2024-03-29T00:29:18Zhttps://kuscholarworks.ku.edu/oai/requestoai:kuscholarworks.ku.edu:1808/218182019-04-12T14:25:04Zcom_1808_231col_1808_290
Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction
Hasan, Anwarul
Khattab, Ahmad
Islam, Mohammad Ariful
Hweij, Khaled Abou
Zeitouny, Joya
Waters, Renae
Sayegh, Malek
Hossain, Monowar
Paul, Arghya
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization time. Injectable hydrogels have emerged as a promising solution for in situ cardiac tissue repair in infarcted hearts after MI. In this review, an overview of various natural and synthetic hydrogels for potential application as injectable hydrogels in cardiac tissue repair and regeneration is presented. The review starts with brief discussions about the pathology of MI, its current clinical treatments and their limitations, and the emergence of injectable hydrogels as a potential solution for post MI cardiac regeneration. It then summarizes various hydrogels, their compositions, structures and properties for potential application in post MI cardiac repair, and recent advancements in the application of injectable hydrogels in treatment of MI. Finally, the current challenges associated with the clinical application of injectable hydrogels to MI and their potential solutions are discussed to help guide the future research on injectable hydrogels for translational therapeutic applications in regeneration of cardiac tissue after MI.
2016-11-04T16:29:18Z
2016-11-04T16:29:18Z
2015-07-15
Article
Hasan A., Khattab A., Islam M. A., Hweij K. A., Zeitouny J., Waters R., Sayegh M., Hossain M. M., Paul A. (2015). Injectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction. Adv. Sci., 2: 1500122. doi: 10.1002/advs.201500122
http://hdl.handle.net/1808/21818
10.1002/advs.201500122
© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
openAccess
application/pdf
Wiley Open Access
oai:kuscholarworks.ku.edu:1808/345712023-07-11T06:05:31Zcom_1808_80col_1808_81
Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model
Pan, Xiaoli
López Acevedo, Sheila N.
Cuziol, Camille
De Tavernier, Evelyn
Fahad, Ahmed S.
Longjam, Priyobarta S.
Rao, Sambasiva P.
Aguilera-Rodríguez, David
Rezé, Mathilde
Bricault, Christine A.
Gutiérrez-González, Matías F.
de Souza, Matheus Oliveira
DiNapoli, Joshua M.
Vigne, Emmanuelle
Shahsavarian, Melody A.
DeKosky, Brandon J.
B cell
Antibody discovery
Antibody repertoire analysis
Yeast surface display
Cytokine
Spleen
Bone marrow
Plasma cells
Molecular characterization of antibody immunity and human antibody discovery is mainly carried out using peripheral memory B cells, and occasionally plasmablasts, that express B cell receptors (BCRs) on their cell surface. Despite the importance of plasma cells (PCs) as the dominant source of circulating antibodies in serum, PCs are rarely utilized because they do not express surface BCRs and cannot be analyzed using antigen-based fluorescence-activated cell sorting. Here, we studied the antibodies encoded by the entire mature B cell populations, including PCs, and compared the antibody repertoires of bone marrow and spleen compartments elicited by immunization in a human immunoglobulin transgenic mouse strain. To circumvent prior technical limitations for analysis of plasma cells, we applied single-cell antibody heavy and light chain gene capture from the entire mature B cell repertoires followed by yeast display functional analysis using a cytokine as a model immunogen. We performed affinity-based sorting of antibody yeast display libraries and large-scale next-generation sequencing analyses to follow antibody lineage performance, with experimental validation of 76 monoclonal antibodies against the cytokine antigen that identified three antibodies with exquisite double-digit picomolar binding affinity. We observed that spleen B cell populations generated higher affinity antibodies compared to bone marrow PCs and that antigen-specific splenic B cells had higher average levels of somatic hypermutation. A degree of clonal overlap was also observed between bone marrow and spleen antibody repertoires, indicating common origins of certain clones across lymphoid compartments. These data demonstrate a new capacity to functionally analyze antigen-specific B cell populations of different lymphoid organs, including PCs, for high-affinity antibody discovery and detailed fundamental studies of antibody immunity.
2023-07-10T18:55:48Z
2023-07-10T18:55:48Z
2023-06-05
Article
Pan, X., López Acevedo, S. N., Cuziol, C., De Tavernier, E., Fahad, A. S., Longjam, P. S., Rao, S. P., Aguilera-Rodríguez, D., Rezé, M., Bricault, C. A., Gutiérrez-González, M. F., de Souza, M. O., DiNapoli, J. M., Vigne, E., Shahsavarian, M. A., & DeKosky, B. J. (2023). Large-scale antibody immune response mapping of splenic B cells and bone marrow plasma cells in a transgenic mouse model. Frontiers in immunology, 14, 1137069. https://doi.org/10.3389/fimmu.2023.1137069
https://hdl.handle.net/1808/34571
10.3389/fimmu.2023.1137069
PMC10280637
© 2023 Pan, Lo´ pez Acevedo, Cuziol, De Tavernier, Fahad, Longjam, Rao, Aguilera-Rodr´ıguez, Reze´, Bricault, Gutie´rrez-Gonza´lez, de Souza, DiNapoli, Vigne, Shahsavarian and DeKosky. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Frontiers Media
oai:kuscholarworks.ku.edu:1808/254572017-11-23T09:02:30Zcom_1808_109col_1808_110
Measurement of exclusive γγ → WþW− production and search for exclusive Higgs boson production in pp collisions at s= 8 TeV using the ATLAS detector
ATLAS Collaboration
Aaboud, M.
Aad, G.
Abbott, B.
Abdallah, J.
Abdinov, O.
Royon, Christophe
Particle Interactions
Hadron colliders
Searches for exclusively produced W boson pairs in the process pp(γγ)→pW+W−p and an exclusively produced Higgs boson in the process pp(gg)→pHp have been performed using e±μ∓final states. These measurements use 20.2 fb− 1 of pp collisions collected by the ATLAS experiment at a center-of-mass energy √s= 8 TeV at the LHC. Exclusive production of W+W− consistent with the Standard Model prediction is found with 3.0σ significance. The exclusive W+W− production cross section is determined to be σ(γγ→W+W−→e±μ∓X)=6.9±2.2(stat)± 1.4 (sys) fb, in agreement with the Standard Model prediction. Limits on anomalous quartic gauge couplings are set at 95% confidence level as −1.7×10−6<aW0/Λ2<1.7× 10−6 GeV−2 and −6.4×10−6<aWC/Λ2<6.3×10−6 GeV−2. A 95% confidence-level upper limit on the total production cross section for an exclusive Higgs boson is set to 1.2 pb.
2017-11-22T18:41:13Z
2017-11-22T18:41:13Z
2016-08-31
Article
Aaboud, M., Aad, G., Abbott, B. et al. Phys. Rev. D (2016) 94: https://doi.org/10.1103/PhysRevD.94.032011
http://hdl.handle.net/1808/25457
10.1103/PhysRevD.94.032011
© 2016 CERN, for the ATLAS Collaboration. This article is available under the terms of the Creative Commons Attribution 3.0 License. Further distribution of this work must maintain attribution to the author(s) and the published article’s title, journal citation, and DOI.
http://creativecommons.org/licenses/by/3.0/
openAccess
application/pdf
American Physical Society
oai:kuscholarworks.ku.edu:1808/315742021-08-25T16:43:33Zcom_1808_19679com_1808_748col_1808_31561
Learning from the Jeffrey Epstein Mess: It’s Time to Add a Cause of Action for Damages to the Crime Victims’ Rights Act
Yin, Tung
2021
2021-03-30T20:42:01Z
2021-03-30T20:42:01Z
2021-03
Article
Tung Yin, "Learning from the Jeffrey Epstein Mess: It’s Time to Add a Cause of Action for Damages to the Crime Victims’ Rights Act", Kansas Law Review, Kansas Law Review Inc. 2020 vol. 69(3)
http://hdl.handle.net/1808/31574
10.17161/1808.31574
https://law.ku.edu/lawreviewissues#
openAccess
application/pdf
Kansas Law Review, Inc.
oai:kuscholarworks.ku.edu:1808/153532019-04-12T14:45:56Zcom_1808_109col_1808_110
Limits on quark compositeness from high energy jets in p-bar p collisions at 1.8 TeV
Baringer, Philip S.
Coppage, Don
Hebert, C.
This is the publisher's version, also available electronically from http://journals.aps.org/prd/abstract/10.1103/PhysRevD.62.031101.
Events in p-bar p collisions at s√=1.8TeV with total transverse energy exceeding 500 GeV are used to set limits on quark substructure. The data are consistent with next-to-leading order QCD calculations. We set a lower limit of 2.0 TeV at 95% confidence on the energy scale ΛLL for compositeness in quarks, assuming a model with a left-left isoscalar contact interaction term. The limits on ΛLL are found to be insensitive to the sign of the interference term in the Lagrangian.
2014-10-22T15:31:26Z
2014-10-22T15:31:26Z
2000-06-27
Article
B. Abbott et al. ((DØ Collaboration)). (2000). "Limits on quark compositeness from high energy jets in p-bar p collisions at 1.8 TeV." Physical Review D, 62(03):031101. http://dx.doi.org/10.1103/PhysRevD.62.031101
1550-7998
http://hdl.handle.net/1808/15353
10.1103/PhysRevD.62.031101
openAccess
application/pdf
American Physical Society
oai:kuscholarworks.ku.edu:1808/206202018-11-01T18:15:09Zcom_1808_231col_1808_290
High Active Surface Area and Durable Multi-Wall Carbon Nanotube-Based Electrodes for the Bromine Reactions in H2-Br2 Fuel Cells
Yarlagadda, Venkata
Lin, Guangyu
Chong, Pau Ying
Van Nguyen, Trung
Carbon nanotubes
Flow batteries
Fuel cells
Hydrogen-bromine
Kinetic and transport effect
The commercially available carbon gas diffusion electrodes (GDEs) with low specific active area but high permeability are often used as Br2 electrodes in the H2-Br2 fuel cell. In order to increase the specific active surface area of the existing carbon GDEs, a study was conducted to grow multi-wall carbon nanotubes (MWCNTs) directly on the surface of carbon fibers of a commercial carbon electrode. Experimental fixtures were developed to promote the electrodeposition of cobalt and the growth of MWCNTs on the carbon GDE. The MWCNT growth across the carbon electrode was confirmed by SEM. The carbon GDE with a dense distribution of short MWCNTs evaluated in a H2-Br2 fuel cell has 29 times higher active surface area than a plain carbon electrode and was found to be highly durable at an electrolyte flow rate of 10 cc/min/cm2. The performance of the best single layer MWCNT GDE measured at 80% discharge voltage efficiency in a H2-Br2 fuel cell was found to be 16% higher compared to that obtained using three layers of plain carbon electrodes. Finally, the preliminary material cost analysis has shown that the MWCNT-based carbon electrodes offer significant cost advantages over the plain carbon electrodes.
2016-04-01T18:34:20Z
2016-04-01T18:34:20Z
2015-10-30
Article
Yarlagadda, Venkata, Guangyu Lin, Pau Ying Chong, and Trung Van Nguyen. "High Active Surface Area and Durable Multi-Wall Carbon Nanotube-Based Electrodes for the Bromine Reactions in H 2 -Br 2 Fuel Cells." Journal of The Electrochemical Society J. Electrochem. Soc. 163.1 (2015): n. pag. doi:10.1149/2.0181601jes
http://hdl.handle.net/1808/20620
10.1149/2.0181601jes
https://orcid.org/0000-0003-4544-066X
http://jes.ecsdl.org/content/163/1/A5134.abstract
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License (CC BY, http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse of the work in any medium, provided the original work is properly cited.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Electrochemical Society
oai:kuscholarworks.ku.edu:1808/66642019-04-12T14:37:30Zcom_1808_21col_1808_23
The Charter Book of Raoul de Campront: A Study of MSD47 at the Kenneth Spencer Research Library Department of Special Collections at the University of Kansas
Whittaker, Beth M.
This master's thesis examines MSD47, a cartulary of legal instruments pertaining to the Campront family of Normandy. Most documents date from the mid-15th century. The social and historical context of the family's affairs is also examined. The text of the Charter Book of Raoul de Campront is included as a supplement to the thesis.
2010-09-16T18:23:34Z
2010-09-16T18:23:34Z
1992
Thesis
http://hdl.handle.net/1808/6664
https://orcid.org/0000-0003-4923-4484
en_US
openAccess
application/pdf
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/217372019-07-23T18:51:25Zcom_1808_287col_1808_288
Exploring the Ecological Association Between Crime and Medical Marijuana Dispensaries
Kepple, Nancy J.
OBJECTIVE: Routine activities theory purports that crime occurs in places with a suitable target, motivated offender, and lack of guardianship. Medical marijuana dispensaries may be places that satisfy these conditions, but this has not yet been studied. The current study examined whether the density of medical marijuana dispensaries is associated with crime. METHOD: An ecological, cross-sectional design was used to explore the spatial relationship between density of medical marijuana dispensaries and two types of crime rates (violent crime and property crime) in 95 census tracts in Sacramento, CA, during 2009. Spatial error regression methods were used to determine associations between crime rates and density of medical marijuana dispensaries, controlling for neighborhood characteristics associated with routine activities. RESULTS: Violent and property crime rates were positively associated with percentage of commercially zoned areas, percentage of one-person households, and unemployment rate. Higher violent crime rates were associated with concentrated disadvantage. Property crime rates were positively associated with the percentage of population 15–24 years of age. Density of medical marijuana dispensaries was not associated with violent or property crime rates. CONCLUSIONS: Consistent with previous work, variables measuring routine activities at the ecological level were related to crime. There were no observed cross-sectional associations between the density of medical marijuana dispensaries and either violent or property crime rates in this study. These results suggest that the density of medical marijuana dispensaries may not be associated with crime rates or that other factors, such as measures dispensaries take to reduce crime (i.e., doormen, video cameras), may increase guardianship such that it deters possible motivated offenders.
2016-10-14T21:10:58Z
2016-10-14T21:10:58Z
2012-07
Article
Kepple, N. J., & Freisthler, B. (2012). Exploring the Ecological Association Between Crime and Medical Marijuana Dispensaries. Journal of Studies on Alcohol and Drugs, 73(4), 523–530. doi: 10.15288/jsad.2012.73.523
http://hdl.handle.net/1808/21737
10.15288/jsad.2012.73.523
Copyright © 2012 by Alcohol Research Documentation, Inc.
openAccess
application/pdf
Alcohol Research Documentation
oai:kuscholarworks.ku.edu:1808/17962019-04-12T14:24:39Zcom_1808_1069com_1808_7105com_1808_8219com_1808_7115com_1808_748com_1808_9961col_1808_7465col_1808_7108col_1808_8220col_1808_7131col_1808_749col_1808_9967
Saudia Arabia, the WTO, and American Trade Law and Policy
Bhala, Raj
International trade law
Saudi Arabia
World trade organization
2008-01-15T20:17:56Z
2008-01-15T20:17:56Z
2004
Article
38 Int'l L. 741
http://hdl.handle.net/1808/1796
en_US
openAccess
application/pdf
The International Lawyer
oai:kuscholarworks.ku.edu:1808/72192019-04-12T14:43:58Zcom_1808_8219com_1808_231com_1808_56col_1808_8220col_1808_385col_1808_57
Fast Compression with a Static Model in High-Order Entropy
Foschini, Luca
Grossi, Roberto
Gupta, Ankur
Vitter, Jeffrey Scott
(c) 2004 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other users, including reprinting/ republishing this material for advertising or promotional purposes, creating new collective works for resale or redistribution to servers or lists, or reuse of any copyrighted components of this work in other works.
We report on a simple encoding format called wzip for decompressing block-sorting
transforms, such as the Burrows-Wheeler Transform (BWT). Our compressor uses the
simple notions of gamma encoding and RLE organized with a wavelet tree to achieve
a slightly better compression ration than bzip2 in less time. In fact, our compres-
sion/decompression time is dependent on Hh, the empirical hth order entropy. Another
key contribution of our compressor is its simplicity. Our compressor can also oper-
ate as a full-text index with a small amount of data, while still preserving backward
compatibility with just the compressor.
2011-03-21T19:33:45Z
2011-03-21T19:33:45Z
2004
Article
L. Foschini, R. Grossi, A. Gupta, and J. S. Vitter. “Fast Compression with a Static Model in High-Order Entropy,” Proceedings of the 2004 IEEE Data Compression Conference (DCC ’04), Snowbird, UT, March 2004, 62–71. http://dx.doi.org/10.1109/DCC.2004.1281451
http://hdl.handle.net/1808/7219
10.1109/DCC.2004.1281451
en_US
openAccess
application/pdf
IEEE
oai:kuscholarworks.ku.edu:1808/337542023-02-08T09:01:14Zcom_1808_4471col_1808_4472
The genomic scale of fluctuating selection in a natural plant population
Kelly, John K.
Adaptation
Balancing selection
Ecological genetics
Evolutionary genomics
This study characterizes evolution at ≈1.86 million Single Nucleotide Polymorphisms (SNPs) within a natural population of yellow monkeyflower (Mimulus guttatus). Most SNPs exhibit minimal change over a span of 23 generations (less than 1% per year), consistent with neutral evolution in a large population. However, several thousand SNPs display strong fluctuations in frequency. Multiple lines of evidence indicate that these ‘Fluctuating SNPs’ are driven by temporally varying selection. Unlinked loci exhibit synchronous changes with the same allele increasing consistently in certain time intervals but declining in others. This synchrony is sufficiently pronounced that we can roughly classify intervals into two categories, “green” and “yellow,” corresponding to conflicting selection regimes. Alleles increasing in green intervals are associated with early life investment in vegetative tissue and delayed flowering. The alternative alleles that increase in yellow intervals are associated with rapid progression to flowering. Selection on the Fluctuating SNPs produces a strong ripple effect on variation across the genome. Accounting for estimation error, we estimate the distribution of allele frequency change per generation in this population. While change is minimal for most SNPs, diffuse hitchhiking effects generated by selected loci may be driving neutral SNPs to a much greater extent than classic genetic drift.
2023-02-07T19:35:48Z
2023-02-07T19:35:48Z
2022-12-11
Article
Kelly J. K. (2022). The genomic scale of fluctuating selection in a natural plant population. Evolution letters, 6(6), 506–521. https://doi.org/10.1002/evl3.308
http://hdl.handle.net/1808/33754
10.1002/evl3.308
https://onlinelibrary.wiley.com/doi/full/10.1002/evl3.308
© 2022 The Authors. Evolution Letters published by Wiley Periodicals LLC on behalf of Society for the Study of Evolution (SSE) and European Society for Evolutionary Biology (ESEB). This is an open access article under the terms of the Creative Commons Attribution License.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Oxford University Press
oai:kuscholarworks.ku.edu:1808/214742019-04-12T14:22:49Zcom_1808_80col_1808_81
Self-chaperoning of the Type III Secretion System Needle Tip Proteins IpaD and BipD
Johnson, Steven
Roversi, Pietro
Espina, Marianela
Olive, Andrew J.
Deane, Janet E.
Birket, Susan
Field, Terry
Picking, William D.
Blocker, Ariel J.
Galyov, Edouard E.
Picking, Wendy Lynn
Lea, Susan M.
Bacteria expressing type III secretion systems (T3SS) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever. The T3SS is composed of a basal body, which traverses both bacterial membranes, and an external needle through which effector proteins are secreted. We report multiple crystal structures of two proteins that sit at the tip of the needle and are essential for virulence; IpaD from Shigella flexneri and BipD from Burkholderia pseudomallei. The structures reveal that the N-terminal domains of the molecules are intra-molecular chaperones that prevent premature oligomerization, as well as sharing structural homology with proteins involved in eukaryotic actin rearrangement. Crystal packing has allowed us to construct a model for the tip complex that is supported by mutations designed using the structure.
