Pharmacy Scholarly Works: Recent submissions
Now showing items 41-60 of 293
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The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases
(MDPI, 2018-09-18)This review article describes and discusses the current knowledge on the general role of the methionine sulfoxide reductase (MSR) system and the particular role of MSR type A (MSRA) in mammals. A powerful tool to investigate ... -
Relative Selectivity of Plant Cardenolides for Na+/K+-ATPases From the Monarch Butterfly and Non-resistant Insects
(Frontiers Media, 2018-09-28)A major prediction of coevolutionary theory is that plants may target particular herbivores with secondary compounds that are selectively defensive. The highly specialized monarch butterfly (Danaus plexippus) copes well ... -
Double deletion of PINK1 and Parkin impairs hepatic mitophagy and exacerbates acetaminophen-induced liver injury in mice
(Elsevier, 2019-02-20)Mitochondria damage plays a critical role in acetaminophen (APAP)-induced necrosis and liver injury. Cells can adapt and protect themselves by removing damaged mitochondria via mitophagy. PINK1-Parkin pathway is one of the ... -
Conditional knockout of UBC13 produces disturbances in gait and spontaneous locomotion and exploration in mice
(Nature Research, 2019-03-13)Here we have characterized the functional impairments resulting from conditional knockout of the ubiquitin-conjugating E2 enzyme (UBC13) in rodent cerebellar granule neurons, which greatly increases the parallel fiber ... -
Dual Effects of Chinese Herbal Medicines on Angiogenesis in Cancer and Ischemic Stroke Treatments: Role of HIF-1 Network
(Frontiers Media, 2019-06-26)Hypoxia-inducible factor-1 (HIF-1)–induced angiogenesis has been involved in numerous pathological conditions, and it may be harmful or beneficial depending on the types of diseases. Exploration on angiogenesis has sparked ... -
A network pharmacology-based study on the anti-hepatoma effect of Radix Salviae Miltiorrhizae
(BMC, 2019-08-06)Background Radix Salviae Miltiorrhizae (RSM), a well-known traditional Chinese medicine, has been shown to inhibit tumorigenesis in various human cancers. However, the anticancer effects of RSM on human hepatocellular ... -
The Antioxidant Enzyme Methionine Sulfoxide Reductase A (MsrA) Interacts with Jab1/CSN5 and Regulates Its Function
(MDPI, 2020-05-24)Methionine sulfoxide (MetO) is an oxidative posttranslational modification that primarily occurs under oxidative stress conditions, leading to alteration of protein structure and function. This modification is regulated ... -
Extracellular vesicles: Novel communicators in lung diseases
(BMC, 2020-07-08)The lung is the organ with the highest vascular density in the human body. It is therefore perceivable that the endothelium of the lung contributes significantly to the circulation of extracellular vesicles (EVs), which ... -
Genipin suppression of growth and metastasis in hepatocellular carcinoma through blocking activation of STAT-3
(BMC, 2020-08-02)Background The signal transducer and activator of transcription-3 (STAT-3) can facilitate cancer progression and metastasis by being constitutively active via various signaling. Abundant evidence has indicated that STAT-3 ... -
TOMM40 ‘523 associations with baseline and longitudinal cognition in APOEε3 homozygotes
(IOS Press, 2019-08-20)TOMM40 ‘523 is associated with Alzheimer’s disease (AD), but APOE linkage disequilibrium confounds this association. In 170 APOE ε3 homozygotes, we evaluated relationships between short and very long TOMM40 alleles and ... -
Acetylshikonin Sensitizes Hepatocellular Carcinoma Cells to Apoptosis through ROS-Mediated Caspase Activation
(MDPI, 2019-11-19)The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has shown strong and explicit cancer cell-selectivity, which results in little toxicity toward normal tissues, and has been recognized as a potential, ... -
NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression
(Frontiers Media, 2019-11-08)The arginine vasopressin 1b receptor (Avpr1b) plays an important role in social behaviors including aggression, social learning and memory. Genetic removal of Avpr1b from mouse models results in deficits in aggression and ... -
Exploring the active mechanism of berberine against HCC by systematic pharmacology and experimental validation
(Spandidos Publications, 2019-09-23)Berberine (BBR) is the main component of Coptidis rhizoma, the dried rhizome of Coptis chinensis and is a potential plant alkaloid used for the treatment of cancer due to its high antitumor activity. The present study ... -
CPG15/Neuritin Mimics Experience in Selecting Excitatory Synapses for Stabilization by Facilitating PSD95 Recruitment
(Elsevier, 2019-08-06)A key feature of brain plasticity is the experience-dependent selection of optimal connections, implemented by a set of activity-regulated genes that dynamically adjust synapse strength and number. The activity-regulated ... -
Creating an Online Interprofessional Collaborative Team Simulation to Overcome Common Barriers of Interprofessional Education
(De Gruyter Open, 2017-09-15)Introduction: Coordinating student schedules, physical space, and faculty time are commonly reported barriers to successful interprofessional education. Use of online technologies to overcome these barriers and support ... -
Relative Contribution of Prolyl Hydroxylase-Dependent and -Independent Degradation of HIF-1alpha by Proteasomal Pathways in Cerebral Ischemia
(Frontiers Media, 2017-05-17)Hypoxia inducible factor-1 (HIF-1) is a key regulator in hypoxia and can determine the fate of brain cells during ischemia. However, the mechanism of HIF-1 regulation is still not fully understood in ischemic brains. We ... -
Effect of Continuous and Sequential Therapy among Veterans Receiving Daptomycin or Linezolid for Vancomycin-Resistant Enterococcus faecium Bacteremia
(American Society for Microbiology, 2017)Vancomycin-resistant Enterococcus faecium bloodstream infections (VREF-BSI) cause significant mortality, highlighting the need to optimize their treatment. We compared the effectiveness and safety of daptomycin (DAP) and ... -
New insights and changing paradigms in the regulation of vitamin A metabolism in development
(Wiley, 2017-05)Vitamin A and its active metabolite retinoic acid are essential for embryonic development and adult homeostasis. Surprisingly, excess or deficiency of vitamin A and retinoic acid can cause similar developmental defects. ... -
Human ApoE ε2 promotes regulatory mechanisms of bioenergetic and synaptic function in female brain: a focus on V-type H+-ATPase
(IOS Press, 2016-08-03)Humans possess three major isoforms of the apolipoprotein E (ApoE) gene encoded by three alleles: ApoE ε2 (ApoE2), ApoE ε3 (ApoE3), and ApoE ε4 (ApoE4). It is established that the three ApoE isoforms confer differential ... -
Aversive properties of negative incentive shifts in Fischer 344 and Lewis rats
(Elsevier, 2017-02-15)Research on incentive contrast highlights that reward value is not absolute but rather is based upon comparisons we make to rewards we have received and expect to receive. Both human and nonhuman studies on incentive ...