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dc.contributor.advisorLiu, Weishi
dc.contributor.authorHe, Feng
dc.date.accessioned2008-09-08
dc.date.available2008-09-08
dc.date.issued2008-08-01
dc.date.submitted2008
dc.identifier.otherhttp://dissertations.umi.com/ku:2488
dc.identifier.urihttp://hdl.handle.net/1808/4128
dc.description.abstractWe study the event of ion flow through ion channel proteins modeled with a one-dimensional Poisson-Nernst-Planck system in presence of two or three types of ions with permanently charges located inside the channel. A singular parameter ε, related to the Debye length, is presented in the PNP system. In the case of two ions, the boundary conditions for the charged region can be specifically solved by solving a scaled algebraic equation. These conditions are then used to solve the PNP system numerically. Multiple solutions emerge from the computation and are probably indicative of more complex functions of ion channels. The system can be solved using numerical approaches and examples of these results are presented in this paper. The PNP system contains information of the current-voltage (I-V) relations of ion channels when reaching steady-state. Analysis of the I-V property is shown and some representative results discussed.
dc.format.extent52 pages
dc.language.isoEN
dc.publisherUniversity of Kansas
dc.rightsThis item is protected by copyright and unless otherwise specified the copyright of this thesis/dissertation is held by the author.
dc.subjectMathematics
dc.subjectPoisson-Nernst-Planck systems
dc.subjectIon channels
dc.titleAnalytical and Numerical Studies of One-Dimensional Poisson-Nernst-Planck Models for Ion Channels
dc.typeThesis
dc.contributor.cmtememberLiu, Weishi
dc.contributor.cmtememberHuang, Weizhang
dc.contributor.cmtememberVan Vleck, Erik
dc.thesis.degreeDisciplineMathematics
dc.thesis.degreeLevelM.A.
kusw.oastatusna
kusw.oapolicyThis item does not meet KU Open Access policy criteria.
kusw.bibid6857371
dc.rights.accessrightsopenAccess


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