Show simple item record

dc.contributor.authorBiswas, Sangita
dc.contributor.authorBenedict, Stephen H
dc.contributor.authorLynch, Sharon G
dc.contributor.authorLeVine, Steven M
dc.date.accessioned2015-05-27T09:39:41Z
dc.date.available2015-05-27T09:39:41Z
dc.date.issued2012-06-07en_US
dc.identifier.urihttp://hdl.handle.net/2271/1321en_US
dc.description.abstractAbstract Corticosteroids are standard treatment for patients with multiple sclerosis experiencing acute relapse. Because dyspeptic pain is a common side effect of this intervention, patients can be given a histamine receptor-2 antagonist, proton pump inhibitor or antacid to prevent or ameliorate this disturbance. Additionally, patients with multiple sclerosis may be taking these medications independent of corticosteroid treatment. Interventions for gastric disturbances can influence the activation state of the immune system, a principal mediator of pathology in multiple sclerosis. Although histamine release promotes inflammation, activation of the histamine receptor-2 can suppress a proinflammatory immune response, and blocking histamine receptor-2 with an antagonist could shift the balance more towards immune stimulation. Studies utilizing an animal model of multiple sclerosis indicate that histamine receptor-2 antagonists potentially augment disease activity in patients with multiple sclerosis. In contrast, proton pump inhibitors appear to favor immune suppression, but have not been studied in models of multiple sclerosis. Antacids, histamine receptor-2 antagonists and proton pump inhibitors also could alter the intestinal microflora, which may indirectly lead to immune stimulation. Additionally, elevated gastric pH can promote the vitamin B12 deficiency that patients with multiple sclerosis are at risk of developing. Here, we review possible roles of gastric acid inhibitors on immunopathogenic mechanisms associated with multiple sclerosis.
dc.titlePotential immunological consequences of pharmacological suppression of gastric acid production in patients with multiple sclerosis
dc.typeArticleen_US
dc.identifier.doi10.1186/1741-7015-10-57en_US
dc.date.updated2012-06-29T15:08:18Z
dc.description.versionPeer Reviewed
dc.rights.holderSangita Biswas et al.; licensee BioMed Central Ltd.
dc.rights.accessrightsopenAccessen_US


Files in this item

Thumbnail
Thumbnail

This item appears in the following Collection(s)

Show simple item record