SOM Faculty and Staff Research: Recent submissions
Now showing items 21-40 of 55
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Adolescent idiopathic scoliosis: natural history and long term treatment effects
(BioMedCentral, 2008-12-31)Adolescent idiopathic scoliosis is a lifetime, probably systemic condition of unknown cause, resulting in a spinal curve or curves of ten degrees or more in about 2.5% of most populations. However, in only about 0.25% does ... -
Hepatocyte RXRalpha deficiency in matured and aged mice: impact on the expression of cancer-related hepatic genes in a gender-specific manner
(BioMedCentral, 2008-05-01)BACKGROUND:The occurrence of liver cancer is higher in males than in females, and the incidence increases during aging. Signaling pathways regulated by retinoid × receptor a (RXRa) are involved in hepatocellular carcinogenesis. ... -
Use of alcoholic beverages in VA medical centers
(BioMedCentral, 2006-08-14)BACKGROUND:Benzodiazepines are the first-line choice for the treatment of alcohol withdrawal syndrome. However, several hospitals continue to provide alcoholic beverages through their formulary for the treatment of alcohol ... -
A rationale and model for addressing tobacco dependence in substance abuse treatment
(BioMedCentral, 2007-04-03)Most persons in drug treatment smoke cigarettes. Until drug treatment facilities systematically treat their patients' tobacco use, millions will flow through the drug treatment system, overcome their primary drug of abuse, ... -
A family of GFP-like proteins with different spectral properties in lancelet Branchiostoma floridae
(BioMedCentral, 2007-12-06)BACKGROUND:Members of the green fluorescent protein (GFP) family share sequence similarity and the 11-stranded ß-barrel fold. Fluorescence or bright coloration, observed in many members of this family, is enabled by the ... -
Evolutionary history of bacteriophages with double-stranded DNA genomes
(BioMedCentral, 2006-05-30)BACKGROUND:Reconstruction of evolutionary history of bacteriophages is a difficult problem because of fast sequence drift and lack of omnipresent genes in phage genomes. Moreover, losses and recombinational exchanges of ... -
Similarity searches in genome-wide numerical data sets
(BioMedCentral, 2008-07-25)We present psi-square, a program for searching the space of gene vectors. The program starts with a gene vector, i.e., the set of measurements associated with a gene, and finds similar vectors, derives a probabilistic model ... -
Motor sequence learning occurs despite disrupted visual and proprioceptive feedback
(BioMedCentral, 2006-07-05)BACKGROUND:Recent work has demonstrated the importance of proprioception for the development of internal representations of the forces encountered during a task. Evidence also exists for a significant role for proprioception ... -
Number of risk genotypes is a risk factor for major depressive disorder: a case control study
(BioMedCentral, 2007-10-31)BACKGROUND:The objective of the study was to determine the genetic basis of Major Depressive Disorder, and the capacity to respond to antidepressant treatment. An association study of 21 candidate polymorphisms relevant ... -
Neurokinin-1 (NK-1) receptor and brain-derived neurotrophic factor (BDNF) gene expression is differentially modulated in the rat spinal dorsal horn and hippocampus during inflammatory pain
(BioMedCentral, 2008-10-24)Persistent pain produces complex alterations in sensory pathways of the central nervous system (CNS) through activation of various nociceptive mechanisms. However, the effects of pain on higher brain centers, particularly ... -
Thank you reviewers- CytoJournal 2007
(BioMedCentral, 2007-01-25)Significant efforts, time, and resources are devoted for peer-reviewing numerous CytoJournal manuscripts. The Editorial Board of CytoJournal shares a significant proportion of this activity. Additional peers are requested ... -
Thank you reviewers- CytoJournal 2006
(BioMedCentral, 2006-06-15)The Editorial Board of CytoJournal devotes significant efforts, time, and resources to review numerous manuscripts. As it is impossible to include all the experts on the editorial board, there is always a need for additional ... -
Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene
(BioMedCentral, 2005-05-27)BACKGROUND:Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol ... -
Improving adherence to medical regimens for juvenile rheumatoid arthritis
(BioMedCentral, 2008-11-17)Poor adherence to medical regimens can compromise the efficacy of treatments for children and adolescents with juvenile rheumatoid arthritis (JRA). The purpose of this review is to describe medical regimens for the treatment ... -
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Resting myocardial perfusion quantification with CMR arterial spin labeling at 1.5 T and 3.0 T
(BioMedCentral, 2008-07-07)BACKGROUND:The magnetic resonance technique of arterial spin labeling (ASL) allows myocardial perfusion to be quantified without the use of a contrast agent. This study aimed to use a modified ASL technique and T1 regression ... -
Physical activity across the curriculum: year one process evaluation results
(BioMedCentral, 2007-11-12)BACKGROUND:Physical Activity Across the Curriculum (PAAC) is a 3-year elementary school-based intervention to determine if increased amounts of moderate intensity physical activity performed in the classroom will diminish ... -
The school food environment and adolescent obesity: qualitative insights from high school principals and food service personnel
(BioMedCentral, 2007-04-10)OBJECTIVES:To examine high school personnel's perceptions of the school environment, its impact on obesity, and the potential impact of legislation regulating schools' food/beverage offerings.METHODS:Semi-structured ... -
Ubp43 gene expression is required for normal Isg15 expression and fetal development
(BioMedCentral, 2006-10-09)BACKGROUND:Isg15 covalently modifies murine endometrial proteins in response to early pregnancy. Isg15 can also be severed from targeted proteins by a specific protease called Ubp43 (Usp18). Mice lacking Ubp43 (null) form ... -
The role of HLA-G in human pregnancy
(BioMedCentral, 2006-02-06)Pregnancy in mammals featuring hemochorial placentation introduces a major conflict with the mother's immune system, which is dedicated to repelling invaders bearing foreign DNA and RNA. Numerous and highly sophisticated ...