little has been reported in the literature regarding its use. Study Design/Setting: We utilized data from two prospective CSM cohort studies to analyze properties of the 30MWT test for patients with CSM. All patients had symptomatic CSM and subsequently underwent surgical decompression. Each patient completed 3 trials of the 30MWT at baseline as well as 6, 12, and 24 months following surgery. Methods: Repeated measures analysis of variance (ANOVA) was used to examine test reproducibility, and Spearman’s correlation coefficients were used to compare the results of the 30MWT to other validated scales used in the CSM population. Additionally, we used paired T-tests to assess the difference between baseline and 6-month post-operative 30MWT times. Standardized response mean was used to measure responsiveness. Results: Moderate correlation (-0.551) was seen between the 30MWT and the modified Japanese Orthopedic Association (mJOA) scale as well as the Nurick score (0.468) at baseline. Low correlation was found between the 30MWT and the NDI (0.253) as well as the physical component of the Short-Form 36 Health Survey (-0.380). Walking time did not vary significantly between the three trials at baseline (p = 0.66). At 6 months post-op, patients completed the 30MWT 9.9 seconds faster compared to baseline (p < 0.0001). Conclusions: The results from two prospective cohort studies demonstrate that the 30MWT is reproducible and moderately correlated with other validated scales used with CSM patients. Because the 30MWT is simple, quick, affordable, and assess gait parameters not accurately assessed by other standard metrics, it should be used as an ancillary test for CSM patients.
17 pages
en
University of Kansas
Copyright held by the author.
openAccess
Surgery
Neurosciences
Cervical
Myelopathy
Spine
Spondylotic
Test
Walking
A 30-METER WALKING TEST AS A MEASURE OF CERVICAL SPONDYLOTIC MYELOPATHY SEVERITY: TEST CHARACTERISTICS AND RESULTS FROM TWO MULTICENTER COHORT STUDIES
Thesis
Clinical Research
M.S.
THUMBNAIL
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Bohm_ku_0099M_14164_DATA_1.pdf
Bohm_ku_0099M_14164_DATA_1.pdf
application/pdf
413642
https://kuscholarworks.ku.edu/bitstream/1808/25381/1/Bohm_ku_0099M_14164_DATA_1.pdf
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MD5
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TEXT
Bohm_ku_0099M_14164_DATA_1.pdf.txt
Bohm_ku_0099M_14164_DATA_1.pdf.txt
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24545
https://kuscholarworks.ku.edu/bitstream/1808/25381/2/Bohm_ku_0099M_14164_DATA_1.pdf.txt
eed5bed0276cdcd6a1dc54ae819d28ff
MD5
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open access
1808/25381
oai:kuscholarworks.ku.edu:1808/25381
2018-11-20 11:37:57.9
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/254352018-01-31T20:07:48Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Mische Lawson, Lisa
Trowbridge, Kelly
Dunn, Winnie
He, Jianghua
Little, Lauren
Turner, George
2017-11-17T22:39:25Z
2017-11-17T22:39:25Z
2015-12-31
2015
http://dissertations.umi.com/ku:14360
http://hdl.handle.net/1808/25435
Mindfulness practices, including mindfulness meditation, show promise for decreasing stress among health care providers. The standard course of Jon Kabat-Zinn’s Mindfulness-Based Stress Reduction (MBSR) requires a participant commitment to eight weeks of instruction comprised of one two-and-a-half hour per week class, a single day retreat, and 45 minutes of practice for six of seven days each week. Studies of abbreviated MBSR typically investigate the “dosing” of instruction and practice required to demonstrate stress reduction effects. This exploratory study investigates the effectiveness of a two-day compressed MBSR course (cMBSR) on pediatric health care social workers. Using t-tests, researchers measured the effect of cMBSR on a) positive and negative experiences in pediatric social work, b) perceived stress, c) mindfulness, and d) caring self-efficacy (as a component of patient- and family-centered care). Results included significant differences between the pre and post intervention outcome variables on the ProQOL Secondary Traumatic Stress subscale, the Mindful Attention and Awareness Scale, and the Caring Effectiveness Scale. Findings partially supported the effect of the cMBSR intervention and found adequate evidence for the feasibility of a more rigorous study of cMBSR.
176 pages
en
University of Kansas
Copyright held by the author.
openAccess
Social work
Alternative medicine
Psychology
health care social work
mindfulness
mindfulness-based stress reduction
social work
social work continuing education
social work stress
A Preliminary Investigation of Compressed Mindfulness-Based Stress Reduction (cMBSR) with Pediatric Medical Social Workers
Dissertation
Occupational Therapy Education
Ph.D.
ORIGINAL
Trowbridge_ku_0099D_14360_DATA_1.pdf
Trowbridge_ku_0099D_14360_DATA_1.pdf
application/pdf
6866239
https://kuscholarworks.ku.edu/bitstream/1808/25435/1/Trowbridge_ku_0099D_14360_DATA_1.pdf
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Trowbridge_ku_0099D_14360_DATA_1.pdf.txt
Trowbridge_ku_0099D_14360_DATA_1.pdf.txt
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244167
https://kuscholarworks.ku.edu/bitstream/1808/25435/2/Trowbridge_ku_0099D_14360_DATA_1.pdf.txt
56680cbb48b0bf51a66c18af60bca34e
MD5
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THUMBNAIL
Trowbridge_ku_0099D_14360_DATA_1.pdf.jpg
Trowbridge_ku_0099D_14360_DATA_1.pdf.jpg
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2b9fbfb0ac22e4b7dafa530c6f069b2a
MD5
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open access
1808/25435
oai:kuscholarworks.ku.edu:1808/25435
2018-01-31 14:07:48.827
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/261722018-05-02T19:24:32Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peterson, Moya
Miller, Aimee
Ogawa, Lisa
2018-03-09T23:26:48Z
2018-03-09T23:26:48Z
2017-12-31
2017
http://dissertations.umi.com/ku:15623
http://hdl.handle.net/1808/26172
https://orcid.org/0000-0002-0733-8050
Problem: Prediabetes is an increasingly prevalent condition, involving the recognition of elevated blood glucose levels through a diagnostic hemoglobin A1C reading between 5.7% and 6.4%; if left unaddressed, severe complications may occur (American Diabetes Association [ADA], 2016; Menke, Casagrande, Geiss & Cowie, 2015). While research has shown that successful incorporation of the lifestyle modifications of diet and exercise can lower the risk for these complications by up to 58%, the utilization of beneficial modifications has not been reported by all of those with this condition (ADA, 2016; Dorsey & Songer, 2011). Project Aim: The purpose of this project was to distinguish if newly diagnosed adults with prediabetes who were provided with both verbal and written education, compared to those who only received verbal education, would experience an improved retention of information regarding necessary lifestyle modifications, and demonstrate a willingness to change in a one-month follow-up survey. Project Method: The theoretical framework for this project is the Transtheoretical Model of behavior change (Prochaska & Velicer, 1997). The project took place across four local, urban primary care clinics. Participants were separated into two groups at the time of agreeing to project involvement using consecutive assignment. Group A received verbal instructions from their healthcare provider regarding prediabetes, and then participated in a teach-back session with the DNP student to further review the ADA’s (2016) recommendations for lifestyle modifications. Group B received the same verbal education, but was also provided with an educational leaflet from the ADA (2016) during their teach-back session. Research has shown that more than half of the education patients receive during office visits is either forgotten or incorrect (AHRQ, 2015). To enhance knowledge retention, emphasis was placed on utilizing the validated Teach Back Method (AHRQ, 2015) for all participants. One-month Likert scale follow-up surveys were electronically delivered to all participants for evaluation and assessment of the project’s outcomes. Project Findings: Follow-up surveys were sent electronically to the 13 project participants, 12 completed surveys were returned. Data were gathered and analyzed. The Mann Whitney U Test (Wilcoxon Rank Sum Test) was used to calculate statistical significance (p=<0.05). Significant improvement was noted with Group B’s responses to how often they felt the verbal instructions they received regarding their condition were easy to understand (U=5, p<0.0455). Significant findings were also noted with Group B’s responses quantifying how often anyone in their healthcare practice asked them to describe how they were going to follow their specific health instructions (U= 3.5, p<0.0251). There were no significant findings seen in the prediabetes management portion of the electronic survey: overall feeling well managing prediabetes (p=0.689), would like to do better with exercising (p=0.873), would like to improve with eating better foods (p=0.749), currently doing well with exercising (p=0.749), currently doing well with eating better foods (p=0.936). No significance was noted on the last health literacy question in the electronic survey regarding how often participants felt their health care providers and staff had spent time with them (p=0.093). Conclusion: Including written materials, along with verbal instruction, regarding the new diagnosis of prediabetes and necessary lifestyle modifications can improve ease of patient learning and foster opportunities for health care workers to utilize the validated teach-back method. Further research is recommended to evaluate the relationship between verbal and written education and retention of prediabetes management instruction and willingness to change by incorporating recommended lifestyle modifications.
63 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health care management
lifestyle modification
prediabetes
verbal education
willingness to change
written education
A QUALITY IMPROVEMENT PROJECT: ENHANCING PATIENT COMPREHENSION AND WILLINGNESS TO CHANGE FOLLOWING PREDIABETES EDUCATION
Dissertation
Nursing
D.N.P.
LICENSE
26172.pdf
26172.pdf
application/pdf
191050
https://kuscholarworks.ku.edu/bitstream/1808/26172/4/26172.pdf
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ORIGINAL
Miller_ku_0099D_15623_DATA_1.pdf
Miller_ku_0099D_15623_DATA_1.pdf
application/pdf
2610317
https://kuscholarworks.ku.edu/bitstream/1808/26172/1/Miller_ku_0099D_15623_DATA_1.pdf
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TEXT
Miller_ku_0099D_15623_DATA_1.pdf.txt
Miller_ku_0099D_15623_DATA_1.pdf.txt
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87783
https://kuscholarworks.ku.edu/bitstream/1808/26172/2/Miller_ku_0099D_15623_DATA_1.pdf.txt
cb285f460a7b1ceb70a309bcada744fb
MD5
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THUMBNAIL
Miller_ku_0099D_15623_DATA_1.pdf.jpg
Miller_ku_0099D_15623_DATA_1.pdf.jpg
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7f67f5791fb8d129e90a66ed6f86977a
MD5
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open access
1808/26172
oai:kuscholarworks.ku.edu:1808/26172
2018-05-02 14:24:32.7
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/248222018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Sharma, Neena K
Mansour, Zaid
Brooks, William M
Burns, Jeffery M
Smirnova, Irina
Yeh, Hung-Wen
2017-08-13T21:50:40Z
2017-08-13T21:50:40Z
2016-05-31
2016
http://dissertations.umi.com/ku:14648
http://hdl.handle.net/1808/24822
Low back pain (LBP) is a common chronic pain condition affecting millions of people worldwide. Conventional methods of diagnosing LBP have provided limited guidance; consequently most patients get a general diagnosis of “nonspecific” LBP. Brain imaging has been proposed to be a method of studying LBP since all pain signals are processed in the brain. Up till today, the relationship between brain structure and LBP is not fully understood. A few studies have examined this relationship but reported inconsistent findings. Additionally, all of those studies examined the chronic LBP population and none have attempted to study acute/subacute LBP population. In this study we have acquired structural brain scans from participants with LBP (acute/subacute and chronic) and healthy controls. A total of 130 participants were included in this study (23 subacute LBP participants, 68 chronic LBP participants, and 39 healthy controls). We compared whole-brain volume between each 2 groups separately using volumetric measurements and using voxel-based morphometry (VBM). We also examined specific regions-of-interest (ROIs) of pain processing. Finally we conducted correlation analyses between brain volumes and clinical outcome measures we collected from the LBP participants in the 2 groups. Our results showed no difference in whole-brain volume between any of the groups measured by volumetric measurements or VBM after correcting for multiple comparisons. We noticed difference in 2 voxels (6.75 mm3) in the cortical affective regions of the brain when comparing participants with chronic LBP to healthy controls. Normal aging can lead to an annual loss of 4-6 mm3 of brain volume; therefore the reduction we have noticed is not clinically significant. No differences were noticed in the other ROIs. Finally, no correlations were noticed between any of the clinical outcome measures and brain volumes. We calculated the effect size of LBP and found it to be <0.1, which is considered a minimal effect size. Our conclusion is that LBP has minimum to no-effect on brain structure regardless of its duration. This information is clinically important for patients, clinicians, and scientists for understanding the underlying neurophysiological consequences of LBP and therapeutic applications.
121 pages
en
University of Kansas
Copyright held by the author.
openAccess
Physical therapy
Brain Imaging
Chronic
Low Back Pain
Neuroimaging
Subacute
Voxel-Based Morphometry
Structural Brain Imaging in People with Low Back Pain
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
THUMBNAIL
Mansour_ku_0099D_14648_DATA_1.pdf.jpg
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845
https://kuscholarworks.ku.edu/bitstream/1808/24822/3/Mansour_ku_0099D_14648_DATA_1.pdf.jpg
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Mansour_ku_0099D_14648_DATA_1.pdf
Mansour_ku_0099D_14648_DATA_1.pdf
application/pdf
2671788
https://kuscholarworks.ku.edu/bitstream/1808/24822/1/Mansour_ku_0099D_14648_DATA_1.pdf
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LICENSE
24822.pdf
24822.pdf
application/pdf
217906
https://kuscholarworks.ku.edu/bitstream/1808/24822/4/24822.pdf
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MD5
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TEXT
Mansour_ku_0099D_14648_DATA_1.pdf.txt
Mansour_ku_0099D_14648_DATA_1.pdf.txt
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264727
https://kuscholarworks.ku.edu/bitstream/1808/24822/2/Mansour_ku_0099D_14648_DATA_1.pdf.txt
26e44c32fac2ae5cb83619391bbb186c
MD5
2
open access
1808/24822
oai:kuscholarworks.ku.edu:1808/24822
2018-01-31 14:07:47.072
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/258862018-02-01T16:57:52Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Si, Kausik
McGinnis, John Patrick
Si, Kausik
Blanco, Gustavo
Fenton, Aron
Fields, Timothy
Krumlauf, Robb
Xie, Ting
Yu, C. Ron
2018-02-01T04:04:58Z
2018-02-01T04:04:58Z
2017-05-31
2017
http://dissertations.umi.com/ku:15161
http://hdl.handle.net/1808/25886
The ability to form, store, and retrieve memories is an essential capacity of many animals. Only in the past half-century, however, have the key neuronal and molecular events that underlie memory been studied. This has revealed a series of molecular cascades that are triggered by neuronal activation, ultimately leading to the stabilization of otherwise transient synaptic modifications. These synaptic modifications either increase or decrease the efficiency of synaptic transmission, thereby leading to altered neuronal communication. The behavioral events that must precede these molecular and neuronal changes, however, begin with the sensory system, where important information from the external world is identified. Generally, in situations involving associative learning, the experience of a reward or punishment is assumed to be remembered because of the relevance it holds for the organism at the moment of learning. Any pattern that deviates from this general idea provides an indication of exactly which features the processes of memory deem valuable. The deviation we explore here—that a more immediately appealing reward is not always better remembered, that D-arabinose is preferred to L-arabinose, but L-arabinose generates more reliable memories—suggests that there are important aspects beyond the momentary appeal of a reward. Further, L-arabinose, because it is remembered despite having no nutritional value, has allowed identification of a subset of 26 sensory neurons in Drosophila that, when activated, are sufficient to form long-term associative memories. In response to this sensory activation, the biochemical cascades of memory will, in further downstream neurons, trigger the oligomerization of the Drosophila cytoplasmic polyadenylation element binding (CPEB) protein, Orb2. Its oligomerization has so far been described as involving a prion-like conversion from a monomeric form to an amyloidogenic oligomer. Since its initial characterization, however, many types of functional protein oligomerization have been described. The question of whether Orb2’s oligomerization is in fact prion-like can best be addressed by substituting its prion domain with a variety of oligomerization domains, from other amyloid domains to more transient ‘liquid droplet’-type domains, or even standard tetramerization domains. Whether formation of less structured and less stable aggregates can still support the regulatory switch of Orb2 required for memory maintenance is the key question. Finally, Orb2 may not be the only functional prion-like protein in Drosophila, though it is the best characterized. Murashka, a RING-domain E3 ubiquitin ligase, is also involved in memory, and possesses both a disordered domain and features that are characteristic of prion-like proteins. If murashka does in fact undergo a prion-like conversion that is relevant for its role in memory, Orb2 will no longer be a curious outlier but instead the first illustration of what may be a widespread biological phenomenon.