2016-09-07T17:48:56Z
2016-09-07T17:48:56Z
2007-02-09
Article
Johnson, S., Roversi, P., Espina, M., Olive, A., Deane, J. E., Birket, S., … Lea, S. M. (2007). Self-Chaperoning of the Type III Secretion System needle tip proteins IpaD and BipD. The Journal of Biological Chemistry, 282(6), 4035–4044. http://doi.org/10.1074/jbc.M607945200
http://hdl.handle.net/1808/21474
10.1074/jbc.M607945200
https://orcid.org/0000-0003-3441-3113
https://orcid.org/0000-0001-7998-0643
This research was originally published in Journal of Biological Chemistry. Steven Johnson, Pietro Roversi, Marianela Espina, Andrew Olive, Janet E. Deane, Susan Birket, Terry Field, William D. Picking, Ariel J. Blocker, Edouard E. Galyov, Wendy L. Picking and Susan M. Lea. Self-Chaperoning of the Type III Secretion System needle tip proteins IpaD and BipD. Journal of Biological Chemistry. 2007; 282, 4035-4044. © the American Society for Biochemistry and Molecular Biology.
openAccess
application/pdf
American Society for Biochemistry and Molecular Biology
oai:kuscholarworks.ku.edu:1808/346922023-08-09T06:05:26Zcom_1808_4471col_1808_4472
Foraging behavior and prey selection of the leather seastar Dermasterias imbricata
Annett, Cynthia
Pierotti, Raymond
Stomach contents of 243 Dermasterias imbricata (Gmbe) from 2 field sites in Monterey Bay, central California (USA), revealed a diet consisting primarily of the corallimorphian anemone Corynactis califomica. A survey of potential prey species demonstrated that C. californica were found in 85 % of 52 randomly placed '/am2 quadrats and 96 % of 45 % m2 quadrats placed around D. irnbn'cata within our study area. All other species of anemones were either rare or absent from the study area, with the exception of a few large individuals. When presented with a choice between C. californica and Anthopleura elegantissima or A. xanthogrammica in the laboratory, D. imbricata consistently ate the Anthopleura spp. and avoided C. californica. In single prey presentations, A. elegantiss~maA, . xanthogrammica, and Metndium senile were all taken and consumed readily within the first day. In contrast, D. irnbricata presented with C. californica initially avoided this species, and 40 % of the D, imbricata did not feed within 3 d. This difference in selectivity appeared to be related to the anti-predator defenses of the varlous anemones. These results suggest that ecologists should be careful in employing terms such as 'specialist' or 'preferred prey item' without conducting controlled experiments on prey selection and examining behavioral interactions between predator and prey.
2023-08-08T21:55:13Z
2023-08-08T21:55:13Z
1983-01-02
Article
Annett, C.A. and R. Pierotti. 1983. Laboratory and field investigations of the foraging behavior of the leather seastar. Dermasterias imbricata, in Monterey Bay, Calif. Marine Ecology Progress Series 13:197 206.
https://hdl.handle.net/1808/34692
https://www.int-res.com/abstracts/meps/v14/
Copyright Inter-Research/Printed in F. R. Germany
openAccess
application/pdf
Inter Research
oai:kuscholarworks.ku.edu:1808/219192018-01-31T20:07:52Zcom_1808_267com_1808_1260col_1808_13988col_1808_1951
Impact of infant feeding status on maternal body composition
Curtis, Michelle
Hull, Holl
Carlson, Susan
Kerling, Beth
Nutrition
Obstetrics
body composition
breastfeeding
maternal
weight loss
Background: Overweight and obesity are related to a greater risk for health problems throughout life. Maternal overweight and obesity is related to complications during pregnancy that endanger the health of the mother and her developing fetus. Pregnancy is also a time when excessive weight can be gained leading the mother susceptible to an increased risk of long term overweight or obesity and entering subsequent pregnancies with a higher BMI. Breastfeeding has been shown to create a caloric deficit to promote weight loss, yet no study has assessed breastfeeding exclusivity at 3 months and maternal body composition at 6 months as well as breastfeeding exclusivity at 6 months and maternal body composition at 6 months. Purpose: The purpose of this study was to explore the relationship between infant feeding status at three and six months post-partum and maternal body composition at six months post-partum. Methods: Twenty-five mothers were included in this analysis. Mothers were included if they met the criteria of a BMI 18.5 – 40 kg/m2, of a singleton pregnancy, healthy, completed a 3 month post-partum follow-up visit with breastfeeding questionnaire and a 6 month post-partum follow-up visit with breastfeeding questionnaire and Bod Pod test. Mothers were dichotomized into exclusive breastfeeding and non-exclusive breastfeeding. Maternal body composition was measured by air displacement plethysmography by the Bod Pod. ANOVA assessed the relationship between maternal breastfeeding status at 3 months and maternal body composition at 6 months as well as the relationship between maternal breastfeeding status at 6 months and maternal body composition at 6 months. Multiple linear regression assessed the relationship between post-partum weight loss 0-3 months and 3-6 months and maternal body composition at 6 months. Significance was determined at a level of p < 0.05. Results: The mean age of the participants was 30.4 years, the mean pre-pregnancy BMI was 26.6 kg/m2, and the mean total PPWL was 11.6 kg ± 5.5 kg. Differences were found between groups for the amount of total PPWL (exclusive: 13.2 ± 5.3 kg and non-exclusive: 8.4 kg ± 4.7 kg; p=0.017) and PPWL 3 to 6 months (exclusive: 2.6 ± 1.7 kg and non-exclusive: 0.06 ± 3.2 kg; p=0.039). When examining breastfeeding status at 3 months, no between group (exclusive vs. non-exclusive) differences were found for maternal body composition. Similarly, when examining differences in breastfeeding status at 6 months, no differences in maternal body composition was found. Linear regression showed post-partum weight loss from 3 to 6 months predicted maternal %fat (β = 1.87, R2=0.22; p = 0.010), FM (β = 0.608, R2=0.34; p = 0.001) and FFM (β = 0.473, R2=0.19; p = 0.017). Conclusion: No relationship was found between breastfeeding exclusivity assessed at 3 and 6 months post-partum and maternal body composition at 6 months post-partum. However, a relationship was found among PPWL 3 – 6 months post-partum and maternal %fat, FM, FFM at 6 months post-partum. Future research is needed to better support these relationships as well as to determine to mechanisms which influence them.
2016-11-11T00:03:01Z
2016-11-11T00:03:01Z
2015-12-31
2015
Thesis
http://dissertations.umi.com/ku:14369
http://hdl.handle.net/1808/21919
en
Copyright held by the author.
openAccess
46 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/318182024-01-16T16:44:30Zcom_1808_1260col_1808_1952
Building Psychological Capital through Leadership Development
Edelman, Lauren Lauren
Twombly, Susan B
Wolf-Wendel, Lisa E
Roney, Marlesa A
Parker, Eugene T
Cole, Brian P
Educational leadership
hope
involvement
leadership
leadership efficacy
psychological capital
resilience
Using the lens of psychological capital (PsyCap), this research study explored the relationship between college women’s involvement in various types of leadership activities and the constructs of hope, resilience, and leadership-efficacy. Data from the Multi-Institutional Study of Leadership, conducted at Washburn University in spring of 2018, were analyzed to determine how co-curricular, immersive, and academic leadership involvement for college women relate to PsyCap development. This study also explored the demographic characteristics of college women who participate in leadership activities and analyzed students’ pre-college perceptions of their own psychological capital. Results reveal higher levels of hope, resilience, and leadership efficacy for students reporting involvement in leadership activities compared to students who reported no involvement. Furthermore, the study suggests correlations between participation in activities categorized as Co-Curricular and Immersive Leadership Involvement and higher levels of PsyCap. Results also indicate that participation in more than one leadership activity is generally associated with higher levels of hope, resilience, and leadership-efficacy, and that class-level is an important predictor of a students’ psychological capital. Co-curricular leadership involvement is particularly relevant to the development of PsyCap, as this involvement was found to be a predictor for both leadership efficacy and resilience. More immersive leadership experiences were found to be predictors of leadership efficacy as well. Implications of this study include consideration of how leadership development programs in higher education institutions can promote learning outcomes beyond those typically associated with leadership education to include enhancing psychological tools that can help students overcome challenges they will undoubtedly face after college.
2021-07-25T21:20:43Z
2021-07-25T21:20:43Z
2020-05-31
2020
Dissertation
http://dissertations.umi.com/ku:17035
http://hdl.handle.net/1808/31818
https://orcid.org/0000-0002-0059-7287
en
Copyright held by the author.
openAccess
98 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/224432019-04-12T14:17:12Zcom_1808_913col_1808_915
“Hit me up and we can get down” U.S. youths’ risk behaviors and sexual self-disclosure in MySpace profiles
Bobkowski, Peter S.
Brown, Jane D.
Neffa, Deborah R.
Adolescents
MySpace
New media
Problem behavior theory
Self-disclosure
Self-presentation
Sexual health
Sexual self-concepts
Social media
Young people’s sexual self-disclosures in social media profiles can be problematic for those who produce them and for those who consume them. This study merged a content analysis with survey data to identify the characteristics of youth who engaged in online sexual self-disclosure. MySpace profiles belonging to 560 National Study of Youth and Religion respondents in the United States (18 to 23 years old) were analyzed (56,462 content units). A third of the profiles contained at least one sexual self-disclosure; their average incidence was less than one per profile. Online sexual self-disclosure was associated with offline sexual risk behaviors (e.g., sex with casual partners), and with increased frequency of alcohol consumption. Among sexually active females, it was associated with early sexual debut. In light of problem behavior theory, these findings suggest that online sexual self-disclosure may be considered a sexual risk behavior.
2017-01-03T21:34:54Z
2017-01-03T21:34:54Z
2011-12-02
Article
Bobkowski, P. S., Brown, J. D., & Neffa, D. R. (2012). "Hit me up and we can get down:" U.S. youths' risk behaviors and sexual self-disclosure in MySpace profiles. Journal of Children and Media, 6, 119-134.
http://hdl.handle.net/1808/22443
10.1080/17482798.2011.633412
This is an Accepted Manuscript of an article published by Taylor & Francis in Journal of Children and Media on 02 December 2011, available online: http://www.tandfonline.com/10.1080/17482798.2011.633412.
openAccess
application/pdf
Taylor & Francis
oai:kuscholarworks.ku.edu:1808/144632019-04-12T14:49:49Zcom_1808_4471col_1808_4472
Floriparicapitus, a new genus of lecanicephalidean tapeworm (Cestoda) from sawfishes (Pristidae) and guitarfishes (Rhinobatidae) in the Indo-West Pacific
Cielocha, Joanna J.
Jensen, Kirsten
Caira, Janine N.
Floriparicapitus n. gen. (Cestoda: Lecanicephalidea), with F. euzeti n. gen. n. sp. as its
type, is erected to house 3 new tapeworm species and 2 known species that are
transferred to the new genus, all parasitizing sawfishes and guitarfishes (order
Rhinopristiformes) in Indo-Pacific waters. The new genus differs from the 20 valid
lecanicephalidean genera in its possession of a large scolex bearing a laterally
expanded apical organ in the form of a rugose sheet in combination with a cirrus
conspicuously armed with spinitriches and 3 pairs of excretory vessels. It most closely
resembles Lecanicephalum, but differs conspicuously in its possession of 3, rather
than 1, pair of excretory vessels. Two new species are described from sawfishes:
Floriparicapitus euzeti n. sp., from Pristis clavata and Floriparicapitus juliani n. sp. from
Pristis microdon, both from Australia. Floriparicapitus plicatilis n. sp. is described from
the guitarfish Glaucostegus typus in Australia and the guitarfish Glaucostegus thouin in
Malaysian Borneo. Two species formerly assigned to Cephalobothrium are transferred
to the new genus; Floriparicapitus variabilis (Southwell, 1911) n. comb. from the
sawfish Anoxypristis cuspidata in Sri Lanka and Floriparicapitus rhinobatidis
(Subhapradha, 1955) n. comb. from the guitarfish Glaucostegus granulatus in India.
The species from guitarfish differ conspicuously from those parasitizing sawfish in their
possession of only 4 (F. plicatilis n. sp.) or 5 (F. rhinobatidis n. comb.) testes per
proglottid, versus 9 or more in the 3 sawfish-parasitizing species. The latter 3 species
differ from one another in scolex width, acetabular size, number of proglottids, and
cirrus sac size. As it stands, the new genus appears to be restricted to a subclade of
the Rhinopristiformes consisting of the sawfishes and species of Glaucostegus.
2014-07-02T21:11:20Z
2014-07-02T21:11:20Z
2013
Article
Joanna J. Cielocha et al. Floriparicapitus, a new genus of
lecanicephalidean tapeworm (Cestoda) from sawfishes (Pristidae)
and guitarfishes (Rhinobatidae) in the Indo-West Pacific. Journal of
Parasitology
http://hdl.handle.net/1808/14463
10.1645/13-468.1
openAccess
application/pdf
Allen Press
oai:kuscholarworks.ku.edu:1808/262282024-01-18T17:12:09Zcom_1808_23770com_1808_19777col_1808_23771
Legislative Report
Policy Watch Weekly Update
Johnson, Paul
Weekly update on the activities of the Kansas Legislature.
2018-03-16T18:40:06Z
2018-03-16T18:40:06Z
2017-03-10
Report
http://hdl.handle.net/1808/26228
This item is protected by copyright and unless otherwise specified the copyright is held by the publisher.
openAccess
application/pdf
League of Women Voters of Kansas
oai:kuscholarworks.ku.edu:1808/86292018-04-23T20:53:32Zcom_1808_7240com_1808_735col_1808_8569
Review: Theorie und Praxis der idiomatisc hen Wörte rbücher
Jesenšek, Vida
2011-12-16T20:01:39Z
2011-12-16T20:01:39Z
2011-02-01
Article
Vida Jesenšek. 2011. Carmen Mellado Blanco (ur.): Theorie und Praxis der idiomatisc hen Wörte rbücher. Tübingen, 2009. Lexicographica. Series Maior; 135. Slavia Centralis IV/2: 120-123. http://dx.doi.org/10.17161/SCN.1808.8629
2385-8753
http://hdl.handle.net/1808/8629
10.17161/SCN.1808.8629
other
All articles are licensed under a Creative Commons Attribution Non-Commercial 4.0 International License (CC-BY-NC)
http://creativecommons.org/licenses/by-nc/4.0/
openAccess
application/pdf
oai:kuscholarworks.ku.edu:1808/8602019-04-12T14:28:54Zcom_1808_7105com_1808_748col_1808_7108col_1808_749
On Teaching Religion at the State University
Casad, Robert C.
First amendment
Religion and public education
2006-01-27T14:01:33Z
2006-01-27T14:01:33Z
1964-03
Article
12 U. Kan. L. Rev. 405
http://hdl.handle.net/1808/860
en_US
openAccess
1014808 bytes
application/pdf
application/pdf
University of Kansas Law Review
oai:kuscholarworks.ku.edu:1808/81272020-08-19T13:37:00Zcom_1808_1260com_1808_87col_1808_1952col_1808_14131
Separating the Kinetic and Sorption Parameters of Mixed Chlorinated Solvents in Contact with Granular Iron
Huang, Bei
Devlin, John F.
Macpherson, Gwendolyn L.
Tsoflias, Georgios P.
Peltier, Edward F.
Brookfield, Andrea
Geology
Chlorinated solvents
Competition
Granular iron
Kinetic iron model
Sorption
Transportat model
Chlorinated solvents and nitroaromatic solvents in drinking-water supplies are an important concern for public health. Granular iron, the most common medium in permeable reactive barriers (PRBs), is very effective at removing organic chemicals, such as chlorinated solvents and nitroaromatic compounds, from groundwater. In an effort to improve barrier designs, studies have been undertaken to examine the iron surface, as well as the reaction kinetics of granular iron. The development of the kinetic iron model (KIM) in 2009, which was derived specifically for PRB settings, made it possible for the first time to assess the simultaneous contributions of sorption and reaction to contaminant degradation rates in iron PRBs, providing a new tool to improve PRB design. This work extended the previous studies that used the KIM by applying the kinetic model to study the effects of iron aging on the reaction kinetics of chlorinated solvents and nitroaromatic solvents. It was found that over time and exposure to water and oxidizing organics, iron tended to lose sorption sites associated with the highest reactivities , but gained reactive sorption capacity to sites with lower reactivity. In the short term, the increasing sorption capacity led to overall faster reaction rates than were observed with new iron. The results also indicated that the KIM parameters were more than simple fitting parameters. As expected, the nitroaromatic compounds tested (4ClNB and 4AcNB) reacted faster than the chlorinated solvents tested (PCE and TCE). Analysis of the data with the KIM indicated the rate differences were due to the surface reaction rate constant, not sorption. This result matched expectations based on earlier studies of these classes of organic chemicals. To test the accuracy of the estimated kinetic and sorption parameters, determined with novel methods in this work, a one dimensional transport model with Langmuir sorption and KIM kinetics was developed to generate synthetic data sets. The model was prepared with the ability to assess intra- and interspecies competition between TCE and PCE in the column experiments. Synthetic data were analyzed with the methods used to interpret the laboratory data and accurate estimates of the input parameters were calculated, validating the methodology. Finally, the activation energy of the 4-chloronitrobenzene reacting with two types of granular iron, Connelly iron and QMP, in batch reactors was obtained to assess the role of mass transfer in controlling the kinetics. Previous work had indicated that mass transfer was not rate controlling with Connelly iron, but QMP was a texturally different form of granular iron that needed further testing. QMP exhibited slower reaction rates compare to Connelly iron. Based on the estimated activation energies (Ea) of the reduction reactions, the reaction mechanism(s) for 4ClNB transformation on Connelly iron and QMP iron were both electron transfer controlled, and the result also suggest that the different transformation rates were therefore related to phases on the solid surface.
2011-10-09T01:04:13Z
2011-10-09T01:04:13Z
2011-08-31
2011
Dissertation
http://dissertations.umi.com/ku:11607
http://hdl.handle.net/1808/8127
en
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
163 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/295642021-03-05T18:33:53Zcom_1808_978com_1808_1260col_1808_8654col_1808_1951
No Longer Your Best Black Friend (BBF): The Roles and Expectations of Black Women in Contemporary Television
Warren, Michaela
Pennington, Dorothy
Anatol, Giselle
Ukpokodu, Peter
African American studies
Gender studies
Film studies
black women
deformation of mastery
history
mastery of form
stereotypes
television
There are still certain expectations held about black women and certain roles that they are expected to fit into. This is heavily prevalent in the film and television industry. This study aims to analyzes the black female lead characters in Scandal, How to Get Away with Murder, Chewing Gum, and Insecure in the conceptual frame work of Houston Baker’s mastery of form and deformation of master. Before the analysis of the shows, secondary research was performed to provide historical context of black women’s history and their stereotypes.
2019-09-06T20:47:36Z
2019-09-06T20:47:36Z
2018-12-31
2018
Thesis
http://dissertations.umi.com/ku:16231
http://hdl.handle.net/1808/29564
en
Copyright held by the author.
openAccess
67 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/75022019-04-12T14:38:38Zcom_1808_21col_1808_23
Index to the Missouri Folklore Society Journal, Volumes 1 - 10
Wolz, Lyn A.
Missouri Folklore Society Journal
Indexes
2011-05-23T18:39:58Z
2011-05-23T18:39:58Z
1989
Article
“Index to the Missouri Folklore Society Journal, Volumes. 1-10,” Missouri Folklore Society Journal 11-12 (1989-90): pp. 225-249.
0731-2946
http://hdl.handle.net/1808/7502
https://orcid.org/0000-0002-9486-375X
en_US
openAccess
application/pdf
oai:kuscholarworks.ku.edu:1808/263452018-12-17T17:41:43Zcom_1808_1260com_1808_87col_1808_1952col_1808_14131
Integrating in situ Geochronology and Metamorphic Petrology: An Example from the Gruf Complex, European Central Alps
Oalmann, Jeffrey Anthony G.
