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    CHARACTERIZATION & TREATMENT OF LARGE SENSORY FIBER PERIPHERAL NEUROPATHY IN DIABETIC MICE

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    umi-ku-2756_1.pdf (6.385Mb)
    Issue Date
    2008-11-17
    Author
    Muller, Karra
    Publisher
    University of Kansas
    Format
    148 pages
    Type
    Dissertation
    Degree Level
    PH.D.
    Discipline
    Anatomy & Cell Biology
    Rights
    This item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
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    Abstract
    Patients with large-fiber diabetic sensorimotor polyneuropathy (DPN) can develop altered sensorimotor function. Gait and balance control are regulated, in part, through large sensory nerves innervating muscle spindles. The overall goal was to characterize DPN in an animal model of diabetes and explore the hypothesis that the symptoms could be due to aberrant spindle innervation. We evaluated sensorimotor behavior in diabetic mice and used immunohistochemistry to quantify the Ia axon innervation of spindles. Diabetic mice displayed altered balance and were found to have variations in the morphology of Ia axons compared to very consistent spindle innervation in nondiabetics. Treatment with insulin successfully reversed sensorimotor deficits and decreased diabetes-driven spindle Ia innervation variability. Low-intensity aerobic exercise therapy also repaired sensorimotor deficits in diabetic mice, but had no effect on muscle spindle Ia axon innervation morphology. This work provides insight into large-fiber DPN, and will hopefully lead to future treatment strategies in humans.
    URI
    http://hdl.handle.net/1808/4326
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    • KU Med Center Dissertations and Theses [464]
    • Dissertations [4321]

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    785-864-8983
    KU Libraries
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    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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