Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders
dc.contributor.author | D'Cruz, Anna-Maria | |
dc.contributor.author | Mosconi, Matthew W. | |
dc.contributor.author | Ragozzino, M. E. | |
dc.contributor.author | Cook, Edwin H. | |
dc.contributor.author | Sweeney, John A. | |
dc.date.accessioned | 2017-11-20T18:01:47Z | |
dc.date.available | 2017-11-20T18:01:47Z | |
dc.date.issued | 2016-10-11 | |
dc.identifier.citation | Dcruz, A., Mosconi, M. W., Ragozzino, M. E., Cook, E. H., & Sweeney, J. A. (2016). Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders. Translational Psychiatry, 6(10). doi:10.1038/tp.2016.161 | en_US |
dc.identifier.uri | http://hdl.handle.net/1808/25443 | |
dc.description.abstract | Restricted and repetitive behaviors, and a pronounced preference for behavioral and environmental consistency, are distinctive characteristics of autism spectrum disorder (ASD). Alterations in frontostriatal circuitry that supports flexible behavior might underlie this behavioral impairment. In an functional magnetic resonance imaging study of 17 individuals with ASD, and 23 age-, gender- and IQ-matched typically developing control participants, reversal learning tasks were used to assess behavioral flexibility as participants switched from one learned response choice to a different response choice when task contingencies changed. When choice outcome after reversal was uncertain, the ASD group demonstrated reduced activation in both frontal cortex and ventral striatum, in the absence of task performance differences. When the outcomes of novel responses were certain, there was no difference in brain activation between groups. Reduced activation in frontal cortex and ventral striatum suggest problems in decision-making and response planning, and in processing reinforcement cues, respectively. These processes, and their integration, are essential for flexible behavior. Alterations in these systems may therefore contribute to a rigid adherence to preferred behavioral patterns in individuals with an ASD. These findings provide an additional impetus for the use of reversal learning paradigms as a translational model for treatment development targeting the domain of restricted and repetitive behaviors in ASD. | en_US |
dc.publisher | Nature Publishing Group | en_US |
dc.rights | © The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | Autism spectrum disorders | en_US |
dc.subject | Human behaviour | en_US |
dc.title | Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorders | en_US |
dc.type | Article | en_US |
kusw.kuauthor | Mosconi, Matthew W. | |
kusw.kudepartment | Life Span Institute | en_US |
dc.identifier.doi | 10.1038/tp.2016.161 | en_US |
kusw.oaversion | Scholarly/refereed, publisher version | en_US |
kusw.oapolicy | This item meets KU Open Access policy criteria. | en_US |
dc.rights.accessrights | openAccess | en_US |
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Except where otherwise noted, this item's license is described as: © The Author(s) 2016 This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/