Möller, Andreas
Walker, Douglas
Stockli, Daniel
Fowle, David
Egbert, Stephen
Geology
Petrology
Geochemistry
Central Alps
Gruf Complex
monazite
rutile
UHT metamorphism
zircon
Understanding the thermal evolution (i.e. the timing, rate, duration, and magnitude of thermal events) within mountain belts has important implications for the geodynamic evolution of both ancient and modern orogenies. Ultra-high temperature (UHT) metamorphism requires geodynamic or tectonic processes that bring excess heat to the lower crust. Therefore, dating UHT metamorphism can shed light on the geodynamic evolution of the geological settings in which UHT rocks are exposed. In recent years, many researchers have used accessory mineral U-Pb geochronology to date (U)HT metamorphic events. However, it is not always clear to what part of the pressure-temperature (P-T) path the ages relate. Using an in situ approach, this study combines accessory mineral U-Pb geochronology with single mineral thermometry, thermobarometric modeling, and trace element geochemistry to elucidate the P-T-time (P-T-t) evolution of sapphirine-bearing granulites from the Gruf Complex in the Central Alps. Two main questions are addressed: (1) When did the Gruf Complex experience UHT metamorphism? (2) What parts of the P-T evolution of high-grade metamorphic rocks can be dated using U-Pb geochronology of different accessory phases? Equilibrium phase diagrams calculated from whole rock and microdomain compositions and Zr-in-rutile thermometry indicate that the Gruf granulites underwent UHT metamorphism at 900–1000°C and 7.0–9.5 kbar after decompressing from ca. 800°C and 9–12 kbar. This decompression-heating event resulted in the breakdown of garnet to form orthopyroxene, sapphirine, and cordierite. A lack of inherited monazite and presence of young (34–30 Ma) monazite within UHT textures is interpreted to indicate that UHT metamorphism was the last main metamorphic event the Gruf granulites experienced, thus precluding a Permian UHT event followed by a lower temperature (700–750°C) Alpine event. Textural observations and Ti-in-zircon thermometry reveal that minor zircon growth occurred in equilibrium with garnet at 34.8 ± 1.1 Ma, and zircon was not growing, but resorbing during UHT metamorphism. Therefore, the youngest zircon rims can only be used to date post-UHT melt crystallization and cooling at 32.7 ± 0.7 Ma. The U-Pb zircon ages of variable deformed felsic dikes indicate that the lower crustal UHT rocks were juxtaposed against the midcrustal migmatites between 30 and 27 Ma and contractional deformation ceased by 25.6 ± 0.3 Ma in the Gruf Complex. Finally, U-Pb rutile ages indicate that the amalgamated Gruf Complex cooled from 700–420°C over an 11 m.y. period from 30 to 19 Ma. These results indicate that different accessory minerals can be used to date different stages of the evolution of UHT rocks. However, depending on the reactions in the rock volume, dateable accessory minerals may be crystallizing, resorbing, or not reacting at a given P-T condition. Therefore, combining accessory mineral ages with textural, geochemical, and petrological information is necessary to elucidate the P-T-t evolution of a particular rock package.
2018-04-20T22:30:27Z
2018-04-20T22:30:27Z
2017-05-31
2017
Dissertation
http://dissertations.umi.com/ku:15310
http://hdl.handle.net/1808/26345
en
Copyright held by the author.
openAccess
275 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/296072019-10-01T16:54:02Zcom_1808_231col_1808_13465col_1808_19739
Construction Of Low-Cracking High-Performance Bridge Decks Incorporating New Technology
Lafikes, James
Darwin, David
O'Reilly, Matthew
Feng, Muzai
Bahadori, Alireza
Khajehdehi, Rouzbeh
bridge decks
concrete construction
cracking
internally-cured low-cracking high-performance concrete
lightweight aggregate
paste content
supplementary cementitious materials
Construction and early-age crack evaluations of four bridge decks in Minnesota placed from 2016
to 2018 that incorporate specifications for Internally-Cured Low-Cracking High-Performance
Concrete (IC-LC-HPC) are documented in this study. Two additional decks that serve as Controls
followed specifications for high-performance concrete and paired with IC-LC-HPC decks are
included. Pre-wetted fine lightweight aggregate was used to provide a targeted internal curing
water content of 8% by total weight of binder. The IC-LC-HPC mixtures included 27 to 30% slag
cement by total binder weight while the Control mixtures included 25 or 35% Class F fly ash by
total weight of binder. For one IC-LC-HPC deck, mixture proportions were modified based on a
higher FLWA absorption than originally used to design the mixture. One IC-LC-HPC placement
failed due to errors in FLWA moisture corrections and concrete batching that led to rejections of
batches, leaving an inadequate supply of material to complete the deck. Crack surveys were
completed for the IC-LC-HPC and Control decks placed in 2016 and 2017. Crack densities at these
ages were low compared to most Low-Cracking High-Performance Concrete decks in Kansas and
Internally-Cured High-Performance Concrete decks in Indiana, with the exception of one IC-LCHPC
deck that exhibited extensive cracking within one year after placement, which had an overlay
with a high cement paste content and no internal curing. This project serves as a foundation for
implementing IC-LC-HPC in upcoming bridge decks in Kansas and Minnesota.
Kansas Department of Transportation and Minnesota Department of Transportation “Construction of Low-Cracking High-Performance Bridge Decks Incorporating New Technology” Transportation Pooled Fund Study, Project No. TPF-5(336).
2019-09-20T15:41:31Z
2019-09-20T15:41:31Z
2019-06-01
Technical Report
Lafikes, J., Darwin, D., O’Reilly, M., Feng, M., Bahadori, A., and, Khajehdehi, R., “Construction of Low-Cracking High-Performance Bridge Decks Incorporating New Technology,” SM Report No. 132, University of Kansas Center for Research, Inc., Lawrence, KS, June 2019, 98 pp.
http://hdl.handle.net/1808/29607
https://orcid.org/0000-0001-5039-3525
SM Report;132
https://iri.ku.edu/reports
openAccess
application/pdf
University of Kansas Center for Research, Inc.
oai:kuscholarworks.ku.edu:1808/162392019-04-12T14:53:44Zcom_1808_3892com_1808_7165col_1808_15801col_1808_7166
Career Preparation for Handicapped Adolescents: A Matter of Appropriate Education
Clark, Gary M.
This research was published by the KU Center for Research on Learning, formerly known as the University of Kansas Institute for Research in Learning Disabilities.
A complete individualization concept is presented as the avenue to achieve "appropriate education" for handicapped adolescents. Exemplified within the context of the educational goal of career preparation, this concept involves the individualization of both content and instructional approach. The need for career preparation is supported by data which suggest that high school youth lack critical information in the areas of occupational development, daily living skills, and
personal-social skills important to one's functioning in today's society.
2015-01-14T19:54:25Z
2015-01-14T19:54:25Z
1980-01-01
Book
Clark, G. M. (1980) Career Preparation for Handicapped Adolescents: A Matter of Appropriate Education [Research Monograph 7]. Institute for Research in Learning Disabilities, Lawrence, KS.
http://hdl.handle.net/1808/16239
Research Monograph / Institute for Research in Learning Disabilities;7
openAccess
application/pdf
Institute for Research in Learning Disabilities
oai:kuscholarworks.ku.edu:1808/269622018-11-16T19:22:29Zcom_1808_109col_1808_110
Search for physics beyond the standard model in events with two leptons of same sign, missing transverse momentum, and jets in proton–proton collisions at s√=13TeV
CMS Collaboration
A data sample of events from proton–proton collisions with two isolated same-sign leptons, missing transverse momentum, and jets is studied in a search for signatures of new physics phenomena by the CMS Collaboration at the LHC. The data correspond to an integrated luminosity of 35.9fb−1, and a center-of-mass energy of 13TeV. The properties of the events are consistent with expectations from standard model processes, and no excess yield is observed. Exclusion limits at 95% confidence level are set on cross sections for the pair production of gluinos, squarks, and same-sign top quarks, as well as top-quark associated production of a heavy scalar or pseudoscalar boson decaying to top quarks, and on the standard model production of events with four top quarks. The observed lower mass limits are as high as 1500GeV for gluinos, 830GeV for bottom squarks. The excluded mass range for heavy (pseudo)scalar bosons is 350–360 (350–410)GeV. Additionally, model-independent limits in several topological regions are provided, allowing for further interpretations of the results.
2018-10-23T18:42:52Z
2018-10-23T18:42:52Z
2017-09
Article
Sirunyan, A.M., Tumasyan, A., Adam, W. et al. Eur. Phys. J. C (2017) 77: 578. https://doi.org/10.1140/epjc/s10052-017-5079-z
http://hdl.handle.net/1808/26962
https://doi.org/10.1140/epjc/s10052-017-5079-z
© CERN for the benefit of the CMS collaboration 2017
Open Access
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Springer Verlag
oai:kuscholarworks.ku.edu:1808/335192022-09-20T08:01:11Zcom_1808_54col_1808_59
Kansas Statistical Abstract 1968 (4th Edition)
The Kansas Statistical Abstract contains the latest available state, county, and city-level data for Kansas on population, vital statistics and health, housing, education, business and manufacturing, exports, employment, income, finance, state and local government, crime, recreation, communications, transportation, agriculture, climate, and energy and natural resources.
2022-09-19T16:34:41Z
2022-09-19T16:34:41Z
1969
Book
http://hdl.handle.net/1808/33519
https://ipsr.ku.edu/ksdata/ksah/KSA4.pdf
openAccess
application/pdf
Center for Regional Studies
oai:kuscholarworks.ku.edu:1808/214422017-12-08T21:40:50Zcom_1808_979com_1808_1260col_1808_14116col_1808_1951
Harold Frederic as a pioneer realist
Herrick, Don Henry
Thesis (M.A.)--University of Kansas, English, 1928.
2016-09-07T13:17:18Z
2016-09-07T13:17:18Z
1928
Thesis
http://hdl.handle.net/1808/21442
eng
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/231032019-04-12T14:21:35Zcom_1808_275col_1808_22736
Overt Object Movement and the Structure of vP in English
Khym, Hangyoo
English language-- Syntax
Movement (Syntax)
Generative grammar
2017-02-14T00:21:14Z
2017-02-14T00:21:14Z
1999
Article
http://hdl.handle.net/1808/23103
Papers of the Mid-America Linguistics Conference;1999
openAccess
application/pdf
Mid-America Linguistics Conference
University of Kansas
oai:kuscholarworks.ku.edu:1808/84142019-04-12T14:46:40Zcom_1808_97col_1808_102
Orientational Dynamics and Dye-DNA Interactions in a Dye-Labeled DNA Aptamer
Wilson, George S.
Unruh, Jay R.
Gokulrangan, Giridharan
Lushington, Gerald H.
Johnson, Carey K.
We report the picosecond and nanosecond timescale rotational dynamics of a dye-labeled DNA oligonucleotide
or ‘‘aptamer’’ designed to bind specifically to immunoglobulin E. Rotational dynamics in combination with fluorescence lifetime
measurements provide information about dye-DNA interactions. Comparison of Texas Red (TR), fluorescein, and tetramethylrhodamine
(TAMRA)-labeled aptamers reveals surprising differences with significant implications for biophysical studies
employing such conjugates. Time-resolved anisotropy studies demonstrate that the TR- and TAMRA-aptamer anisotropy
decays are dominated by the overall rotation of the aptamer, whereas the fluorescein-aptamer anisotropy decay displays
a subnanosecond rotational correlation time much shorter than that expected for the overall rotation of the aptamer. Docking
and molecular dynamics simulations suggest that the low mobility of TR is a result of binding in the groove of the DNA helix.
Additionally, associated anisotropy analysis of the TAMRA-aptamer reveals both quenched and unquenched states that experience
significant coupling to the DNA motion. Therefore, quenching of TAMRA by guanosine must depend on the configuration
of the dye bound to the DNA. The strong coupling of TR to the rotational dynamics of the DNA aptamer, together with the
absence of quenching of its fluorescence by DNA, makes it a good probe of DNA orientational dynamics. The understanding of
the nature of dye-DNA interactions provides the basis for the development of bioconjugates optimized for specific biophysical
measurements and is important for the sensitivity of anisotropy-based DNA-protein interaction studies employing such
conjugates.
Dynamic Aspects of Chemical
Biology Training Grant (National Institutes of Health 5 T32 GM08545-09),
Support from the Petroleum Research Fund, administered by the American
Chemical Society.
2011-11-18T19:57:58Z
2011-11-18T19:57:58Z
2005-05
Article
J.R. Unruh, G. Gokulrangan, G.H. Lushington, C.K. Johnson, and G.S. Wilson, Orientational Dynamics and Dye-DNA Interactions in a DNA Aptamer, Biophysical Journal. 88, 3455-3465 (2005). http://dx.doi.org/10.1529/biophysj.104.054148
http://hdl.handle.net/1808/8414
10.1529/biophysj.104.054148
https://orcid.org/0000-0003-3077-4990
en_US
openAccess
application/pdf
Biophysical Society
oai:kuscholarworks.ku.edu:1808/330852022-08-04T08:00:58Zcom_1808_1260col_1808_1952
A problem driven approach to the miniaturizsation and automation of enzyme-based assays and an investigation of the dissipation of cyanazine and bromide in wetland mesocosms
Fintschenko, Yolanda
Chemistry
Environmental science
Dissertation (Ph.D.)--University of Kansas, Chemistry, 1997.
Analytical chemistry, as a discipline, has something of an identity crisis. Its role in the development of instrumental methods frequently relegates it into the category of a technology, while the curiosity-driven fundamental studies of the technology drive it into the category of a science. Fortunately, it is possible to do both science and technology simultaneously. Fundamental studies and innovation in technology lead to the same result, better analyses. For this reason, regardless of the strategy of the study, analytical chemistry at its best is problem driven research. This work reflects the approach that it is of paramount importance to answer fundamental and technological questions in the context of real world problems.
Biological recognition elements have enjoyed popularity recently in analytical chemistry. Receptors such as antibodies have been demonstrated to achieve low limits of detection in diverse complex matrices from serum to ground water. Enzymes are an integral part of such bioassays, providing increased sensitivity as a result of the time dependence of their product production. The power of enzyme based immunoassays has been demonstrated since their introduction in 1971. However, enzymes alone have been shown to be valuable bioanalytical tools as exemplified by the plethora of research in the area of implantable amperometric glucose oxidase (GOx) based biosensors for glucose.
Biosensors or biologically based analytical methods must continue to evolve to prove useful in the changing landscape. Recent trends in new drug development have made different demands on the analytical chemist. No longer are simply good limits of detection, sensitivities, or high theoretical plates satisfactory for pharmaceutical companies. As thousands of combinatorial libraries queue up for analysis, speed and sample throughput have become increasingly important. Joining drug companies are hundreds of superfund sites, with millions of complex, toxic samples to be analyzed in a limited time frame. New demands brought about by the political climate in hospitals are forcing clinical labs to consider innovations to improve the speed and cost effectiveness of routine screening. Other considerations, such as minimizing contact with biological fluids brought about by concerns over hepatitis and HIV, renew interest in fundamental research in sample handling and preparation.
This work reflects the approach that it is of paramount importance to answer fundamental and technological questions in the context of real world problems. In Part One two related problems are described. Chapter One demonstrates that the enzyme linked immunosorbent assay (ELISA) may be used to assess the immunogenicity of the immobilized GOx on an implantable glucose sensor. Chapter Two addresses the problem of how enzyme based analytical methods such as those used in Chapter One are automated and miniaturized.
Part Two presents in Chapter Three the results of the environmental analysis of pond water drawn from wetland mesocosms treated with a herbicide and a volume tracer. The significance of this work is two-fold. First, inherent in a field study of this scope is the analytical challenges associated with sampling, sample handling and analysis specifically with respect to throughput. Explicitly, and more importantly, are the valuable discoveries related to the non-conservative behavior of both compounds applied.
2022-08-03T19:46:59Z
2022-08-03T19:46:59Z
1997-12-31
Dissertation
http://hdl.handle.net/1808/33085
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/67932019-04-12T14:34:43Zcom_1808_748col_1808_749
Improving Regulation Through Incremental Adjustment
Glicksman, Robert L.
Shapiro, Sidney A.
2010-10-05T21:48:02Z
2010-10-05T21:48:02Z
2004-03
Article
Robert L. Glicksman & Sidney A. Shapiro, Improving Regulation Through Incremental Adjustment, 52 University of Kansas Law Review 1179-1248 (2003-2004).
http://hdl.handle.net/1808/6793
en_US
openAccess
application/pdf
University of Kansas School of Law
oai:kuscholarworks.ku.edu:1808/183602020-06-24T18:09:36Zcom_1808_1260com_1808_82col_1808_7158col_1808_14224
A survey of national voluntary social welfare organizations in the United States
Starrett, Ellis L.
Thesis (M.A.)--University of Kansas, Sociology, 1920. ; Includes bibliographical references.
2015-08-19T21:03:16Z
2015-08-19T21:03:16Z
1920
Thesis
http://hdl.handle.net/1808/18360
eng
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/308042022-11-09T16:58:05Zcom_1808_7165com_1808_109col_1808_7166col_1808_110
Proceedings of the 3rd World Summit on Exploring the Dark Side of the Universe (EDSU2020): March 9–13, 2020, Guadeloupe Islands
Novikov, Alexander
Pétroff, Pierre
Royon, Christophe
The 3rd World Summit on Exploring the Dark Side of the Universe (EDSU2020) (https://indico.cern.ch/event/801461/overview) took place from March 9 to 13 in the Guadeloupe Islands, a picturesque French archipelago in the Caribbean. This was the 3rd meeting in this series of workshops, with previous editions held in the Galapagos Islands and Guadeloupe. The workshop was attended by 89 participants from 27 countries, including a large number of students. During the entire workshop, more than 60 talks were presented and many discussion sessions were held.
These Proceedings contain research presented at the 3rd World Summit on Exploring the Dark Side of the Universe (EDSU2020), one of the major venues of interaction between cosmologists and particle physicists. Topics include Cosmological Microwave Background, Large Scale Structure, Inflation and Early Universe, Particle Astrophysics, Dark Matter and Dark Energy, and Particle Physics.
2020-11-03T15:29:43Z
2020-11-03T15:29:43Z
2020-12-23
Book
978-1-936153-23-7
http://hdl.handle.net/1808/30804
Copyright of each chapter is held by the author. This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0)..
https://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
University of Kansas Libraries
oai:kuscholarworks.ku.edu:1808/345442024-01-16T16:39:36Zcom_1808_1260col_1808_1952
Assessing the Potential Aversiveness of Vicarious Reinforcement Arrangements in Preschool Children
Glaze, Stephanie
Neidert, Pamela L
Dozier, Claudia L
Morris, Edward K
Travers, Jason
Watson-Thompson, Jomella
Behavioral psychology
Psychology
Aversiveness
Behavior Analysis
Side Effects
Typically developing children
Vicarious Arrangements
Vicarious Reinforcement
Vicarious reinforcement (VSR) refers to a change in behavior as a result of observing the delivery of reinforcement to another person (Kazdin, 1973). As such, VSR procedures would appear to be a viable teaching strategy for use in group settings (e.g., preschool classrooms) as it may prove to be an efficient and effective strategy. However, some researchers have reported the emergence of problem behavior under conditions in which only the model’s behavior is reinforced and reinforcement is withheld from observers’ behavior (Gureghian, et al., 2013). The purpose of this study was to experimentally examine the extent to which a VSR positive arrangement may be aversive for young children by arranging conditions under which the observer can terminate (i.e., escape or avoid) the delivery of positive reinforcement to the model. To date, 5 typically developing preschool children have participated, and an experimental arrangement has been proposed for a follow-up study assessing the potential aversiveness of a vicarious negative reinforcement arrangement. Although results were mixed, the majority of observers displayed behavior suggesting that a VSR positive arrangement was aversive, and some participants exhibited negative side effects (e.g., problem behavior and negative vocalizations). Results are discussed in terms of implications and applied issues related to the use of VSR in the classroom and other applied settings.