121 pages
en
University of Kansas
Copyright held by the author.
openAccess
Neurosciences
Molecular biology
Drosophila
Gustatory
Memory
Protein Conformation
Reward
Ubiquitin Ligase
Memory: From Sensory Circuits To Protein Conformations
Dissertation
Molecular & Integrative Physiology
Ph.D.
TEXT
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McGinnis_ku_0099D_15161_DATA_1.pdf
McGinnis_ku_0099D_15161_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/25886
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oai:kuscholarworks.ku.edu:1808/184242018-01-31T20:07:54Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Fridley, Brooke L.
Jones, Bridgette
Rosenwasser, Lanny J.
Leeder, James S.
2015-09-09T01:45:47Z
2015-09-09T01:45:47Z
2014-12-31
2014
http://dissertations.umi.com/ku:13741
http://hdl.handle.net/1808/18424
Rationale: Previous studies have suggested that antihistamines may be therapeutic in some patients with asthma. Variation in genes along the histamine production, response, and degradation pathway may be important in predicting response to antihistamines. We hypothesize that genetic variation in genes of the histamine pathway differs between children with allergic versus non-allergic asthma. Methods: Children 7-18 years of age (n=118) with asthma participated in this IRB-approved protocol and were classified as allergic (N = 68) or non-allergic (N = 50) based on allergy skin testing. DNA isolation and genotyping were performed for 10 SNPs within 4 genes (HDC, HNMT, ABP1, HRH1, HRH4) within the histamine pathway. Chi Square tests were used to test for associations between genotypes and allergic or non-allergic asthma among participants. Significance was determined by p <0.05. Results: We observed differences in genotype frequency between participants with allergic versus non-allergic asthma for 2 SNPs: HNMT-1639(rs6430764) (31% allergic with TT vs. 14% non-allergic with TT, p=0.04) and HNMT -464 (rs2071048) genotype (33% allergic with TT vs. 12% non-allergic with TT, p=0.03) after controlling for race. Differences in genotype frequency were also observed between allergic and non-allergic phenotypes in stratified analyses among African Americans. Conclusion: Genetic variants within the histamine pathway appear to be associated with an allergic versus non-allergic asthma phenotype. Further studies are needed to validate our findings in a larger cohort. There is also the need to determine the functional significance of identified SNPs and their impact on antihistamine response in patients with asthma and allergic disease.
28 pages
en
University of Kansas
Copyright held by the author.
openAccess
Medicine
Genetics
Molecular biology
asthma
genetics
histamine
single nucleotide polymorphisms
GENETIC VARIATION ALONG THE HISTAMINE PATHWAY IN CHILDREN WITH ALLERGIC VS NON-ALLERGIC ASTHMA
Thesis
Preventive Medicine and Public Health
M.S.
ORIGINAL
Jones_ku_0099M_13741_DATA_1.pdf
Jones_ku_0099M_13741_DATA_1.pdf
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152370
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Jones_ku_0099M_13741_DATA_1.pdf.txt
Jones_ku_0099M_13741_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/144972020-06-22T21:09:30Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Kluding, Patricia M
Rucker, Jason Lee
Burns, Jeffrey M
Mahnken, Jonathan D
McDowd, Joan M
Sabus, Carla H
2014-07-05T15:28:11Z
2014-07-05T15:28:11Z
2014-05-31
2014
http://dissertations.umi.com/ku:13215
http://hdl.handle.net/1808/14497
There is growing evidence that older adults with type 2 diabetes exhibit deficits in executive function, the set of processes responsible for planning, organizing, sequencing, and monitoring goal-oriented behavior. However, the specific nature of these executive impairments and their functional consequences in this population remain poorly understood. The primary purpose of this work was to determine whether older adults with type 2 diabetes demonstrated impairments in the executive process of multi-tasking when compared to their peers without diabetes, and to examine how multi-tasking abilities contributed to gait and other functional abilities in these individuals. We also sought to examine the integrity of other executive functions in those with diabetes, including the processes responsible for updating information, shifting between different tasks, inhibiting predominant responses, and organizing and recalling visuospatial and verbal data, and to explore their relationships to gait and functional ability. Chapter 2 describes the results of our pilot investigation, in which we administered a measure of multi-tasking, the Cognitive Timed Up and Go (cTUG), and a battery of 7 common executive function tests to 20 adults (age 40-65 years) with diabetes and diabetic peripheral neuropathy (DPN) and 20 individuals of similar age without diabetes. We found that those with DPN performed worse on the cTUG test, and also demonstrated poorer performance on executive function measures assessing visuospatial and verbal processing. Moreover, we observed that overall cognitive performance and symptoms of depression were significantly related to each other and to a measure of functional ability, whereas signs and symptoms of DPN were not associated with this functional measure. Although preliminary, this study illustrated the potential relationships between neuropsychological and physical function, and highlighted that functional impairments, fall risk, and disability in those with DPN is likely the result of a complex and multi-factorial process that extends beyond somatosensory and proprioceptive impairment. Building upon the data and experience we obtained from this pilot project, we next selected two instruments, the Walking and Remembering and Pursuit Rotor tests, in an effort to describe multi-tasking in much greater detail than was possible with the cTUG alone. As described in Chapter 3, these multi-tasking assessments, along with measures of single-task gait and self-reported functional ability and limitation, were administered to a group of 40 older adults (age 60 years and older) with type 2 diabetes and a group of 40 individuals without diabetes, pair-matched according to age, sex, education, and the presence or absence of hypertension. Our analysis of this data revealed that those with diabetes performed worse than comparison subjects when asked to multi-task while walking, appearing to preserve less critical task demands at the expense of gait stability. Interestingly, we observed little association between multi-tasking ability and our gait and functional measures. However, we did note rather striking relationships between these measures and symptoms of depression, physical activity level, and sleep quality. Overall, this data suggested that older adults with type 2 diabetes did exhibit disturbances that could impair safety when required to multi-task while walking. Furthermore, although these changes did not appear to substantially influence single-task gait mechanics or self-reported functional ability, we also found that commonly overlooked variables such as depression, physical activity, and sleep quality may make important contributions to everyday gait and function in this population. Examining these relationships in further detail, we next performed a series of regression analyses investigating the contributions of multi-tasking ability, depression, physical activity, and sleep quality to single-task gait speed and variability, and self-reported physical function and disability in our group with diabetes. Described in Chapter 4, this data demonstrated that there was little association between multi-tasking ability and single-task gait parameters or self-reported physical function and disability. However, our secondary analyses revealed significant adverse relationships between depression and gait variability and disability, between physical activity levels and walking speed and physical function, and between sleep quality and gait variability. Although often overlooked, factors such as depression, physical inactivity, and poor sleep quality are widespread in those with diabetes. Our analysis emphasizes the importance of appropriately identifying and treating such modifiable comorbidities, as well as the need for further research examining their relationships to different aspects of physical function and disability. Having completed our examination of multi-tasking, we turned our attention to exploring the integrity of other executive functions in those with diabetes. Alongside of our multi-tasking measures, we administered a battery of executive function tests assessing the processes of information updating, task shifting, response inhibition, and visuospatial and verbal processing and memory. Analysis of this data revealed that those with diabetes appeared to perform more poorly than comparison subjects on a specific measure of updating and a measure of visuospatial processing. However, we did not observe deficits on a second updating measure, or on any other executive test. Interestingly, although there was little relationship between executive performance and gait or functional abilities in the diabetes group, we observed a number of significant correlations between updating, shifting, and visuospatial memory and gait and function in the comparison group. These findings clearly emphasize the need for further research examining executive function in those with diabetes, and investigating how these processes contribute to physical deficits, falls, and/or disability in health and disease. In summary, the results of this body of work suggest that older adults with type 2 diabetes demonstrate significant changes in gait stability when required to walk while multi-tasking, and may also exhibit deficits in areas of executive function related to the ability to update information and process visuospatial stimuli. The influence of these and other executive functions on gait and functional ability remains unclear, but may differ between those with and without diabetes. Certainly, it appears that factors such as depression, physical activity, and sleep quality make important contributions to everyday function. Overall, our findings emphasize the need for further research investigating the physiological, psychological, and functional consequences of type 2 diabetes in older adults, and the diverse factors that may contribute to the higher incidence of falls, functional deficits, or disability in this high risk patient population.
216 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Physical therapy
Neurosciences
Diabetes
Executive function
Multi-tasking
Rehabilitation
Multi-tasking, Executive Function, and Functional Abilities in Older Adults with Type 2 Diabetes Mellitus
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
8086449
ORIGINAL
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Rucker_ku_0099D_13215_DATA_1.pdf
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Rucker_ku_0099D_13215_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/279662020-10-13T19:42:55Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Ford, Debra
Camp, Kiersten
Barnes, Pamela
Ogawa, Lisa
2019-05-18T18:32:49Z
2019-05-18T18:32:49Z
2018-08-31
2018
http://dissertations.umi.com/ku:16125
http://hdl.handle.net/1808/27966
https://orcid.org/0000-0002-9303-1927
Cost effective, quality, error-free medical care is essential to positive health outcomes. The healthcare system has historically had difficulty with application of quality improvement processes because of the complex processes and systems and the transactional nature of the business. To Err is Human shed light on the disparities in health care delivery and quality of care issues (Institute of Medicine, 1999). In addition, the Affordable Care Act in 2010 has challenged the healthcare system to provide quality care in an efficient manner and reduce waste to gain the most financial benefit (US Department of Health and Human Services, 2012). Like other facets of healthcare, the occupational health clinic is attempting to provide quality, cost effective care in an attempt to minimize lost productivity and save money for the company. One way the healthcare system has responded is by the application of Lean Six Sigma principles borrowed from the manufacturing world. Lean Six Sigma provides a structured method of approaching quality improvement along with tools for sustainability by focusing on waste reduction and reduction of process variation (Koning, 2009). This project utilized the Six Sigma quality improvement process to create baseline metrics of existing processes within the occupational health clinic, collect real-time operational data and analyze ways to improve efficiency and decrease patient time in clinic. Through this process, it was determined that the greatest impact on patient time in clinic resulted from three primary variables: Issues with clinic flow, lack of appropriate standing orders for the nursing staff and inefficiencies with the scheduling process in the clinic. Through control of these variables, the clinic was able to identify process improvements to improve efficiency and quality and reduce costs.
40 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
DMAIC
Efficiency
Occupational Health
Six Sigma
Six Sigma Lean Methodologies to Improve Efficiency and Reduce Patient Time in Clinic in an Occupational Health Clinic
Dissertation
Nursing
D.N.P.
ORIGINAL
Camp_ku_0099D_16125_DATA_1.pdf
Camp_ku_0099D_16125_DATA_1.pdf
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885561
https://kuscholarworks.ku.edu/bitstream/1808/27966/1/Camp_ku_0099D_16125_DATA_1.pdf
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Camp_ku_0099D_16125_DATA_1.pdf.txt
Camp_ku_0099D_16125_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/184272018-01-31T20:07:50Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bott, Marge
Thompson, Diane
Dunton, Nancy
Cramer, Emily
Lee, Robert
Ford, Debbie
2015-09-09T01:50:44Z
2015-09-09T01:50:44Z
2014-12-31
2014
http://dissertations.umi.com/ku:13811
http://hdl.handle.net/1808/18427
Abstract Introduction: Health-care literature is diverse in studying and addressing the health-care work environment related to safety and nursing. Evidence found in the literature demonstrates that the health-care work environment and patient safety are being studied for the purposes of reducing errors and improving care delivery. Burnout also is a widespread issue among health-care workers. What is not evident in the literature is empirical research related to nurse burnout and missed care and their impact on patient care outcomes. Purpose: The purpose of the study was to determine what influenced the nurse at the bedside to avoid or address burnout and to improve patient care quality and safety. A secondary analysis of data from the National Database of Nurse Quality Indicators® (NDNQI®) 2011 and 2012 RN Surveys and quarterly clinical data collection was conducted. The study used a sequential regression analysis to examine the relationships among nurse worklife environment, nurse burnout levels, the practice patterns of missed care, and a patient outcome, hospital-acquired pressure ulcers. Results: The linear weighted combination of the variables in the model explained only 1% to 3% of the variance in prevalence rate of pressure ulcers for 2011 and 2012, respectively. Findings revealed that only academic teaching status was significantly related to pressure ulcer prevalence rates in 2011. In 2012, academic teaching status, RN hours per patient day (RNHPPD), and the practice environment subscales (PES) of hospital affairs and quality of care were significantly related to pressure ulcer prevalence rates. Neither burnout nor missed care had direct relationships with pressure ulcer prevalence; however, other environmental factors were related to burnout and missed care. Conclusions: Relationships between environmental factors, nurse burnout, missed care, and pressure ulcer prevalence rates were described in this study, appreciating the influence of hospital level (teaching status, region, size, and Magnet® status) and unit level (RNHPPD, skill mix [RNHPPD/THPPD], BS or higher degrees, specialty certification, and total years on unit) parameters. With only a small amount of variance in the prevalence rate of pressure ulcers explained, other relationships among the variables within the model were noted and described. All five domains of the Practice Environment Scale (PES) had significant relationships with the variables (i.e., burnout and missed care) within the model. Most importantly, this was an introduction to proposed future studies that could use complexity science as a framework to appreciate the ever-changing health-care environment and interactions of relationships emerging that potentially impact patient safety and quality.
124 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
environment of care
missed care
patient safety
The examination of practice environment, burnout, and missed care on pressure ulcer prevalence rates using a complexity science framework
Dissertation
Nursing
Ph.D.
