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dc.contributor.authorHill, Tom
dc.contributor.authorKoseva, Boryana S.
dc.contributor.authorUnckless, Robert L.
dc.date.accessioned2020-11-19T17:30:07Z
dc.date.available2020-11-19T17:30:07Z
dc.date.issued2019-03-13
dc.identifier.citationHill, T., Koseva, B. S., & Unckless, R. L. (2019). The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes. Molecular biology and evolution, 36(7), 1405–1417. https://doi.org/10.1093/molbev/msz059en_US
dc.identifier.urihttp://hdl.handle.net/1808/30890
dc.descriptionThis is a pre-copyedited, author-produced version of an article accepted for publication in Molecular Biology and Evolution following peer review. The version of record Hill, T., Koseva, B. S., & Unckless, R. L. (2019). The Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genes. Molecular biology and evolution, 36(7), 1405–1417. https://doi.org/10.1093/molbev/msz059 is available online at: doi.org/10.1093/molbev/msz059. This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.en_US
dc.description.abstractPathogenic microbes can exert extraordinary evolutionary pressure on their hosts. They can spread rapidly and sicken or even kill their host to promote their own proliferation. Because of this strong selective pressure, immune genes are some of the fastest evolving genes across metazoans, as highlighted in mammals and insects. Drosophila melanogaster serves as a powerful model for studying host/pathogen evolution. While Drosophila melanogaster are frequently exposed to various pathogens, little is known about D. melanogaster’s ecology, or if they are representative of other Drosophila species in terms of pathogen pressure. Here, we characterize the genome of Drosophila innubila, a mushroom-feeding species highly diverged from D. melanogaster and investigate the evolution of the immune system. We find substantial differences in the rates of evolution of immune pathways between D. innubila and D. melanogaster. Contrasting what was previously found for D. melanogaster, we find little evidence of rapid evolution of the antiviral RNAi genes and high rates of evolution in the Toll pathway. This suggests that, while immune genes tend to be rapidly evolving in most species, the specific genes that are fastest evolving may depend either on the pathogens faced by the host and/or divergence in the basic architecture of the host’s immune system.en_US
dc.description.sponsorshipNIH Grant P20 GM103638en_US
dc.description.sponsorshipP20 GM103418en_US
dc.description.sponsorshipMax Kade foundation postdoctoral fellowshipen_US
dc.description.sponsorshipNIH grant P20 GM103418en_US
dc.description.sponsorshipNIH R00 GM114714en_US
dc.description.sponsorshipNIH R01 AI139154en_US
dc.publisherSociety for Molecular Biology and Evolutionen_US
dc.rightsCopyright © 2020 Society for Molecular Biology and Evolutionen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/en_US
dc.subjectDrosophilaen_US
dc.subjectViral immunityen_US
dc.subjectTollen_US
dc.subjectAntiviralen_US
dc.titleThe Genome of Drosophila innubila Reveals Lineage-Specific Patterns of Selection in Immune Genesen_US
dc.typeArticleen_US
kusw.kuauthorHill, Tom
kusw.kuauthorKoseva, Boryana S.
kusw.kuauthorUnckless, Robert L.
kusw.kudepartmentMolecular Biosciencesen_US
kusw.kudepartmentK-INBRE Bioinformatics Coreen_US
dc.identifier.doi10.1093/molbev/msz059en_US
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6573480en_US
dc.rights.accessrightsopenAccessen_US


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Except where otherwise noted, this item's license is described as: Copyright © 2020 Society for Molecular Biology and Evolution