2023-07-04T20:58:10Z
2023-07-04T20:58:10Z
2020-08-31
2020
Dissertation
http://dissertations.umi.com/ku:17396
https://hdl.handle.net/1808/34544
https://orcid.org/0000-0003-1127-0447
en
Copyright held by the author.
openAccess
98 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/67752020-06-25T18:20:49Zcom_1808_1260com_1808_267col_1808_1952col_1808_13988
A COMPARISON OF 2D IMAGE ANALYSIS AND DESIGN-BASED STEREOLOGY FOR EVALUATING MORPHOLOGICAL AND ANATOMICAL CHANGES IN THE DOPAMINERGIC SYSTEM OF THE RODENT MIDBRAIN
Park, Ji-Hyuk
Ahmad, Syed Omar
Radel, Jeff
Levant, Beth
Stanford, John A
Albertini, David F
Nanoscience
Biology
Morphology
Background. 2D analyses produce systematic errors in quantifying anatomical and morphological features in the brain. Design-based stereology overcomes this limitation by applying probability theory, yet many neuroscience investigators still use 2D analyses. The purpose of this study is to compare 2D analysis with design-based stereology in quantifying differences of morphological and anatomical features between groups. Methods. Brain tissue samples of three different rodent models were analyzed; chronic MPTP/probenecid PD (MPD) mouse model, alcohol preferring (AP) rat model, and the enriched environment (EE) rat model. 2D analyses and design-based stereology were used to quantify neuronal number, neuronal volume and regional volume. Student's t-test (two-tailed) was used to compare quantitative data. Results. 2D analyses generated significantly different estimation form design-based stereology in neuronal number and did not find relatively small differences of neuronal number. 2D analysis generated comparable value to design-based stereology in normalized data but not in actual value. 2D estimated accurately regional volume. Discussion. 2D analyses may be used for rough screening to find a difference of neuronal number and volume but should not for the estimation of actual value. Design-based stereology should be used to estimate neuronal number and volume. Both 2D analyses and design based stereology can be used for the estimation of regional volume.
2010-10-03T14:06:20Z
2010-10-03T14:06:20Z
2010-06-13
2010
Dissertation
http://dissertations.umi.com/ku:10993
http://hdl.handle.net/1808/6775
en
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
229 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/199382018-11-27T16:58:30Zcom_1808_231col_1808_19739
Improving Highway Work Zone Safety
Li, Yue
Chan, Mark Sai Leong
Firman, Umar
Finger, Kris
Mills, Megan M.
Bai, Yong
Schrock, Steven D.
Chong, Oswald
Atchley, Paul
Perlmutter, David D.
Highway work zones disrupt normal traffic flow and can create severe safety problems. Due to the rising needs in highway maintenance and construction in the United States, the number of work zones is increasing nationwide. With a total of 1,010 fatalities and more than 40,000 injuries occurring in 2006, improvements in work zone safety are necessary. The three
primary objectives of this research project included: 1) to determine the effectiveness of a Portable Changeable Message Sign (PCMS) in reducing vehicle speeds on two-lane, rural highway work zones; 2) to determine the effectiveness of a Temporary Traffic Sign (TTS), (W20-1, “Road Work Ahead”); and 3) to determine motorists’ responses to the signage. To accomplish these objectives, field experiments were conducted at US-36 and US-73 in Seneca and Hiawatha, Kansas, respectively. During the field experiments, an evaluation of the effectiveness of the PCMS was conducted under three different conditions: 1) PCMS on; 2)
PCMS off, but still visible; and 3) PCMS removed from the road and out of sight. The researchers also divided the vehicles into three classes (passenger car, truck, and semitrailer) and compared the mean speed change of these classes based on three different sign setups: PCMS on, PCMS off, and the use of the TTS (W20-1, “Road Work Ahead”). A survey was also conducted
at the experimental work zones to obtain a general understanding of the motorists’ attitudes as they traveled through the construction areas. Based on the data analysis results, researchers concluded that the presence of the PCMS effectively reduced vehicle speeds on two-lane highway work zones. A slow speed is more likely to reduce the probability of a crash or the
severity of a crash. In addition, researchers performed a univariate analysis of the variance test to determine if a significant interaction existed between motorists’ responses and the sign conditions. The results showed a significant interaction between the signs and passenger car vehicles.
2016-02-09T20:07:05Z
2016-02-09T20:07:05Z
2009-01
Technical Report
Li, Y., Chan, M., Firman, U., Finger, K., Mills, M., Bai, Y. Schrock, S., Chong, O., Atchley, P., and Perlmutter, D., "Improving Highway Work Zone Safety," Final Report, KU Transportation Research Institute, Kansas Department of Transportation, Federal Highway Administration, January 2009, 196 pgs.
http://hdl.handle.net/1808/19938
https://orcid.org/0000-0002-2814-0422
https://iri.ku.edu/reports
openAccess
application/pdf
University of Kansas Center for Research, Inc.
oai:kuscholarworks.ku.edu:1808/304232020-06-10T08:00:47Zcom_1808_5423col_1808_5425
Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits
Chakraborty, Mahul
Emerson, J.J.
Macdonald, Stuart J.
Long, Anthony D.
Evolution
Evolutionary biology
Genome
Genomics
Heritable quantitative trait
This work is licensed under a Creative Commons Attribution 4.0 International License.
It has been hypothesized that individually-rare hidden structural variants (SVs) could account for a significant fraction of variation in complex traits. Here we identified more than 20,000 euchromatic SVs from 14 Drosophila melanogaster genome assemblies, of which ~40% are invisible to high specificity short-read genotyping approaches. SVs are common, with 31.5% of diploid individuals harboring a SV in genes larger than 5kb, and 24% harboring multiple SVs in genes larger than 10kb. SV minor allele frequencies are rarer than amino acid polymorphisms, suggesting that SVs are more deleterious. We show that a number of functionally important genes harbor previously hidden structural variants likely to affect complex phenotypes. Furthermore, SVs are overrepresented in candidate genes associated with quantitative trait loci mapped using the Drosophila Synthetic Population Resource. We conclude that SVs are ubiquitous, frequently constitute a heterogeneous allelic series, and can act as rare alleles of large effect.
2020-06-09T18:59:24Z
2020-06-09T18:59:24Z
2019-10-25
Article
Chakraborty, M., Emerson, J. J., Macdonald, S. J., & Long, A. D. (2019). Structural variants exhibit widespread allelic heterogeneity and shape variation in complex traits. Nature communications, 10(1), 4872. https://doi.org/10.1038/s41467-019-12884-1
http://hdl.handle.net/1808/30423
10.1038/s41467-019-12884-1
https://orcid.org/0000-0003-2414-9187
https://orcid.org/0000-0001-9474-0891
https://orcid.org/0000-0002-9421-002X
https://orcid.org/0000-0002-5007-8514
PMC6814777
Copyright © 2019, Springer Nature
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Nature Research
oai:kuscholarworks.ku.edu:1808/215592019-04-12T14:23:52Zcom_1808_5634col_1808_5635
Humor in romantic relationships: A meta-analysis
Hall, Jeffrey A.
This record contains a table from an article that is currently in press for the journal "Personal Relationships." The accepted manuscript will be added to this record as soon as it is finalized.
2016-09-22T20:42:12Z
2016-09-22T20:42:12Z
2016
Article
Hall, J. A. (in press). Humor in romantic relationships: A meta-analysis. Personal Relationships.
http://hdl.handle.net/1808/21559
openAccess
application/pdf
Wiley
oai:kuscholarworks.ku.edu:1808/210652017-12-08T21:36:09Zcom_1808_979com_1808_1260col_1808_14116col_1808_1951
American interest in Chinese literature
Wilson, Emma Webber
Thesis (M.A.)--University of Kansas, English, 1924.
2016-06-30T14:47:27Z
2016-06-30T14:47:27Z
1924
Thesis
http://hdl.handle.net/1808/21065
eng
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/151842019-04-12T14:41:23Zcom_1808_5423col_1808_5425
Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans
Gracheva, Elena O.
Burdina, Anna O.
Holgado, Andrea M.
Berthelot-Grosjean, Martine
Ackley, Brian D.
Hadwiger, Gayla
Nonet, Michael L.
Weimer, Robby M.
Richmond, Janet E.
This is the publisher's version, also available electronically from http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.0040261.
Caenorhabditis elegans TOM-1 is orthologous to vertebrate tomosyn, a cytosolic syntaxin-binding protein implicated in the modulation of both constitutive and regulated exocytosis. To investigate how TOM-1 regulates exocytosis of synaptic vesicles in vivo, we analyzed C. elegans tom-1 mutants. Our electrophysiological analysis indicates that evoked postsynaptic responses at tom-1 mutant synapses are prolonged leading to a two-fold increase in total charge transfer. The enhanced response in tom-1 mutants is not associated with any detectable changes in postsynaptic response kinetics, neuronal outgrowth, or synaptogenesis. However, at the ultrastructural level, we observe a concomitant increase in the number of plasma membrane-contacting vesicles in tom-1 mutant synapses, a phenotype reversed by neuronal expression of TOM-1. Priming defective unc-13 mutants show a dramatic reduction in plasma membrane-contacting vesicles, suggesting these vesicles largely represent the primed vesicle pool at the C. elegans neuromuscular junction. Consistent with this conclusion, hyperosmotic responses in tom-1 mutants are enhanced, indicating the primed vesicle pool is enhanced. Furthermore, the synaptic defects of unc-13 mutants are partially suppressed in tom-1 unc-13 double mutants. These data indicate that in the intact nervous system, TOM-1 negatively regulates synaptic vesicle priming.
2014-10-06T18:40:50Z
2014-10-06T18:40:50Z
2006-07-25
Article
Gracheva, Elena O. et al. (2006). "Tomosyn Inhibits Synaptic Vesicle Priming in Caenorhabditis elegans." PLOS Biology, 4(8):e261. http://www.dx.doi.org/10.1371/journal.pbio.0040261
1544-9173
http://hdl.handle.net/1808/15184
10.1371/journal.pbio.0040261
openAccess
application/pdf
Public Library of Science
oai:kuscholarworks.ku.edu:2271/2472019-07-17T05:18:02Zcom_2271_237com_2271_236com_2271_235com_1808_197col_2271_238
Homophobia: Does it Affect Quality of Care?
Henrici, Roxane
The University of Kansas School of Nursing
Martin, David
Homophobia
Homosexuals/Ethical Issues
Nursing Care
2007-07-18T15:57:49Z
2007-07-18T15:57:49Z
2007-07-18
Article
1938-9345
http://hdl.handle.net/2271/247
en
en_US
openAccess
application/pdf
oai:kuscholarworks.ku.edu:1808/133992019-04-12T14:35:04Zcom_1808_275col_1808_745
Acoustic characteristics of clearly spoken English fricatives
Maniwa, Kazumi
Jongman, Allard
This is the publisher's version, also available electronically from http://scitation.aip.org/content/asa/journal/jasa/125/6/10.1121/1.2990715
Speakers can adopt a speaking style that allows them to be understood more easily in difficult communication situations, but few studies have examined the acoustic properties of clearly produced consonants in detail. This study attempts to characterize the adaptations in the clear production of American English fricatives in a carefully controlled range of communication situations. Ten female and ten male talkers produced fricatives in vowel-fricative-vowel contexts in both a conversational and a clear style that was elicited by means of simulated recognition errors in feedback received from an interactive computer program. Acoustic measurements were taken for spectral, amplitudinal, and temporal properties known to influence fricative recognition. Results illustrate that (1) there were consistent overall style effects, several of which (consonant duration, spectral peak frequency, and spectral moments) were consistent with previous findings and a few (notably consonant-to-vowel intensity ratio) of which were not; (2) specific acoustic modifications in clear productions of fricatives were influenced by the nature of the recognition errors that prompted the productions and were consistent with efforts to emphasize potentially misperceived contrasts both within the English fricative inventory and based on feedback from the simulated listener; and (3) talkers differed widely in the types and magnitude of all modifications.
2014-04-03T13:52:55Z
2014-04-03T13:52:55Z
2009-06-01
Article
Maniwa, Kazumi and Jongman, Allard and Wade, Travis. 2009. “Acoustic characteristics of clearly spoken English fricatives.” The Journal of the Acoustical Society of America, 125, 3962-3973. http://dx.doi.org/10.1121/1.2990715
0001-4966
http://hdl.handle.net/1808/13399
10.1121/1.2990715
openAccess
application/pdf
The Acoustical Society of America
oai:kuscholarworks.ku.edu:1808/42012020-07-22T12:06:04Zcom_1808_1260com_1808_275col_1808_1952col_1808_13662
Acoustic Realization and Perception of English Lexical Stress by Mandarin Learners
Lai, Yuwen
Jongman, Allard
Sereno, Joan
Zhang, Jie
Gabriele, Alison
Vitevitch, Michael
Language, linguistics
Production
Perception
English
Stress
Chinese language
L2 learning
Mandarin Chinese
The acquisition of English lexical stress by Mandarin L2 learners was examined. An acoustic study focusing on the implementation of mean F0, max F0, duration, intensity, and F2 in stressed and unstressed vowels in noun-verb word pairs contrasting in stress location (e.g. object-object) was conducted. The results indicate that native English speakers use all correlates in nouns but rely mostly on duration in verbs. The learners use these cues more consistently across different contexts. A perceptual study utilizing the disyllabic nonword 'dada', with resynthesized max F0, duration, and vowel quality indicates that full vowels induce stronger stress perception in all listener groups. Beginning listeners relied on duration, advanced listeners focused on max F0, while native listeners used both in perception. The similarities and differences in prosodic systems between Mandarin and English, as well as the possible discrepancies in production and perception data from second language learning research were discussed.
2008-09-15T04:39:05Z
2008-09-15T04:39:05Z
2008-08-21
2008
Dissertation
http://dissertations2.umi.com/ku:2669
http://hdl.handle.net/1808/4201
https://orcid.org/0000-0003-0136-4677
EN
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
146 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/299552020-10-13T21:01:40Zcom_1808_4471col_1808_4472
A comparison of Kato-Katz technique to three other methods for diagnosis of Amphimerus spp. liver fluke infection and the prevalence of infection in Chachi Amerindians of Ecuador
Calvopina, Manuel
Romero-Alvarez, Daniel
Diaz, Fernando
Cevallos, William
Sugiyama, Hiromu
Diemert, David Joseph
Background
Recently, a high prevalence of infection by the liver fluke Amphimerus spp. has been documented
in the Chachi Amerindians of Ecuador. For diagnosis, no studies exist that compare
the sensitivity of different coproparasitological detection techniques. The present study compares
the Kato-Katz technique with three other coproparasitological methods for detecting
eggs of Amphimerus in stools, as well as determines the prevalence of infection in Chachi
residents in a Tropical rain forest area in the northwest coast of Ecuador.
Methodology/Results
A total of 105 samples, utilizing the Kato-Katz technique (KK), the spontaneous sedimentation
technique in tube (SSTT), the formalin-ether concentration technique (FEC), and direct
smear microscopy (DM), were examined. Combining the four methods (fixed ªgoldº standard),
38 samples were positive with a prevalence of infection of 36.2%. The sensitivities of
individual methods were 71%, 58%, 50% and 3% for KK, SSTT, FEC, and DM respectively.
Our results indicated that KK alone had the best performance, detecting 27 (71%) of the 38
positive samples. The combination of KK and SSTT detected amphimeriasis in 36 (95%)
samples, and KK and FEC in 31 (82%) samples.
Conclusions
DM showed the lowest sensitivity, which raises concern for its value, because it is the standard
technique for stool examination for detection of parasites in both public and private
laboratories in Ecuador. SSTT alone detected eggs in 22 samples (58%) and would be recommended
for field studies because of its simplicity. Performing two techniques on a single
sample enhances the detection of Amphimerus infection. Its sensitivity is relative to a fixed ªgoldº standard, determined as the combined results of the four techniques performed. This
study confirms the high prevalence of human infection by Amphimerus in the indigenous
Chachi group where the first human cases were described.
CUP 91750000.0000.374072
KAKENHI: Grant No.16H05820
2020-02-07T15:46:47Z
2020-02-07T15:46:47Z
2018-10-04
Article
Calvopina M, Romero-Alvarez D, Diaz F,
Cevallos W, Sugiyama H (2018) A comparison of
Kato-Katz technique to three other methods for
diagnosis of Amphimerus spp. liver fluke infection
and the prevalence of infection in Chachi
Amerindians of Ecuador. PLoS ONE 13(10):
e0203811.
http://hdl.handle.net/1808/29955
10.1371/journal.pone.0203811
https://orcid.org/0000-0002-0286-0747
© 2018 Calvopina et al. This is an open
access article distributed under the terms of the
Creative Commons Attribution License, which
permits unrestricted use, distribution, and
reproduction in any medium, provided the original
author and source are credited.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Public Library of Science
oai:kuscholarworks.ku.edu:1808/212332021-08-27T17:44:27Zcom_1808_979com_1808_1260col_1808_14116col_1808_7158
Attitudes toward death and immortality in modern American verse
Wallace, Ernest Leon
Thesis (M.A.)--University of Kansas, English, 1925.
2016-07-29T15:13:07Z
2016-07-29T15:13:07Z
1925
Thesis
http://hdl.handle.net/1808/21233
eng
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/136992019-04-12T14:33:50Zcom_1808_4471col_1808_4472
Assessments of Biodiversity Based on Molecular Markers and Morphological Traits among West-Bank, Palestine Fig Genotypes (Ficus carica L.)
Basheer-Salimia, Rezq
Awad, Murad
Ward, Joy K.
Cluster Analysis
Ficus carica L.
Genetic Variability
Random Amplified Polymorphic DNA
Morphological Descriptors
This is the publisher's version, also available electronically from http://www.scirp.org/journal/ajps/
Both morphological characters and PCR-based RAPD approaches were used to determine the genetic diversity and re- latedness among nine fig genotypes grown at the northern region of the West-Bank, Palestine. Although we tested 28 primers for the RAPD technique, only 9 produced reasonable amplification products. A total of 57 DNA loci were de- tected in which 70.2% were polymorphic. DNA fragments presented a minimum of 3 and a maximum of 9 polymorphic bands using primers OPT-10 and OPA-18, respectively. Primers exhibited collective resolving power values (Rp) of 18.826. The Mwazi genotype showed the highest genetic distances among all of the other genotypes. Morphologically, considerable variations were found using 41 quantitative and qualitative traits. Adloni could be a very promising geno- type for fresh consumption due to its very late maturation period, extended harvesting period, variable fruit size, and easy skin peeling. In addition, 7 genotypes presented firm fruits, which are a very important criterion for exporting purposes. Dendrogram constructed by UPGMA based on RAPD banding patterns appear somewhat contradictory to the morphological descriptors particularly with Swadi and Biadi genotypes (closed genetically and distanced morphologi- cally), which might be attributed to the phenotypic modifications caused by environmental differences across regions. These preliminary results will make a fundamental contribution to further genetic improvement of fig crops for the region.
2014-05-20T16:27:46Z
2014-05-20T16:27:46Z
2012-09-26
Article
Rezq Basheer-Salimia, Murad Awad, and Joy Ward. "Assessments of Biodiversity Based on Molecular Markers and Morphological Traits among West-Bank, Palestine Fig Genotypes (Ficus carica L.)." American Journal of Plant Sciences 3:1241-1251. http://dx.doi.org/10.4236/ajps.2012.39150
http://hdl.handle.net/1808/13699
10.4236/ajps.2012.39150
openAccess
application/pdf
Scientific Research
oai:kuscholarworks.ku.edu:1808/328192024-01-16T16:12:07Zcom_1808_97col_1808_102
One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles
Aksenov, Nicolai A.
Aksenov, Alexander V.
Kurenkov, Igor A.
Kirillov, Nikita K.
Aksenov, Dmitrii A.
Arutiunov, Nikolai A.
Aksenova, Daria S.
Rubin, Michael
Nitroalkanes
Brønsted acid catalysis
Indoles
Rearrangements
Cascade transformations
A highly efficient and expeditious one-pot approach towards 2-(3-oxoindolin-2-yl)acetonitriles was designed, which involves a base-assisted aldol reaction of ortho-nitroacetophenones, followed by hydrocyanation, triggering an unusual reductive cyclization reaction.
2022-07-11T18:43:27Z
2022-07-11T18:43:27Z
2022-04-28
Article
Aksenov, N.A.; Aksenov, A.V.; Kurenkov, I.A.; Kirillov, N.K.; Aksenov, D.A.; Arutiunov, N.A.; Aksenova, D.S.; Rubin, M. One-Pot Synthesis of (E)-2-(3-Oxoindolin-2-ylidene)-2-arylacetonitriles. Molecules 2022, 27, 2808. https://doi.org/10.3390/molecules27092808
http://hdl.handle.net/1808/32819
10.3390/molecules27092808
https://orcid.org/ 0000-0002-7125-9066
https://orcid.org/ 0000-0002-0911-4093
https://orcid.org/ 0000-0002-1668-9311
PMC35566159
© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
MDPI
oai:kuscholarworks.ku.edu:1808/240222019-04-12T14:16:38Zcom_1808_80col_1808_81
cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells
Chittasupho, Chuda
Manikwar, Prakash
Krise, Jeffrey P.
