Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass
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Issue Date
2018-09-07Author
Funk, Graham A.
Burkes, Jonathan C.
Cole, Kimberly A.
Rahaman, Mohamed N.
McIff, Terence E.
Publisher
Ivyspring International Publisher
Type
Article
Article Version
Scholarly/refereed, publisher version
Rights
This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
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Show full item recordAbstract
Introduction: Local delivery of antibiotics using bone cement as the delivery vehicle is an
established method of managing implant-associated orthopedic infections. Various fillers have been
added to cement to increase antibiotic elution, but they often do so at the expense of strength. This
study evaluated the effect of adding a borate bioactive glass, previously shown to promote bone
formation, on vancomycin elution from PMMA bone cement.
Methods: Five cement composites were made: three loaded with borate bioactive glass along with
0, 1, and 5 grams of vancomycin and two without any glass but with 1 and 5 grams vancomycin to
serve as controls. The specimens were soaked in PBS. Eluate of vancomycin was collected every 24
hours and analyzed by HPLC. Orthopedic-relevant mechanical properties of each composite were
tested over time.
Results: The addition of borate bioactive glass provided an increase in vancomycin release at Day 1
and an increase in sustained vancomycin release throughout the treatment period. An 87.6% and
21.1% increase in cumulative vancomycin release was seen for both 1g and 5g loading groups,
respectively. Compressive strength of all composites remained above the weight-bearing threshold
of 70 MPa throughout the duration of the study with the glass-containing composites showing
comparable strength to their respective controls.
Conclusion: The incorporation of borate bioactive glass into commercial PMMA bone cement can
significantly increase the elution of vancomycin. The mechanical strength of the cement-glass
composites remained above 70 MPa even after soaking for 8 weeks, suggesting their suitability for
orthopedic weight-bearing applications.
Description
A grant from the One-University Open Access Fund at the University of Kansas was used to defray the author's publication fees in this Open Access journal. The Open Access Fund, administered by librarians from the KU, KU Law, and KUMC libraries, is made possible by contributions from the offices of KU Provost, KU Vice Chancellor for Research & Graduate Studies, and KUMC Vice Chancellor for Research. For more information about the Open Access Fund, please see http://library.kumc.edu/authors-fund.xml.
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Citation
Funk GA, Burkes JC, Cole KA, Rahaman MN, McIff TE. Antibiotic Elution and Mechanical Strength of PMMA Bone Cement Loaded With Borate Bioactive Glass. J Bone Jt Infect 2018; 3(4):187-196. doi:10.7150/jbji.27348. Available from http://www.jbji.net/v03p0187.htm
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