THUMBNAIL
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https://kuscholarworks.ku.edu/bitstream/1808/18427/2/Thompson_ku_0099D_13811_DATA_1.pdf.txt
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ORIGINAL
Thompson_ku_0099D_13811_DATA_1.pdf
Thompson_ku_0099D_13811_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/18427/1/Thompson_ku_0099D_13811_DATA_1.pdf
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MD5
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1808/18427
oai:kuscholarworks.ku.edu:1808/18427
2018-01-31 14:07:50.942
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/97242020-06-23T00:35:58Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Zhu, Hao
Smirnova, Irina V
Deng, Bin
Zhu, Hao
Smirnova, Irina V
Benson, David R
Wang, WenFang
Fenton, Aron W
2012-06-03T14:09:28Z
2012-06-03T14:09:28Z
2011-12-31
2011
http://dissertations.umi.com/ku:11746
http://hdl.handle.net/1808/9724
NADH cytochrome b5 oxidoreductase (Ncb5or) is a multi-domain redox enzyme found in all animal tissues and associated with the endoplasmic reticulum (ER). Ncb5or contains (from N-terminus to C terminus) a novel N-terminal region, the b5 domain (Ncb5or-b5), the CS domain, and the b5R domain (Ncb5or-b5R). Ncb5or-b5, the heme binding domain, is homologous to microsomal cytochrome b5 (Cyb5A) and belongs to cytochrome b5 superfamily. Ncb5or-b5R, the FAD (flavin adenine dinucleotide) binding domain, is homologous to cytochrome b5 reductase (Cyb5R3) and belongs to ferredoxin NADP+ reductase superfamily. Both superfamilies are of great biological significance whose members have important functions. The CS domain can be assigned into the heat shock protein 20 (HSP20, or p23) family, whose members are known to mediate protein-protein interactions. Ncb5or is unique in containing these domains and employing a novel sequence as the N-terminal region. Cyb5A and Cyb5R3 have been shown to form a complex to donate electrons to stearoyl-CoA desaturase (SCD) in fatty acid desaturation in vitro. Monounsaturated fatty acids are preferentially used in triglyceride synthesis for lipid storage. Mice with hepatic deletion of Cyb5A show no significant defect in lipid metabolism, whereas Ncb5or null mice exhibit diabetes, lipoatrophy and impaired SCD activity. We hypothesize that Ncb5or, as a fusion of both Cyb5A and Cyb5R3-like domains, serves as an alternative electron donor to SCD in vivo. Ncb5or-b5 shows unique structural and functional features, such as, low sequence homology to other family members, displacement of the second heme-ligating His residue, a decrease in the number of surface-charged residues, and a much lower redox potential at the heme center compared with Cyb5A. In order to understand how these differences between Ncb5or and Cyb5A contribute to their unique structural and functional properties in electron transfer, we solved the crystal structure of Ncb5or-b5 and performed kinetic assays by using various domain combinations. Our 1.25 Å crystal structure shows that Ncb5or-b5 has a general b5 fold. However, Ncb5or-b5 has a unique heme environment, namely the two heme-ligating His residues are nearly perpendicular to each other. The latter feature agrees with a large gmax value in electron paramagnetic resonance (EPR) spectra. This makes Ncb5or the first example with a tetragonally distorted heme environment in the cytochrome b5 superfamily. Lower density of charge on the surface of Ncb5or-b5 suggests weaker ionic interaction between Ncb5or-b5 and Ncb5or-b5R than that between Cyb5A and Cyb5R3. The lack of Ncb5or-b5/Ncb5or-b5R complex formation and lower rates of electron transfer than Cyb5A/Cyb5R3 are consistent with this hypothesis. Low affinity between Ncb5or-b5 and Ncb5or-b5R prompted a search for other factors that facilitate the inter-domain electron transfer. Specifically, the role of the N-terminal region, a region rich in random coils but with little homology to known proteins, was explored. A reductionist approach was used to test various domains of Ncb5or with kinetic assays and spectral analyses, such as circular dichroism and nuclear magnetic resonance. I have unveiled the role of the N-terminal region for the first time: the N-terminal region facilitates inter-domain electron transfer by cooperatively interacting with the CS domain and the heme center of Ncb5or-b5. The formation of tertiary structure in the N-terminal region is governed by the region from Gly22 through Trp37, especially Trp37, and this region is essential for electron transfer. This feature suggests a potential mechanism to facilitate the inter-domain electron transfer in Ncb5or.
231 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Biochemistry
Structural basis of inter-domain electron transfer in Ncb5or, a redox enzyme implicated in diabetes and lipid metabolism
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7643123
ORIGINAL
Deng_ku_0099D_11746_DATA_1.pdf
Deng_ku_0099D_11746_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/9724/1/Deng_ku_0099D_11746_DATA_1.pdf
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1808/9724
oai:kuscholarworks.ku.edu:1808/9724
2020-06-22 19:35:58.52
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/249872017-12-08T21:43:43Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Koeneke, Irene Anita
2017-09-21T14:45:23Z
2017-09-21T14:45:23Z
1932
http://hdl.handle.net/1808/24987
Thesis (M.S.)--University of Kansas, Surgery, 1932.
eng
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
Uterine hemorrhage due to extra-uterine influences
Thesis
Surgery
M.S.
3425286
TEXT
koeneke_1932_3425286.pdf.txt
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129746
https://kuscholarworks.ku.edu/bitstream/1808/24987/2/koeneke_1932_3425286.pdf.txt
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MD5
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open access
ORIGINAL
koeneke_1932_3425286.pdf
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108682231
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MD5
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open access
THUMBNAIL
koeneke_1932_3425286.pdf.jpg
koeneke_1932_3425286.pdf.jpg
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MD5
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open access
1808/24987
oai:kuscholarworks.ku.edu:1808/24987
2017-12-08 15:43:43.641
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/157662019-07-17T05:18:03Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Neuberger, Geri
Adkins, Barbara
Bott, Marjorie
Popkess-Vawter, Sue
Choi, Won
Klemp, Jennifer
Mahnken, Jonathan
2014-11-18T04:09:51Z
2014-11-18T04:09:51Z
2014-08-31
2014
http://dissertations.umi.com/ku:13599
http://hdl.handle.net/1808/15766
Breast cancer is the second most common cancer among women in the United States. Sentinel lymph node biopsy for staging early breast cancer in clinically node negative patients is supported by the American Society of Clinical Oncology due to a greater morbidity associated with axillary lymph node dissection. Quality of life benefits of sentinel lymph node biopsy compared to axillary lymph node dissection are inconsistent and many studies have used quality of life questionnaires alone. This descriptive correlational study was a primary analysis of factors that predicted quality of life over two years based on a modified Health Related Quality of Life Model. The sample consisted of 185 women, ages 29 to 88 who had the new axillary reverse mapping surgical procedure following an axillary lymph node dissection with sentinel lymph node biopsy or axillary lymph node dissection with or without sentinel lymph node biopsy. Descriptive analyses were conducted for occurrence of lymphedema and measures of physical function, general health perceptions, and health-related quality of life over two years. Individual characteristics, relationships of biological factors, symptoms, and functional status to general health perception and health-related quality of life were evaluated through separate regression analyses conducted at three time points over two years. Data were collected from the SF-36 and the axillary reverse mapping surgery form. Up to 31% of the variance in General Health Perception was explained by seven variables (age, body mass index, surgery, pain, lymphedema, physical functioning, and strength) with physical functioning and pain contributing the most. As much as 37% of variance in mental component summary was explained by the same seven variables with physical functioning and pain contributing the most. Only 19% of the variance for physical component summary was explained by five variables (age, body mass index, surgery, lymphedema, and muscle strength) with body mass index and muscle strength contributing the most at two years. Results provide information to help nurses formulate extended interventions and education for improving the perceptions and objective outcomes of women after undergoing axillary surgery for breast cancer.
110 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Axillary reverse mapping
Breast cancer
Quality of life
PREDICTORS OF QUALITY OF LIFE WITH AXILLARY REVERSE
Dissertation
Nursing
Ph.D.
THUMBNAIL
Adkins_ku_0099D_13599_DATA_1.pdf.jpg
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ORIGINAL
Adkins_ku_0099D_13599_DATA_1.pdf
Adkins_ku_0099D_13599_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/15766/1/Adkins_ku_0099D_13599_DATA_1.pdf
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license.txt
license.txt
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2569
https://kuscholarworks.ku.edu/bitstream/1808/15766/4/license.txt
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MD5
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TEXT
Adkins_ku_0099D_13599_DATA_1.pdf.txt
Adkins_ku_0099D_13599_DATA_1.pdf.txt
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193172
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98caf2d80dca3a20473e3781fbc1eb0f
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1808/15766
oai:kuscholarworks.ku.edu:1808/15766
2019-07-17 00:18:03.365
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/114452020-06-22T21:24:04Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Williams, Phoebe D.
Heinze, Sylvia B.
Bott, Marjorie
Pierce, Janet
Popkess-Vawter, Sue
Diaz-Ceballos, Francisco
2013-07-14T15:00:22Z
2013-07-14T15:00:22Z
2012-08-31
2012
http://dissertations.umi.com/ku:12401
http://hdl.handle.net/1808/11445
Background: Breast cancer survivors confront ongoing symptoms following diagnosis and treatment. Studies examining the relationship between biomarkers and symptoms are scarce. Purpose: To explore symptom occurrence and severity as reported by breast cancer survivors and their relationship to the BDNF Val66Met SNP (a biomarker), daily activities, quality of life and other selected subject characteristics and health variables. In addition, self-care methods used by survivors to alleviate symptoms and perceptions of the methods¡¯ usefulness were considered. Methods: Breast cancer survivors (6 months or more post-treatment) were invited by a coalition from a Mid-Atlantic state to participate in an online survey in Phase 1 (N = 195). The survey results provided the basis for a purposive sub-sampling. In Phase 2, two groups were identified from their scores on the Therapy-Related Symptoms Checklist (TRSC; low-scoring [¡Ü 14, n = 26] and high-scoring [¡Ý 23, n = 25]) for BDNF genotyping (by the Taqman probe assay) and exploration of self-care. All self-report tools have good psychometric properties: the TRSC, Daily Activities Rating (DAR), Health-Related Quality of Life-Linear Analogue Scale Assessment (HRQOL-LASA), and Symptom Alleviation: Self-Care Methods (SA: SCM). Fisher¡¯s exact test, logistic and multiple regression, and descriptive and content analyses were conducted. Findings: (a) The presence of the BDNF Val66Met SNP biomarker was related to lower symptom scores, but effect size was small and the relationship did not persist when controlling for confounders; (b) TRSC scores were not impacted by time since completion of treatment; (c) high total scores on the TRSC (high symptom occurrence and severity) were significantly related to high scores on the DAR (difficulty with activities of daily life) and to lower quality of life on the HRQOL-LASA; (d) the odds of a low TRSC score increased with increased education and increased age, and diminished if treatment included chemotherapy; (e) the self-care method used most commonly was diet/nutrition/lifestyle; the least common was herbs/vitamins/complementary therapy, and the methods that were used were perceived as effective. Clinical Implications and Need for Further Research: Beginning evidence that the BDNF Val66Met SNP may have a protective effect for ongoing symptoms in breast cancer survivors.
165 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Oncology
Nursing
Genetics
Brain-derived neurotrophic factor (bdnf)
Breast cancer
Self-care
Symptom alleviation: self-care methods (sa: scm)
Symptoms
Therapy-related symptom checklist
Relationships Among Symptoms, Brain-Derived Neurotrophic Factor (BDNF), Daily Activities, Self-Care, and Quality of Life in Breast Cancer Survivors
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085863
ORIGINAL
Heinze_ku_0099D_12401_DATA_1.pdf
Heinze_ku_0099D_12401_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/11445/1/Heinze_ku_0099D_12401_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/11445
2020-06-22 16:24:04.243
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/145482019-07-17T05:15:56Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bosak, Kelly
Platt, Adrienne Milligan
Smith, Carol E.
Kim, Heejung
Faseru, Babalola
Egan, Anna
2014-07-05T16:41:01Z
2014-07-05T16:41:01Z
2014-05-31
2014
http://dissertations.umi.com/ku:13346
http://hdl.handle.net/1808/14548
ABSTRACT Childhood obesity has become epidemic in the United States. Coinciding with this rapid increase in obesity is the development of type-2 diabetes in youth. Little is known about the progression of insulin resistance to type-2 diabetes or association of depressive symptoms and impaired glucose metabolism in at-risk obese youth. A retrospective chart review and a secondary data analysis was done using a descriptive correlational design exploring the incidence of insulin resistance, hyperinsulinemia, impaired fasting glucose, impaired glucose tolerance, and progression to type-2 diabetes in a cohort of 78 high-risk obese youth age 11 to 17 years presenting to a pediatric endocrinology clinic from 2007 to 2009. Association between self-reported depressive symptom scores using the Center for Epidemiological Studies Depression Scale for Children (CES-DC) and measures above were also explored. Of the 78 participants enrolled in the original study, 44 (56.4%) underwent oral glucose tolerance testing, and 4 (9.1%) were diagnosed with impaired glucose tolerance. None had a confirmed diagnosis of type-2 diabetes over the 6 year study period. Two hour oral glucose tolerance results significantly correlated with the initial HbA1c (r=.470, p=.007), the sum of insulin levels (r=.518, p=.001), and HOMA-IR (r=.429, p=.007). The insulin total correlated with HOMA-IR (r=.553, p=.001). The incidence of self-reported depressive symptoms was high in 35 (49 %) participants (n=71). None of the measures of impaired glucose metabolism correlated with depression scores. These results indicate that even with a small sample of obese youth, 78 % met criteria for insulin resistance. The HbA1c correlated with 2-hour glucose tolerance test results. Glucose tolerance testing is used clinically for confirmatory diagnosis of impaired glucose tolerance and type-2 diabetes which support the use of HbA1c for screening youth. Despite lack of association between depressive symptoms and impaired glucose metabolism, 49% reported symptoms of depression with 11% moderate or severe. It would be prudent to screen all obese youth for depressive symptoms as this may impact their ability to implement lifestyle changes. Future research is needed with a larger prospective sample of high-risk obese youth to identify those more likely to develop type-2 diabetes and benefit from lifestyle interventions.
96 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Endocrinology
Childhood obesity
Depressive symptoms
Insulin resistance
Insulin Resistance, Depression, and the Progression to Type-2 Diabetes in Youth
Dissertation
Nursing
Ph.D.
LICENSE
license.txt
license.txt
text/plain
2569
https://kuscholarworks.ku.edu/bitstream/1808/14548/5/license.txt
c51a2a8181b7df93e55a9d6314ced7e1
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ORIGINAL
Platt_ku_0099D_13346_DATA_1.pdf
Platt_ku_0099D_13346_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/14548/1/Platt_ku_0099D_13346_DATA_1.pdf
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Platt_ku_0099D_13346_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/14548
2019-07-17 00:15:56.41
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/55742020-06-22T20:27:42Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Durham, Dianne
Karnes, Hope Elizabeth
Imig, Thomas J
Nishimune, Hiroshi
Robertson, John D
Staecker, Hinrich
Wright, Douglas E
2009-11-02T19:19:06Z
2009-11-02T19:19:06Z
2009-06-17
2009
http://dissertations.umi.com/ku:10426
http://hdl.handle.net/1808/5574
Forty percent of elderly Americans suffer from hearing loss. Hearing loss is a significant public health concern, associated with social withdrawal, communication delays, and reduced comprehension, that is growing in magnitude as the population ages. It is a frustrating disorder, which is expensive and difficult to treat. Hearing loss occurs as a consequence of damage to inner ear or central nervous system (CNS) structures. Current technologies to restore hearing, like hearing aids and cochlear implants, have broadened the therapeutic options to treat this disorder, but these therapies solely target inner ear structures. The CNS component is equally as important in preserving auditory function, but little is known about the process of auditory neuronal damage and recovery. In this series of studies, the avian auditory system is used as a model in which to evaluate the CNS response to disruptions in auditory signaling. Neurons in the chick cochlear nucleus, nucleus magnocellularis (NM), receive excitatory input exclusively from the ipsilateral cochlea. Cochlea removal permanently abolishes this input, and NM neurons undergo rapid morphologic and functional changes, including calcium dysregulation, mitochondrial and ribosomal compromise, and oxidative metabolic stress. Ultimately, a subset (30-50%) of deafferented NM neurons dies. To better characterize the cellular factors that influence whether a deafferented NM neuron dies or survives, auditory brainstems from unilaterally deafened hatchling chicks were examined using a variety of immunocytochemical, histochemical, and molecular approaches. Compared to contralateral NM neurons with intact afferent support, NM neurons ipsilateral to cochlea removal undergo activation of apoptotic mediators, functional impairment of mitochondrial inner membrane constituents, and alterations in the expression levels of certain genes. Specific differences in mitochondrial nucleic acid integrity and ATP coupling state, as well as in the expression of genes related to calcium signaling, glutamate receptor signaling, GABA receptor signaling, and phospholipid degradation, distinguish deafferented NM neurons that die from deafferented NM neurons that will survive. These results suggest that molecular signaling pathways involving mitochondrial function and calcium regulation play pivotal roles in cell fate determination of chick brainstem auditory neurons following peripheral deafferentation (i.e. deafness).
255 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Biology
Neurosciences
Cell biology
Molecular biology
Apoptosis
Auditory system
Laser capture microdissection
Mitochondria
Sensory system
Deafferentation-Induced Neuroplasticity in Chick Auditory Neurons: A Matter of Life or Death
Dissertation
Anatomy & Cell Biology
Ph.D.
na
This item does not meet KU Open Access policy criteria.