Siahaan, Teruna J.
Berkland, Cory J.
LFA-1
Leukocytes
Peptide
Nanoparticles
Targeting
Leukocyte function associated antigen-1 (LFA-1) is a primary cell adhesion molecule of leukocytes required for mediating cellular transmigration into sites of inflammation via the vascular endothelium. A cyclic peptide, cIBR, possesses high affinity for LFA-1 and conjugation to the surface of poly(dl-lactic-co-glycolic acid) nanoparticles can specifically target and deliver the encapsulated agents to T cells expressing LFA-1. The kinetics of targeted nanoparticle uptake by acute lymphoblastic leukemia T cells was investigated by flow cytometry and microscopy and compared to untargeted nanoparticles. The specificity of targeted nanoparticles binding to the LFA-1 integrin was demonstrated by competitive inhibition using free cIBR peptide or using the I domain of LFA-1 to inhibit the binding of targeted nanoparticles. The uptake of targeted nanoparticles was concentration and energy dependent. The cIBR-conjugated nanoparticles did not appear to localize with lysosomes whereas untargeted nanoparticles were detected in lysosomes in 6 hrs and steadily accumulated in lysosomes for 24 hrs. Finally, T-cell adhesion to epithelial cells was inhibited by cIBR-nanoparticles. Thus, nanoparticles displaying the cIBR ligand may offer a useful targeted drug delivery system as an alternative treatment of inflammatory diseases involving transmigration of leukocytes.
2017-05-08T18:41:55Z
2017-05-08T18:41:55Z
2010-02-01
Article
Chittasupho, C., Manikwar, P., Krise, J. P., Siahaan, T. J., & Berkland, C. (2010). cIBR effectively targets nanoparticles to LFA-1 on acute lymphoblastic T cells. Molecular Pharmaceutics, 7(1), 146. http://doi.org/10.1021/mp900185u
http://hdl.handle.net/1808/24022
10.1021/mp900185u
PMC2815130
This document is the Accepted Manuscript version of a Published Work that appeared in final form in Molecular Pharmaceutics, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see http://doi.org/10.1021/mp900185u.
openAccess
application/pdf
American Chemical Society
oai:kuscholarworks.ku.edu:1808/174022018-04-25T18:19:12Zcom_1808_774col_1808_775
The impact of reverberant self-masking and overlap-masking effects on speech intelligibility by cochlear implant listeners (L)
Kokkinakis, Kostas
Loizou, Philipos C.
Phonetic segments
Speech Intelligibility
Cochlear implants
Acoustical effects
Speech
This is the published version, also available here: http://dx.doi.org/10.1121/1.3614539.
The purpose of this study is to determine the relative impact of reverberant self-masking and overlap-masking effects on speech intelligibility by cochlear implant listeners. Sentences were presented in two conditions wherein reverberant consonant segments were replaced with clean consonants, and in another condition wherein reverberant vowel segments were replaced with clean vowels. The underlying assumption is that self-masking effects would dominate in the first condition, whereas overlap-masking effects would dominate in the second condition. Results indicated that the degradation of speech intelligibility in reverberant conditions is caused primarily by self-masking effects that give rise to flattened formant transitions.
2015-04-13T21:33:58Z
2015-04-13T21:33:58Z
2011-05-05
Article
Kokkinakis, Kostas & Loizou, Philipos C. "The impact of reverberant self-masking and overlap-masking effects on speech intelligibility by cochlear implant listeners (L)." J. Acoust. Soc. Am. 130, 1099 (2011); http://dx.doi.org/10.1121/1.3614539.
http://hdl.handle.net/1808/17402
10.1121/1.3614539
openAccess
application/pdf
Acoustical Society of America
oai:kuscholarworks.ku.edu:1808/122892020-10-08T14:23:00Zcom_1808_1260com_1808_1815col_1808_1952col_1808_14127
RECONSTRUCTING CLIMATE ON THE GREAT PLAINS FROM BURIED SOILS: A QUANTITATIVE APPROACH
Zung, Ashley B.
Feddema, Johannes J.
Mandel, Rolfe D
Slocum, Terry A.
Billings, Sharon A
Hofman, Jack L.
Physical geography
Paleoclimate science
Geomorphology
Buried soils
Great plains
Late-quaternary
Paleoclimate
Paleoenvironmental reconstructions
Stable carbon isotopes
The Great Plains, U.S.A. lack quantitative paleoclimatic data for the late Quaternary largely because two common sources of paleoclimatic data, tree ring and pollen records, are rare in the region. Sequences of buried soils, however, are commonly preserved in eolian and alluvial sediments on the Great Plains and have the potential to enhance the region's paleoclimate record. This research presents a study of buried soils preserved in the Caddo Canyons of central Oklahoma to highlight opportunities and considerations for using buried soils to reconstruct past climate. Results indicate that sequences of buried soils dating to the mid- and late-Holocene are commonly preserved in the canyons. Canyon geomorphology dictates the nature of the fill contained in the canyons, and the effect of geomorphology and microclimate on soil formation must be carefully considered when interpreting the buried soil and stable carbon isotope record from the canyons. In an effort to capitalize on the rich paleoenvironmental record that buried soils can provide, this study presents the Buried Soil Reconstruction Model (BuSCR), a method for reconstructing paleoclimate based on properties of buried soils. The model was developed based on a study of modern analogue soils and climate on the Great Plains. BuSCR reconstructs mean annual precipitation (MAP), moisture index (Im), and mean annual temperature (MAT) with statistically significant results (r2 = 0.4, p < .0001) and low mean average errors. While error increases on the edges of the Great Plains climate envelope, application of BuSCR to a series of buried soils across the Great Plains, including soils from the Caddo Canyons, shows that it corroborates both paleoenvironmental reconstructions using other proxies (e.g. dune activation histories) and model-simulated hindcasts. In particular, BuSCR reconstructions corroborate model simulations of a -25% MAP anomaly during the Medieval Warm Period and a drastic reduction in MAP and Im across the Great Plains during the Altithermal. These results indicate that the BuSCR model, with further testing and if applied widely to buried soils across the Great Plains, could provide quantitative reconstructions of past climate that fill a current hole in the North American paleoclimate database.
2013-09-29T17:53:10Z
2013-09-29T17:53:10Z
2013-05-31
2013
Dissertation
http://dissertations.umi.com/ku:12828
http://hdl.handle.net/1808/12289
en
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
129 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/57172018-04-04T19:30:20Zcom_1808_1776col_1808_1778
Review of Negotiating Island Identities: the Use of Pottery in the Middle and Late Bronze Age Cyclades, by Ina Berg
Younger, John G.
Aegean
Cyclades
Prehistoric
Theory
Book review.
2010-01-21T23:51:53Z
2010-01-21T23:51:53Z
2009-10
Article
Review of: Negotiating Island Identities: the Use of Pottery in the Middle and Late Bronze Age Cyclades (Gorgias Dissertations 31, Classics 5), by Ina Berg (Piscataway NJ: Gorgias Press, 2007). In: Cambridge Archaeological Journal 19.3 (October 2009) 457-59.
http://hdl.handle.net/1808/5717
openAccess
application/pdf
Cambridge Archaeological Journal
oai:kuscholarworks.ku.edu:1808/322292021-12-02T09:01:04Zcom_1808_100col_1808_101
Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay
Zhao, Yuanzi
Joshi, Anand A.
Aldrich, Jane V.
Murray, Thomas F.
Opioid
Kappa receptor
Hyperpolarization
Fluorescence
Dynorphin
Efficacy
We explored the utility of the real-time FLIPR Membrane Potential (FMP) assay as a method to assess kappa opioid receptor (KOR)-induced hyperpolarization. The FMP Blue dye was used to measure fluorescent signals reflecting changes in membrane potential in KOR expressing CHO (CHO-KOR) cells. Treatment of CHO-KOR cells with kappa agonists U50,488 or dynorphin [Dyn (1−13)NH2] produced rapid and concentration-dependent decreases in FMP Blue fluorescence reflecting membrane hyperpolarization. Both the nonselective opioid antagonist naloxone and the κ-selective antagonists nor-binaltorphimine (nor-BNI) and zyklophin produced rightward shifts in the U50,488 concentration-response curves, consistent with competitive antagonism of the KOR mediated response. The decrease in fluorescent emission produced by U50,488 was blocked by overnight pertussis toxin pretreatment, indicating the requirement for PTX-sensitive G proteins in the KOR mediated response. We directly compared the potency of U50,488 and Dyn (1−13)NH2 in the FMP and [35S]GTPγS binding assays, and found that both were approximately 10 times more potent in the cellular fluorescence assay. The maximum responses of both U50,488 and Dyn (1−13)NH2 declined following repeated additions, reflecting receptor desensitization. We assessed the efficacy and potency of structurally distinct KOR small molecule and peptide ligands. The FMP assay reliably detected both partial agonists and stereoselectivity. Using KOR-selective peptides with varying efficacies, we found that the FMP assay allowed high throughput quantification of peptide efficacy. These data demonstrate that the FMP assay is a sensitive method for assessing κ-opioid receptor induced hyperpolarization, and represents a useful approach for quantification of potency, efficacy and desensitization of KOR ligands.
2021-12-01T21:06:45Z
2021-12-01T21:06:45Z
2021-11
Article
Zhao, Y., Joshi, A. A., Aldrich, J. V., & Murray, T. F. (2021). Quantification of kappa opioid receptor ligand potency, efficacy and desensitization using a real-time membrane potential assay. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 143, 112173. https://doi.org/10.1016/j.biopha.2021.112173
http://hdl.handle.net/1808/32229
10.1016/j.biopha.2021.112173
© 2021 The Author(s). Published by Elsevier Masson SAS. This is an open access article under the CC BY-NC-ND license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
openAccess
application/pdf
Elsevier
oai:kuscholarworks.ku.edu:1808/267832018-11-29T17:53:00Zcom_1808_231col_1808_290
Deficiencies in Traditional Oral Dosage Forms and the Emergence of Controlled-Release Powder Manufacturing
Teresk, Martin G.
Berkland, Cory J.
Dormer, Nathan Henry
The importance of providing safe and effective delayed- and extended-release oral formulations that can replace products requiring multiple administrations has been continually cited as an area in need of improvement for pharmaceutical companies. Such controlled release challenges become especially critical when they must be adapted for paediatrics, those suffering from dysphagia, or patients with specific dosage administration limitations. More often than not, lack of palatability and taste-masking compound this formulation challenge. Many particulate approaches show promise, but can be fraught with broad particle size distributions, initial drug burst, poor drug entrapment efficiency, low drug loading, and limited scalability. Here, we summarize the key factors that drive formulation development of format-flexible controlled-release oral powders, and the manufacturing aspects involved with some of the foremost marketed products, including next-generation single-step layered powder manufacturing (below).
2018-10-04T18:27:57Z
2018-10-04T18:27:57Z
2017
Article
Teresk, M.G., Berkland, C.J., Dormer, N. H.: Deficiencies in Traditional Oral Dosage Forms and the Emergence of Controlled-Release Powder Manufacturing, KONA Powder and Particle Journal, https://doi.org/10.14356/kona.2017013
http://hdl.handle.net/1808/26783
https://doi.org/10.14356/kona.2017013
Copyright © 2016 The Authors. Published by Hosokawa Powder Technology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0)
http://creativecommons.org/licenses/by/4.0
openAccess
application/pdf
Hosokawa Powder Technology Foundation
oai:kuscholarworks.ku.edu:1808/346122023-11-07T19:46:15Zcom_1808_1260col_1808_1952
De Cortés al Mago de Oz: Estrategias posmodernas en el teatro latinoamericano: 1980-1992
Seda, Laurietz
Latin American literature
Theater
Caribbean literature
Dissertation (Ph.D.)--University of Kansas, Spanish and Portuguese, 1995.
This work analyzes nine postmodern Latin American plays written between 1980 and 1992. A series of strategies including the combination of elite and mass culture, the mixture of various literary and nonliterary genres, anachronism, ahistoricity, metafiction, transvestism and parody are used by the playwrights to question the traditional beliefs of history, genre, gender and art. By exploring these strategies, I demonstrate how the plays dismantle not only the traditions and conventions already established in different Latin American societies, but the very discourses that created them. These plays question the way in which a vision of reality and of human nature has been constructed.
In chapter one, I analyze Sabina Berman's Aguila o sol (Mexico), Roberto Ramos-Perea's Mistiblu (Puerto Rico), and Marco Antonio de la Parra's La secreta obscenidad de cada dia (Chile). The concept of "historiographic metafiction" is used to study how each play uses different historical discourses to reveal the way in which history has been constructed, and its implications for the countries represented in these plays.
Chapter two emphasizes the disappearance of the dividing lines between elite and mass culture. In Consuelo de Castro's Aviso Previo (Brazil), Rodolfo Santana's Santa Isabel del Video (Venezuela), and Mauricio Kartun's Chau Misterix (Argentina), I explore how the disappearance of these lines impugns the grand narratives, the centralized vision of power, and power relations respectively.
Chapter three analyzes the way in which human genders are constructed by patriarchal societies in Latin America. Diana Raznovich's Casa Matriz (Argentina) dismantles the role of mothers in society. Susana Torres Molina's...Y a otra cosa mariposa (Argentina), uses the technique of transvestism to denaturalize the traditional definitions of gender.
In chapter four, the study of Joel Cano's Timeball (Cuba) explains how the playwright proposes a new way of viewing the world where the ideas of margin and center are no longer able to exist. Barriers established by the theatrical conventions are also eliminated as he presents a different kind of drama, one that he will call "theatrical cartomancy."
2023-07-12T14:07:40Z
2023-07-12T14:07:40Z
1995-12-31
Dissertation
https://hdl.handle.net/1808/34612
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/143822019-04-12T14:41:35Zcom_1808_8689com_1808_8675col_1808_19783
KU Today, April 9, 2013
KU Today is the daily e-newsletter of the University of Kansas
2014-06-26T21:06:52Z
2014-06-26T21:06:52Z
2013-04-09
Other
http://hdl.handle.net/1808/14382
en_US
openAccess
application/pdf
News and Media Relations, Office of
oai:kuscholarworks.ku.edu:1808/71532019-04-12T14:35:44Zcom_1808_592col_1808_593
Sustainable Transportation Design In the United States: Background, Current Initiatives and Optimization
Schroer, Anne
Decades of increased highway maintenance and construction, the constant use of finite resources, the severity of highway accidents, increased congestion, harmful emissions, and other negative environmental impacts have created an unsustainable highway system in the United States. While the modern environmental movement began in the 1960’s, American’s have only recently realized that something must be done regarding the environmental impacts due to the development of transportation systems.
To date, there isn’t a single most commonly used definition of sustainable transportation, however; sustainable transportation can be linked to sustainable development which is most commonly defined as, “development that meets the needs of the present without compromising the ability of future generations to meet their own needs”.
Thus far, much of the focus on sustainable transportation has been on green-house gases (GHG’s) and other harmful emissions of the automobiles which use U.S. highways. While this is indeed a significant factor negatively affecting the environment, economy and social well-being of American’s, it is not the only issue with transportation systems in the United States.
Since the development of the modern federal highway system began in the 1950’s, highway design, construction, operations and maintenance efforts have enjoyed nearly infinite use of America’s valuable resources. Unfortunately the use of these valuable resources is now outpacing the rate at which they can be renewed, which could soon result in the elimination or unavailability of certain resources if the development of America’s roadways doesn’t change.
In response to this new dilemma, several initiatives have recently been introduced across America to address the unsustainable nature of transportation projects. Some of these include sustainable rating systems similar to the LEED (Leadership in Energy and Environmental Design) rating system for buildings developed by the United States Green Building Council (USGBC). Most of these systems are in the infant stages of development and implementation and the actual environmental benefits that result from using these systems is yet to be seen.
There are several pros and cons for sustainable transportation rating systems. The pros are the environmental and sustainable benefits that result in using a system directed toward sustainability. The cons are a little more complex. They include the unknowns like the time, cost and effort for certification, the integrity of the system, and the question of whom, in the end, is responsible for certification. Even so, with the success of the LEED rating system, it would be surprising if these systems were unsuccessful.
However, just because these systems are expected to succeed, does not infer that other avenues toward sustainable transportation should not be explored.
Sustainable transportation optimization is a new concept presented in this paper which combines rating systems with linear programming models by using cost and public input as well as site specific environmental concerns as part of the decision-making process for inclusion of sustainable measures in a given project. Like sustainable transportation rating systems, further research is needed to determine if it is worth the extra effort that may be required for implementing a sustainable transportation optimization system.
2011-03-04T15:53:01Z
2011-03-04T15:53:01Z
2010-12-17
Project
http://hdl.handle.net/1808/7153
en_US
openAccess
application/pdf
oai:kuscholarworks.ku.edu:1808/274222018-11-28T09:02:35Zcom_1808_1260com_1808_5423col_1808_1952col_1808_8662
A study of rennin action
Wahlin, Joel G.
Dissertation (Ph.D.)--University of Kansas, Bacteriology, 1927.
2018-11-27T15:55:19Z
2018-11-27T15:55:19Z
1927
Dissertation
http://hdl.handle.net/1808/27422
eng
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/85162020-08-27T14:26:16Zcom_1808_231com_1808_1260col_1808_18153col_1808_7158
Appraisal Seattle, Renton and Southern Railway Company
Fletcher, John H.
2011-11-23T16:48:00Z
2011-11-23T16:48:00Z
1913
Thesis
http://hdl.handle.net/1808/8516
en_US
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
59 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/19772020-07-15T12:08:03Zcom_1808_231com_1808_1260col_1808_18153col_1808_1951
Prime Number-Based Hierarchical Data Labeling Scheme for Relational Databases
Morozov, Serhiy
Saiedian, Hossein
Agah, Arvin
Sterbenz, James
Computer science
Hierarchical data structures are an important aspect of many computer science fields including data mining, terrain modeling, and image analysis. A good representation of such data accurately captures the parent-child and ancestor-descendent relationships between nodes. There exist a number of different ways to capture and manage hierarchical data while preserving such relationships. For instance, one may use a custom system designed for a specific kind of hierarchy. Object oriented databases may also be used to model hierarchical data. Relational database systems, on the other hand, add an additional benefit of mature mathematical theory, reliable implementations, superior functionality and scalability. Relational databases were not originally designed with hierarchical data management in mind. As a result, abstract information can not be natively stored in database relations. Database labeling schemes resolve this issue by labeling all nodes in a way that reveals their relationships. Labels usually encode the node's position in a hierarchy as a number or a string that can be stored, indexed, searched, and retrieved from a database. Many different labeling schemes have been developed in the past. All of them may be classified into three broad categories: recursive expansion, materialized path, and nested sets. Each model has its strengths and weaknesses. Each model implementation attempts to reduce the number of weaknesses inherent to the respective model. One of the most prominent implementations of the materialized path model uses the unique characteristics of prime numbers for its labeling purposes. However, the performance and space utilization of this prime number labeling scheme could be significantly improved. This research introduces a new scheme called reusable prime number labeling (rPNL) that reduces the effects of the mentioned weaknesses. The proposed scheme advantage is discussed in detail, proven mathematically, and experimentally confirmed.
2008-03-01T15:13:52Z
2008-03-01T15:13:52Z
2007-12-13
2007
Thesis
http://dissertations.umi.com/ku:2323
http://hdl.handle.net/1808/1977
EN
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
84 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/173652019-04-12T14:50:32Zcom_1808_5423col_1808_5425
Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch
Marquez, Rebecca T.
Xu, Liang
Apoptosis
autophagy
Bcl-2
Beclin 1
Gossypol
BH3 mimetics
This is the published version, also available here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/.
Cancer cells have developed novel mechanisms for evading chemotherapy-induced apoptosis and autophagy-associated cell death pathways. Upon the discovery that chemotherapeutics could target these cell death pathways in a manner that was not mutually exclusive, new discoveries about the interrelationship between these two pathways are emerging. Key proteins originally thought to be “autophagy-related proteins” are now found to be involved in either inducing or inhibiting apoptosis. Similarly, apoptosis inhibiting proteins can also block autophagy-associated cell death. One example is the complex formed by the autophagy protein, Beclin 1, and anti-apoptotic protein Bcl-2, which leads to inhibition of autophagy-associated cell death. Researchers have been investigating additional mechanisms that form/disrupt this complex in order to better design chemotherapeutics. This review will highlight the role Bcl-2 and Beclin 1 play in cancer development and drug resistance, as well as the role the Bcl-2:Beclin 1 complex in the switch between autophagy and apoptosis.
