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    Grafting MAP peptide to dental polymer inhibits MMP-8 activity

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    Dixit_Wiley_2015.pdf (597.1Kb)
    Issue Date
    2015-02
    Author
    Dixit, Namrata
    Settle, Jenifer K.
    Ye, Qiang
    Berrie, Cindy L.
    Spencer, Paulette
    Laurence, Jennifer S.
    Publisher
    Wiley
    Type
    Article
    Article Version
    Scholarly/refereed, author accepted manuscript
    Rights
    This is the peer reviewed version of the following article: Dixit, N., Settle, J. K., Ye, Q., Berrie, C. L., Spencer, P., & Laurence, J. S. (2015). Grafting MAP peptide to dental polymer inhibits MMP-8 activity. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 103(2), 324–331. http://doi.org/10.1002/jbm.b.33205, which has been published in final form at http://doi.org/10.1002/jbm.b.33205. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
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    Abstract
    Matrix metalloproteinases (MMPs) are a class of zinc and calcium-dependent endopeptidases responsible for degrading extracellular matrix (ECM) components. Their activity is critical for both normal biological function and pathological processes (Dejonckheere et al., Cytokine Growth Factor Rev 2011;22:73–81). In dental restorations, the release and subsequent acid activation of MMPs contributes to premature failure. In particular, MMP-8 accelerates degradation by cleaving the collagen matrix within the dentin substrate in incompletely infiltrated aged bonded dentin (Buzalaf et al., Adv Dent Res 2012;24:72–76), hastening the need for replacement of restorations. Therefore, development of a dental adhesive that better resists MMP-8 activity is of significant interest. We hypothesize that modification of the polymer surface with an inhibitor would disable MMP-8 activity. Here, we identify the metal abstraction peptide (MAP) as an inhibitor of MMP-8 and demonstrate that tethering MAP to methacrylate polymers effectively inhibits catalysis. Our findings indicate complete inhibition of MMP-8 is achievable using a grafting approach. This strategy has potential to improve longevity of dental adhesives and other polymers and enable rational design of a new generation of biocompatible materials.
    URI
    http://hdl.handle.net/1808/24884
    DOI
    https://doi.org/10.1002/jbm.b.33205
    Collections
    • Bioengineering Program Scholarly Works [146]
    Citation
    Dixit, N., Settle, J. K., Ye, Q., Berrie, C. L., Spencer, P., & Laurence, J. S. (2015). Grafting MAP peptide to dental polymer inhibits MMP-8 activity. Journal of Biomedical Materials Research. Part B, Applied Biomaterials, 103(2), 324–331. http://doi.org/10.1002/jbm.b.33205

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    Contact KU ScholarWorks
    785-864-8983
    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    785-864-8983

    KU Libraries
    1425 Jayhawk Blvd
    Lawrence, KS 66045
    Image Credits
     

     

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