7078942
ORIGINAL
Karnes_ku_0099D_10426_DATA_1.pdf
Karnes_ku_0099D_10426_DATA_1.pdf
application/pdf
5467709
https://kuscholarworks.ku.edu/bitstream/1808/5574/1/Karnes_ku_0099D_10426_DATA_1.pdf
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LICENSE
license.txt
license.txt
text/plain
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Karnes_ku_0099D_10426_DATA_1.pdf.txt
Karnes_ku_0099D_10426_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/5574
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open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/43242020-06-22T20:12:39Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wright, Douglas
Stehno-Bittel, Lisa
Sharma, Neena
Geiger, Paige
Kluding, Patricia
Searls, Yvonne
2009-02-02T05:28:54Z
2009-02-02T05:28:54Z
2008-08-22
2008
http://dissertations2.umi.com/ku:2702
http://hdl.handle.net/1808/4324
Most people suffering from various chronic pain syndromes report deep tissue pain. However, our knowledge about chronic musculoskeletal pain is primarily based on rodent models of cutaneous pain. Little is known about muscle nociception and its modulation with exercise training. The overall purpose of this dissertation was to assess muscle pain and determine the role of aerobic exercise in reducing chronic pain induced by acidic saline in mice. This animal model mimics a human condition, fibromyalgia and similar diseases that present with widespread hypersensitivity to mechanical stimuli. All experiments were carried out in 2 different strains of female mice, C57Bl/6 and CF-1. Widespread chronic pain was induced by injections of acidic saline into the gastrocnemius muscle, and treadmill running was chosen as a mode of aerobic exercise training. Hypersensitivity to mechanical stimulation was tested in the cutaneous and muscle tissues utilizing standard methods of von Frey monofilaments, instrumented forceps device and Fos expression of the dorsal horn spinal cells. The effect of aerobic exercise on chronic pain state was tested with behavioral and molecular measures. The results indicated that acid injections induced cutaneous and muscle hyperalgesia in female mice, yet the development of widespread pain is subjected to the variability of genetic background in both strains of mice. In C57BL/6 mice, the effect of acid injections was less robust. The CF-1 mice developed muscle hyperalgesia that lasted up to 2 weeks, suggesting chronic phase of muscle pain. This finding was confirmed with increased Fos activity in the corresponding spinal cord level. Furthermore, the central projection of nociceptors from the paw and the gastrocnemious muscle evoked different Fos activation pattern. The molecular basis for the positive actions of exercise remains poorly understood. Therefore, we tested the effects of exercise training of 2-intensivity levels (mildly-intense on C57BL/6 mice and moderately-intense on CF-1 mice) on widespread chronic pain and neurotrophin-3 (NT-3) synthesis. The results indicated that moderate exercise training reduced widespread hyperalgesia, whereas the effect of mild exercise training was less robust. Likewise, moderately-intense exercise training upregulated NT-3 synthesis in the skeletal muscle; mild exercise training had no effect of NT-3 levels. The increase in NT-3 was more pronounced at the protein levels compared to mRNA expression. In addition, the protein levels were significant only in the gastrocnemius and not in the soleus muscle, suggesting that exercise can preferentially target NT-3 synthesis in specific muscles. In summary, this body of work indicates a novel finding of chronic muscle pain and adds new information to our understanding of deep tissue nociception as well as its spinal distribution. This study is the first to demonstrate the beneficial effect of aerobic exercise training on chronic muscle pain in the acid-pain model. These results strengthen the role of NT-3 as an anti-nociceptive neurotrophin in treating muscle pain and provide further support for exercise training as a therapeutic intervention for the growing field of pain medicine.
204 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Rehabilitation and therapy
Biology
Neurosciences
ANALYZING MUSCULAR PAIN AND THE EFFECTS OF EXERCISE ON CHRONIC PAIN
Dissertation
Physical Therapy & Rehabilitation Sciences
PH.D.
na
This item does not meet KU Open Access policy criteria.
6857283
ORIGINAL
umi-ku-2702_1.pdf
umi-ku-2702_1.pdf
application/pdf
7183960
https://kuscholarworks.ku.edu/bitstream/1808/4324/1/umi-ku-2702_1.pdf
d735f131e81811efe94b016c510fd769
MD5
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open access
umi-ku-2702_2.pdf
umi-ku-2702_2.pdf
Dissertation_NSharma_2008
application/pdf
7184151
https://kuscholarworks.ku.edu/bitstream/1808/4324/2/umi-ku-2702_2.pdf
d484cafee9b0f6e1ec53f66b501bafd5
MD5
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open access
LICENSE
license.txt
license.txt
text/plain
2569
https://kuscholarworks.ku.edu/bitstream/1808/4324/7/license.txt
c51a2a8181b7df93e55a9d6314ced7e1
MD5
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open access
THUMBNAIL
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umi-ku-2702_1.pdf.jpg
Generated Thumbnail
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https://kuscholarworks.ku.edu/bitstream/1808/4324/5/umi-ku-2702_1.pdf.jpg
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umi-ku-2702_2.pdf.jpg
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umi-ku-2702_1.pdf.txt
umi-ku-2702_1.pdf.txt
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287392
https://kuscholarworks.ku.edu/bitstream/1808/4324/3/umi-ku-2702_1.pdf.txt
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MD5
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umi-ku-2702_2.pdf.txt
umi-ku-2702_2.pdf.txt
Extracted text
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287385
https://kuscholarworks.ku.edu/bitstream/1808/4324/4/umi-ku-2702_2.pdf.txt
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1808/4324
oai:kuscholarworks.ku.edu:1808/4324
2020-06-22 15:12:39.405
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/301362021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Cheng, Nikki
Brummer, Gage Adam
Iwakuma, Tomoo
Behbod, Fariba
Fields, Tim
Fan, Fang
2020-03-23T19:58:44Z
2020-03-23T19:58:44Z
2019-05-31
2019
http://dissertations.umi.com/ku:16626
http://hdl.handle.net/1808/30136
Abstract The presence of immune cells within a tumor is often a good prognostic indicator, but in breast cancer the presence of tumor-promoting macrophages within the tumor predicts poor prognosis. The current model by which macrophages promote tumor progression is that tumor cells secrete chemokines to recruit the macrophages to the tumor microenvironment, which then promote vascularization and invasion of the tumor cells. The most important chemokine in this process is CCL2 (also called monocyte-chemoattract protein 1). CCL2 is a chemotactic cytokine secreted by all cell types after injury or inflammation, and by carcinoma cells. Macrophages and monocytes express CCR2, the receptor for CCL2, through which they receive this chemotactic signal. Expression of CCR2 correlates with poor prognosis and advanced disease in breast cancer. The role CCR2 expression by cancer cells is unclear, as most studies have focused on the effects of macrophage CCR2 signaling in breast cancer. These studies show that CCR2 signaling promotes tumor-cell growth and invasion directly, and indirectly by affecting the tumor microenvironment to increase CCL2 levels and decrease levels of an immune-stimulating and tumor-suppressing molecule, CD154. CCR2-expressing tumors rely on the suppression of CD154 to support the tumor-promoting macrophage phenotype. Inhibiting CCR2 signaling in tumor cells significantly alters macrophage recruitment and tumor-promoting phenotype, resulting in decreased tumor growth and invasion. Here I present a novel mechanism where tumoral CCR2 signaling orchestrates M2 macrophage polarization, angiogenesis, and suppression of CD8+ T cells to promote growth and invasion in breast cancers, with potential applications to immunotherapeutic regimens.
200 pages
en
University of Kansas
Copyright held by the author.
openAccess
Cellular biology
Immunology
Pathology
Breast
Cancer
CCR2
CD154
CD40L
macrophage
Epithelial CCR2 promotes breast cancer progression directly and indirectly thru crosstalk with microenvironment populations
Dissertation
Pathology & Laboratory Medicine
Ph.D.
TEXT
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oai:kuscholarworks.ku.edu:1808/269272018-10-25T19:48:52Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Godwin, Andrew K
Hirst, Jeffrey J.
Behbod, Fariba
Krieg, Adam
Paul, Soumen
Li, Benyi
Zhang, Yuxia
2018-10-22T22:03:00Z
2018-10-22T22:03:00Z
2017-05-31
2017
http://dissertations.umi.com/ku:15140
http://hdl.handle.net/1808/26927
Since the introduction of paclitaxel in 1992, the overall survival for women diagnosed with ovarian cancer has remained relatively stagnant. This unsatisfactory outcome is in part attributed to the presence of subpopulations of tumor cells with stem cell-like properties, which are resistance to front-line therapies. Efforts to identify unappreciated drugs to combat these resistant cell populations typically have used traditional two-dimensional (2D) cell culture models which do not always reflect the tumor heterogeneity seen in clinical samples including reduced cell proliferation, hypoxia, and cancer stem-like cells. The lack of congruency between in vitro screening models and the patient’s outcome has limited the number of successful anti-cancer drugs that demonstrate clinical benefit. In order to identify drugs that are more likely to benefit patients, a drug screening model that better represents clinical disease was required. Towards this goal, I developed and characterized a three-dimensional (3D) cell culture model in which ovarian cancer cells were grown as multicellular tumor spheroids (MCTS) and directly compared drug activity in 2D and 3D models. Compared to a panel of ovarian cancer cell lines grown in 2D, MCTS formation induced many different phenotypes associated with clinical drug resistance including reduced cell proliferation, cellular hypoxia, and stem-like gene expression and function. Cells grown as MCTS better mimicked the response to chemotherapy seen in the clinic as compared to 2D. Specifically, paclitaxel treatment of MCTS revealed significant increases in expression of stem cell-related genes, e.g., CD133, CD44, OCT4, SOX2, and NANOG. Correspondingly, significant reduction in cell proliferation with accompanying resistance to paclitaxel was observed in MCTS compared to 2D cultures, providing an in vitro model that reflects certain aspects of clinical progression and drug resistance. Interestingly, the drug resistance and stem-like properties observed in MCTS were maintained in cells grown under 2D conditions when these cells were derived from MCTS, indicating a potential long-term change in phenotype. These changes provided an in vitro model that better reflects clinical disease that can be exploited for drug screening. To exploit these differences, the MCTS model was used to compare the activity of 304 repurposed drugs, most that are FDA approved for indication other than cancer, in four established ovarian cancer cell lines grown in 2D and 3D. I identified a number of compounds with selective activity in MCTS that can target subpopulations of resistant cells with stem-cell like properties. In a primary drug screen between 2D and 3D cultures designed to directly compare response to 10 µM of the 304 clinically approved drugs revealed fifteen compounds with preferential activity against cells grown as MCTS as measured by CellTiter-Glo. Drug hits were classified to have 3D specific activity based on >75% viability reduction in MCTS but 75% viability reduction in MCTS but <50% viability reduction in 2D cultures. Secondary screening using a range 0 to 25 µM drug identified licofelone and glafenine to have the most robust and selective activity in MCTS across a genetically diverse panel of ovarian cancer cell lines. Both are anti-inflammatory drugs that had not previously been considered for the treatment of cancer. Since an increasing number of drugs are removed from the market because of unacceptable toxicity, subsequent experiments focused on licofelone. Licofelone has demonstrated a better safety profile as compared to glafenine, i.e., reported increased risk of anaphylaxis and kidney failure. Importantly, treatment of MCTS using IC50 concentration of licofelone significantly reduced expression of stem cell markers by up to 90%, as measured using qRT-PCR and immunofluorescent (IF) immunohistochemistry in cells grown as MCTS. Consequently, Ki67 positive cells were increased from vehicle treatments (30%) in response to licofelone (57%) treatment in MCTS. Combination treatment in MCTS showed significant synergy (Combination Index <1) for sequential additions of licofelone followed by paclitaxel, or vice-versa. Likewise, licofelone addition reversed stemness (gene expression, colony forming and spheroid forming assays) in ovarian cancer cells that were induced by paclitaxel treatment in MCTS. By performing drug screens using a MCTS model, I identified two previously unappreciated candidate anti-cancer drugs that had preferential activity on ovarian cancer cells with stem cell-like properties. When used in combination with paclitaxel, licofelone showed significant synergy and reversed the drug resistant phenotypes of MCTS.
188 pages
en
University of Kansas
Copyright held by the author.
openAccess
Cellular biology
Oncology
Drug development
Drug resistance
Ovarian cancer
Three-dimensional cell culture
Identification of licofelone through three-dimensional cell culture drug screening as a repurposed agent able to reverse drug resistant and cancer stem cell-like subpopulations in ovarian cancer
Dissertation
Pathology & Laboratory Medicine
Ph.D.
TEXT
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KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/114402020-06-22T20:30:55Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Williams, Kristine Nordlier
Noimuenwai, Premruetai
Bergquist-Beringer, Sandra
Domian, Elaine Williams
Rojjanasrirat, Wilaiporn
LaPierre, Tracey A.
2013-07-14T14:50:22Z
2013-07-14T14:50:22Z
2012-12-31
2012
http://dissertations.umi.com/ku:12475
http://hdl.handle.net/1808/11440
Adult day care (ADC) is recognized as a supportive intervention for persons with dementia (PWD) and family caregivers during the day time. The primary aim of this study was to evaluate the effect of the Thai ADC programs for PWD on caregiver outcomes (burden, depression, health status, social support, and quality of life) between baseline and after using ADC for one and three months. The second aim of the study was to explore the caregivers' experiences of how ADC has helped the PWD and family caregivers and how their life has changed. An exploratory prospective study with a single group repeated-measures design and two main open-ended questions was employed. Sixteen caregivers were recruited from two ADC sites including Somdet Chaophaya Institute of Psychiatry and Chiangmai Neurological Hospital. Caregiver outcomes were measured with the Zarit Burden Interview (ZBI), the Center for Epidemiologic Studies-Depression Scale (CES-D), the Short form 12-item health survey (SF-12v2), the Sarason's Social Support Questionnaire (SSQ-6), and the WHO QOL-BREF-THAI. The General Personal Data Survey and the Caregiver Evaluation of ADC (CEADC) were included. Each participant was interviewed for approximately 45-60 minutes after using ADC for 3 months. The results of the repeated measures ANOVA showed that only mean physical component scores (PCS) of the SF-12v2 and mean physical domain scores on the WHO QOL-BREF-THAI were significantly higher than baseline after using ADC for one and three months. Interviews with sixteen participants were audio-recorded, transcribed verbatim in Thai, and back-translated. Seven main categories that emerged from content analysis of the interview data included: "Requiring medical care for persons with dementia", "Challenges for family caregivers", "Seeking help, access to ADC", "Expectations for ADC", "Perception of benefits and effects of ADC", and "ADC in the future." ADC improved caregiver-reported health after using ADC. This study verified the use of Smith's Model of Caregiving Effectiveness in dementia care including efficient use of ADC as an external resource for caregivers. The findings of this study should be interpreted with caution due to the limitations of the study.
303 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Nursing
Health care management
Aging
Adult day care
Caregiver burden
Caregiver depression
Dementia
Health and social support
Quality of life
Effectiveness of Adult Day Care Programs on Health Outcomes of Thai Family Caregivers of Persons with Dementia
Dissertation
Nursing
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085906
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KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/74342020-06-23T00:52:05Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Wright, Douglas E
Smirnova, Irina V
Farmer, Kevin
Kluding, Patricia M
Smith, Peter G
Stehno-Bittel, Lisa A
2011-04-26T03:26:44Z
2011-04-26T03:26:44Z
2010-09-16
2010
http://dissertations.umi.com/ku:11133
http://hdl.handle.net/1808/7434
Neuropathic pain results from damage to peripheral sensory axons, which can occur due to physical trauma (via nerve trauma) or metabolic diseases (via diabetes). Neuropathic pain can be a debilitating disease that often responds poorly from pharmacological interventions. The ability of exercise to reduce behavioral sensitivity associated with neuropathic pain in rodents has been reported; however, the exercise-induced mechanisms were not researched in this study. Increases in neurotrophic factors (e.g. glial cell line-derived neurotrophic factor [GDNF]) have been proposed as a possible mechanism for reducing neuropathic pain. Therefore, the purpose of this study is to determine whether voluntary exercise can attenuate or delayed mechanical sensitivity associated with neuropathic pain and assess GDNF levels as a possible mechanism. Two neuropathic pain models (SNI and streptozotocin [STZ]-induced diabetes [type 1 model]) were assessed. Following surgery and/or injections, animals in the exercised groups were housed in standard cages with voluntary running wheels while the sedentary group was housed without wheels. To quantify neuropathic pain mechanical allodynia and hyperalgesia were assessed. GDNF protein levels and mRNA expression were examined in the lumbar region of the spinal cord, dorsal root ganglion (DRG), sciatic nerve, and skeletal muscle. Our results showed that both models produced mechanical hypersensitivity. However, voluntary exercise significantly reduced mechanical hypersensitivity within 2 to 3 weeks. Within the spinal cord, the SNI surgery increased GDNF protein levels, whereas diabetes significantly decreased GDNF levels. Voluntary exercise had no effect on GDNF levels after nerve injury; however, among diabetic animals voluntary exercise significantly increased GDNF protein levels in the spinal cord and sciatic nerve, mRNA expression in skeletal muscle, along with axonal transport in the sciatic nerve. Intrathecal injections of recombinant GDNF ameliorated mechanical sensitivity associated with diabetic neuropathy, therefore implicating the potential therapeutic actions of GDNF. In summary, voluntary exercise caused favorable changes in behavioral sensitivity in both nerve-injured and diabetic rodents. In diabetic rodents this reduction in mechanical sensitivity may be due to an increase in GDNF and axonal transport, whereas the exercise-induced mechanism after nerve injury remains unknown. This investigation supports the use of exercise to complement current treatment strategies aimed at decreasing neuropathic pain associated with peripheral nerve injury and diabetes.