2015-04-09T17:00:54Z
2015-04-09T17:00:54Z
2012-02-28
Article
Marquez, Rebecca T. & Xu, Liang. "Bcl2:Beclin 1 complex: multiple mechanisms regulating autophagy/apoptosis toggle switch." (2011) Am J Cancer Res. 2012; 2(2): 214–221.
http://hdl.handle.net/1808/17365
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3304572/
openAccess
application/pdf
e-Century Publishing
oai:kuscholarworks.ku.edu:1808/83252019-04-16T16:58:45Zcom_1808_3892col_1808_18180col_1808_3929
Efficacy of Learning Strategies Instruction in Adult Basic Education
Hock, Mike
Mellard, Daryl F.
Adult Literacy
Strategic Instruction
Learning Strategies
Results from randomized controlled trials of learning strategies instruction with 375 adult basic
education (AE) participants are reported. Reading outcomes from whole group strategic instruction in one of four learning strategies were compared to outcomes of reading instruction delivered in the context of typical adult education units on social studies, history, and science. Both experimental and control conditions experienced high attrition and low attendance, resulting in only 105 control and 100 experimental participants’ data in outcome analyses for the trials of the four learning strategies. Reading outcomes for these completers were not significantly different between experimental and control conditions, and each group achieved minimal gains. We discuss possible reasons for the non-significant effect from the intervention, including insufficient instructional dosage.
2011-11-01T16:25:48Z
2011-11-01T16:25:48Z
2011
Article
Hock, M., & Mellard, D.F. (2011). Efficacy of learning strategies instruction in adult basic education. Journal of Research on Educational Effectiveness. 4(2), 134-153.
http://hdl.handle.net/1808/8325
en_US
openAccess
application/pdf
Journal of Research on Educational Effectiveness
oai:kuscholarworks.ku.edu:1808/269452018-10-25T20:10:16Zcom_1808_1260com_1808_197col_1808_1952col_1808_18171
Role of MicroRNA-29 and ADAM12 in the Regulation of REST Dependent Signaling Pathways in Uterine Fibroids
Farahbakhsh, Mina
Chennathukuzhi, Vargheese M
Blanco, Gustavo
Rongish, Brenda J
Nothnick, Warren B
Jensen, Roy A
Physiology
ADAM12
Leiomyoma
MicroRNA-29
Notch
REST
Uterine Fibroids
Uterine fibroids, also known as leiomyomas, are benign smooth muscle cell (SMC) tumors of the myometrium and are the most frequent reason for a hysterectomy. Although benign, these tumors pose a significant burden on patients with symptoms of abdominal pain, pressure, uterine bleeding, and infertility; creating a great liability for the US economy with an annual estimated cost of up to $34 billion. Currently there are no long-term treatments for fibroids that will leave fertility intact, mainly because the mechanism of pathogenesis of these tumors is largely unknown. One of the key characteristics of uterine fibroids is the excessive deposition and reorganization of extracellular matrix (ECM). Altered ECM, which amplifies growth factor signaling and disrupts mechanosensing, has been proposed to promote fibroid tumor growth. Analysis of available gene expression datasets from GEO database indicates that ADAM12 expression is dramatically upregulated in fibroids. As a member of the A-Disintegrin And Metalloprotease family of matrix modifying enzymes, ADAM12 is known to cleave ECM proteins, activate epidermal growth factor (EGF) and Insulin-like growth factor (IGF) signaling and promote tumorigenesis. Our lab has recently shown the expression of RE1 suppressing transcription factor /neuron-restrictive silencing factor (REST/NRSF), a known tumor suppressor, to be lost in fibroids. Upon further analysis, we found silencing REST in primary myometrial SMCs led to an increase in a number of downstream target genes, a profile similar to what is seen in fibroid tumor samples. Furthermore, Ingenuity® pathway analyses of gene expression datasets for fibroids indicate that the loss of REST and the increase in ADAM12 expression in leiomyomas could be linked through microRNA-29 (miR-29). In addition, in cultured mammary tumor cell lines, miR-29 is known to directly regulate ADAM12 expression. Compared to normal myometrium, uterine fibroids express significantly lower levels of miR-29. In its promoter, miR-29 contains an RE1 element, a putative binding site for REST. In order to see how the loss of REST in fibroids could affect miR-29, we silenced REST in primary myometrial SMCs and saw a significant decrease in miR-29 expression. In addition, Western blot analysis showed an increase in ADAM12 expression and EGF receptor (EGFR) phosphorylation when REST was knocked-down in primary myometrial cells. We further investigated the link between miR-29 and ADAM12 expression by treating primary myometrial and leiomyoma cells with miR-29 inhibitors and mimics, respectively. We found that inhibiting miR-29 in myometrial cells results in an increase in the expression of ADAM12. Conversely, the opposite effects were seen when fibroid cells were treated with miR-29 mimics. Furthermore, overexpression of ADAM12 in primary myometrial SMCs was found to induce activation of multiple tumorigenic signaling pathways including EGFR, Mitogen-activated protein kinase (MAPK), the phosphatidylinositol 3-kinase (PI3K), protein kinase B (PKB/Akt), and mammalian target of rapamycin (mTOR) and Notch pathways. In conclusion, we report a novel druggable pathway that links the loss of REST, down regulation of miR-29, increased ADAM12 expression, and the activation of multiple tumorigenic pathways in uterine fibroids.
2018-10-22T22:34:37Z
2018-10-22T22:34:37Z
2017-05-31
2017
Dissertation
http://dissertations.umi.com/ku:15247
http://hdl.handle.net/1808/26945
en
Copyright held by the author.
openAccess
137 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/344942023-08-11T16:34:46Zcom_1808_1260col_1808_1951
Small scale hydrogeomorphic features influence macroinvertebrate food webs in two Great Plains rivers
Lutchen, Jackob
Thorp, James H
Short, Andrew
deNoyelles, Frank
Ecology
Food web
Grassland
Hydrogeomorphic
Hydrogeomorphology
Macroinvertebrate
River
Food resources that support river food webs and food web structure have been shown to be influenced by hydrogeomorphology, and its influence on food webs has been gaining support with ecologists over the years. I analyzed the influence of local hydrogeomorphic variables on the structure and function of food webs in two U.S. Great Plains rivers, the Little Missouri and Niobrara. I used stable isotope analysis to reveal hydrogeomorphic relationships with δ13C in the food web, consumer resource use, trophic community metrics and size corrected standard ellipse area (SEAc) a measure of consumer niche breadth. I found river sinuosity and percent fine grain sediment to have a large influence on the food web. Increasing sinuosity was associated with a decrease in the stable isotope composition (δ13C) of the entire food web and trophic diversity (p=0.038, R2=31.1%), but an increase in trophic niche specialization (p=0.013, R2=41.1%). Increasing percent fine sediment was also associated with a decrease in the δ13C of the food web, as well as higher consumption of autochthonous resources and terrestrial coarse particulate organic matter (CPOM); and a decrease in trophic redundancy (fewer species occupying the same trophic niche). These results suggest that the decrease in stable substrate probably caused an overall decrease in primary productivity and limited autochthonous growth to pools and slackwater areas. This decrease in primary productivity also caused the decrease in overall food web δ13C. The consumption of autochthonous resources and CPOM increased with slow water due to the lack of stable substrate in the majority of the system. Results also indicated that species became more specialized in their trophic niche likely due to decreased diversity. My study gives support to the importance of local hydrogeomorphic variables such as sediment size and sinuosity, on food web structure and trophic interactions in Great Plains rivers. Future studies could expand the number of study rivers in the Great Plains to increase the number and diversity of hydrogeomorphic variables and organisms analyzed.
2023-07-04T16:58:50Z
2023-07-04T16:58:50Z
2020-05-31
2020
Thesis
http://dissertations.umi.com/ku:17190
https://hdl.handle.net/1808/34494
en
Copyright held by the author.
openAccess
48 pages
application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
University of Kansas
oai:kuscholarworks.ku.edu:1808/132672018-07-12T17:46:33Zcom_1808_4471col_1808_4472
The Statistics of Bulk Segregant Analysis Using Next Generation Sequencing
Magwene, Paul M.
Willis, John H.
Kelly, John K.
Alleles
Bandwidth (Singal processing)
DNA recombination
DNA sequencing
Genomic libraries
High throughput sequencing
Sequence alignment
Signal filtering
We describe a statistical framework for QTL mapping using bulk segregant analysis (BSA) based on high throughput, short-read sequencing. Our proposed approach is based on a smoothed version of the standard statistic, and takes into account variation in allele frequency estimates due to sampling of segregants to form bulks as well as variation introduced during the sequencing of bulks. Using simulation, we explore the impact of key experimental variables such as bulk size and sequencing coverage on the ability to detect QTLs. Counterintuitively, we find that relatively large bulks maximize the power to detect QTLs even though this implies weaker selection and less extreme allele frequency differences. Our simulation studies suggest that with large bulks and sufficient sequencing depth, the methods we propose can be used to detect even weak effect QTLs and we demonstrate the utility of this framework by application to a BSA experiment in the budding yeast Saccharomyces cerevisiae.
This research was supported by NIH grant P50GM081883-04 (to PMM), NIH grant R01-GM073990 (to JKK and JHW), NSF grant DEB-10-19753 (to PMM) and NSF grant IOS-10-24966 (to JHW).
2014-03-19T19:11:23Z
2014-03-19T19:11:23Z
2011-11-03
Article
Magwene, P. M., Willis, J. H., & Kelly, J. K. (2011). The Statistics of Bulk Segregant Analysis Using Next Generation Sequencing. PLoS Comput Biol, 7(11). http://dx.doi.org/10.1371/journal.pcbi.1002255
http://hdl.handle.net/1808/13267
10.1371/journal.pcbi.1002255
© 2011 Magwene et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Public Library of Science
oai:kuscholarworks.ku.edu:1808/81122020-08-20T14:22:42Zcom_1808_291com_1808_1260col_1808_14109col_1808_7158
Some Proposed Experiments Relating to Taxation
Smith, Harry Denman
2011-10-06T15:09:42Z
2011-10-06T15:09:42Z
1887
Thesis
http://hdl.handle.net/1808/8112
en_US
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
18 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/197222017-12-08T21:31:50Zcom_1808_231com_1808_1260col_1808_18153col_1808_7158
Electrostatic dust precipitation and the Miami smelter
Albers, George Rockwell
Thesis (Elect. Engin.)--University of Kansas, Electrical Engineering, 1916. ; Includes bibliographical references.
2016-01-06T17:16:23Z
2016-01-06T17:16:23Z
1916
Thesis
http://hdl.handle.net/1808/19722
eng
This work is in the public domain according to U.S. copyright law and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/158602019-04-12T14:50:46Zcom_1808_97col_1808_102
Quantum dynamics of molecular multiphoton excitation in intense laser and static electric fields: Floquet theory, quasienergy spectra, and application to the HF molecule
Chu, Shih-I
Tietz, James V.
Datta, Krishna K.
Multiphoton excitation
Field theory
Molecular dynamics
Molecular spectra
Static electric fields
This is the published version, also available here: http://dx.doi.org/10.1063/1.444219.
The multiphoton excitationdynamics of vibration‐rotation states in diatomic molecules in intense laser and static electric fields is investigated. The Floquet matrix method is used to calculate the quasienergy and multiphoton absorptionspectra of the HF molecule as functions of field strengths and frequency. Nonlinear effects such as power broadening, dynamic Stark shift, Autler–Townes multiplet splitting, hole burning, and S‐hump behaviors, etc., are observed and discussed in terms of quasienergy diagrams. Many of the salient features in the spectral line shapes may be qualitatively understood in terms of an analytical three‐level model. The addition of a dc electric field removes the restriction of the rotational dipole selection rule and causes significant intermixing of the bare molecular vibrator states. Due to the greater number of strongly coupled nearby states in the dc field, nonlinear effects such as those mentioned above appear at a much lower ac field strength than they would in the absence of the dc field. The introduction of an external dc field, therefore, strongly enhances the multiphoton excitation probabilities and results in a much richer spectrum.
2014-11-25T17:24:25Z
2014-11-25T17:24:25Z
1982-01-01
Article
Chu, Shih-I., Tietz, James V., Datta, Krishna K. "Quantum dynamics of molecular multiphoton excitation in intense laser and static electric fields: Floquet theory, quasienergy spectra, and application to the HF molecule." The Journal of Chemical Physics 77, 2968 (1982); http://dx.doi.org/10.1063/1.444219.
http://hdl.handle.net/1808/15860
10.1063/1.444219
openAccess
application/pdf
Elsevier
oai:kuscholarworks.ku.edu:1808/44332018-01-31T20:07:56Zcom_1808_1260com_1808_89col_1808_1952col_1808_14037
Orthographic and phonological neighborhood effects within a priming context
Fugett-Fuller, April
Simpson, Greg B
Vitevitch, Michael
Atchley, Ruth Ann
Kellas, George
Catts, Hugh
Cognitive psychology
Neighborhood size
Orthography
Phonology
Priming
Semantics
Two experiments were completed investigating orthographic neighborhood size in the context of phonological neighborhood size and priming, at various SOAs. Experiment 1 exhibited that words from larger phonological neighborhoods were processed more quickly than those that are not. Also, targets were responded to more quickly at long SOAs and being from a large orthographic neighborhood was facilitative at the 500 ms SOA. There was a three-way interaction between phonological and orthographic neighborhood size and relatedness qualified by two two-way interactions between orthography and phonology and phonology and relatedness. Experiment 2 employed a manipulation of the prime with the same stimuli as Experiment 1. Experiment 2 also exhibited main effects of priming and of SOA. There was also a significant three-way interaction between orthographic and phonological neighborhood size and relatedness, whereby, in the related condition, words from both a small orthographic and a small phonological neighborhood were processed more quickly.
2009-03-23T03:38:37Z
2009-03-23T03:38:37Z
2008-01-01
2008
Dissertation
http://dissertations.umi.com/ku:10098
http://hdl.handle.net/1808/4433
EN
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
94 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/11162019-04-12T14:37:08Zcom_1808_1050com_1808_1049col_1808_1053
Static light scattering and small-angle neutron
scattering study on aggregated recombinant
gelatin in aqueous solution
Sutter, Marc
2006-11-14T21:34:21Z
2006-11-14T21:34:21Z
2006-10-25
Presentation
http://hdl.handle.net/1808/1116
en
PD
05
openAccess
2674669 bytes
application/pdf
application/pdf
oai:kuscholarworks.ku.edu:1808/303552020-05-16T08:01:06Zcom_1808_231col_1808_13465col_1808_19739
Headed and High-Strength Shear Reinforcement in Concrete Members
Al-Sabawy, Abdalkader
Lequesne, Rémy D.
O’Reilly, Matthew
Darwin, David
Lepage, Andrés
Crack width
Headed bars
Headed shear reinforcement
High-strength steel
High- strength concrete
Member depth
Shear reinforcement
Results are reported from 29 large-scale tests of reinforced concrete beams designed to investigate the use of Grade 80 (550) steel and headed deformed bars as shear reinforcement, both of which are expected to alleviate reinforcement congestion and improve constructability when used in heavily reinforced members. The specimens were tested under three-point bending with a shear span-to-effective depth ratio of 3. Shear reinforcement consisted of either stirrups or headed deformed bars made with Grade 60 or 80 (420 or 550) steel. Headed bars were evaluated both engaging and not engaging the longitudinal reinforcement to determine whether such engagement is necessary for acceptable performance. Other variables included beam depth, shear reinforcement size and spacing, longitudinal reinforcement ratio, and concrete compressive strength.
Test results showed that when headed deformed shear reinforcement (of diameter db) is placed with at least 6db of side cover and having at least one longitudinal bar within the side cover, or when headed reinforcement is engaged with longitudinal bars at each end, beam shear strength was similar to that of companion specimens with stirrups. Specimens designed for the same nominal shear strength, Vn, using either Grade 60 or 80 (420 or 550) shear reinforcement exhibited similar shear strengths and crack widths at service-level loads (taken as 0.6Vn). Test results indicate there may be cause to reevaluate the ACI Building Code minimum for ρtfytm of 50 psi (0.34 MPa): 9 out of 12 specimens with ρtfytm < 90 psi (0.62 MPa) had measured shear strengths less than Vn calculated using measured material properties, whereas only 2 out of 13 specimens with ρtfytm > 90 psi (0.62 MPa) did. The statistically significant difference between these groups persisted when Vn was based on the number of adequately anchored stirrup legs intercepted by the failure surface.
2020-05-15T19:22:44Z
2020-05-15T19:22:44Z
2020-05
Technical Report
Al-Sabawy, A., Lequesne, R. D., O’Reilly, M., Darwin, D., and Lepage, A., “Headed and High-Strength Shear Reinforcement in Concrete Members,” SM Report No. 139, University of Kansas Center for Research, Inc., Lawrence, KS, May 2020, 498 pp.
http://hdl.handle.net/1808/30355
https://orcid.org/0000-0001-5039-3525
SM Report;139
https://iri.ku.edu/reports
openAccess
application/pdf
University of Kansas Center for Research, Inc.
oai:kuscholarworks.ku.edu:1808/250022018-04-10T19:29:34Zcom_1808_5423col_1808_5425
Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling
Xu, Bao-Qing
Fu, Zhi-Guang
Meng, Yao
Wu, Xiaoqing
Wu, Bo
Xu, Liang
Jiang, Jian-Li
Li, Ling
Chen, Zhi-Nan
Gemcitabine
Stress
Invasion
HAb18G/CD147
EGFR
Pancreatic cancer, one of the most lethal cancers, has very poor 5-year survival partly due to gemcitabine resistance. Recently, it was reported that chemotherapeutic agents may act as stressors to induce adaptive responses and to promote chemoresistance in cancer cells. During long-term drug treatment, the minority of cancer cells survive and acquire an epithelial-mesenchymal transition phenotype with increased chemo-resistance and metastasis. However, the short-term response of most cancer cells remains unclear. This study aimed to investigate the short-term response of pancreatic cancer cells to gemcitabine stress and to explore the corresponding mechanism. Our results showed that gemcitabine treatment for 24 hours enhanced pancreatic cancer cell invasion. In gemcitabine-treated cells, HAb18G/CD147 was up-regulated; and HAb18G/CD147 down-regulation or inhibition attenuated gemcitabine-enhanced invasion. Mechanistically, HAb18G/CD147 promoted gemcitabine-enhanced invasion by activating the EGFR (epidermal growth factor receptor)-STAT3 (signal transducer and activator of transcription 3) signaling pathway. Inhibition of EGFR-STAT3 signaling counteracted gemcitabine-enhanced invasion, and which relied on HAb18G/CD147 levels. In pancreatic cancer tissues, EGFR was highly expressed and positively correlated with HAb18G/CD147. These data indicate that pancreatic cancer cells enhance cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling. Our findings suggest that inhibiting HAb18G/CD147 is a potential strategy for overcoming drug stress-associated resistance in pancreatic cancer.
2017-09-22T17:38:05Z
2017-09-22T17:38:05Z
2016-08-19
Article
Xu, B.-Q., Fu, Z.-G., Meng, Y., Wu, X.-Q., Wu, B., Xu, L., … Chen, Z.-N. (2016). Gemcitabine enhances cell invasion via activating HAb18G/CD147-EGFR-pSTAT3 signaling. Oncotarget, 7(38), 62177–62193. http://doi.org/10.18632/oncotarget.11405
http://hdl.handle.net/1808/25002
10.18632/oncotarget.11405
PMC5308719
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Impact Journals
oai:kuscholarworks.ku.edu:1808/310422021-01-06T09:00:56Zcom_1808_1815col_1808_19344
A New Perspective on Coastally Trapped Disturbances Using Data from the Satellite Era
Juliano, Timothy W.
Lebo, Zachary J.
Thompson, Gregory
Rahn, David A.
