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dc.contributor.authorAvram, Sarah K. Williams
dc.contributor.authorLee, Heon-Jin
dc.contributor.authorFastman, Jarrett
dc.contributor.authorCymerblit-Sabba, Adi
dc.contributor.authorSmith, Adam
dc.contributor.authorVincent, Matthew
dc.contributor.authorSong, June
dc.contributor.authorGranovetter, Michael C.
dc.contributor.authorLee, Su-Hyun
dc.contributor.authorCilz, Nicholas I.
dc.contributor.authorStackmann, Michelle
dc.contributor.authorChaturvedi, Rahul
dc.contributor.authorYoung, Scott
dc.date.accessioned2020-06-10T20:26:41Z
dc.date.available2020-06-10T20:26:41Z
dc.date.issued2019-11-08
dc.identifier.citationWilliams Avram, S. K., Lee, H. J., Fastman, J., Cymerblit-Sabba, A., Smith, A., Vincent, M., Song, J., Granovetter, M. C., Lee, S. H., Cilz, N. I., Stackmann, M., Chaturvedi, R., & Young, W. S. (2019). NMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggression. Frontiers in behavioral neuroscience, 13, 218. https://doi.org/10.3389/fnbeh.2019.00218en_US
dc.identifier.urihttp://hdl.handle.net/1808/30436
dc.descriptionThis work is licensed under a Creative Commons Attribution 4.0 International License.en_US
dc.description.abstractThe arginine vasopressin 1b receptor (Avpr1b) plays an important role in social behaviors including aggression, social learning and memory. Genetic removal of Avpr1b from mouse models results in deficits in aggression and short-term social recognition in adults. Avpr1b gene expression is highly enriched in the pyramidal neurons of the hippocampal cornu ammonis 2 (CA2) region. Activity of the hippocampal CA2 has been shown to be required for normal short-term social recognition and aggressive behaviors. Vasopressin acts to enhance synaptic responses of CA2 neurons through a NMDA-receptor dependent mechanism. Genetic removal of the obligatory subunit of the NMDA receptor (Grin1) within distinct hippocampal regions impairs non-social learning and memory. However, the question of a direct role for NMDA receptor activity in Avpr1b neurons to modulate social behavior remains unclear. To answer this question, we first created a novel transgenic mouse line with Cre recombinase knocked into the Avpr1b coding region to genetically target Avpr1b neurons. We confirmed this line has dense Cre expression throughout the dorsal and ventral CA2 regions of the hippocampus, along with scattered expression within the caudate-putamen and olfactory bulb (OB). Conditional removal of the NMDA receptor was achieved by crossing our line to an available floxed Grin1 line. The resulting mice were measured on a battery of social and memory behavioral tests. Surprisingly, we did not observe any differences between Avpr1b-Grin1 knockout mice and their wildtype siblings. We conclude that mice without typical NMDA receptor function in Avpr1b neurons can develop normal aggression as well as short-term social and object memory performance.en_US
dc.publisherFrontiers Mediaen_US
dc.rights© 2019 Williams Avram, Lee, Fastman, Cymerblit-Sabba, Smith, Vincent, Song, Granovetter, Lee, Cilz, Stackmann, Chaturvedi and Young.en_US
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.subjectVasopressinen_US
dc.subjectAvpr1ben_US
dc.subjectNMDAen_US
dc.subjectAggressionen_US
dc.subjectSocial memoryen_US
dc.subjectCA2en_US
dc.subjectHippocampusen_US
dc.subjectSocial interactionen_US
dc.titleNMDA Receptor in Vasopressin 1b Neurons Is Not Required for Short-Term Social Memory, Object Memory or Aggressionen_US
dc.typeArticleen_US
kusw.kuauthorSmith, Adam
kusw.kudepartmentPharmacology & Toxicologyen_US
dc.identifier.doi10.3389/fnbeh.2019.00218en_US
kusw.oaversionScholarly/refereed, publisher versionen_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US
dc.identifier.pmidPMC6856057en_US
dc.rights.accessrightsopenAccessen_US


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© 2019 Williams Avram, Lee, Fastman, Cymerblit-Sabba, Smith, Vincent, Song, Granovetter, Lee, Cilz, Stackmann, Chaturvedi and Young.
Except where otherwise noted, this item's license is described as: © 2019 Williams Avram, Lee, Fastman, Cymerblit-Sabba, Smith, Vincent, Song, Granovetter, Lee, Cilz, Stackmann, Chaturvedi and Young.