239 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Rehabilitation and therapy
Allodynia
Diabetes
Exercise
Gdnf
Hyperalgesia
Peripheral nerve injury
THE EFFECT OF VOLUNATARY EXERCISE ON NEUROPATHIC PAIN
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085569
TEXT
Farmer_ku_0099D_11133_DATA_1.pdf.txt
Farmer_ku_0099D_11133_DATA_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/7434
2020-06-22 19:52:05.141
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/301732021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Mahnken, Jonathan
Montgomery, Robert
Gajewski, Byron
Wick, Jo
Koestler, Devin
Gibbs, Heather
2020-03-25T18:31:02Z
2020-03-25T18:31:02Z
2019-12-31
2019
http://dissertations.umi.com/ku:16893
http://hdl.handle.net/1808/30173
https://orcid.org/0000-0002-1423-0590
The application of statistical procedures to real data sets seldom proceeds as seamlessly as a textbook problem where all assumptions are verified, and sample sizes are adequate. Common issues include lack of adherence to the statistical analysis plan, missing data and in early stage research, small sample sizes and a large number of variables of interest, i.e. multiplicity considerations. We present novel statistical methodologies that have been developed for use in these adverse scenarios with applications to research into Alzheimer's Disease. Specifically, we have developed an approach for the analysis of paired categorical data when the pairing has been lost, in the context of a study examining the effectiveness of a type of therapy on perceptions of Alzheimer's. We used a weighted bootstrap approach to compare the euclidean distance between the pre and post centers of mass the pre and post therapy groups and despite the loss of the pairing, were able to make conclusions about the research hypothesis. In addition, we developed a new global hypothesis test, the Prediction Test, which is intended for use in early stage research when the sample size is small and the number of endpoints of interest is large. We utilize researcher's predictions about the direction different endpoints will move, e.g. increase/decrease, and weight these predictions based on the sample correlation matrix. Using this test, we are able to come to a go/no-go decision concerning the feasibility of continuing to study the current research hypothesis, a common concern in early and exploratory studies. The prediction test had good power properties even for very small sample sizes and a large number of variables of interest, a situation in which most tests fail, while also controlling the Type I error rate. We demonstrate the methodology with a data set consisting of Arterial Spin Labeling (ASL) measures on older adults before and after a 12-week exercise regimen. The research hypothesis for this study was that the exercise intervention would alter the structural/functional aspects of the brain, specifically that ASL would increase in the different regions of the brain. We then provide extensions to the predictions that can be made in the Prediction Test and compare the method to a Linear Mixed Model and a set of t-test on a data set consisting of Diffusion Tensor Imaging (DTI) measures on pre and post kidney transplant patients. The research hypothesis of this study is that kidney transplantation will lead to a normalization of DTI measures, which are emerging bio markers for cognition and Alzheimer's Disease. We also discuss power calculations and conduct a simulation comparison between a set of t-tests and the prediction test.
95 pages
en
University of Kansas
Copyright held by the author.
openAccess
Statistics
Novel Statistical Methods for Missing Data and Multiplicity in Alzheimer’s Research
Dissertation
Biostatistics
Ph.D.
ORIGINAL
Montgomery_ku_0099D_16893_DATA_1.pdf
Montgomery_ku_0099D_16893_DATA_1.pdf
application/pdf
713655
https://kuscholarworks.ku.edu/bitstream/1808/30173/1/Montgomery_ku_0099D_16893_DATA_1.pdf
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Montgomery_ku_0099D_16893_DATA_1.pdf.txt
Montgomery_ku_0099D_16893_DATA_1.pdf.txt
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159268
https://kuscholarworks.ku.edu/bitstream/1808/30173/2/Montgomery_ku_0099D_16893_DATA_1.pdf.txt
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1808/30173
oai:kuscholarworks.ku.edu:1808/30173
2021-03-05 10:53:01.527
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/42382020-07-21T14:33:53Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Choi, Won
Cronk, Benjamin B.
Dubinsky, Richard
Johnson, David
Yeh, Henry
2008-09-29T05:16:49Z
2008-09-29T05:16:49Z
2008-08-08
2008
http://dissertations2.umi.com/ku:2614
http://hdl.handle.net/1808/4238
Abstract Objective: To examine body mass index (BMI) and cognitive decline in subjects diagnosed with mild cognitive impairment (MCI). Methods: Neuropsychological testing was conducted of 286 MCI subjects. General estimating equations (GEE) assessed the relationships of baseline BMI with one-year change in global cognition. Logistic GEE assessed the relationship of BMI with a clinically significant decline in assessments of global cognition and conversion to Alzheimer's disease (AD). Results: Baseline BMI was associated with a significant decline in cognitive performance in MCI. We observed that a low baseline BMI as associated with an increased risk of a clinically significant decline in global cognition. No association between baseline BMI and conversion to AD was observed. Conclusions: Lower BMI is associated with a more rapid decline in cognition in MCI. This relationship suggests changes in metabolism are present in MCI or body composition may influence the rate of cognitive decline in MCI.
21 pages
EN
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Epidemiology
BODY WEIGHT AND COGNITIVE DECLINE IN MCI
Thesis
Preventive Medicine and Public Health
M.S.
na
This item does not meet KU Open Access policy criteria.
6857331
THUMBNAIL
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umi-ku-2614_1.pdf.txt
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oai:kuscholarworks.ku.edu:1808/248162019-01-17T17:21:09Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Mahnken, Jonathan D.
Chen, Xueyi
Fisher, Mark T.
Mayo, Matthew S.
Diaz, Francisco J.
Wick, Jo A.
2017-08-13T21:37:17Z
2017-08-13T21:37:17Z
2016-12-31
2016
http://dissertations.umi.com/ku:14926
http://hdl.handle.net/1808/24816
Chromatography is widely used as a technology for separating mixtures of compounds by partitioning into the mobile and stationary phases. A mathematical model is essential not only for predicting the retention time and the peak shape of the chromatography analyte concentration distribution, but also for understanding the separation mechanism of chromatography and detecting whether the conditions were correct (e.g., whether there was an overload of the sample). A variety of statistical distribution functions such as exponential, Gaussian (normal), exponential modified Gaussian, Weibull, log-normal have been used to approximate the chromatography analyte concentration distributions, and were further applied to the deconvolution of stacked peaks. The dissertation consists of five chapters. The first chapter presents an overall introduction of the current prevailing mathematical models of chromatography analyte concentration distributions, the generalized chromatography theorem derived from chromatography table and its proof, the relation between on-chromatography analyte concentration distributions and out flow analyte concentration distributions, the asymptotic distribution of on-chromatography analyte concentration distributions and out flow analyte concentration distributions and their applications. The second chapter presents the mathematical model for the separation process of chromatography. In this chapter the first generalized theorem for modeling almost all types of chromatography was developed, and was found to match the mathematical formulas for well-known discrete distribution functions. These empirical formulas were rigorously proven by mathematical induction based on chromatography principle and chromatography process assumptions. The outflow chromatography analyte concentration distributions are demonstrated by simulation to be better approximated by the mathematical model that matches the negative binomial distribution function versus using a Gaussian distribution function, which currently is widely used for approximation. The third chapter establishes the mathematic bridge between on-chromatography and outflow analyte concentration distributions. In following with the previous chapter, which found the on chromatography and outflow analyte concentrations distributions to mathematically match the binomial and negative binomial distributions, respectively, this mathematical bridge can apply to relate these statistical distributions given they mathematical formulas are the same. This theorem is rigorously proved by mathematical induction. This relation is also demonstrated by 3D-plot of on-chromatography and outflow analyte concentration distributions for the first several stages. The fourth chapter proposed the transformation of data collected by chromatography (i.e., the analyte concentration distributions from chromatography experiments) into data that can be used for estimation to the approximate the underlying parameters that govern a particular chromatography process. Outflow chromatography analyte concentration distribution from original data were used to demonstrate this process and to compare the approach derived in this work using parameter estimated by method of moment (MOM) to the currently approach based on the Gaussian statistical distribution’s formula The fifth chapter is the summary of my dissertation work.
88 pages
en
University of Kansas
Copyright held by the author.
openAccess
Statistics
Chemistry
Mathematics
Mathematical Modeling of the Separation Process of Chromatography and Estimation of Parameters
Dissertation
Biostatistics
Ph.D.
ORIGINAL
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oai:kuscholarworks.ku.edu:1808/269292018-10-25T19:50:18Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Christianson, Julie A
Fuentes, Isabella
Geiger, Paige C
Griebling, Tomas L
McCarson, Kenneth E
Wright, Douglas E
2018-10-22T22:06:09Z
2018-10-22T22:06:09Z
2017-05-31
2017
http://dissertations.umi.com/ku:15251
http://hdl.handle.net/1808/26929
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is frequently co-diagnosed with other functional pain disorders, most significantly interstitial cystitis/painful bladder syndrome (IC/PBS), as well as mood disorders, particularly depression and/or anxiety. Patients suffering from functional pain disorders frequently report a history of early life stress, which has been associated with maladjusted stress response in adulthood. Basal function of the hypothalamic-pituitary-adrenal (HPA) axis, a major neuroendocrine stress response system, is programed during this critical period of development. Regular voluntary exercise has been shown to have a beneficial impact on depression and anxiety, as well as decreased perceptions of pain associated with HPA axis dysfunction in clinical and pre-clinical studies; however, to our knowledge, exercise has not been investigated as a potential intervention for comorbid urogenital pain disorders. This project reports neonatal maternal separation (NMS) induced mechanical perigenital allodynia, increased susceptibility to experimental colitis, altered micturition patterns, increased mast cell degranulation, and decreased HPA axis output. NMS did not, however, result in anxiety-like nor depression-like behaviors. Acute adult stress did significantly impact some of these measures, but did not enhance the effect of NMS. Lastly, we did see improvement of perigenital sensitivity following early and late exercise interventions, but did see more robust improvements in behavioral measurements after early exercise than late exercise. Late exercise, however, made a greater impact on central gene expression changes in limbic structures involved in HPA axis activity. Here, I have provided novel insight into the mechanisms potentially underlying significantly debilitating chronic pelvic pain disorders following early life stress, as well as evidence on the efficacy of therapeutic exercise, an easily translatable intervention, as a potential treatment strategy for these comorbid disorders. This work presents the first evidence of the impact of exercise on the effects of NMS on male mice, providing preclinical evidence for a treatment option for patients.
126 pages
en
University of Kansas
Copyright held by the author.
openAccess
Neurosciences
chronic pelvic pain
early life stress
hypothalamic-pituitary-adrenal axis
mast cells
neonatal maternal separation
voluntary exercise
Neonatal maternal separation in mice as a pre-clinical model for male chronic pelvic pain and voluntary exercise interventions
Dissertation
Anatomy & Cell Biology
Ph.D.
ORIGINAL
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oai:kuscholarworks.ku.edu:1808/157742019-07-17T05:18:03Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Fridley, Brooke L
Michaels, Whitney Lee
Kimler, Bruce F
Fabian, Carol J
2014-11-18T05:18:50Z
2014-11-18T05:18:50Z
2014-08-31
2014
http://dissertations.umi.com/ku:13506
http://hdl.handle.net/1808/15774
Introduction: Hormone replacement therapy (HRT) is an effective treatment option for women experiencing symptoms of menopause but long-term use is associated with an increased risk of breast cancer. HRT-related breast cancer risk is dependent on many other factors including age at menopause, age at initiation of therapy, duration of use, dose and method of delivery. Differences in genetic factors, specifically single nucleotide polymorphisms (SNP) may identify those women whose breast tissue is likely or unlikely to be seriously affected by HRT. Methods: Post-menopausal women at increased risk for breast cancer underwent breast tissue sampling by random periareolar fine needle aspiration (RPFNA) and epithelial cells were characterized as to whether they exhibited cytologic evidence of hyperplasia with atypia. DNA was isolated from buccal cells for assessment of candidate genes involved in steroid metabolism, receptor function, cell cycle control, DNA repair and/or carcinogen metabolism. Associations between each SNP and RPFNA atypia were examined by unconditional logistic regression in three different genetic models: a log-additive, dominant, and co-dominant. Linear regression was used to assess the association between each SNP and worsening cytomorphology while taking systemic HRT for ≥ 6 months vs. off systemic HRT. The adjusted significance level, pResults: RAD54 Gln929Glu, TFR Gly142Ser, VEGF 3'UTR and ACE16 I/D were associated with RPFNA atypia in all women at pTFR Gly142Ser reached borderline significance (p=0.0025). Interestingly, the cohort of women with RPFNA cytomorphology both while taking HRT and off HRT showed the most significant results. RAD23B Ala249Val was significantly associated with worsening cytomorphology while on HRT vs. off HRT (p=0.0009) and ERCC1 3'UTR was borderline (p=0.0015). SNPs associated with worse cytomorphology showed similar effects when we defined the outcome variable as evidence of atypia while on systemic HRT with no atypia while off systemic HRT. Conclusion: Promising associations exist between polymorphisms involved in DNA repair and worse RPFNA cytomorphology as a consequence of HRT use. However, given the probability of chance finding due to multiple testing, these results will need to be validated in an independent cohort.
36 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Epidemiology
Genetics
Oncology
Breast cancer
Hormone replacement therapy
Postmenopause
Random periareolar fine-needle aspiration
Singel nucleotide polymorphism
ASSOCIATIONS BETWEEN POLYMORPHISMS AND ABNORMAL RPFNA CYTOMORPHOLOGY IN HIGH-RISK POSTMENOPAUSAL WOMEN TAKING HRT
Thesis
Clinical Research
M.S.