The ability of global climate models to simulate accurately marine stratiform clouds continues to challenge the atmospheric science community. These cloud types, which account for a large uncertainty in Earth’s radiation budget, are generally difficult to characterize due to their shallowness and spatial inhomogeneity. Previous work investigating marine boundary layer (MBL) clouds off the California coast has focused on clouds that form under the typical northerly flow regime during the boreal warm season. From about June through September, however, these northerly winds may reverse and become southerly as part of a coastally trapped disturbance (CTD). As the flow surges northward, it is accompanied by a broad cloud deck. Because these events are difficult to forecast, in situ observations of CTDs are few and far between, and little is known about their cloud physical properties. A climatological perspective of 23 CTD events—spanning the years from 2004 to 2016—is presented using several data products, including model reanalyses, buoys, and satellites. For the first time, satellite retrievals suggest that CTD cloud decks may play a unique role in the radiation budget due to a combination of aerosol sources that enhance cloud droplet number concentration and reduce cloud droplet effective radius. This particular type of cloud regime should therefore be treated differently than that which is more commonly found in the summertime months over the northeast Pacific Ocean. The potential influence of a coherent wind stress cycle on sea surface temperatures and sea salt aerosol is also explored.
2021-01-05T22:02:16Z
2021-01-05T22:02:16Z
2019-04-01
Article
Juliano, T. W., Lebo, Z. J., Thompson, G., & Rahn, D. A. (2019). A New Perspective on Coastally Trapped Disturbances Using Data from the Satellite Era, Bulletin of the American Meteorological Society, 100(4), 631-651. Retrieved Jan 5, 2021, from https://journals.ametsoc.org/view/journals/bams/100/4/bams-d-18-0002.1.xml
http://hdl.handle.net/1808/31042
10.1175/BAMS-D-18-0002.1
©2019 American Meteorological Society
For information regarding reuse of this content and general copyright
information, consult the AMS Copyright Policy (https://www.ametsoc.org/ams/index.cfm/publications/ethical-guidelines-and-ams-policies/ams-licenses-for-journal-article-reuse/).
openAccess
application/pdf
American Meteorological Society
oai:kuscholarworks.ku.edu:1808/229702019-04-12T14:20:32Zcom_1808_275col_1808_22736
On Extraposition and Expletive-Movement
Stroik, Thomas S.
Government Binding Theory (Linguistics)
Agreement
2017-02-14T00:06:16Z
2017-02-14T00:06:16Z
1994
Article
http://hdl.handle.net/1808/22970
Papers of the Mid-America Linguistics Conference;1994
openAccess
application/pdf
Mid-America Linguistics Conference
University of Kansas
oai:kuscholarworks.ku.edu:1808/213372018-12-17T18:04:03Zcom_1808_109col_1808_110
Measurement of the inclusive jet cross-section in pp collisions at √s=2.76 TeV and comparison to the inclusive jet cross-section at √s=7 TeV using the ATLAS detector
Aad, G.
Abajyan, T.
Abbott, B.
Abdallah, J.
Abdelalim, A. A.
Royon, Christophe
The inclusive jet cross-section has been measured in proton–proton collisions at √s=2.76 TeV in a dataset corresponding to an integrated luminosity of 0.20 pb−1 collected with the ATLAS detector at the Large Hadron Collider in 2011. Jets are identified using the anti-kt algorithm with two radius parameters of 0.4 and 0.6. The inclusive jet double-differential cross-section is presented as a function of the jet transverse momentum pT and jet rapidity y, covering a range of 20≤pT<430 GeV and |y|<4.4. The ratio of the cross-section to the inclusive jet cross-section measurement at √s=7 TeV, published by the ATLAS Collaboration, is calculated as a function of both transverse momentum and the dimensionless quantity xT=2pT/√s, in bins of jet rapidity. The systematic uncertainties on the ratios are significantly reduced due to the cancellation of correlated uncertainties in the two measurements. Results are compared to the prediction from next-to-leading order perturbative QCD calculations corrected for non-perturbative effects, and next-to-leading order Monte Carlo simulation. Furthermore, the ATLAS jet cross-section measurements at √s=2.76 TeV and √s=7 TeV are analysed within a framework of next-to-leading order perturbative QCD calculations to determine parton distribution functions of the proton, taking into account the correlations between the measurements.
2016-08-15T19:00:04Z
2016-08-15T19:00:04Z
2013
Article
The ATLAS Collaboration, Aad, G., Abajyan, T.,Measurement of the inclusive jet cross-section in pp collisions at √s=2.76 TeV and comparison to the inclusive jet cross-section at √s=7 TeV using the ATLAS detector, et al. Eur. Phys. J. C (2013) 73: 2509. doi:10.1140/epjc/s10052-013-2509-4
http://hdl.handle.net/1808/21337
10.1140/epjc/s10052-013-2509-4
© CERN for the benefit of the ATLAS collaboration 2013. This article is published with open access at Springerlink.com
openAccess
application/pdf
American Physical Society
oai:kuscholarworks.ku.edu:1808/63562019-04-12T14:42:19Zcom_1808_263col_1808_264
On the topology of graph picture spaces
Martin, Jeremy L.
This is the author's accepted manuscript.
2010-06-17T21:02:35Z
2010-06-17T21:02:35Z
2005-03
Article
On the topology of graph picture spaces, Advances in Mathematics 191, no. 2 (2005), 312--338.
http://hdl.handle.net/1808/6356
10.1016/j.aim.2004.03.010
http://arxiv.org/abs/math.CO/0307405
openAccess
application/pdf
Elsevier
oai:kuscholarworks.ku.edu:1808/340332023-07-06T16:22:48Zcom_1808_287col_1808_288
Opening the Word-Gate: The Innovative Style of a Korean Shaman
Kang, Nam-Chu
Canda, Edward R.
2023-03-09T19:04:53Z
2023-03-09T19:04:53Z
1995
Article
Kang, N., & Canda, E. R. (1995). Opening the word-gate: The innovative style of a Korean shaman. Shaman’s Drum, (Summer), 49-55.
https://hdl.handle.net/1808/34033
https://orcid.org/0000-0002-6751-1820
Copyright 1995 by the Cross-Cultural Shamanism Network
openAccess
application/pdf
Cross-Cultural Shamanism Network
oai:kuscholarworks.ku.edu:1808/180242018-12-19T16:44:54Zcom_1808_118com_1808_5894col_1808_119col_1808_7025
Editorial: The Human Genome Project
Crawford, Michael H.
Baer, A. S.
Hall, R.
Omenn, G. S.
Thomson, G. J.
Wilson, A. C.
This is the publisher's version, also available electronically from www.jstor.org.
No abstract is available for this item.
2015-06-04T13:55:57Z
2015-06-04T13:55:57Z
1990-08-01
Article
Crawford, Michael H. (1990). "Editorial: The Human Genome Project." Human Biology, 62(4):iii-v. http://www.jstor.org/stable/41932339.
http://hdl.handle.net/1808/18024
http://www.jstor.org/stable/41932339
openAccess
application/pdf
Wayne State University Press
oai:kuscholarworks.ku.edu:1808/205992020-06-24T15:38:35Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
The effect of thyroparathyroidectomy on body activities
Bryant, Homer L.
Thesis (M.A.)--University of Kansas, Physiology, 1924.
2016-03-29T16:05:05Z
2016-03-29T16:05:05Z
1924
Thesis
http://hdl.handle.net/1808/20599
en_US
This work is in the public domain and is available for users to copy, use, and redistribute in part or in whole. No known restrictions apply to the work.
openAccess
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/69812020-08-06T12:15:52Zcom_1808_1260com_1808_89col_1808_1952col_1808_14037
The Effects of Hope on Mental Health and Chronic Sorrow in Parents of Children with Autism Spectrum Disorder
Monsson, Yngve
Karpowitz, Dennis H.
Higgins, Raymond L.
Kirk, Sarah
Little, Todd D.
Sherman, James A.
Psychology
Clinical psychology
Autism
Chronic sorrow
Coping behavior
Hope
Parent
Parents' hope for their child
This study examined the relationships among hope as defined by Snyder et al. (1991), a parents' hope for their child, autism severity, chronic sorrow, and mental health in parents of children diagnosed with an Autism Spectrum Disorder. The study yielded evidence of good internal consistency and validity for a new measurement of parents' hope for their child. Significant positive relationships were found between hope and parents' hope for their child, and between both types of hope and positive affect and satisfaction with support. Significant negative relationships were found between both forms of hope and autism severity, chronic sorrow, anxiety, and depression. The findings are interpreted as suggesting that hope and parents' hope for their child are important factors in positive coping in parents of children with autism. The representativeness of the sample is discussed as an important limitation of the current study.
2011-01-03T03:08:03Z
2011-01-03T03:08:03Z
2010-05-07
2010
Dissertation
http://dissertations.umi.com/ku:10980
http://hdl.handle.net/1808/6981
en
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
145 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/256942018-02-07T23:22:33Zcom_1808_1483col_1808_1502
GIS For The Petroleum Industry
Hood, Ken
Becker, Ulf
GIS Day
This presentation was given as part of the GIS Day@KU symposium on November 15, 2017. For more information about GIS Day@KU activities, please see http://gis.ku.edu/gisday/2017/
PLATINUM SPONSORS:
KU Department of Geography and Atmospheric Science
KU Institute for Policy & Social Research
GOLD SPONSORS:
KU Libraries
State of Kansas Data Access & Support Center (DASC)
SILVER SPONSORS:
Bartlett & West
Kansas Applied Remote Sensing Program
KU Center for Global and International Studies
BRONZE SPONSORS:
Boundless
2018-01-09T22:29:24Z
2018-01-09T22:29:24Z
2017-11-15
Presentation
http://hdl.handle.net/1808/25694
openAccess
application/pdf
video/mp4
GIS Day @ KU Planning Committee
oai:kuscholarworks.ku.edu:1808/239882018-01-31T20:07:51Zcom_1808_197com_1808_1260col_1808_18171col_1808_1951
The Modified Rapid Emergency Medicine Score: A Novel Trauma Triaging Tool for Predicting In-hospital Mortality
Miller, Ross
Cannon, Chad M
Cannon, Chad M
Nazir, Niaman
Barth, Bradley
Thornton, Stephen
Medicine
Emergency Medicine
Mortality
Trauma
Trauma Score
Triage
Objectives: Trauma systems currently rely on imperfect and subjective tools to prioritize responses and resources, thus there is a critical need to develop a more accurate trauma severity score. Our objective was to modify the Rapid Emergency Medicine Score (REMS is a simple, non-invasive, and objective version of the APACHE II score) for the trauma population and test its accuracy as a predictor of in-hospital mortality when compared to other currently used scores, including the Revised Trauma Score (RTS), the Injury Severity Score (ISS), the “Mechanism, Glasgow Coma Scale, Age and Arterial Pressure” (MGAP) score, and the Shock Index (SI) score. Methods: This was a two-part study design. The first part incorporated a retrospective analysis of a local trauma database (3,680 patients) where three components of REMS were modified to more accurately represent the trauma population. Using clinical judgment and goodness of fit tests, systolic blood pressure was substituted for mean arterial pressure, the weighting of age was reduced, and the weighting of GCS was increased. The second part comprised of validating the new mREMS score retrospectively on a U.S. national trauma database that included 429,711 patients admitted with trauma over a 1-year period. The discriminate power of modified REMS (mREMS) was compared to other trauma scores using the area under the receiver operating characteristic (ROC) curve. Results: The mREMS score (AUC 0.97) was demonstrated to be higher than RTS (AUC 0.96), ISS (AUC 0.78), MGAP (AUC 0.96), and SI (AUC 0.67) in predicting in-hospital mortality. Discussion: In the trauma population, mREMS is an accurate predictor of in-hospital mortality, outperforming other used scores. Simple and objective, mREMS may hold value in the pre-hospital and emergency department setting in order to guide trauma team responses.
2017-05-08T02:38:59Z
2017-05-08T02:38:59Z
2016-05-31
2016
Thesis
http://dissertations.umi.com/ku:14539
http://hdl.handle.net/1808/23988
en
Copyright held by the author.
openAccess
26 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/221322018-12-21T17:19:28Zcom_1808_1815col_1808_19344
Sheet, stream and shelf flow as progressice ice-bed uncoupling: Byrd Glacier, Antarctica and Jakobshavn Isbrae, Greenland
Hughes, T. J.
Sargent, A.
Fastook, J.
Li, Jilu
Yan, J.-B.
Gogineni, Sivaprasad
The first-order control of ice thickness and height above sea level is linked to the decreasing strength of ice-bed coupling along flowlines from an interior ice divide to the calving front of an ice shelf. Uncoupling progresses as a frozen bed progressively thaws for sheet flow, as a thawed bed is progressively drowned for stream flow, and as lateral and/or local grounding vanish for shelf flow. This can reduce ice thicknesses by 90 % and ice elevations by 99 % along flowlines. Original work presented here includes (1) replacing flow and sliding laws for sheet flow with upper and lower yield stresses for creep in cold overlying ice and basal ice sliding over deforming till, respectively, (2) replacing integrating the Navier–Stokes equations for stream flow with geometrical solutions to the force balance, and (3) including resistance to shelf flow caused by lateral confinement in a fjord and local grounding at ice rumples and ice rises. A comparison is made between our approach and two approaches based on continuum mechanics. Applications are made to Byrd Glacier in Antarctica and Jakobshavn Isbrae in Greenland.
2016-12-05T17:12:15Z
2016-12-05T17:12:15Z
2016-01-21
Article
Hughes, T., Sargent, A., Fastook, J., Purdon, K., Li, J., Yan, J.-B., and Gogineni, S.: Sheet, stream, and shelf flow as progressive ice-bed uncoupling: Byrd Glacier, Antarctica and Jakobshavn Isbrae, Greenland, The Cryosphere, 10, 193-225, doi:10.5194/tc-10-193-2016, 2016.
http://hdl.handle.net/1808/22132
10.5194/tc-10-193-2016
© Author(s) 2016. This work is distributed under the Creative Commons Attribution 3.0 License.
http://creativecommons.org/licenses/by/3.0/
openAccess
application/pdf
European Geosciences Union
oai:kuscholarworks.ku.edu:1808/5172019-04-12T14:20:16Zcom_1808_21col_1808_23
No Leafcaster? No Problem! Using the suction table to fill large lacunae in an entire volume
Baker, Whitney
Conservation, treatment
Conservation, library and archival material
The poster presentation follows the treatment of a badly mold- and vermin-damaged 17th c. English herbal of roughly 600 pages. The developed treatment protocol calls for pulp fills using a vacuum suction table in place of a leafcaster, which was not available. The poster documents the decisions and workflow involved in a treatment procedure that other conservators could adapt for their own special collections treatments.
Library Research Fund FY05 award
2005-07-07T22:04:55Z
2005-07-07T22:04:55Z
2005-07-22
Presentation
http://hdl.handle.net/1808/517
en_US
openAccess
148438 bytes
application/pdf
application/pdf
The Changing Book Conference: Transitions in Design, Production, and Preservation, University of Iowa, Iowa City
oai:kuscholarworks.ku.edu:1808/165032019-04-12T14:56:04Zcom_1808_4471col_1808_4472
Corolla Morphology Facilitates Both Autogamy and Bumblebee Pollination in Mimulus guttatus
Arathi, H. S.
Kelly, John K.
The showy corolla of Mimulus guttatus is generally considered an adaptation to attract pollinators. We use phenotypic manipulations to demonstrate that corolla morphology plays a critical mechanical role in both outcrossing and self‐fertilization. In the absence of pollinators, the lower portion of the corolla facilitates autogamy by retaining pollen released from the anthers. A substantial portion of self‐fertilization seems to occur late in the floral life span as the stigma contacts the corolla. When pollinators are present, the corolla facilitates outcrossing before, during, and after insect visitation. A large fraction of cross‐pollen is actually captured by the corolla and not by the stigma. This “indirect” pathway for pollen reception suggests that a large fraction of cross‐pollination in M. guttatus actually occurs long after a pollinator departs from a flower.
2015-02-03T21:25:07Z
2015-02-03T21:25:07Z
2004-11-01
Article
Arathi, H. S.; Kelly, John K. (2007). "Corolla Morphology Facilitates Both Autogamy and Bumblebee Pollination in Mimulus guttatus." International Journal of Plant Science, 165(6):1039-1045. http://www.dx.doi.org/10.1086/423876
1058-5893
http://hdl.handle.net/1808/16503
10.1086/423876
openAccess
application/pdf
University of Chicago Press
oai:kuscholarworks.ku.edu:1808/104542018-10-31T15:31:08Zcom_1808_979com_1808_1260col_1808_14116col_1808_1951
The Freedom to Choose: The Aesthetics of Choice in Short Stories by Zora Neale Hurston, Richard Wright, Amiri Baraka, and Toni Cade Bambara
Rambsy, Kenton
Graham, Maryemma
Harris, William J.
American literature
African American studies
African American
Choice
Fiction
Freedom
Short stories
Black Arts' writer Amiri Baraka observes in his essay "Northern Iowa: Short Story and Poetry," that "For black people, freedom is our aesthetic and our ideology." The focus on liberation has artistic and political resonance for African Americans. Freedom--as communal aesthetic and ideology--provides a useful starting point for better understanding major themes in black writing. A closer look at short stories, which have typically received less critical attention than novels in the study of African American literature, can yield valuable information about the diverse ways in which writers present varying degrees of what I am calling "freedom aesthetics" in their works. Overall, my project will examine the context of choice in selected African American short stories. To what ends do the works by Hurston, Wright, Bambara, and Baraka emphasize the "choices" African Americans make in the face of social barriers? Addressing this question will help to better explain how characters, within specific short stories, make specific decisions to gain higher degrees of social agency and what authorial judgments black writers use to create varied conceptions of freedom for diverse sets of black characters. The short stories selected in this study reflect struggles against constraints that are racially, socially, sexually, economically or politically motivated. These choices, I argue, help explain why those works have remained so well known and most frequently reprinted in anthologies that privilege freedom as a unifying theme.
2012-11-26T22:08:03Z
2012-11-26T22:08:03Z
2012-05-31
2012
Thesis
http://dissertations.umi.com/ku:12100
http://hdl.handle.net/1808/10454
https://orcid.org/0000-0002-6827-3457
en
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
52 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/136762019-04-12T14:33:14Zcom_1808_8219com_1808_4471col_1808_8220col_1808_4472
The First Permineralized Microsporophyll of the Glossopteridales: Eretmonia macloughlinii sp. nov.
Ryberg, Patricia Elizabeth
Taylor, Edith L.
Taylor, Thomas N.
Glossopterids
Permian
Antarctica
Pollen
Microsporophyll
Eretmonia
This is the publisher's version, which has been made available with permission of the publisher. The original version may be found at the following link: http://dx.doi.org/10.1086/666667
Eretmonia du Toit is a microsporophyll genus attributed to the Permian Glossopteridales. Microsporophylls
are scale leaves (smaller leaves with morphology similar to that of Glossopteris leaves) that bear clusters of
sporangia at the end of stalks attached to the petiole of the sporophyll. Late Permian permineralized specimens
of Eretmonia from the central Transantarctic Mountains in Antarctica reveal the first anatomical information
of the genus. Numerous veins run the length of the petiole and alternate with large canals/air spaces; the veins
and canals are separated by increasing amounts of parenchyma. The ground tissue of the leaves is composed of
isodiametric parenchyma of varying diameters. Beneath the epidermis is a hypodermis two to three layers
thick. Pollen sac walls are a single layer thick with a tapered apex and bulbous base. The simplicity of the
bisaccate pollen grains does not suggest a specialized form of pollination but rather that the glossopterids were
wind pollinated.
2014-05-19T19:24:50Z
2014-05-19T19:24:50Z
2012
Article
Ryberg, P., Taylor, E., and Taylor, T. 2012 The First Permineralized Microsporophyll of the Glossopteridales: Eretmonia macloughlinii sp. nov. International Journal of Plant Sciences, 173(7): 812-822.
http://hdl.handle.net/1808/13676
10.1086/666667
openAccess
application/pdf
University of Chicago Press
oai:kuscholarworks.ku.edu:1808/189802019-04-12T14:54:51Zcom_1808_231col_1808_8649
A High-Order Unifying Discontinuous Formulation for the Navier-Stokes Equations on 3D Mixed Grids
Haga, T.
Gao, H.
