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dc.contributor.authorHiggins, Stephen T.
dc.contributor.authorBergeria, Cecilia L.
dc.contributor.authorDavis, Danielle R.
dc.contributor.authorStreck, Joanna M.
dc.contributor.authorVillanti, Andrea C.
dc.contributor.authorHughes, John R.
dc.contributor.authorSigmon, Stacey C.
dc.contributor.authorTidey, Jennifer W.
dc.contributor.authorHeil, Sarah H.
dc.contributor.authorGaalema, Diann E.
dc.contributor.authorStitzer, Maxine L.
dc.contributor.authorPriest, Jeff S.
dc.contributor.authorSkelly, Joan M.
dc.contributor.authorReed, Derek D.
dc.contributor.authorBunn, Janice Y.
dc.contributor.authorTromblee, Morgan A.
dc.contributor.authorArger, Christopher A.
dc.contributor.authorMiller, Mollie E.
dc.identifier.citationHiggins, S. T., Bergeria, C. L., Davis, D. R., Streck, J. M., Villanti, A. C., Hughes, J. R., … Miller, M. E. (2018). Response to reduced nicotine content cigarettes among smokers differing in tobacco dependence severity. Preventive medicine, 117, 15–23. doi:10.1016/j.ypmed.2018.04.010en_US
dc.description.abstractThis study examines whether tobacco dependence severity moderates the acute effects of reducing nicotine content in cigarettes on the addiction potential of smoking, craving/withdrawal, or smoking topography. Participants (N = 169) were daily smokers with mild, moderate, or high tobacco-dependence severity using the Heaviness of Smoking Index. Following brief abstinence, participants smoked research cigarettes varying in nicotine content (0.4, 2.4, 5.2, 15.8 mg nicotine/g tobacco) in a within-subject design. Results were analyzed using repeated measures analysis of co-variance. No main effects of dependence severity or interactions with nicotine dose were noted in relative reinforcing effects in concurrent choice testing or subjective effects on the modified Cigarette Evaluation Questionnaire. Demand for smoking in the Cigarette Purchase Task was greater among more dependent smokers, but reducing nicotine content decreased demand independent of dependence severity. Dependence severity did not significantly alter response to reduced nicotine content cigarettes on the Minnesota Tobacco Withdrawal Scale nor Questionnaire of Smoking Urges-brief (QSU) Factor-2 scale; dependence severity and dose interacted significantly on the QSU-brief Factor-1 scale, with reductions dependent on dose among highly but not mildly or moderately dependent smokers. Dependence severity and dose interacted significantly on only one of six measures of smoking topography (i.e., maximum flow rate), which increased as dose increased among mildly and moderately but not highly dependent smokers. These results suggest that dependence severity has no moderating influence on the ability of reduced nicotine content cigarettes to lower the addiction potential of smoking, and minimal effects on relief from craving/withdrawal or smoking topography.en_US
dc.rights© 2018 Published by Elsevier Inc.en_US
dc.subjectTobacco dependenceen_US
dc.subjectDependence severityen_US
dc.subjectHeaviness of Smoking Indexen_US
dc.subjectCigarette smokingen_US
dc.subjectReduced nicotine content cigarettesen_US
dc.subjectSmoking topographyen_US
dc.subjectVulnerable populationsen_US
dc.titleResponse to reduced nicotine content cigarettes among smokers differing in tobacco dependence severityen_US
kusw.kuauthorReed, Derek R.
kusw.kudepartmentApplied Behavioral Scienceen_US
kusw.oanotesPer SHERPA/RoMEO 11/01/2019 Author's Pre-print: green tick author can archive pre-print (ie pre-refereeing) Author's Post-print: green tick author can archive post-print (ie final draft post-refereeing) Publisher's Version/PDF: cross author cannot archive publisher's version/PDF General Conditions:

Authors pre-print on any website, including arXiv and RePEC Author's post-print on author's personal website immediately Author's post-print on open access repository after an embargo period of 12 months Permitted deposit due to Funding Body, Institutional and Governmental policy or mandate, may be required to comply with embargo period of 12 months Author's post-print may be used to update arXiv and RepEC Publisher's version/PDF cannot be used Must link to publisher version with DOI Author's post-print must be released with a Creative Commons Attribution Non-Commercial No Derivatives License
kusw.oaversionScholarly/refereed, author accepted manuscripten_US
kusw.oapolicyThis item meets KU Open Access policy criteria.en_US

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