THUMBNAIL
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oai:kuscholarworks.ku.edu:1808/301272021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Dunn, Winnie
Mische-Lawson, Lisa
Broski, Julie Ann
Dunn, Winnie
Mische-Lawson, Lisa
Dean, Evan
Lineberry, Matt
Williams, Kristine
2020-03-23T18:13:05Z
2020-03-23T18:13:05Z
2019-05-31
2019
http://dissertations.umi.com/ku:16438
http://hdl.handle.net/1808/30127
https://orcid.org/0000-0002-3753-9195
Individuals structure their lives around their expectations associated with phases of life (Becker, 1997). Starting a new job, starting a family and even dropping a child off for their first day of kindergarten are events that represent a change in an individual’s social role. Individuals expectations about these changes and the meanings that are assigned to these events help people make sense of their world. An unanticipated transition can occur when an individual’s life unfolds in surprising ways, such as when a child’s development is different from what the parent expects (Broski & Dunn, 2018; Messias, Gilliss, Sparacino, Tong, & Foote, 1995). Transition theories guide professional practice with families and children; and they inform how professionals describe events and stages in family life. Transition theories underpin how family research is conducted and in turn, may influence how families see themselves. For example, Kubler Ross’s “stages of grief” is often used to describe how parents experience becoming the parent of a child with developmental differences (Burrell, Ives, & Unwin, 2017; Frye, 2015). My dissertation study builds on the work of my three written comprehensive examinations. In my first comprehensive examination “Fostering Insights: A Strengths-Based Theory of Parental Transformation,” I proposed an alternative to transition theories that are deficit based. I used theory derivation, a method of theory development that uses a source theory from a different field, to “open” an area of research for new insights. I used Dr. Martha Baird’s “Theory of Cultural Transition in Refugee Women” as the source theory for the strengths-based theory of parental transformation. Theory derivation also includes reviewing relevant literature. Additionally, I conducted a content analysis of 5 autobiographies written by parents of a child with an autism spectrum disorder to provide examples of the theory’s concepts. The theory proposes that there are 3 stages associated with parental transition, an initial stage of parents’ awareness of their child’s differences, a liminal stage where parents are in between social roles, and a stage of transformation where parents adapt to their new social role. The theory also proposes there are three primary domains associated with parents’ transition. The child domain relates to the parents’ focus on the child’s differences and strengths. The connections with others domain relates to changes that occur in parents’ relationships with their family, friends, and others in the community. The parental competence domain relates to parents’ ability to discern what is best for themselves and for their family. This manuscript was the original submission and the basis for the article published in the Journal of Child and Family Studies (Broski & Dunn, 2018). My second comprehensive exam, “Evaluating the Strengths Based Theory of Parental Transformation” builds on the work of my first paper by exploring questions about the adequacy of the theory to describe parents’ experiences. An assumption of the theory is that parents transition involves “stages” of transition. While this concept is commonly accepted in transition theories, I wanted to evaluate this aspect of the theory, and challenge the notion that parents transition involves three stages. Thirty-two parents completed an online questionnaire consisting of 81 items derived from the strengths- based theory of parental transformation. The findings of this study indicate that parents associated the first stage of transition with becoming aware of their child’s differences, the liminal stage was associated with uncertainty, the transformation stage was associated with recognizing their child’s strengths and confidence in their parenting skills. My third comprehensive exam, “Exploring the Development of Parents’ Mental Models Related to Their Child’s Developmental Diagnosis” builds on the work of my first and second papers by exploring how parents experience transition. In this study, I conducted a discourse analysis of responses to six open-ended survey questions. Twenty-two parents were eligible for inclusion in this study. The results revealed that parents associate awareness of their child’s differences with searching for information and feelings of uncertainty and fearfulness. Parents associated the liminal stage of transition with frustration and confusion as the adapt to a new state. Parents associated the transformation stage with confidence, pride and adaptation. My comprehensive examinations provided the foundational work leading to my dissertation study. My previous research indicated that parents experience changes in their thoughts, feelings, and behaviors throughout transition (Broski & Dunn, 2018a, 2018b). I also found discernible differences in the social contexts parents referenced throughout transition, however it was not clear what facilitated transition and what process may stand in the way. My dissertation study focuses on characterizing incidents that parents describe as helping and hindering their transition related to their child’s developmental diagnosis. The findings of this study indicate that incidents that helped parents in the early stages of transition are associated with using and allocating resources. Incidents that helped parents in the later stages of transition are associated with seeing possibilities for their child and for themselves. Incidents that that hindered parents' transition involved parents discovering a need to set boundaries, as well as the parent feeling uncertain or obligated. Because parents influence outcomes for children, there is a need to provide an alternative to deficit-based frameworks to describe their transition. My dissertation research advances knowledge related to children and families by contributing to a growing body of research that provides an alternative to studies that suggest parents of children with developmental differences must grieve, be in denial or experience on-going sorrow. The strengths-based theory of parental transformation contributes to child and family research by providing a framework that aligns with contemporary paradigms of disability.
197 pages
en
University of Kansas
Copyright held by the author.
openAccess
Disability studies
Individual & family studies
Developmental diagnosis
Parents
Strength-Based
Critical Insights: Incidents that Help and Hinder Parents’ Transition Related to Their Child’s Developmental Diagnosis
Dissertation
Occupational Therapy Education
Ph.D.
ORIGINAL
Broski_ku_0099D_16438_DATA_1.pdf
Broski_ku_0099D_16438_DATA_1.pdf
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3695175
https://kuscholarworks.ku.edu/bitstream/1808/30127/1/Broski_ku_0099D_16438_DATA_1.pdf
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1808/30127
oai:kuscholarworks.ku.edu:1808/30127
2021-03-05 10:53:01.513
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/279642019-08-27T18:09:08Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Buller, Carol
Pattison, Sally
Williams, Kristine
2019-05-18T18:29:59Z
2019-05-18T18:29:59Z
2018-08-31
2018
http://dissertations.umi.com/ku:16115
http://hdl.handle.net/1808/27964
Abstract Problem: The unnecessary or inappropriate use of prescription antibiotics is a public health problem. An estimated 40% to 75% of antibiotics prescribed in U.S. nursing homes may be unwarranted, and moreover, the most commonly treated infection in nursing homes is a urinary tract infection (UTI). Up to one-third to one-half of prescriptions used to treat suspected UTIs in nursing home residents are actually aimed at asymptomatic bacteriuria (ASB). Consistent findings show the treatment of ASB is unnecessary and can be harmful, leading to increased rates of Clostridium difficile, multidrug resistant organisms, adverse drug events, hospital admissions, and higher health care costs. The Centers for Disease Control and Prevention (CDC) recommends that all nursing homes take steps to improve antibiotic prescribing practices through the utilization of antibiotic stewardship activities. The CDC defines antibiotic stewardship as a set of commitments and actions designed optimize the treatment of infections while reducing adverse events associated with antibiotic use. Project Aim: The purpose of this quality improvement project was to assess if the implementation of an antibiotic stewardship program in the nursing home setting decreases the rate of antibiotics prescribed for ASB in older adults. Project Method: A retrospective chart review of data was utilized to record baseline rates of antibiotics prescribed for UTIs and ASB. The chart review included the analysis of nursing notes, progress notes, provider visits, and nursing home infection logs to determine if an antibiotic was prescribed for a symptomatic UTI versus ASB. An antibiotic stewardship program consisting of an educational session about antibiotic stewardship and a decision-making tool was implemented and utilized by nurses and providers. Recommendations regarding antibiotic prescribing practices for suspected UTIs and a toolkit for suspected UTIs developed by the Agency for Healthcare Research and Quality served as core elements of the antibiotic stewardship program. The rate of antibiotics prescribed for UTIs and ASB was evaluated and compared to baseline data at two months. Project Results: Baseline data revealed that 64% of antibiotic prescriptions written for suspected UTIs were aimed at ASB. Exposure to the antibiotic stewardship program decreased the rate of antibiotic prescriptions written for ASB by 18%, as the rate of antibiotics written for ASB in the post intervention period was 46%. Conclusion: The antibiotic stewardship program and decision-making tool decreased the rate of antibiotics prescribed for ASB in older adults in the long-term care setting.
57 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Gerontology
antibiotic stewardship
asymptomatic bacteriuria
long-term care
Older adults
suspected urinary tract infection
IMPROVING THE MANAGEMENT OF ASYMPTOMATIC BACTERIURIA IN OLDER ADULTS IN LONG-TERM CARE
Dissertation
Nursing
D.N.P.
THUMBNAIL
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Pattison_ku_0099D_16115_DATA_1.pdf
Pattison_ku_0099D_16115_DATA_1.pdf
application/pdf
3495058
https://kuscholarworks.ku.edu/bitstream/1808/27964/1/Pattison_ku_0099D_16115_DATA_1.pdf
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1808/27964
oai:kuscholarworks.ku.edu:1808/27964
2019-08-27 13:09:08.718
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/278572019-08-27T18:09:08Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Buller, Carol
Wenner, Karen Ann
Foecke, Jan
2019-05-10T17:07:30Z
2019-05-10T17:07:30Z
2018-12-31
2018
http://dissertations.umi.com/ku:16238
http://hdl.handle.net/1808/27857
Abstract Extended hospitalizations for non-medical reasons are a contributing factor to the rising health care costs in the United States. Length of stay after elective orthopaedic surgery is highly variable and often prolonged unnecessarily due to lack of coordinated care. The project setting was a rural regional trauma center in a Midwestern state. Discharge assessment tools and early discharge planning have demonstrated promising results at optimizing organizational resources and reducing length of stay. The purpose of this pilot, quality improvement project was to implement a discharge risk assessment tool and discharge planning, prior to admission for patients undergoing elective, primary total knee arthroplasty and evaluate the impact on hospital length of stay in the orthopaedic surgery population. The project setting was a rural regional trauma center in a Midwestern state. The organization did not use a discharge assessment tool for orthopaedic surgical patients and had inconsistent, prolonged length of stay with multiple barriers to a hospital discharge. The project implemented the Blaylock Risk Assessment Screening Score (BRASS) prior to admission, at the pre-anesthesia testing visit. The BRASS has consistently demonstrated validity and reliability of predicting patient’s disposition at discharge. Patients who obtained a BRASS score greater than 20 were referred to the outpatient social worker for probable skilled nursing placement upon discharge. The collaborating outpatient social worker began discharge planning and coordination of discharge needs before and during hospital admission, guided by the BRASS results. Data was collected on a group of 10 patients and matched to 10 control patients through a retrospective chart review. The control group was selected after the intervention to allow case-control matching and minimize confounding variables. Controls were matched based on age, gender, and BRASS results. Data collection included: age, gender, ethnicity, co-morbidities, smoking status, attendance of pre-operative joint education class (within 30 days or longer), post-operative complications, discharge disposition, length of stay, and accuracy of BRASS prediction in the intervention group. Length of stay was compared, and resulted in over 80% of the intervention group being discharged by post-operative day two; reduced from 60% being discharged on post-operative day three in the control group. Further qualitative data provided insight to the patient population undergoing primary total knee arthroplasty in the organization. The project demonstrated a significant cost-savings strategy for the organization and enhanced patient care and coordination using a discharge assessment tool and proactive discharge planning. Keywords: discharge planning, length of stay, discharge assessment tool, Blaylock Risk Assessment Screening Score (BRASS)
49 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
EFFECTS OF DISCHARGE PLANNING ON LENGTH OF STAY IN PATIENTS UNDERGOING PRIMARY TOTAL KNEE ARTHROPLASTY
Dissertation
Nursing
D.N.P.
ORIGINAL
Wenner_ku_0099D_16238_DATA_1.pdf
Wenner_ku_0099D_16238_DATA_1.pdf
application/pdf
1815838
https://kuscholarworks.ku.edu/bitstream/1808/27857/1/Wenner_ku_0099D_16238_DATA_1.pdf
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oai:kuscholarworks.ku.edu:1808/27857
2019-08-27 13:09:08.647
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/239292018-01-31T20:07:47Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Bott, Margorie
Zhao, Yunchuan
He, Jianghua
Kim, Heejung
Park, Shin Hye
Dunton, Nancy
2017-05-07T16:45:20Z
2017-05-07T16:45:20Z
2016-05-31
2016
http://dissertations.umi.com/ku:14550
http://hdl.handle.net/1808/23929
Inpatient falls and injurious falls in acute care settings have significant impact on patients. Despite the implementation of several federal initiatives in preventing falls and injurious falls, inpatient falls and injurious falls still are prevalent in the United States. Inpatient falls and injurious falls are a complicated phenomenon and can be contributed to multilevel factors including organization at the hospital and unit levels, nursing care process, and patient-specific factors. However, gaps exist in the literature on the associations of injurious falls with multilevel factors. The purpose of this study was to examine the associations of injurious falls in acute care hospitals with multilevel factors including hospital and unit structure, nursing care process, and patient-specific factors. The modified Donabedian Structure–Process–Outcome (SPO) model was used as a conceptual framework to guide the study. This cross-sectional, correlational study used July 2013 to June 2014 data from the National Database of Nursing Quality Indicators® (NDNQI®). The STATA (Version 14) was used to conduct hierarchical regression analyses to examine the significance of association of injurious falls with multilevel factors including organizational structure (i.e., hospital size, teaching status, and Magnet® status), unit structure (i.e., nurse staffing and unit type), nursing care process (i.e., falls without employee assistance, fall risk assessment, implementation of fall prevention protocol, and physical restrain use) and unit patient population factors for patients who fell (i.e., gender, and fall risk status). The results of the study suggested hospital structure (i.e. teaching status), unit structure (i.e. surgical unit and RN hours per patient day), unit nursing care process (i.e. falls without employee assistance), unit patient population characteristics (i.e. at fall risk) and 1000 patient days were significantly associated with incidence of injurious falls. The findings from this study provide further knowledge on multilevel factors contributing to inpatient injurious falls. Nurse leaders, researchers and policy makers may develop, implement and improve fall prevention programs based on the identified risk factors. The study also provides important implications for future research on injurious fall prevention in acute care hospitals.
149 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Health care management
acute care hospitals
injurious falls
nurse staffing
nursing care process
organizational structure
patient safety
Factors Associated with Inpatient Falls and Injurious Falls in Acute Care Hospitals
Dissertation
Nursing
Ph.D.
ORIGINAL
Zhao_ku_0099D_14550_DATA_1.pdf
Zhao_ku_0099D_14550_DATA_1.pdf
application/pdf
1214418
https://kuscholarworks.ku.edu/bitstream/1808/23929/1/Zhao_ku_0099D_14550_DATA_1.pdf
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Zhao_ku_0099D_14550_DATA_1.pdf.txt
Zhao_ku_0099D_14550_DATA_1.pdf.txt
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253365
https://kuscholarworks.ku.edu/bitstream/1808/23929/2/Zhao_ku_0099D_14550_DATA_1.pdf.txt
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1808/23929
oai:kuscholarworks.ku.edu:1808/23929
2018-01-31 14:07:47.147
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/41052020-06-22T21:20:58Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Boyd, Lara A
Smirnova, Irina V
Vidoni, Eric Dennis
Liu, Wen
McKiernan, Brian
Nudo, Randolph J
Radel, Jeff
2008-09-07T19:37:27Z
2008-09-07T19:37:27Z
2008-01-24
2008
http://dissertations.umi.com/ku:2366
http://hdl.handle.net/1808/4105
It has long been a goal of the human movement research community to develop a more complete understanding of how individuals learn complex patterns of movement. This knowledge is useful to both those engaged in precision activities such as the hitting a baseball as well as those determined to improve motor function following neurologic injury such as a stroke. The following dissertation explores one component of the motor learning process: the role of sensation, specifically proprioception, in motor learning. Two questions were addressed. First, does peripheral disruption of proprioceptive sensation impair sequence-specific learning? Second, what is the relationship between sequence-specific learning and stroke related proprioceptive deficit? Because little is known about the role of proprioception in learning movement patterns the first aim of this study, presented in Chapter 2, sought to characterize skill acquisition in healthy adults when proprioceptive sensation was disrupted. Twelve participants (DIS) were randomly assigned to receive vibration to the upper arm while performing a continuous tracking task. Twelve additional subjects (CTL) served as a comparison group and received vibration to the arm that was not being used to track. Despite initially less accurate performance by the DIS group, both groups learned to track a repeated sequence of movements, indicating that accurate peripheral report of limb state may not be crucial for motor learning. Rather the motor learning system appears to be robust and capable of utilizing other sources of information for error correction and motor plan development. Vision is one likely source of information used by the central nervous system (CNS), concomitant with or in place of proprioception. Previous work has consistently demonstrated a close link between visual and manual motor performance. Further, the visual system is capable of learning stimulus regularities. However, visual and manual learning during continuous sequence tracking has not been investigated previously. To address this gap in the literature, 9 healthy young adults performed a continuous tracking task similar to that described in Chapter 2. Eye movements were recorded during manual tracking. It was found that though performance improved for both visual and manual tracking over practice, eye and motor accuracy were relatively independent. Tracking performance of either effector (i.e., arm versus eye) on individual trials was not predictive of performance on the other effector. Thus, reflecting somewhat the findings on proprioception in Chapter 2, it was concluded that though vision may be an important component of sensory information, a high degree of visual tracking accuracy is not critical for continuous motor sequence learning. In Chapter 4, the focus shifted to proprioceptive disruption following central neurological insult. Ten survivors of stroke and 9 age-matched, neurologically intact control participants engaged in a continuous tracking task similar to that presented in Chapter 2. However, no exogenous sensory disruption was applied during training. Instead, sensory disruption was an endogenous consequence of stroke. The level of central proprioceptive disruption was indexed using a limb-position matching task. The healthy participant group was able to learn sequence-specific components of the task. As a group, stroke survivors also demonstrated continuous sequence learning. However, proprioceptive accuracy was strongly correlated with sequence-specific versus general task improvement in continuous tracking within this group. These data support the animal literature that suggests central somatosensory integrity is critical for novel skill learning. Finally, the cerebellum is often identified as a substrate of motor learning. Furthermore, the cerebellum has extensive access to ascending afferent somatosensory information. To examine the use of proprioceptive information by the cerebellum, 7 individuals with cerebellar damage were recruited to perform the same continuous tracking task. Contrary to previous reports, some individuals in this study learned to perform a sequence of movements with their more involved hand. However, two exhibited no such learning. These individuals had large lesions encompassing the lateral cerebellar cortex. They also demonstrated proprioceptive deficit and motor ataxia. These results suggest that learning of movement sequences may be in part related to somatosensory discrimination and error-feedback learning performed in the cerebellar cortex. In summary, the results suggest that though body state information may be important for learning, central and peripheral disruption of proprioceptive information are not analogous in terms of the impact on continuous motor sequence learning. Rather, in addition to proprioception, other sources of afferent information may be used to learn a new skill. In some situations these sources of information, including vision and planning, can operate and encode movement sequence components independent of each other, resulting in skill learning. However, integrity of central information processing systems appears to be an important component of continuous sequence learning. Rehabilitation professionals should consider the state of a client's proprioceptive system when developing a plan of care.
