Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome
dc.contributor.author | Gu, Liuqi | |
dc.contributor.author | Walters, James R. | |
dc.contributor.author | Knipple, Douglas C | |
dc.date.accessioned | 2018-11-16T19:41:20Z | |
dc.date.available | 2018-11-16T19:41:20Z | |
dc.date.issued | 2017-03-01 | |
dc.identifier.citation | Liuqi Gu, James R. Walters, Douglas C. Knipple; Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome, Genome Biology and Evolution, Volume 9, Issue 3, 1 March 2017, Pages 802–816, https://doi.org/10.1093/gbe/evx039 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/27388 | |
dc.description.abstract | Where previously described, patterns of sex chromosome dosage compensation in the Lepidoptera (moths and butterflies) have several unusual characteristics. Other female-heterogametic (ZW/ZZ) species exhibit female Z-linked expression that is reduced compared with autosomal expression and male Z expression. In the Lepidoptera, however, Z expression typically appears balanced between sexes but overall reduced relative to autosomal expression, that is Z ≈ ZZ < AA. This pattern is not easily reconciled with theoretical expectations for the evolution of sex chromosome dosage compensation. Moreover, conflicting results linger due to discrepancies in data analyses and tissues sampled among lepidopterans. To address these issues, we performed RNA-seq to analyze sex chromosome dosage compensation in the codling moth, Cydia pomonella, which is a species from the earliest diverging lepidopteran lineage yet examined for dosage compensation and has a neo-Z chromosome resulting from an ancient Z:autosome fusion. While supported by intraspecific analyses, the Z ≈ ZZ < AA pattern was further evidenced by comparative study using autosomal orthologs of C. pomonella neo-Z genes in outgroup species. In contrast, dosage compensation appears to be absent in reproductive tissues. We thus argue that inclusion of reproductive tissues may explain the incongruence from a prior study on another moth species and that patterns of dosage compensation are likely conserved in the Lepidoptera. Notably, this pattern appears convergent with patterns in eutherian mammals (X ≈ XX < AA). Overall, our results contribute to the notion that the Lepidoptera present challenges both to classical theories regarding the evolution of sex chromosome dosage compensation and the emerging view of the association of dosage compensation with sexual heterogamety | en_US |
dc.description.sponsorship | 6217449 | en_US |
dc.description.sponsorship | 1398103-00514 | en_US |
dc.description.sponsorship | NSF-DEB 1457758 | en_US |
dc.publisher | Oxford University Press | en_US |
dc.rights | © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ | en_US |
dc.subject | Cydia pomonella | en_US |
dc.subject | Lepidoptera | en_US |
dc.subject | Sex chromosome dosage compensation | en_US |
dc.subject | Neo-Z chromosome | en_US |
dc.subject | Sex-biased gene expression | en_US |
dc.title | Conserved Patterns of Sex Chromosome Dosage Compensation in the Lepidoptera (WZ/ZZ): Insights from a Moth Neo-Z Chromosome | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Walters, James R. | |
kusw.kudepartment | Ecology and Evolutionary Biology | en_US |
dc.identifier.doi | 10.1093/gbe/evx039 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.