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dc.contributor.advisorWright, Douglas Een_US
dc.contributor.authorMuller, Karra
dc.date.accessioned2009-02-02T05:32:28Z
dc.date.available2009-02-02T05:32:28Z
dc.date.issued2008-11-17en_US
dc.date.submitted2008en_US
dc.identifier.otherhttp://dissertations2.umi.com/ku:2756en_US
dc.identifier.urihttp://hdl.handle.net/1808/4326en_US
dc.description.abstractPatients with large-fiber diabetic sensorimotor polyneuropathy (DPN) can develop altered sensorimotor function. Gait and balance control are regulated, in part, through large sensory nerves innervating muscle spindles. The overall goal was to characterize DPN in an animal model of diabetes and explore the hypothesis that the symptoms could be due to aberrant spindle innervation. We evaluated sensorimotor behavior in diabetic mice and used immunohistochemistry to quantify the Ia axon innervation of spindles. Diabetic mice displayed altered balance and were found to have variations in the morphology of Ia axons compared to very consistent spindle innervation in nondiabetics. Treatment with insulin successfully reversed sensorimotor deficits and decreased diabetes-driven spindle Ia innervation variability. Low-intensity aerobic exercise therapy also repaired sensorimotor deficits in diabetic mice, but had no effect on muscle spindle Ia axon innervation morphology. This work provides insight into large-fiber DPN, and will hopefully lead to future treatment strategies in humans.
dc.format.extent148 pagesen_US
dc.language.isoen_USen_US
dc.publisherUniversity of Kansasen_US
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.en_US
dc.subjectBiology
dc.subjectNeurosciences
dc.subjectBiology
dc.subjectAnatomy
dc.subjectMuscle spindle
dc.subjectDiabetic neuropathy
dc.subjectInsulin
dc.subjectExercise
dc.subjectDiabetes
dc.subjectSensorimotor
dc.titleCHARACTERIZATION & TREATMENT OF LARGE SENSORY FIBER PERIPHERAL NEUROPATHY IN DIABETIC MICE
dc.typeDissertationen_US
dc.contributor.cmtememberDurham, Dianne
dc.contributor.cmtememberFowler, Stephen C
dc.contributor.cmtememberKluding, Patricia
dc.contributor.cmtememberNishimune, Hiroshi
dc.thesis.degreeDisciplineAnatomy & Cell Biology
dc.thesis.degreeLevelPH.D.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
dc.rights.accessrightsopenAccessen_US


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