189 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Rehabilitation and therapy
Biology
Neurosciences
Human
Motor learning
Proprioception
Stroke
Tracking
Sensorimotor
PROPRIOCEPTION IS "CENTRAL" TO MOTOR SEQUENCE LEARNING: DIFFERENT CONSEQUENCES OF PERIPHERAL AND CENTRAL PROPRIOCEPTIVE DISRUPTION TO SEQUENCE LEARNING
Dissertation
Physical Therapy & Rehabilitation Sciences
PH.D.
na
This item does not meet KU Open Access policy criteria.
6599431
TEXT
umi-ku-2366_1.pdf.txt
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umi-ku-2366_1.pdf
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KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/225412019-07-17T05:15:56Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Shireman, Theresa I
Britt, Nicholas
El Atrouni, Wissam
Steed, Molly E
2017-01-08T19:37:09Z
2017-01-08T19:37:09Z
2014-05-31
2014
http://dissertations.umi.com/ku:13398
http://hdl.handle.net/1808/22541
Background: Treatment failure is increasingly common in Staphylococcus aureus bacteremia (SAB). Vancomycin tolerance may be playing a role in clinical outcomes in SAB that has yet to be fully explored. Methods: This was a single-center retrospective cohort study of 166 patients (September 2012 - January 2014) evaluating the relationship between vancomycin tolerance and clinical failure in SAB. Vancomycin minimum inhibitory concentration (MIC) was determined by broth microdilution and Etest. Vancomycin tolerance was defined as a vancomycin minimum bactericidal concentration (MBC)/MIC greater than or equal to 32. Univariable and multivariable analyses were conducted to determine the relationship between vancomycin tolerance and clinical failure after adjusting for other factors. Results: Of the 166 patients evaluated, 26.5% had vancomycin tolerant clinical isolates. Tolerance to vancomycin was more common in methicillin-susceptible S. aureus bacteremia (MSSA-B) than methicillin-resistant S. aureus bacteremia (MRSA-B; n=29/101 [28.7%] vs. n=15/65 [23.1%]), although not significantly (P=0.422). Clinical failure was frequently observed (50% overall). Elevated vancomycin MIC by Etest (greater than or equal to 1.5 mcg/mL) was not associated with clinical failure (P=0.50). Vancomycin tolerance was significantly associated with SAB clinical failure in univariable analysis (P=0.014). This relationship persisted even when adjusting for other factors in multivariable analysis (adjusted odds ratio [AOR], 2.70; 95% confidence interval [CI], 1.27-5.70; P=0.010). Conclusions: Vancomycin tolerance is a clinically significant predictor of clinical failure in SAB independent of methicillin susceptibility and antibiotic choice. Future research is needed to determine optimal treatment of vancomycin tolerant SAB.
23 pages
en_US
University of Kansas
Copyright held by the author.
openAccess
Microbiology
Medicine
antibiotic resistance
antibiotic tolerance
Staphylococcus aureus
vancomycin
The relationship between vancomycin tolerance and clinical outcomes in patients with Staphylococcus aureus bacteremia
Thesis
Clinical Research
M.S.
ORIGINAL
Britt_ku_0099M_13398_DATA_1.pdf
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2019-07-17 00:15:56.427
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oai:kuscholarworks.ku.edu:1808/248152019-01-17T17:00:24Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Stehno-bittel, Lisa A
Smirnova, Irina V
Rawal, Sonia
Aljitawi, Omar
Liu, Wen
Zhu, Hao
2017-08-13T21:33:42Z
2017-08-13T21:33:42Z
2016-12-31
2016
http://dissertations.umi.com/ku:14970
http://hdl.handle.net/1808/24815
Islets are clusters of cells in the pancreas that monitor and regulate blood glucose levels. In culture, single islet cells reaggregate into clusters, but the reaggregation process is random, resulting in large variation in the cluster numbers, sizes and cell composition. Our laboratory created a micromold, a specialized cell culture plate, to efficiently bioengineer small, uniformly-sized islet clusters that we called Kanslets. Currently, very little is known about the implications of islet cell clusters for the treatment of diabetes. The purpose of this dissertation was to optimize the experimental conditions necessary for islet storage (cryopreservation), drug discovery screening procedures, and islet health in culture utilizing Kanslets. The conventional methods of cryopreservation of islets use intact native islets, and the viability and function achieved after thawing with these methods is poor. In this dissertation work, we cryopreserved islets as single cells and, after thawing, reaggregated islet cells to form cryopreserved Kanslets using the micromold technology. We observed that the viability of cryopreserved Kanslets was superior to cryopreserved intact islets and cryopreserved Kanslets had the potential to lower blood glucose levels of diabetic rats for 10 months. Next, the effect of creating hybrid islets/spheroids using mixtures of cells was tested by combining cells from different human donors, or by combining mesenchymal stem cells (MSCs) and islet cells. In order to minimize the need for assay repetition during the drug screening procedures, multi-donor Kanslets, consisting of islet cells from different donors, were created. We observed that the multi-donor Kanslets were highly viable, but showed little response to drugs such as glibenclamide (insulin stimulator) and somatostatin (insulin inhibitor). To improve islet health in culture, islet cells were integrated with bone marrow MSCs and reaggregated into spheroids; these spheroids were highly viable even long-term in culture, but secreted less insulin irrespective of the proportion of MSCs and islet cells in the spheroids, when compared to the spheroids containing only islet cells. Overall, these findings greatly enhance the utilization of islets for islet transplantation, and also provide valuable insight for future work in reaggregating islet cells with MSCs. The work provides a platform for future researchers to further explore the implications of islet cell reaggregation for diabetes research or therapy.
150 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health sciences
Beta cells
Co-culture
Cyopreservation
Diabetes
Insulin secretion
Pancreatic islets
REAGGREGATION OF PANCREATIC ISLET CELLS: IMPLICATIONS FOR ISLET HEALTH, STORAGE AND NEW DRUG DISCOVERY
Dissertation
Physical Therapy & Rehabilitation Sciences
Ph.D.
ORIGINAL
Rawal_ku_0099D_14970_DATA_1.pdf
Rawal_ku_0099D_14970_DATA_1.pdf
Available after: 2018-12-31
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lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/104792020-09-21T14:48:47Zcom_1808_197com_1808_1260col_1808_18171col_1808_7158
Gruber, Charles M.
2012-12-03T21:13:07Z
2012-12-03T21:13:07Z
1912-06
http://hdl.handle.net/1808/10479
en
The University of Kansas
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
A Comparison of Cranial and Artificially Aroused Impulses Under the Influence of Nerve Blocks
Thesis
Physiology
na
This item does not meet KU Open Access policy criteria.
3424183
ORIGINAL
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open access
1808/10479
oai:kuscholarworks.ku.edu:1808/10479
2020-09-21 09:48:47.34
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/295342021-10-28T19:34:34Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Peltzer, Jill
Gray, Jason Gordon
Peterson, JoAnn
2019-09-04T22:23:51Z
2019-09-04T22:23:51Z
2019-05-31
2019
http://dissertations.umi.com/ku:16366
http://hdl.handle.net/1808/29534
https://orcid.org/0000-0003-1893-8921
Objective This paper briefly reviews the literature about increased smoking among lesbian, gay, bisexual, transgender, and queer (LGBTQ) adolescents and evaluates both the deployment of a primary smoking prevention intervention and the surveying methodology used to query LGBTQ adolescents. Methods The authors designed an educational intervention with three components, including education about the long-term effects of smoking and how the tobacco industry has targeted the LGBTQ community; a guided discussion about select images and messages that normalize smoking among the LGBTQ community; and a group activity to storyboard, or draw and write, primary smoking prevention messages designed for distribution on social media platforms. Items evaluated in pre- and post-questionnaires included basic demographics, sexual orientation and gender identity, smoking and tobacco-related behaviors, curiosity about smoking, and goal-directed behavior (or hope). Results Participants (n = 9) in this pilot project demonstrated increased smoking and tobacco-related behaviors than previously reported in the literature. Statistically significant changes in pre- and post-questionnaire items emerged for goal-directed behavior. Low non-response to questionnaire items used in this project was evident. Conclusion A lack of primary smoking prevention interventions among LGBTQ adolescents make this project worthy of further examination, though the authors recommend that deployment of this intervention would be best accomplished in collaboration with a formal support group structure such as Gay-Straight Alliances.
65 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Health education
LGBTQ studies
Health Education
LGBTQ Adolescent
Primary Prevention
Sexual and Gender Minority
Smoking
Social Media
LGBTQ Adolescent Smoking: A Social Media Approach to Primary Prevention
Dissertation
Nursing
D.N.P.
TEXT
Gray_ku_0099D_16366_DATA_1.pdf.txt
Gray_ku_0099D_16366_DATA_1.pdf.txt
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text/plain
102154
https://kuscholarworks.ku.edu/bitstream/1808/29534/2/Gray_ku_0099D_16366_DATA_1.pdf.txt
7366c65d2bdc0bbce0b64c9f8a1ededd
MD5
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Gray_ku_0099D_16366_DATA_1.pdf
Gray_ku_0099D_16366_DATA_1.pdf
Available after: 2021-05-31
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https://kuscholarworks.ku.edu/bitstream/1808/29534/1/Gray_ku_0099D_16366_DATA_1.pdf
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1808/29534
oai:kuscholarworks.ku.edu:1808/29534
2021-10-28 14:34:34.709
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/301122021-03-05T16:53:01Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Radel, Jeff
Burghart, Mark A
Dean, Evan
Pierce, Janet D
Waitman, Russ
Lauer, Stephen J
2020-03-23T17:29:13Z
2020-03-23T17:29:13Z
2018-12-31
2018
http://dissertations.umi.com/ku:16276
http://hdl.handle.net/1808/30112
Concussions have become a prominent injury treated across medical care settings. Due to a complicated underlying pathophysiological process, concussions are subtle and produce a wide array of signs, including cognitive, somatic, and sensorimotor symptoms. The diverse symptomatology makes clinical assessment and management of concussions challenging for clinicians. Additionally, this complexity makes determining recovery trajectory after injury difficult for practitioners. Identifying individuals at risk for long durations of treatment early in their care would allow for early restorative interventions, reduced cost of care, and improved patient quality of life. This need lead to a series of studies attempting to add evidence to support the clinical assessment process of individuals following both suspected and diagnosed concussions. Our first study evaluated the rates and reasons for under-reporting of concussions and symptoms in female high school athletes, a neglected population of study in concussion research. We found female athletes often failed to report concussion symptoms to coaches and trainers. Additionally, only 2/3rds of athletes reported receiving concussion education that may explain the lack of reporting. Different clinical assessment techniques were also explored. Balance and reaction time assessment are commonly completed to help identify individuals with suspected concussion, but these assessments are subjective and often require equipment not available outside of clinical settings. We evaluated the validity and reliability of a mobile device application to assess balance and reaction time as part of a concussion screening. We found SwayTM to be comparable to force platform balance assessments and computerized reaction time measurement in healthy subjects, indicating these assessments have clinical utility. Additionally, the assessment only required a mobile device, allowing for assessment in clinics and sports settings without computers or force platform equipment. The last assessment method we evaluated involved neuroimaging techniques. Diffusion tensor imaging (DTI) has been used in the assessment of individuals with moderate to severe brain injury to objectively track recovery of function after trauma. We explored the similar use of DTI to objectively track recovery of function after concussion. We assessed 10 female participants experiencing slowed recovery of function after a concussion. We found no significant associations between DTI metrics for white matter pathway integrity and changes in symptoms over time, indicating that symptom improvement may occur in a non-congruent fashion with underlying neurological functioning. We did find improvements in pathway integrity were associated with improved reaction time and visual processing, adding to the clinical importance of assessing these skills. A lack of understanding as to which objective clinical features leads to increased risk of prolonged care adds to the complexity of determining a person’s recovery trajectory following concussion. This gap in evidence lead to an exploratory study evaluating differences in clinical presentation patterns between groups of individuals with typical treatment durations (≤ 28 days) and extended lengths of care ( 28 days). The exploratory factor analysis yielded different factor structures for each group. Notable differences included age, sex, history of psychiatric disorders, and neurocognitive abilities at the evaluation. These findings suggest clinical differences between individuals with longer and shorter lengths of care are observable at evaluation. After detecting differences between these groups, we sought to clarify the impact of each variable on length of care. A survival analysis was completed, evaluating the effects of clinical, demographic, and social factors on estimating length of care after concussion. We found males had shorter durations of care, while individuals with a history of concussion and better access to housing and transportation had longer durations of care. This study added evidence to support sex and concussion history as influential of longer durations of care. Additionally, while significant, housing and transportation access is likely not a protective feature for concussion recovery, but likely reflects the ability to attend follow-up treatments for concussion care. A final study was conducted to assess the predictive ability for each variable identified in the previous studies, with the primary outcome focused on determining which features best predict whether someone will have a typical duration of care (≤ 28 days) or an extended duration of care ( 28 days). A multivariable, logistic regression model was used to evaluate the significance of each variable. History of previous concussion and slowed reaction times at the evaluation had significant effects. Additionally, individuals from lower socioeconomic areas had lower odds of an extended length of care, although these findings should reflect ability to pursue care, rather than a reduction of recovery time. In summary, these studies add to the foundational knowledge of concussion assessment for diagnostic and recovery purposes. Additionally, these studies contribute to our understanding of factors that contribute to prolonged lengths of care for individuals after concussion. Clinicians should continue to complete thorough evaluation of individuals with suspected concussion, documenting concussion histories, sex, age, reaction times, and external social factors that may prevent or impede necessary follow-up care.
251 pages
en
University of Kansas
Copyright held by the author.
openAccess
Health sciences
Neurosciences
Assessment
Clinical Management
Concussion
Head Trauma
Mild Traumatic Brain Injury
Recovery
Predicting Length of Care Following Concussion
Dissertation
Occupational Therapy Education
Ph.D.
