Prodrugs: Do They Have Advantages in Clinical Practice?
Issue Date
1985-05Author
Stella, Valentino J.
Charman, W. N. A.
Naringrekar, V. H.
Publisher
Adis Press Limited
Type
Article
Article Version
Scholarly/refereed, publisher version
Metadata
Show full item recordAbstract
Prodrugs are pharmacologically inactive chemical derivatives of a drug molecule that require a transformation within the body in order to release the active drug. They are designed to overcome pharmaceutical and/or pharmacokinetically based problems associated with the parent drug molecule that would otherwise limit the clinical usefulness of
the drug.
The scientific rationale, based on clinical pharmaceutical and chemical experience,
for the design of various currently used prodrugs is presented in this review. The examples presented are by no means comprehensive, but are representative of the different ways in which the prodrug approach has been used to enhance the clinical efficacy of various drug molecules.
Description
This is the published version, also available from the publisher at http://adisonline.com/drugs/Abstract/1985/29050/Prodrugs__Do_They_Have_Advantages_in_Clinical.2.aspx
ISSN
0012-6667Collections
Citation
Prodrugs: Do They Have Advantages in Clinical Practice? V.J. Stella, W.N.A. Charman and V.H. Naringrekar, Drugs, 29, 455-473 (1985).
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