Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses
dc.contributor.author | Zhang, Haonan | |
dc.contributor.author | Xie, Xinyi | |
dc.contributor.author | Li, Jia | |
dc.contributor.author | Qin, Yu | |
dc.contributor.author | Zhang, Wei | |
dc.contributor.author | Cheng, Qian | |
dc.contributor.author | Yuan, Songtao | |
dc.contributor.author | Liu, Qinghuai | |
dc.contributor.author | Paulus, Yannis M. | |
dc.contributor.author | Wang, Xueding | |
dc.contributor.author | Yang, Xinmai | |
dc.date.accessioned | 2019-11-25T15:10:19Z | |
dc.date.available | 2019-11-25T15:10:19Z | |
dc.date.issued | 2018-08-27 | |
dc.identifier.citation | Zhang, Haonan et al. “Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses.” Scientific reports vol. 8,1 12848. 27 Aug. 2018, doi:10.1038/s41598-018-31045-w | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/29805 | |
dc.description.abstract | Pathologic microvasculature plays a crucial role in innumerable diseases causing death and major organ impairment. A major clinical challenge is the development of selective therapies to remove these diseased microvessels without damaging surrounding tissue. This report describes our development of novel photo-mediated ultrasound therapy (PUT) technology for precisely removing choroidal blood vessels in the eye. PUT selectively removes microvessels by concurrently applying nanosecond laser pulses with ultrasound bursts. In PUT experiments on rabbit eyes in vivo, we applied 55–75 mJ/cm2 of light fluence at the retinochoroidal surface at 532-nm and 0.5 MPa of ultrasound pressure at 0.5 MHz. PUT resulted in significantly reduced blood perfusion in the choroidal layer which persisted to four weeks without causing collateral tissue damage, demonstrating that PUT is capable of removing choroidal microvasculature safely and effectively. With its unique advantages, PUT holds potential for the clinical management of eye diseases associated with microvessels and neovascularization. | en_US |
dc.description.sponsorship | National Eye Institute 4K12EY022299 (YMP) | en_US |
dc.description.sponsorship | National Nature Science Foundation of China through grant No. 81770973, No. 11574231 and No. 11674239. | en_US |
dc.publisher | Nature Research | en_US |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2018 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.title | Removal of choroidal vasculature using concurrently applied ultrasound bursts and nanosecond laser pulses | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Yang, Xinmai | |
kusw.kudepartment | Mechanical Engineering | en_US |
dc.identifier.doi | 10.1038/s41598-018-31045-w | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-9212-0664 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0003-4257-8970 | en_US |
dc.identifier.orcid | https://orcid.org/0000-0001-8120-6593 | en_US |
kusw.oaversion | Scholarly/refereed, author accepted manuscript | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.identifier.pmid | PMC6110758 | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: Open Access This article is licensed under a Creative Commons Attribution 4.0 International
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article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the
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by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the
copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2018