TEXT
Burghart_ku_0099D_16276_DATA_1.pdf.txt
Burghart_ku_0099D_16276_DATA_1.pdf.txt
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377572
https://kuscholarworks.ku.edu/bitstream/1808/30112/2/Burghart_ku_0099D_16276_DATA_1.pdf.txt
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MD5
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Burghart_ku_0099D_16276_DATA_1.pdf
Burghart_ku_0099D_16276_DATA_1.pdf
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1808/30112
oai:kuscholarworks.ku.edu:1808/30112
2021-03-05 10:53:01.477
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/261732018-04-19T20:39:25Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Ebbert, Diane
Robinson, Jane
Peterson, Moya
Graham, Libby
2018-03-09T23:28:40Z
2018-03-09T23:28:40Z
2017-12-31
2017
http://dissertations.umi.com/ku:15614
http://hdl.handle.net/1808/26173
Abstract People with serious mental illness (SMI), as a population, are typically underserved and likely to have barriers to accessing primary care services. When these patients do seek primary care, it is often fragmented and communication between multiple providers lacks efficiency and coordination. A co-located primary care clinic was recently established in a large behavioral health setting to improve access to primary care for this population. Prior to opening the clinic, of 499 client survey respondents, 82 indicated they needed help managing their diabetes. Multiple providers with varied backgrounds are providing care in the new clinic setting where potential gaps in the delivery of diabetes related care are likely. The purpose of this project is to evaluate the care provided to patients with type 2 diabetes mellitus in the primary care clinic by multiple providers compared to the standard of medical care for diabetes management according to the American Diabetes Association (ADA) 2015 guidelines. A retrospective chart review using a standards checklist based on the ADA guidelines was implemented to evaluate care provided by a number of different providers. Identified gaps in care, potential improvements in documentation and use of the checklist as a tool for improving delivery of care to meet standards were shared with providers in a post-study discussion.
34 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
behavioral health
diabetes mellitus
integrated care
primary care
quality improvement
Improving Diabetes Care Delivery in an Integrated Health Clinic
Dissertation
Nursing
D.N.P.
ORIGINAL
Robinson_ku_0099D_15614_DATA_1.pdf
Robinson_ku_0099D_15614_DATA_1.pdf
application/pdf
395874
https://kuscholarworks.ku.edu/bitstream/1808/26173/1/Robinson_ku_0099D_15614_DATA_1.pdf
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MD5
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TEXT
Robinson_ku_0099D_15614_DATA_1.pdf.txt
Robinson_ku_0099D_15614_DATA_1.pdf.txt
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56633
https://kuscholarworks.ku.edu/bitstream/1808/26173/2/Robinson_ku_0099D_15614_DATA_1.pdf.txt
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MD5
2
open access
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26173.pdf
26173.pdf
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1808/26173
oai:kuscholarworks.ku.edu:1808/26173
2018-04-19 15:39:25.614
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/301372021-03-05T19:10:11Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Pierce, Janet
Rincon, Teresa A
Pierce, Janet
Manos, E. LaVerne
Bosak, Kelly A
Shen, Qiuhua
Koestler, Devin C
2020-03-23T20:10:47Z
2020-03-23T20:10:47Z
2018-08-31
2018
http://dissertations.umi.com/ku:16129
http://hdl.handle.net/1808/30137
https://orcid.org/0000-0003-2655-2543
Sepsis is an elusive and costly syndrome that is one of the leading causes of death globally. Annually, there are approximately 19 million cases of sepsis that result in more than 5 million deaths. The Agency for Healthcare Research and Quality (AHRQ) ranked sepsis as the most expensive condition ($23.7 billion) for patients treated in hospitals in the United States (U.S.). Nurses are critical in the early identification of sepsis and implementation of therapeutic interventions known as the “sepsis bundle”. Previously, sepsis was described as a systemic, pro-inflammatory response to an infection. Sepsis was defined as two or more systemic inflammatory response syndrome (SIRS) criteria with a suspected infection, severe sepsis was defined as sepsis with organ failure and septic shock was defined as severe sepsis with shock. For several decades SIRS criteria with organ failure criteria have been used to develop measurement systems for detection of sepsis. A recent study comparing SIRS criteria to the sepsis-related organ failure assessment (SOFA) score demonstrated that SOFA had greater prognostic accuracy of mortality in patients with an infection than SIRS. This led to sepsis definition changes in 2016. The term “severe sepsis” was dropped and sepsis was defined as a life-threatening organ dysfunction caused by a dysregulated host response to an infection leading to tissue injury and organ failure. Many clinicians were concerned that this new definition might lead to late detection of sepsis. What was unknown was how well SIRS with organ failure criteria compared with SOFA in detection of sepsis. Many clinicians in the U.S. working in a TeleICU had been using SIRS with organ failure criteria to support early identification of sepsis. Using human factors science concepts, their practice was studied and an electronic sepsis alert (sepsis prompt) was developed. Thus, the overall objective of this dissertation was to conduct a retrospective study using a large U.S. data repository to determine if an electronic prompt, that uses SIRS and organ failure (OF) criteria, can detect sepsis. Another objective of this study was to determine the prognostic accuracy of the SOFA score and the sepsis prompt in discriminating in-hospital mortality among patients with sepsis in the intensive care unit. Among 2,020,489 patients admitted to ICUs associated with a TeleICU from January 1, 2010, to December 31, 2015, at 459 hospitals throughout the U.S., we identified 912,509 (45%) eligible patients at 183 hospitals. We compared the performance of the SOFA score and sepsis prompt criteria in detecting sepsis. Of those in the primary cohort, a secondary cohort was derived based on presence of sepsis resulting 186,870 (20.5%) patients. To assess performances of the SOFA score and the sepsis prompt (a Fuzzy Logic SIRS and OF algorithm) to detect sepsis, we calculated diagnostic performance of an increase in the SOFA score of 2 or more and criteria met for the Fuzzy Logic SIRS and OF algorithm. For predictive validity, training of baseline risk models was performed on training sets with prediction and performance analytics completed on test sets for each cohort for the outcomes of mortality and sepsis. Results were expressed as the fold change in outcome over deciles of baseline risk of death or risk of sepsis, area under the receiver operating characteristic curve (AUROC), and sensitivity, specificity, and negative and positive predictive values. In the primary cohort (912,509) there were 86,219 (9.4%) who did not survive their hospital stay and 186,870 (20.5%) with suspected sepsis of whom 34,617 (18.5%) did not survive hospitalization. The Fuzzy Logic SIRS/OF (crude AUROC 0.67, 99% CI: 0.66-0.67 and adjusted AUROC 0.77, 99% CI: 0.77-0.77) outperformed SOFA (crude AUROC 0.61, 99% CI: 0.61-0.61 and adjusted AUROC 0.74, 99% CI: 0.74-0.74) in discrimination of sepsis in both crude and adjusted AUROC (in-between differences AUROC 0.06; z-value 49.06 and AUROC 0.03; z-value 36.22, respectively). In the primary cohort, Fuzzy Logic SIRS/OF (crude AUROC 0.67, 99% CI: 0.67-0.68 and adjusted AUROC 0.78, 99% CI: 0.77-0.78) outperformed SOFA (crude AUROC 0.64, 99% CI: 0.64-0.64 and adjusted AUROC 0.76, 99% CI: 0.76-0.76) in prognostic accuracy of mortality in both crude and adjusted AUROC (in-between differences AUROC 0.03; z-value 24.68 and AUROC 0.02; z-value 14.74, respectively). In the secondary cohort, Fuzzy Logic SIRS/OF (crude AUROC 0.57, 99% CI: 0.57-0.58 and adjusted AUROC 0.69, 99% CI: 0.68-0.70) outperformed SOFA (crude AUROC 0.56, 99% CI: 0.56-0.56 and adjusted AUROC 0.68, 99% CI: 0.67-0.68) in prognostic accuracy of mortality in both crude and adjusted AUROC (in-between differences AUROC 0.01; z-value 6.86 and AUROC 0.01; z-value 7.53, respectively). The results of this study demonstrated that among adult ICU patients, the predictive validity for sepsis and in-hospital mortality of a complex algorithm based on Fuzzy Logic applied to expanded SIRS criteria with organ failure criteria was better than SOFA for detection of sepsis and for prognostic accuracy of mortality. The findings of this study support the use of a computer-enhanced algorithm that includes a combination of expanded SIRS with organ failure criteria as a tool to assist nurses and healthcare providers in early identification of sepsis.
180 pages
en
University of Kansas
Copyright held by the author.
openAccess
Nursing
Detection
Human Factors
Sepsis
SIRS
SOFA
Usability
Detecting Sepsis Using Sepsis-Related Organ Failure Assessment (SOFA) and an Electronic Sepsis Prompt in Intensive Care Unit Adult Patients
Dissertation
Nursing
Ph.D.
ORIGINAL
Rincon_ku_0099D_16129_DATA_1.pdf
Rincon_ku_0099D_16129_DATA_1.pdf
Available after: 2020-08-31
application/pdf
3036019
https://kuscholarworks.ku.edu/bitstream/1808/30137/1/Rincon_ku_0099D_16129_DATA_1.pdf
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Rincon_ku_0099D_16129_DATA_1.pdf.txt
Rincon_ku_0099D_16129_DATA_1.pdf.txt
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309427
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1808/30137
oai:kuscholarworks.ku.edu:1808/30137
2021-03-05 13:10:11.948
open access
KU ScholarWorks
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oai:kuscholarworks.ku.edu:1808/42372020-07-21T14:40:01Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
Ellerbeck, Edward F.
Griebling, Tomas L.
Lai, Sue Min
Reker, Dean M.
2008-09-29T05:15:13Z
2008-09-29T05:15:13Z
2008-07-29
2008
http://dissertations2.umi.com/ku:2659
http://hdl.handle.net/1808/4237
Urinary incontinence (UI) and fecal incontinence (FI) commonly occur after stroke. The causes are multifactorial. Both conditions can negatively impact recovery, care needs, and health-related quality of life. This study examined if clinical characteristics assessed within two weeks after stroke (baseline) predicted continence at 6 months. The Kansas City Stroke Study, a prospective cohort of 459 subjects examined longitudinally for 6 months using validated functional assessment tools, was used for this analysis. Baseline predictor variables were compared to final continence outcomes assessed with the Barthel Index. Of the 321 eligible subjects who were continent of bladder and bowel pre-stroke, 64 had UI, 48 had FI, and 28 had both at 6 months. Multiple logistic regression models showed age and UI at baseline to be independent predictors for UI. Age, stroke severity, visual impairment, and lack of independence for dressing at baseline were independent predictors for FI at 6 months.
83 pages
EN
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Health sciences
Public health
Epidemiology
Urinary incontinence
Fecal incontinence
Stroke
Bladder
Bowel
Predictors of Urinary and Fecal Continence Status After Stroke
Thesis
Preventive Medicine and Public Health
M.Ph.
na
This item does not meet KU Open Access policy criteria.
6857333
TEXT
umi-ku-2659_1.pdf.txt
umi-ku-2659_1.pdf.txt
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110010
https://kuscholarworks.ku.edu/bitstream/1808/4237/2/umi-ku-2659_1.pdf.txt
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MD5
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1808/4237
oai:kuscholarworks.ku.edu:1808/4237
2020-07-21 09:40:01.245
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
oai:kuscholarworks.ku.edu:1808/114482020-06-23T01:04:37Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Rongish, Brenda J
Aleksandrova, Anastasiia
Czirok, Andras
Fontes, Joseph D
Gibson, Matthew C
Kulesa, Paul M
Wright, Douglas E
2013-07-14T15:06:32Z
2013-07-14T15:06:32Z
2012-12-31
2012
http://dissertations.umi.com/ku:12549
http://hdl.handle.net/1808/11448
Vertebrate cardiogenesis involves heart progenitor cell movements from their initial lateral positions to the embryonic midline, where they assemble into a primitive heart. This early heart tube consists of an outer myocardium, a medial extracellular matrix (ECM), and an endocardial lining. Cardiac morphogenesis in avians and mammals is inseparable from development of the foregut, which provides molecular cues to regulate endocardial and myocardial differentiation from mesodermal progenitors. Concomitantly with the initiation of midline-directed cardiac progenitor movements, foregut endoderm undergoes dramatic folding and elongation. Following their initial assembly, the heart and foregut are transiently connected through a mesentery. Previous research focused on the molecular factors involved in guiding cardiac progenitors to the midline, yet cellular and tissue mechanisms coordinating these movements remain poorly understood. This work investigates movements of all three early heart constituents - the endocardial and myocardial progenitors, and surrounding ECM - in live quail embryos using a combination of time-lapse microscopy, chemical and mechanical perturbations, computational analysis and modeling. By visualizing the tissue environment for cell displacements, we distinguish the active (tissue-independent) movements from those cells undergo in a manner coordinated with the surrounding tissues. First, we analyzed the movements of endocardial progenitors and fluorescently-labeled ECM (fibronectin, fibrillin-2) fibrils. We found the bulk of midline-directed movement of pre-endocardial cells is coordinated with their surrounding ECM. Further, that ECM from extracardiac sources is transferred to and incorporated into the growing heart. By assessing the contributions of active cell motility to the observed midline endocardial displacements we found its role to be secondary to that of convective tissue movement within the anterior embryo. Second, we assessed myocardial progenitor movements relative to fibronectin ECM and endoderm. We discovered that observed antero-medial myocardial displacements are driven by a combination of: 1) medial tissue motion, and 2) anterior movement, accomplished via a coordinated deformation of myocardial progenitors, organized into a continuous epithelial sheet. Finally, we investigated the effects of VEGF overexposure on progenitor movements during early cardiogenesis. We found a dramatic VEGF-induced increase in cardiac inflow region size, which affected the coordinated movements/deformations displayed by myocardial progenitors, and resulted in heart tube elongation defects.
267 pages
en_US
University of Kansas
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
Developmental biology
Cell biology
Cell motility
Endocardium
Extracellular matrix
Foregut endoderm
Heart morphogenesis
Myocardium
Tissue-level Mechanisms Driving Cardiac Progenitor and Extracellular Matrix Movements during Early Vertebrate Heart Development
Dissertation
Anatomy & Cell Biology
Ph.D.
na
This item does not meet KU Open Access policy criteria.
8085900
TEXT
Aleksandrova_ku_0099D_12549_DATA_1.pdf.txt
Aleksandrova_ku_0099D_12549_DATA_1.pdf.txt
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302898
https://kuscholarworks.ku.edu/bitstream/1808/11448/2/Aleksandrova_ku_0099D_12549_DATA_1.pdf.txt
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MD5
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Aleksandrova_ku_0099D_12549_DATA_1.pdf
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https://kuscholarworks.ku.edu/bitstream/1808/11448/1/Aleksandrova_ku_0099D_12549_DATA_1.pdf
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1808/11448
oai:kuscholarworks.ku.edu:1808/11448
2020-06-22 20:04:37.591
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
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oai:kuscholarworks.ku.edu:1808/267112018-09-08T08:01:19Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Kirk, John Shaw
2018-09-07T13:12:28Z
2018-09-07T13:12:28Z
1948
http://hdl.handle.net/1808/26711
Dissertation (Ph.D.)--University of Kansas, Physiology, 1948.
eng
University of Kansas
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
Visceral capillary permeability changes produced in the dog by histamine, anaphylactic shock and portal and hepatic venous stasis
Dissertation
Physiology
Ph.D.
3427009
TEXT
kirk_1948_3427009.pdf.txt
kirk_1948_3427009.pdf.txt
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text/plain
42752
https://kuscholarworks.ku.edu/bitstream/1808/26711/2/kirk_1948_3427009.pdf.txt
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MD5
2
open access
THUMBNAIL
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ORIGINAL
kirk_1948_3427009.pdf
application/pdf
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https://kuscholarworks.ku.edu/bitstream/1808/26711/1/kirk_1948_3427009.pdf
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1
open access
1808/26711
oai:kuscholarworks.ku.edu:1808/26711
2018-09-08 03:01:19.798
open access
KU ScholarWorks
lib-it-server-appl-support@ku.edu
xoai///col_1808_18171/100