Wang, Zhi Jian
High-order
Mixed unstructured grids
Navier-Stokes equations
Discontinuous Galerkin
Spectral collocation
Finite difference
This is the published version. Copyright 2011 © EDP Sciences
The newly developed unifying discontinuous formulation named the correction procedure via reconstruction (CPR) for conservation laws is extended to solve the Navier-Stokes equations for 3D mixed grids. In the current development, tetrahedrons and triangular prisms are considered. The CPR method can unify several popular high order methods including the discontinuous Galerkin and the spectral volume methods into a more efficient differential form. By selecting the solution points to coincide with the flux points, solution reconstruction can be completely avoided. Accuracy studies confirmed that the optimal order of accuracy can be achieved with the method. Several benchmark test cases are computed by solving the Euler and compressible Navier-Stokes equations to demonstrate its performance.
2015-11-23T15:18:01Z
2015-11-23T15:18:01Z
2011-05-16
Article
Haga, T., H. Gao, and Z. J. Wang. "A High-Order Unifying Discontinuous Formulation for the Navier-Stokes Equations on 3D Mixed Grids." Mathematical Modelling of Natural Phenomena Math. Model. Nat. Phenom. 6.3 (2011): 28-56. http://dx.doi.org/10.1051/mmnp/20116302
http://hdl.handle.net/1808/18980
10.1051/mmnp/20116302
openAccess
application/pdf
EDP Sciences
oai:kuscholarworks.ku.edu:1808/271942018-11-20T20:02:22Zcom_1808_267col_1808_16903
How English Language Arts Teachers Are Prepared for Twenty-First-Century Classrooms: Results of a National Study
Caughlan, Samantha
Pasternak, Donna L.
Hallman, Heidi L.
Renzi, Laura
Rush, Leslie S.
Frisby, Michael
A national study of English teacher preparation in U.S. colleges and universities revealed
that faculty address changes in content and context salient to English education, particu-
larly curricular, demographic, political, and technological changes, through initiatives
at both the program and methods course levels. Programs require many hours of field
placements and high numbers of credit hours in the subject area and in subject-specific
methods, and also distribute the responsibility for addressing institutional and pedagogi-
cal change across courses. Methods courses raise awareness of focal issues and allow
opportunities for preservice teachers to discuss these issues. However, opportunities are
scarcer for applying knowledge by putting it into practice. This article discusses tensions
in English education as they relate to conceptual coherence at the program and course
levels, as well as tensions between what we call awareness versus application.
2018-11-02T19:49:41Z
2018-11-02T19:49:41Z
2017-04
Article
Caughlan, S., et al. “How English Language Arts Teachers Are Prepared for Twenty-First-Century Classrooms: Results of a National Study” English Education, vol. 49, no. 3, 2017, pp. 265–297.
http://hdl.handle.net/1808/27194
http://www.ncte.org/journals/ee/issues/v49-3
openAccess
application/pdf
National Council of Teachers of English
oai:kuscholarworks.ku.edu:1808/319182021-10-22T19:35:53Zcom_1808_5423col_1808_5425
Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan
Sung, Calvin T.
Chang, Shu-Lin
Entwistle, Ruth
Ahn, Green
Lin, Tzu-Shyang
Petrova, Vessela
Yeh, Hsu-Hua
Praseuth, Mike B.
Chiang, Yi-Ming
Oakley, Berl R.
Wang, Clay C. C.
Aspergillus nidulans
Nonribosomal peptide synthetase (NRPS)
Pigment biosynthesis
Tryptophan N-acetyltransferase
N-acetyltryptophan oxidase
This work is licensed under a Creative Commons Attribution Non-Commercial-No Derivatives 4.0 International License.
Fungal nonribosomal peptide synthetases (NRPSs) are megasynthetases that produce cyclic and acyclic peptides. In Aspergillus nidulans, the NRPS ivoA (AN10576) has been associated with the biosynthesis of grey-brown conidiophore pigments. Another gene, ivoB (AN0231), has been demonstrated to be an N-acetyl-6-hydroxytryptophan oxidase that putatively acts downstream of IvoA. A third gene, ivoC, has also been predicted to be involved in pigment biosynthesis based on publicly available genomic and transcriptomic information. In this paper, we report the replacement of the promoters of the ivoA, ivoB, and ivoC genes with the inducible promoter alcA in a single cotransformation. Co-overexpression of the three genes resulted in the production of a dark-brown pigment in hyphae. In addition, overexpression of each of the Ivo genes, ivoA-C, individually or in combination, allowed us to isolate intermediates and confirm the function of each gene. IvoA was found to be the first known NRPS to carry out the acetylation of the amino acid, tryptophan.
2021-10-05T20:35:00Z
2021-10-05T20:35:00Z
2017-01-17
Article
Sung, C. T., Chang, S. L., Entwistle, R., Ahn, G., Lin, T. S., Petrova, V., … Wang, C. (2017). Overexpression of a three-gene conidial pigment biosynthetic pathway in Aspergillus nidulans reveals the first NRPS known to acetylate tryptophan. Fungal genetics and biology : FG & B, 101, 1–6. doi:10.1016/j.fgb.2017.01.006
http://hdl.handle.net/1808/31918
10.1016/j.fgb.2017.01.006
PMC6430764
© 2017 Elsevier Inc. All rights reserved.
http://creativecommons.org/licenses/by-nc-nd/4.0/
openAccess
application/pdf
Elsevier
oai:kuscholarworks.ku.edu:1808/110472019-04-12T14:13:30Zcom_1808_11004com_1808_54col_1808_11005
REDCap and DDI Exporting Data and Metadata with the API
Hoyle, Larry
Van Roekel, Ada
DDI
NADDI
Metadata
Data documentation
REDCap
Presentation at the North American Data Documentation Conference (NADDI) 2013
The REDCap (Research Electronic Data Capture) consortium is a group of over 450 institutions that supports a web application which supports data capture for research studies (see http://project-redcap.org/). The application allows interactive survey instrument development and data collection. Data and scripts for SPSS, SAS and R can be exported from REDCap. Survey metadata including question text and flow control can be also exported as a csv file. This paper describes code in the R language to convert the REDCap survey metadata from csv to DDI 3.1. It includes a discussion of which REDCap instrument attributes can be represented by DDI 3.1 elements other than Note. This presentation includes information on the REDCap API and metadata about mapping data entry forms to events in a longitudinal study.
Institute for Policy & Social Research, University of Kansas; University of Kansas Libraries; Alfred P. Sloan Foundation; Data Documentation Initiative Alliance
2013-04-20T16:06:27Z
2013-04-20T16:06:27Z
2013-04-03
Presentation
Hoyle, Larry, & Roekel, Ada Van. (2013). REDCap and DDI Exporting Data and Metadata with the API. Paper presented at the North American Data Documentation Initiative Conference (NADDI 2013), University of Kansas, Lawrence, Kansas April 3, 2013. http://hdl.handle.net/1808/11047
http://hdl.handle.net/1808/11047
en_US
openAccess
application/octet-stream
application/octet-stream
application/octet-stream
application/pdf
oai:kuscholarworks.ku.edu:1808/4062018-12-19T18:24:20Zcom_1808_7799col_1808_14283
A report on the XIX IAMHIST Congress, Leipzig, 18-22 July 2001
Tibbetts, John C.
Welsh, James M.
2005-05-05T20:24:32Z
2005-05-05T20:24:32Z
2002-03
Preprint
Tibbetts, JC; Welsh, JM. A report on the XIX IAMHIST Congress, Leipzig, 18-22 July 2001. HISTORICAL JOURNAL OF FILM RADIO AND TELEVISION. March 2002, 22(1):83-92.
ISI:000174493400008
http://hdl.handle.net/1808/406
en_US
http://www.tandf.co.uk/journals/titles/01439685.asp
openAccess
99205 bytes
application/pdf
application/pdf
CARFAX PUBLISHING
oai:kuscholarworks.ku.edu:1808/115842019-04-12T14:32:09Zcom_1808_7105com_1808_748col_1808_7108col_1808_749
Planted Obsolescence: Synagriculture and the Law
Torrance, Andrew W.
Synagriculture
Synthetic biological agriculture
Agriculture
Genetically-modified crop
Genetically-modified livestock
Gm agriculture
Gm crop
Gm livestock
Genetic engineering
Genetically engineered crop
Genetically engineered livestock
Ge agriculture
Ge crop
Ge livestock
Agricultural law
Full-text available at SSRN. See link in this record.
Supporters of GM agriculture have had a long row to hoe in achieving public acceptance for the safety of this important technology. Controversy has surrounded the foundational technology of recombinant DNA methods, the application of genetic engineering to crop plants and livestock, the safety of GM “Frankenfoods” as sources of human and animal nutrition, the potential environmental threats posed by the possible development of GM “superweeds,” and the corporate control over GM agriculture exercised by a relatively small number of agricultural companies armed with vast financial resources and powerful patent portfolios. Nevertheless, as exemplified by the United States and Canadian Supreme Court cases, Diamond v. Chakrabarty, J.E.M. v. Pioneer Hi-Bred, Monsanto Canada v. Schmeiser, and Monsanto v. Geertson, the law, and the society it reflects, have finally managed to accommodate the important technology of GM agriculture. However, a new paradigm in biological science — synthetic biology — has begun to remake the face of GM agriculture. Synthetic biology seeks to purge biology of some of its fundamental inefficiencies through the rigorous application of engineering principles. Rather than tinkering around the edges, biological engineering would remake living organisms from first principles, and employ standard parts to make qualitatively new biological devices and systems. Traditional arguments that GM crops and livestock are simply slightly-modified versions of their conventional counterparts may no longer be either appropriate or accurate in the face of synthetic biological approaches to engineering new plants. Moreover, both synthetic biology and do-it-yourself biology (“DIYbio”) seek to shift biological research and development out of traditional laboratories and the hands of credentialed biologists, and, instead, allow any interested and motivated user to become a research biologist, biotinkerer, or synthetic biological engineer. Home and community laboratories are already springing up at a rapid rate, and farm laboratories are sure to follow, as participation in this new, open, and democratized movement burgeons. In short, large numbers of individual and collaborating users, spread over many small and local laboratories, are beginning fundamentally to reengineer genes, cells, organisms, and systems composed of organisms or their substituent parts. The comfortable acceptance of GMOs at which society has only recently begun to arrive may soon be misplaced in the face of both fundamentally new scientific approaches and the democratization of innovation. The results for agriculture may be beneficial: enhanced rates of agricultural innovation through new biological approaches and wide participation. Moreover, synthetic biological agriculture (“synagriculture”) may prove to be as safe as GM agriculture or even conventional agriculture. However, assumptions about current GM crops and livestock may not easily apply to synthetic versions, nor may the current paradigm of GM regulation be possible when innovation becomes atomized among millions of farmers. Some of the “settled” legal issues surrounding GM crops and livestock may have to be revisited as new perceived or actual threats and benefits arise. One irony may be that the same patent system that has so often been criticized in the past for providing agricultural companies with too much control over farmers may soon represent one of the most effective methods for monitoring and regulating GM agricultural innovation. Although some farmer innovators may eschew patent coverage for their agricultural inventions, others may opt to seek patent protection for their innovative new synthetic crops and livestock. Because the USPTO will have to examine any new GM crop inventions prior to issuing letters patent, disclosures to the USPTO synthetic biological inventors who opt for patent protection may become a vital centralized locus for monitoring and regulating otherwise highly-decentralized synagricultural innovation. New methods of biological engineering and new models of user, collaborative, and open innovation are soon to affect the trajectory of GM agricultural innovation. Even if such changes turn out to be salutary, they will be changes nevertheless. To ensure that society receives the full benefits of open and democratized synthetic biological innovation in crops and livestock, it would be well and wise for the law to prepare itself to reexamine the brave new world of synagriculture with brand new eyes.
2013-08-02T21:32:22Z
2013-08-02T21:32:22Z
2012
Article
Andrew W. Torrance, Planted Obsolescence: Synagriculture and the Law, 48 IDAHO L. REV. 321 (2012).
http://hdl.handle.net/1808/11584
en_US
http://ssrn.com/abstract=2094440
openAccess
application/msword
University of Idaho College of Law
oai:kuscholarworks.ku.edu:1808/73662019-04-12T14:43:09Zcom_1808_748col_1808_749
Consumer Arbitration As Exceptional Consumer Law (With A Contractualist Reply to Carrington & Haagen)
Ware, Stephen J.
Arbitration
Consumers
This article is part of a symposium on arbitration held by the McGeorge School of Law. It replies to an article co- authored by Paul Carrington, the keynote speaker for the symposium. See Paul Carrington and Paul Haagen, Contract and Jurisdiction, 1996 Sup. Ct. Rev. 331. Carrington and Haagen, like many commentators, criticize recent Supreme Court decisions on arbitration law and the contractual approach underlying those decisions. This article defends the contractual approach.
2011-04-08T14:16:44Z
2011-04-08T14:16:44Z
1998
Article
Stephen J. Ware, Consumer Arbitration As Exceptional Consumer Law (With A Contractualist Reply to Carrington & Haagen), 29 McGeorge Law Review 195-221 (1998).
http://hdl.handle.net/1808/7366
en_US
openAccess
application/pdf
Pacific McGeorge School of Law
oai:kuscholarworks.ku.edu:1808/308322020-11-12T09:00:53Zcom_1808_984col_1808_985
Climate change influences on the potential distribution of Dianthus polylepis Bien. ex Boiss. (Caryophyllaceae), an endemic species in the Irano-Turanian region
Behroozian, Maryam
Ejtehadi, Hamid
Peterson, A. Townsend
Memariani, Farshid
Mesdaghi, Mansour
This work is licensed under a Creative Commons Attribution 4.0 International License.
Endemic and restricted-range species are considered to be particularly vulnerable to the effects of environmental change, which makes assessing likely climate change effects on geographic distributions of such species important to the development of integrated conservation strategies. Here, we determined distributional patterns for an endemic species of Dianthus (Dianthus polylepis) in the Irano-Turanian region using a maximum-entropy algorithm. In total, 70 occurrence points and 19 climatic variables were used to estimate the potential distributional area under current conditions and two future representative concentration pathway (RCP2.6 and RCP8.5) scenarios under seven general circulation models for 2050. Mean diurnal range, iso-thermality, minimum temperature of coldest quarter, and annual precipitation were major factors that appeared to structure the distribution of the species. Most current potential suitable areas were located in montane regions. Model transfers to future-climate scenarios displayed upward shifts in elevation and northward shifts geographically for the species. Our results can be used to define high-priority areas in the Irano-Turanian region for conservation management plans for this species and can offer a template for analyses of other endangered and threatened species in the region.
Office of the Vice-President for Research and Technology of Ferdowsi University of Mashhad (3/42756)
2020-11-11T15:45:00Z
2020-11-11T15:45:00Z
2020-08-18
Article
Behroozian, M., Ejtehadi, H., Peterson, A. T., Memariani, F., & Mesdaghi, M. (2020). Climate change influences on the potential distribution of Dianthus polylepis Bien. ex Boiss. (Caryophyllaceae), an endemic species in the Irano-Turanian region. PloS one, 15(8), e0237527. https://doi.org/10.1371/journal.pone.0237527
http://hdl.handle.net/1808/30832
10.1371/journal.pone.0237527
https://orcid.org/0000-0002-6128-2481
https://orcid.org/0000-0001-5478-1859
PMC7437464
© 2020 Behroozian et al.
http://creativecommons.org/licenses/by/4.0/
openAccess
application/pdf
Public Library of Science
oai:kuscholarworks.ku.edu:1808/111442018-02-26T18:12:31Zcom_1808_267col_1808_16904
Strategies for functional community-based instruction and inclusion of children with mental retardation
Beck, Joni
Broers, Janet
Hogue, Elonda
Shipstead, Jacque
Knowlton, H. Earle
This is the publisher's version, also found at http://sped.org/
2013-05-14T21:03:15Z
2013-05-14T21:03:15Z
1994
Article
Beck, J., Broers, J., Hogue, E. Shipstead, J. and Knowlton, H.E. (1994) Strategies for functional community-based instruction and inclusion of children with mental retardation. TEACHING Exceptional Children, 26.2, 44-48.
http://hdl.handle.net/1808/11144
en_US
openAccess
application/pdf
The Council for Exceptional Children
oai:kuscholarworks.ku.edu:1808/230042019-04-12T14:21:01Zcom_1808_275col_1808_22736
Focus and Multiple CPs in English and Bulgarian
van Gelderen, Elly
Grozeva, Lily
Focus (Linguistics)
English language-- Topic and comment
Bulgarian language-- Topic and comment.
2017-02-14T00:06:19Z
2017-02-14T00:06:19Z
1994
Article
http://hdl.handle.net/1808/23004
Papers of the Mid-America Linguistics Conference;1994
openAccess
application/pdf
Mid-America Linguistics Conference
University of Kansas
oai:kuscholarworks.ku.edu:1808/41632018-01-31T20:08:15Zcom_1808_231com_1808_1260col_1808_18153col_1808_1951
In Situe Synthesis of Iron Oxide within Polyvinylamine nanoparticles
Mohammadi, Zahra
Berkland, Cory J
Gehrke, Stevin
Southard, Marylee
Biomedical engineering
Magnetic nanoparticles that display high saturation magnetization and high magnetic susceptibility with a size less than 200 nm are of great interest for medical applications. Investigations of magnetic nanoparticles have been increasing over the last decade. Magnetite nanoparticles are particularly desirable since the biocompatibility of these particles has already been proven. Several synthetic and natural polymers have been employed to stabilize magnetite nanoparticles and enhance their function in vivo. The goal of this work has been to develop a unique methodology for synthesizing magnetite within polymer nanoparticle dispersions so that the resultant magnetite-polymer particles may be used in a range of biomedical applications, specifically as an MRI contrast agent. A method was developed for preparing ≈150 nm polyvinylamine (PVAm) nanoparticles containing iron oxide. These polymeric nanoparticles offer colloidal stability and reactive primary amines for drug conjugation or surface modification. The polymer-magnetite nanoparticles described in this thesis exhibited a maximum of 12% wt. magnetite and a saturation magnetization of ~30 emu/mg. Transmission electron microscopy (TEM) images showed that the dispersions contained ≈100 to 150 nm diameter PVAm nanoparticles incorporated with iron oxide particles with a size less than ≈10 nm. The ability to synthesize iron oxide inside functionalized polymeric nanoparticles offers an effective approach to prevent nanoparticle agglomeration and the potential to enable ligand grafting. Stabilized magnetic PVAm nanoparticles may provide a unique synthetic approach to enhance MRI contrast and may offer a platform for molecular imaging.
2008-09-15T03:12:39Z
2008-09-15T03:12:39Z
2008-07-17
2008
Thesis
http://dissertations.umi.com/ku:2641
http://hdl.handle.net/1808/4163
EN
This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
openAccess
70 pages
application/pdf
University of Kansas
oai:kuscholarworks.ku.edu:1808/44942019-04-12T14:16:11Zcom_1808_7105com_1808_4471com_1808_7115col_1808_7108col_1808_4472col_1808_7131
Hoplopleura janzeni n. sp. (Phthiraptera: Anoplura), a new sucking louse from a Central American swimming mouse
Durden, Lance A.
Timm, Robert M.
Hoplopleura
Hoplopleuridae
Phthiraptera
Rheomys raptor
Rodentia
Anoplura
Central America
Swimming mouse
Costa Rica
Both sexes of a new species of sucking louse Hoplopleura janzeni (Phthiraptera: Hoplopleuridae) are described and illustrated from the Central American ichthyomyine swimming mouse Rheomys raptor (Rodentia: Muridae) collected in Costa Rica. The morphology of the new species is compared with that of Hoplopleura exima Johnson, the only other species of sucking louse known to parasitize an ichthyomyine rodent. Hoplopleura janzeni is unique in having posteriorly directed spurs on the first antennal segment, the fore- and midcoxae, and the hind femora of both sexes.
2009-04-22T01:26:36Z
2009-04-22T01:26:36Z
2001-12
Article
Durden, L. A. and R. M. Timm. 2001. Hoplopleura janzeni n. sp. (Phthiraptera: Anoplura), a new sucking louse from a Central American swimming mouse. Journal of Parasitology 87(6):1409–1413
http://hdl.handle.net/1808/4494
en
openAccess
application/pdf
Journal of Parasitology
oai_dc////100